IT1243859B - Composizioni farmaceutiche comprendenti associazioni fra sali di s-adenosil-l-metionina e acido 5-metil (o 5-formil)-tetraidrofolico per la terapia di complicanze neurologiche negli ammalati di aids. - Google Patents

Composizioni farmaceutiche comprendenti associazioni fra sali di s-adenosil-l-metionina e acido 5-metil (o 5-formil)-tetraidrofolico per la terapia di complicanze neurologiche negli ammalati di aids.

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Publication number
IT1243859B
IT1243859B IT02183390A IT2183390A IT1243859B IT 1243859 B IT1243859 B IT 1243859B IT 02183390 A IT02183390 A IT 02183390A IT 2183390 A IT2183390 A IT 2183390A IT 1243859 B IT1243859 B IT 1243859B
Authority
IT
Italy
Prior art keywords
adenosyl
acid
formyl
methyl
pharmaceutical compositions
Prior art date
Application number
IT02183390A
Other languages
English (en)
Other versions
IT9021833A1 (it
IT9021833A0 (it
Inventor
Greca Pietro La
Original Assignee
Bioresearch Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioresearch Spa filed Critical Bioresearch Spa
Publication of IT9021833A0 publication Critical patent/IT9021833A0/it
Priority to IT02183390A priority Critical patent/IT1243859B/it
Priority to AT91117638T priority patent/ATE199319T1/de
Priority to DE69132542T priority patent/DE69132542T2/de
Priority to EP91117638A priority patent/EP0482493B1/en
Priority to FI914919A priority patent/FI914919L/fi
Priority to ZA918355A priority patent/ZA918355B/xx
Priority to CA002053826A priority patent/CA2053826C/en
Priority to AU86708/91A priority patent/AU645854B2/en
Priority to PT99300A priority patent/PT99300B/pt
Priority to NO914157A priority patent/NO914157D0/no
Priority to JP30260091A priority patent/JP3289928B2/ja
Priority to KR1019910018639A priority patent/KR100187992B1/ko
Publication of IT9021833A1 publication Critical patent/IT9021833A1/it
Priority to US08/108,005 priority patent/US6093703A/en
Application granted granted Critical
Publication of IT1243859B publication Critical patent/IT1243859B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT02183390A 1990-10-23 1990-10-23 Composizioni farmaceutiche comprendenti associazioni fra sali di s-adenosil-l-metionina e acido 5-metil (o 5-formil)-tetraidrofolico per la terapia di complicanze neurologiche negli ammalati di aids. IT1243859B (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
IT02183390A IT1243859B (it) 1990-10-23 1990-10-23 Composizioni farmaceutiche comprendenti associazioni fra sali di s-adenosil-l-metionina e acido 5-metil (o 5-formil)-tetraidrofolico per la terapia di complicanze neurologiche negli ammalati di aids.
AT91117638T ATE199319T1 (de) 1990-10-23 1991-10-15 Pharmazeutische zusammensetzung mit therapeutischer wirkung auf die neuronalen schädigungen in aids-patienten, enthaltend als wirkstoff wenigstens ein salz von s-adenosyl-l- methionine.
DE69132542T DE69132542T2 (de) 1990-10-23 1991-10-15 Pharmazeutische Zusammensetzung mit therapeutischer Wirkung auf die neuronalen Schädigungen in Aids-Patienten, enthaltend als Wirkstoff wenigstens ein Salz von S-Adenosyl-L-methionine.
EP91117638A EP0482493B1 (en) 1990-10-23 1991-10-15 Pharmaceutical compositions active in the therapy of neurological affections in aids patients, containing as an active principle at least S-adenosyl-L-methionine salt.
FI914919A FI914919L (fi) 1990-10-23 1991-10-18 Farmaceutiska kompositioner som aer aktiva vid behandling av aids-patienters neurologiska sjukdomar, vilka kompositioner innehaoller, som ett paoverkande aemne aotminstone en foerening som valts fraon en grupp som bestaor av s-adenosyl-l-metioninsalt, 5- metyltetrahydrofolsyra och 5-formyltetrahydrofolsyra
ZA918355A ZA918355B (en) 1990-10-23 1991-10-18 Pharmaceutical compositions active in the therapy of neurological affections in aids patients,containing as an active principle at least one compound selected from the group consisting of s-adenosyl-l-methionine salt,5-methyl-tetrahydrofolic acid,5-formyltetrahydrofolic acid
CA002053826A CA2053826C (en) 1990-10-23 1991-10-21 Pharmaceutical compositions active in the therapy of neurological affections in aids patients
AU86708/91A AU645854B2 (en) 1990-10-23 1991-10-22 Pharmaceutical compositions active in the therapy of neurological affections in aids patients, containing as an active principle at least one compound selected from the group consisting of S-adenosyl-L-methionine salt, 5-methyl- tetrahydrofolic acid, 5-formyltetrahydrofolic acid
PT99300A PT99300B (pt) 1990-10-23 1991-10-22 Processo para a preparacao de composicoes farmaceuticas para a terapia de afeccoes neurologicas em doentes com sida que contem, como ingrediente activo, pelo menos um composto escolhido do grupo que consiste em sais de s-adenosilmetionina, acido 5-metiltetra-hidrofolico e acido 5-formiltetra-hidrofolico e os seus sais
NO914157A NO914157D0 (no) 1990-10-23 1991-10-23 Fremgangsmaate for fremstilling av et farmasoeytisk preparat
JP30260091A JP3289928B2 (ja) 1990-10-23 1991-10-23 Ｓ−アデノシル−ｌ−メチオニン塩、５−メチル−テトラヒドロ葉酸、５−ホルミルテトラヒドロ葉酸から成る群から選択される少なくとも１つの化合物を活性成分として含む、ａｉｄｓ患者の神経障害の治療に有効な医薬組成物
KR1019910018639A KR100187992B1 (ko) 1990-10-23 1991-10-23 S-아데노실-l-메티오닌 염, 5-메틸테트라하이드로폴산 및 5-포르밀테트라하이드로폴산으로 이루어진 그룹으로부터 선택된 하나 이상의 화합물을 활성 성분으로서 함유하는, aids환자의 신경학적 질환의 치료시 활성을 나타내는 약제학적 조성물
US08/108,005 US6093703A (en) 1990-10-23 1993-08-18 Pharmaceutical compositions, containing S-adenosyl-L-methionine salt, 5-methyl-tetrahydrofolic acid and 5-formyltetrahydrofolic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02183390A IT1243859B (it) 1990-10-23 1990-10-23 Composizioni farmaceutiche comprendenti associazioni fra sali di s-adenosil-l-metionina e acido 5-metil (o 5-formil)-tetraidrofolico per la terapia di complicanze neurologiche negli ammalati di aids.

