IT1195262B - PROCESS FOR THE PREPARATION OF 2,5-BIS (2,2,2-TRIFLUROETOSSI) -N- (2-PIPERIDILMETIL) BENZAMIDE - Google Patents
PROCESS FOR THE PREPARATION OF 2,5-BIS (2,2,2-TRIFLUROETOSSI) -N- (2-PIPERIDILMETIL) BENZAMIDEInfo
- Publication number
- IT1195262B IT1195262B IT20746/80A IT2074680A IT1195262B IT 1195262 B IT1195262 B IT 1195262B IT 20746/80 A IT20746/80 A IT 20746/80A IT 2074680 A IT2074680 A IT 2074680A IT 1195262 B IT1195262 B IT 1195262B
- Authority
- IT
- Italy
- Prior art keywords
- trifluroetossi
- piperidilmetil
- benzamide
- bis
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2133179A | 1979-03-19 | 1979-03-19 | |
US2133279A | 1979-03-19 | 1979-03-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8020746A0 IT8020746A0 (en) | 1980-03-18 |
IT1195262B true IT1195262B (en) | 1988-10-12 |
Family
ID=26694559
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT20746/80A IT1195262B (en) | 1979-03-19 | 1980-03-18 | PROCESS FOR THE PREPARATION OF 2,5-BIS (2,2,2-TRIFLUROETOSSI) -N- (2-PIPERIDILMETIL) BENZAMIDE |
Country Status (14)
Country | Link |
---|---|
JP (8) | JPH01125339A (en) |
CA (1) | CA1137486A (en) |
CH (1) | CH643829A5 (en) |
DE (1) | DE3010195A1 (en) |
DK (3) | DK167062B1 (en) |
ES (1) | ES8104227A1 (en) |
FR (7) | FR2454438A1 (en) |
GB (2) | GB2045760B (en) |
IE (1) | IE49558B1 (en) |
IL (1) | IL59623A (en) |
IT (1) | IT1195262B (en) |
NL (1) | NL191486C (en) |
PT (1) | PT70967A (en) |
SE (5) | SE447992B (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2519974A1 (en) * | 1982-01-21 | 1983-07-22 | Rhone Poulenc Spec Chim | PROCESS FOR THE ACYLATION OF HALOGENO OR TRIHALOGENOMETHYLBENZENES |
FR2519979A1 (en) * | 1982-01-21 | 1983-07-22 | Rhone Poulenc Spec Chim | PROCESS FOR THE PREPARATION OF TRIFLUOROMETHOXY OR TRIFLUOROMETHYLTHIOPHENYLSULFONES |
FR2519975A1 (en) * | 1982-01-21 | 1983-07-22 | Rhone Poulenc Spec Chim | PROCESS FOR PREPARING TRIFLUOROMETHOXY OR TRIFLUOROMETHYLTHIOPHENYLCETONES |
FR2519980A1 (en) * | 1982-01-21 | 1983-07-22 | Rhone Poulenc Spec Chim | PROCESS FOR THE SULFONYLATION OF HALOGENO OR TRIHALOGENOMETHYLBENZENES |
FR2525588A1 (en) * | 1982-04-22 | 1983-10-28 | Rhone Poulenc Spec Chim | PROCESS FOR PREPARING PHENYLCETONES FROM HALOGENO OR TRIHALOGENOMETHYLBENZENES AND ALIPHATIC OR AROMATIC TRIHALOGENOMETHYL COMPOUNDS |
EP0175188A1 (en) * | 1984-09-11 | 1986-03-26 | Nihon Tokushu Noyaku Seizo K.K. | Carbamoylimidazole derivatives |
US4675448A (en) * | 1985-02-13 | 1987-06-23 | Ethyl Corporation | Chlorination process |
FR2579591B1 (en) * | 1985-03-29 | 1988-10-14 | Rhone Poulenc Spec Chim | PROCESS FOR THE PREPARATION OF PENTAFLUOROETHOXY AND PENTAFLUOROETHYLTHIOBENZENIQUE DERIVATIVES |
FR2579594B1 (en) * | 1985-03-29 | 1987-06-05 | Rhone Poulenc Spec Chim | PROCESS FOR THE PREPARATION OF TRIFLUOROETHOXY OR TRIFLUOROETHYLTHIOBENZENES |
