FR2454438A1 - PROCESS FOR THE PREPARATION OF 2,5-BIS (2,2,2-TRIFLUORETHOXY) -N- (2-PIPERIDYLMETHYL) BENZAMIDE - Google Patents

PROCESS FOR THE PREPARATION OF 2,5-BIS (2,2,2-TRIFLUORETHOXY) -N- (2-PIPERIDYLMETHYL) BENZAMIDE

Info

Publication number
FR2454438A1
FR2454438A1 FR8006019A FR8006019A FR2454438A1 FR 2454438 A1 FR2454438 A1 FR 2454438A1 FR 8006019 A FR8006019 A FR 8006019A FR 8006019 A FR8006019 A FR 8006019A FR 2454438 A1 FR2454438 A1 FR 2454438A1
Authority
FR
France
Prior art keywords
preparation
trifluorethoxy
piperidylmethyl
benzamide
bis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8006019A
Other languages
French (fr)
Other versions
FR2454438B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Riker Laboratories Inc
Original Assignee
Riker Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riker Laboratories Inc filed Critical Riker Laboratories Inc
Publication of FR2454438A1 publication Critical patent/FR2454438A1/en
Application granted granted Critical
Publication of FR2454438B1 publication Critical patent/FR2454438B1/fr
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46Friedel-Crafts reactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups

Abstract

PREPARATION DU 2,5-BIS(2,2,2-TRIFLUORETHOXY)-N-(2-PIPERIDYLMETHYL)BENZAMIDE. CE PROCEDE DE PREPARATION COMPREND LAPREPARATION OF 2,5-BIS (2,2,2-TRIFLUORETHOXY) -N- (2-PIPERIDYLMETHYL) BENZAMIDE. THIS PREPARATION PROCESS INCLUDES THE

FR8006019A 1979-03-19 1980-03-18 PROCESS FOR THE PREPARATION OF 2,5-BIS (2,2,2-TRIFLUORETHOXY) -N- (2-PIPERIDYLMETHYL) BENZAMIDE Granted FR2454438A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2133179A 1979-03-19 1979-03-19
US2133279A 1979-03-19 1979-03-19

Publications (2)

Publication Number Publication Date
FR2454438A1 true FR2454438A1 (en) 1980-11-14
FR2454438B1 FR2454438B1 (en) 1982-07-23

Family

ID=26694559

Family Applications (7)

Application Number Title Priority Date Filing Date
FR8006019A Granted FR2454438A1 (en) 1979-03-19 1980-03-18 PROCESS FOR THE PREPARATION OF 2,5-BIS (2,2,2-TRIFLUORETHOXY) -N- (2-PIPERIDYLMETHYL) BENZAMIDE
FR8100142A Granted FR2468571A1 (en) 1979-03-19 1981-01-07 2,5-BIS (2,2,2-TRIFLUORETHOXY) -A, A, A-TRICHLORACETOPHENONE, PROCESS FOR PREPARATION AND APPLICATION THEREOF TO THE MANUFACTURE OF KNOWN DRUG
FR8100143A Granted FR2468576A1 (en) 1979-03-19 1981-01-07 PROCESS FOR THE PREPARATION OF 2,5-BIS (2,2,2-TRIFLUORETHOXY) -BENZOIC ACID
FR8100144A Granted FR2468590A1 (en) 1979-03-19 1981-01-07 PROCESS FOR THE PREPARATION OF 2,5-BIS (2,2,2-TRIFLUORETHOXY) -N- (2-PIPERIDYLMETHYL) BENZAMIDE FROM 2,5-BIS (2,2,2-TRIFLUORETHOXY) -A, A, A -TRICHLORACETOPHENONE
FR8100141A Granted FR2468570A1 (en) 1979-03-19 1981-01-07 2,5-BIS (2,2,2-TRIFLUORETHOXY) -A, A-DICHLORACETOPHENONE, PROCESS FOR PREPARING THE SAME AND APPLICATION THEREOF TO THE MANUFACTURE OF A KNOWN DRUG
FR8100145A Granted FR2468591A1 (en) 1979-03-19 1981-01-07 PROCESS FOR THE PREPARATION OF 2,5-BIS (2,2,2-TRIFLUORETHOXY) -N- (2-PIPERIDYLMETHYL) BENZAMIDE FROM 2,5-BIS (2,2,2-TRIFLUORETHOXY) BENZOIC ACID CHLORIDE
FR8100140A Granted FR2468569A1 (en) 1979-03-19 1981-01-07 2,5-BIS (2,2,2-TRIFLUORETHOXY) ACETOPHENONE, PROCESS FOR PREPARING THE SAME AND APPLICATION THEREOF TO THE MANUFACTURE OF A KNOWN DRUG