Publications (3)

Publication Number Publication Date
IT9021833A0 IT9021833A0 (it) 1990-10-23
IT9021833A1 IT9021833A1 (it) 1992-04-23
IT1243859B true IT1243859B (it) 1994-06-28

Family

ID=11187495

Family Applications (1)

Application Number Title Priority Date Filing Date
IT02183390A IT1243859B (it) 1990-10-23 1990-10-23 Composizioni farmaceutiche comprendenti associazioni fra sali di s-adenosil-l-metionina e acido 5-metil (o 5-formil)-tetraidrofolico per la terapia di complicanze neurologiche negli ammalati di aids.

Country Status (13)

Country Link
US (1) US6093703A (it)
EP (1) EP0482493B1 (it)
JP (1) JP3289928B2 (it)
KR (1) KR100187992B1 (it)
AT (1) ATE199319T1 (it)
AU (1) AU645854B2 (it)
CA (1) CA2053826C (it)
DE (1) DE69132542T2 (it)
FI (1) FI914919L (it)
IT (1) IT1243859B (it)
NO (1) NO914157D0 (it)
PT (1) PT99300B (it)
ZA (1) ZA918355B (it)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5660835A (en) * 1995-02-24 1997-08-26 East Carolina University Method of treating adenosine depletion
ES2218662T3 (es) * 1996-01-31 2004-11-16 South Alabama Medical Science Foundation Preparaciones de alimento y vitaminas que contienen isomeros naturales de folatos reducidos.
DE19628514C1 (de) * 1996-07-05 1997-09-25 E Dr Grundmann Kombination von S-Adenosylmethionin und Azidothymidin zur Hemmung der HIV-Replikation
DE19632823C1 (de) * 1996-08-14 1997-11-20 Symbio Herborn Group Gmbh & Co Komplexe zwischen S-(+)-Adenosylmethionin und 3'-Azido-2',3'-didesoxynucleosid als potente Inhibitoren der HIV-Replikation
US7071230B2 (en) 1997-10-02 2006-07-04 Board Of Trustees Of Southern Illinois University Therapeutic use of D-methionine to reduce the toxicity of noise
US8642581B1 (en) 2000-02-11 2014-02-04 Brian D. Halevie-Goldman Compositions and methods for the production of S-adenosylmethionine within the body
IT1317920B1 (it) * 2000-10-20 2003-07-15 Univ Roma S-adenosilmetionina e suoi derivati per il trattamento e laprevenzione della malattia di alzheimer.
US6759395B2 (en) 2000-12-18 2004-07-06 Orchid Chemicals & Pharmaceuticals, Ltd. Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same
ITMI20012462A1 (it) * 2001-11-22 2003-05-22 Gnosis Srl Processo per la preparazione di compresse comprendenti s-adenosilmetionina
US20030155045A1 (en) * 2002-02-05 2003-08-21 Williams Peter C. Lubricated low temperature carburized stainless steel parts
JP4956942B2 (ja) * 2004-09-15 2012-06-20 ニプロ株式会社 安定化された注射用水溶液製剤
CN1748704B (zh) * 2004-09-15 2011-05-04 尼普洛株式会社 注射用水溶液制剂及其稳定化方法
ITMI20050485A1 (it) * 2005-03-23 2006-09-24 Truffini & Regge Farmaceutici Formulazioni granulari rivestite
FR2884421B1 (fr) 2005-04-15 2007-08-10 Virbac Sa Nouveaux moyens de regulation des troubles du comportement chez les animaux de compagnie
EP1874937A2 (en) * 2005-04-20 2008-01-09 BASF Plant Science GmbH Expression cassettes for seed-preferential expression in plants
WO2006119589A2 (en) * 2005-05-11 2006-11-16 Ramaekers, Vincent Prevention and therapy of cerebral folate deficiency