DE3786037T2 (en) * | 1986-04-25 | 1993-11-25 | Abbott Lab | Tracer for use in immunological fluorescence polarization methods for the detection of flecainide. |
NZ219913A (en) * | 1986-04-25 | 1990-08-28 | Riker Laboratories Inc | Various flecainide derivatives and antibodies raised thereto |
DE3644798A1 (en) * | 1986-12-31 | 1988-07-14 | Hoechst Ag | NEW NITROHALOALCOXYBENZOLS, METHOD FOR THEIR PRODUCTION AND THEIR USE |
FR2640262B1 (en) * | 1988-12-14 | 1991-05-31 | Rhone Poulenc Chimie | PROCESS FOR THE PREPARATION OF TRIFLUOROETHOXYLATED ARYLIC KETONES |
IL120715A (en) * | 1997-04-21 | 2000-07-16 | Finetech Ltd | Process for the preparation of (2,2,2,-trifluoroethoxy)benzoic acids |
US6316627B1 (en) * | 1997-04-21 | 2001-11-13 | Fine Tech Ltd. | Process for the preparation of flecainide |
IL121288A (en) | 1997-07-11 | 2000-10-31 | Finetech Ltd | Process and a novel intermediate for the preparation of flecainide |
US7196197B2 (en) | 2003-09-17 | 2007-03-27 | Apotex Pharmachem Inc. | Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof |
JP4894226B2 (en) * | 2005-10-31 | 2012-03-14 | Dic株式会社 | Method for producing fluorine-containing liquid crystal compound having hydroquinone skeleton |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3539642A (en) * | 1967-07-19 | 1970-11-10 | Geigy Chem Corp | 2-phenyl-2-(1-naphthyl)acetamides |
US3772304A (en) * | 1969-10-30 | 1973-11-13 | Hoffmann La Roche | 4-hydroxy-isoquinolines and processes for their preparation |
US3719687A (en) * | 1970-07-22 | 1973-03-06 | Riker Laboratories Inc | N-(2-dialkylaminoalkylene)amides of 1,1-dihydroperfluoroalkoxy-substituted aryl acids and salts thereof |
US3655728A (en) | 1970-07-22 | 1972-04-11 | Riker Laboratories Inc | N-(2 - dialkylaminoalkylene)-esters of fluoroalkoxy-substituted aryl carboxylic acid and salts thereof |
US3967949A (en) * | 1973-06-18 | 1976-07-06 | Eli Lilly And Company | Fluoroalkoxyphenyl-substituted nitrogen heterocycles as plant stunting agents |
US4169108A (en) * | 1973-08-16 | 1979-09-25 | Sterling Drug Inc. | 5(OR 6)-[(Substituted-amino)alkyl]-2,3-naphthalenediols |
US4005209A (en) * | 1974-04-01 | 1977-01-25 | Riker Laboratories, Inc. | Antiarrhythmic method utilizing fluoroalkoxy-N-piperidyl and pyridyl benzamides |
US4013670A (en) * | 1974-04-01 | 1977-03-22 | Riker Laboratories, Inc. | Derivatives of pyrrolidine and piperidine |
US3900481A (en) * | 1974-04-01 | 1975-08-19 | Riker Laboratories Inc | Derivatives of pyrrolidine and piperidine |
IL49803A (en) * | 1975-06-28 | 1979-11-30 | Fisons Ltd | Preparation of pyrogallol |
DE2616478C2 (en) * | 1976-04-14 | 1986-05-22 | Brickl, Rolf, Dr., 7951 Warthausen | Medicines, biocides and cosmetics containing fluoroacylresorcins |
JPS6023656B2 (en) * | 1976-09-02 | 1985-06-08 | 川研フアインケミカル株式会社 | Method for producing alkoxy aromatic compounds |