Family Applications After (6)

Application Number Title Priority Date Filing Date
FR8100142A Granted FR2468571A1 (en) 1979-03-19 1981-01-07 2,5-BIS (2,2,2-TRIFLUORETHOXY) -A, A, A-TRICHLORACETOPHENONE, PROCESS FOR PREPARATION AND APPLICATION THEREOF TO THE MANUFACTURE OF KNOWN DRUG
FR8100143A Granted FR2468576A1 (en) 1979-03-19 1981-01-07 PROCESS FOR THE PREPARATION OF 2,5-BIS (2,2,2-TRIFLUORETHOXY) -BENZOIC ACID
FR8100144A Granted FR2468590A1 (en) 1979-03-19 1981-01-07 PROCESS FOR THE PREPARATION OF 2,5-BIS (2,2,2-TRIFLUORETHOXY) -N- (2-PIPERIDYLMETHYL) BENZAMIDE FROM 2,5-BIS (2,2,2-TRIFLUORETHOXY) -A, A, A -TRICHLORACETOPHENONE
FR8100141A Granted FR2468570A1 (en) 1979-03-19 1981-01-07 2,5-BIS (2,2,2-TRIFLUORETHOXY) -A, A-DICHLORACETOPHENONE, PROCESS FOR PREPARING THE SAME AND APPLICATION THEREOF TO THE MANUFACTURE OF A KNOWN DRUG
FR8100145A Granted FR2468591A1 (en) 1979-03-19 1981-01-07 PROCESS FOR THE PREPARATION OF 2,5-BIS (2,2,2-TRIFLUORETHOXY) -N- (2-PIPERIDYLMETHYL) BENZAMIDE FROM 2,5-BIS (2,2,2-TRIFLUORETHOXY) BENZOIC ACID CHLORIDE
FR8100140A Granted FR2468569A1 (en) 1979-03-19 1981-01-07 2,5-BIS (2,2,2-TRIFLUORETHOXY) ACETOPHENONE, PROCESS FOR PREPARING THE SAME AND APPLICATION THEREOF TO THE MANUFACTURE OF A KNOWN DRUG

Country Status (14)