ITMI20060629A1 (it) * 2006-03-31 2007-10-01 Daniele Giovannone Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento
US20090088404A1 (en) * 2007-01-31 2009-04-02 Methylation Sciences International Srl Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
EP2189154A1 (en) * 2008-11-25 2010-05-26 Gnosis S.p.A. Effervescent tablets and mouth-soluble granulates of S-adenosyl methionine and process for the preparation thereof
CN101862333B (zh) * 2009-04-20 2013-07-24 天津药物研究院 左亚叶酸钠稳定的口服制剂及其制备方法
US20110027342A1 (en) * 2009-07-28 2011-02-03 Msi Methylation Sciences, Inc. S-adenosylmethionine formulations with enhanced bioavailability
WO2012012902A1 (en) * 2010-07-28 2012-02-02 Msi Methylation Sciences Inc. S-adenosylmethionine formulations with enhanced bioavailability
US8329208B2 (en) 2009-07-28 2012-12-11 Methylation Sciences International Srl Pharmacokinetics of S-adenosylmethionine formulations
US8372451B2 (en) * 2010-02-12 2013-02-12 Alexander Vuckovic, M.D., Llc Compositions and methods for treating depression
CA2888302C (en) 2012-10-17 2016-05-31 Methylation Sciences International Srl Compositions comprising s-adenosylmethionine and a gallic acid ester
WO2016185413A1 (en) 2015-05-20 2016-11-24 Nestec S.A. Modified release formulations
CA3042699A1 (en) 2016-11-03 2018-08-09 Alexander Vuckovic, M.D., Llc Compositions and methods for treating depression
US12239623B2 (en) 2023-05-15 2025-03-04 Bonafide Health, Llc Sleep-improving compositions and methods of use
EP4501315A1 (en) 2023-08-04 2025-02-05 Lesaffre et Compagnie Liquid formulations of folates

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1227049B (it) * 1988-07-29 1991-03-14 Bioresearch Spa Impiego di derivati adenosinici per la preparazione di composizioni farmaceutiche aventi attivita' immunostimolante.
GB8900812D0 (en) * 1989-01-14 1989-03-08 Univ Manchester Pharmaceutical method and compositions
DE68922745D1 (de) * 1989-02-09 1995-06-22 Geoffrey James Barton Prozessor zur signalverbesserung für stereosystem.
IT1229203B (it) * 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
DE4005275A1 (de) * 1990-02-20 1991-08-22 Grundmann Ewald Verwendung von s-adenosylmethionin als mittel gegen virale infektionen durch retroviren

Also Published As

Publication number Publication date
AU645854B2 (en) 1994-01-27
DE69132542D1 (de) 2001-04-05
PT99300A (pt) 1992-08-31
KR920007629A (ko) 1992-05-27
ATE199319T1 (de) 2001-03-15
IT9021833A1 (it) 1992-04-23
DE69132542T2 (de) 2001-06-21
PT99300B (pt) 1999-04-30
AU8670891A (en) 1992-04-30
JPH04264031A (ja) 1992-09-18
US6093703A (en) 2000-07-25
JP3289928B2 (ja) 2002-06-10
EP0482493B1 (en) 2001-02-28
KR100187992B1 (ko) 1999-06-01
EP0482493A2 (en) 1992-04-29
FI914919A7 (fi) 1992-04-24
FI914919A0 (fi) 1991-10-18
EP0482493A3 (en) 1992-09-02
FI914919L (fi) 1992-04-24
IT9021833A0 (it) 1990-10-23
ZA918355B (en) 1992-07-29
NO914157D0 (no) 1991-10-23
CA2053826C (en) 2002-12-17
CA2053826A1 (en) 1992-04-24

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