US4097481A (en) * | 1976-11-08 | 1978-06-27 | Riker Laboratories, Inc. | Tertiary amide derivatives of pyrrolidine and piperidine |
US4071524A (en) * | 1976-11-08 | 1978-01-31 | Riker Laboratories, Inc. | Derivatives of urea |
-
0
- GB GB8214964A patent/GB2097000B/en not_active Expired
-
1980
- 1980-03-04 CA CA000346919A patent/CA1137486A/en not_active Expired
- 1980-03-14 SE SE8002003A patent/SE447992B/en not_active IP Right Cessation
- 1980-03-14 DK DK112180A patent/DK167062B1/en not_active IP Right Cessation
- 1980-03-14 IL IL59623A patent/IL59623A/en unknown
- 1980-03-16 NL NL8001551A patent/NL191486C/en not_active IP Right Cessation
- 1980-03-17 DE DE19803010195 patent/DE3010195A1/en active Granted
- 1980-03-17 ES ES489629A patent/ES8104227A1/en not_active Expired
- 1980-03-18 PT PT70967A patent/PT70967A/en active IP Right Revival
- 1980-03-18 GB GB8009041A patent/GB2045760B/en not_active Expired
- 1980-03-18 IT IT20746/80A patent/IT1195262B/en active Protection Beyond IP Right Term
- 1980-03-18 CH CH212880A patent/CH643829A5/en not_active IP Right Cessation
- 1980-03-18 FR FR8006019A patent/FR2454438A1/en active Granted
- 1980-03-18 IE IE549/80A patent/IE49558B1/en not_active IP Right Cessation
-
1981
- 1981-01-07 FR FR8100143A patent/FR2468576A1/en active Granted
- 1981-01-07 FR FR8100144A patent/FR2468590A1/en active Granted
- 1981-01-07 FR FR8100141A patent/FR2468570A1/en active Granted
- 1981-01-07 FR FR8100142A patent/FR2468571A1/en active Granted
- 1981-01-07 FR FR8100145A patent/FR2468591A1/en active Granted
- 1981-01-07 FR FR8100140A patent/FR2468569A1/en active Granted
-
1984
- 1984-03-21 SE SE8401554A patent/SE447993B/en not_active IP Right Cessation
- 1984-03-21 SE SE8401555A patent/SE463260B/en not_active IP Right Cessation
-
1988
- 1988-06-01 JP JP63135366A patent/JPH01125339A/en active Granted
- 1988-06-01 JP JP63135365A patent/JPH01104044A/en active Granted
- 1988-06-01 JP JP63135369A patent/JPH01125343A/en active Granted
- 1988-06-01 JP JP63135368A patent/JPH01125342A/en active Granted
- 1988-06-01 JP JP63135367A patent/JPH01125341A/en active Granted
- 1988-06-01 JP JP63135370A patent/JPH01125344A/en active Granted
- 1988-06-01 JP JP63135363A patent/JPH01104045A/en active Granted
- 1988-06-01 JP JP63135364A patent/JPH01104043A/en active Granted
-
1989
- 1989-04-27 SE SE8901533A patent/SE463419B/en not_active IP Right Cessation
- 1989-04-27 SE SE8901532A patent/SE463418B/en not_active IP Right Cessation
-
1990
- 1990-05-17 DK DK122290A patent/DK164857C/en not_active IP Right Cessation
-
1991
- 1991-04-30 DK DK91798A patent/DK79891D0/en unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ITCP | Complementary protection certificate |
Free format text: CCP 161 |
|
MEDD | Supplementary protection certificate for pharmaceutical products: granted |
Free format text: CCP 161, 19920424; RIKER LABORATORIES, INC. |
|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19980327 |