IT1250411B - Oligopeptidi eterociclici dotati di attivita' antitumorale - Google Patents
Oligopeptidi eterociclici dotati di attivita' antitumoraleInfo
- Publication number
- IT1250411B IT1250411B ITMI910572A ITMI910572A IT1250411B IT 1250411 B IT1250411 B IT 1250411B IT MI910572 A ITMI910572 A IT MI910572A IT MI910572 A ITMI910572 A IT MI910572A IT 1250411 B IT1250411 B IT 1250411B
- Authority
- IT
- Italy
- Prior art keywords
- hydrogen
- formula
- previously defined
- heterocyclic
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Quinoline Compounds (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
L'invenzione si riferisce a derivati di oligopeptidi eterociclici con attività citostatica di formula: (FORMULA I) in cui A è idrogeno; -NHCOR1 in cui R1 è un gruppo acrilico sostituito in posizione 2 con alogeno, ossiranile non sostituito o sostituito in posizione 2 o 3 con metile, aziridinile, ciclopropile, 4 - [N, N - bis - (2 - cloroetil) amino] fenile, un chetone aliciclico ? ? - insaturo oppure un lattone;(FORMULA) in cui R2 e R3 hanno entrambi lo stesso significato di gruppo alchile C2 - C4 sostituito in posizione 2 con alogeno o con un gruppo - OSO2R4, in cui R4 è alchile C2 -C4 oppure un gruppo fenile, oppure uno di R2 e R3 è idrogeno e l'altro ha il significato precedentemente definito;B è idrogeno ; - (CH2) NHCOR1, in cui R1 è quello precedentemente definito ed m ha il valore zero oppure è un numero intero da 1 a 3;purchè quando A è idrogeno B sia diverso da idrogeno, e quando A ha gli altri significati come precedentemente definiti ad eccezione di idrogeno, B sia soltanto idrogeno; Z e Z' sono ciascuno, indipendentemente, - CH= oppure - CH=CH-; X ed X' sono ciascuno, indipendentemente, N, O oppure S; e n è zero o 1; e loro esomeri e sali farmaceuticamente accettabili, e metodo e intermedi per il loro ottenimento.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9005529A GB2241950B (en) | 1990-03-12 | 1990-03-12 | Heterocyclic oligopeptides endowed with antitumor activity |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI910572A0 ITMI910572A0 (it) | 1991-03-05 |
ITMI910572A1 ITMI910572A1 (it) | 1991-09-13 |
IT1250411B true IT1250411B (it) | 1995-04-07 |
Family
ID=10672473
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI910572A IT1250411B (it) | 1990-03-12 | 1991-03-05 | Oligopeptidi eterociclici dotati di attivita' antitumorale |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPH05148227A (it) |
DE (1) | DE4106860A1 (it) |
GB (1) | GB2241950B (it) |
IT (1) | IT1250411B (it) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006511562A (ja) * | 2002-12-20 | 2006-04-06 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 泌尿器系疾患の処置のための置換2,5−ジアミドインドール類の使用 |
WO2016025692A1 (en) * | 2014-08-13 | 2016-02-18 | The Scripps Research Institute | Treatment of c9ftd/als by targeting rna expanded repeat sequences |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1521471A (en) * | 1974-06-05 | 1978-08-16 | Randall & Son Ltd J | Token-deposit locks |
-
1990
- 1990-03-12 GB GB9005529A patent/GB2241950B/en not_active Expired - Fee Related
-
1991
- 1991-03-04 DE DE4106860A patent/DE4106860A1/de not_active Withdrawn
- 1991-03-05 IT ITMI910572A patent/IT1250411B/it active IP Right Grant
- 1991-03-07 JP JP3067875A patent/JPH05148227A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DE4106860A1 (de) | 1991-09-19 |
ITMI910572A0 (it) | 1991-03-05 |
JPH05148227A (ja) | 1993-06-15 |
GB2241950A (en) | 1991-09-18 |
GB2241950B (en) | 1993-05-12 |
ITMI910572A1 (it) | 1991-09-13 |
GB9005529D0 (en) | 1990-05-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970310 |