Country Link
JP (8) JPH01125341A (en)
CA (1) CA1137486A (en)
CH (1) CH643829A5 (en)
DE (1) DE3010195A1 (en)
DK (3) DK167062B1 (en)
ES (1) ES8104227A1 (en)
FR (7) FR2454438A1 (en)
GB (2) GB2045760B (en)
IE (1) IE49558B1 (en)
IL (1) IL59623A (en)
IT (1) IT1195262B (en)
NL (1) NL191486C (en)
PT (1) PT70967A (en)
SE (5) SE447992B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2519980A1 (en) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim PROCESS FOR THE SULFONYLATION OF HALOGENO OR TRIHALOGENOMETHYLBENZENES
FR2519974A1 (en) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim PROCESS FOR THE ACYLATION OF HALOGENO OR TRIHALOGENOMETHYLBENZENES
FR2519979A1 (en) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim PROCESS FOR THE PREPARATION OF TRIFLUOROMETHOXY OR TRIFLUOROMETHYLTHIOPHENYLSULFONES
FR2519975A1 (en) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim PROCESS FOR PREPARING TRIFLUOROMETHOXY OR TRIFLUOROMETHYLTHIOPHENYLCETONES
FR2525588A1 (en) * 1982-04-22 1983-10-28 Rhone Poulenc Spec Chim PROCESS FOR PREPARING PHENYLCETONES FROM HALOGENO OR TRIHALOGENOMETHYLBENZENES AND ALIPHATIC OR AROMATIC TRIHALOGENOMETHYL COMPOUNDS
EP0175188A1 (en) * 1984-09-11 1986-03-26 Nihon Tokushu Noyaku Seizo K.K. Carbamoylimidazole derivatives
US4675448A (en) * 1985-02-13 1987-06-23 Ethyl Corporation Chlorination process
FR2579594B1 (en) * 1985-03-29 1987-06-05 Rhone Poulenc Spec Chim PROCESS FOR THE PREPARATION OF TRIFLUOROETHOXY OR TRIFLUOROETHYLTHIOBENZENES
FR2579591B1 (en) * 1985-03-29 1988-10-14 Rhone Poulenc Spec Chim PROCESS FOR THE PREPARATION OF PENTAFLUOROETHOXY AND PENTAFLUOROETHYLTHIOBENZENIQUE DERIVATIVES
NZ219913A (en) * 1986-04-25 1990-08-28 Riker Laboratories Inc Various flecainide derivatives and antibodies raised thereto
DE3786037T2 (en) * 1986-04-25 1993-11-25 Abbott Lab Tracer for use in immunological fluorescence polarization methods for the detection of flecainide.
DE3644798A1 (en) * 1986-12-31 1988-07-14 Hoechst Ag NEW NITROHALOALCOXYBENZOLS, METHOD FOR THEIR PRODUCTION AND THEIR USE
FR2640262B1 (en) * 1988-12-14 1991-05-31 Rhone Poulenc Chimie PROCESS FOR THE PREPARATION OF TRIFLUOROETHOXYLATED ARYLIC KETONES
US6316627B1 (en) * 1997-04-21 2001-11-13 Fine Tech Ltd. Process for the preparation of flecainide
IL120715A (en) 1997-04-21 2000-07-16 Finetech Ltd Process for the preparation of (2,2,2,-trifluoroethoxy)benzoic acids
IL121288A (en) * 1997-07-11 2000-10-31 Finetech Ltd Process and a novel intermediate for the preparation of flecainide
US7196197B2 (en) 2003-09-17 2007-03-27 Apotex Pharmachem Inc. Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof
JP4894226B2 (en) * 2005-10-31 2012-03-14 Dic株式会社 Method for producing fluorine-containing liquid crystal compound having hydroquinone skeleton

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3719687A (en) * 1970-07-22 1973-03-06 Riker Laboratories Inc N-(2-dialkylaminoalkylene)amides of 1,1-dihydroperfluoroalkoxy-substituted aryl acids and salts thereof

Family Cites Families (13)

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US3539642A (en) * 1967-07-19 1970-11-10 Geigy Chem Corp 2-phenyl-2-(1-naphthyl)acetamides
US3772304A (en) * 1969-10-30 1973-11-13 Hoffmann La Roche 4-hydroxy-isoquinolines and processes for their preparation
US3655728A (en) 1970-07-22 1972-04-11 Riker Laboratories Inc N-(2 - dialkylaminoalkylene)-esters of fluoroalkoxy-substituted aryl carboxylic acid and salts thereof
US3967949A (en) * 1973-06-18 1976-07-06 Eli Lilly And Company Fluoroalkoxyphenyl-substituted nitrogen heterocycles as plant stunting agents
US4169108A (en) * 1973-08-16 1979-09-25 Sterling Drug Inc. 5(OR 6)-[(Substituted-amino)alkyl]-2,3-naphthalenediols
US4005209A (en) * 1974-04-01 1977-01-25 Riker Laboratories, Inc. Antiarrhythmic method utilizing fluoroalkoxy-N-piperidyl and pyridyl benzamides
US3900481A (en) * 1974-04-01 1975-08-19 Riker Laboratories Inc Derivatives of pyrrolidine and piperidine
US4013670A (en) * 1974-04-01 1977-03-22 Riker Laboratories, Inc. Derivatives of pyrrolidine and piperidine
IL49803A (en) * 1975-06-28 1979-11-30 Fisons Ltd Preparation of pyrogallol
DE2616478C2 (en) * 1976-04-14 1986-05-22 Brickl, Rolf, Dr., 7951 Warthausen Medicines, biocides and cosmetics containing fluoroacylresorcins
JPS6023656B2 (en) * 1976-09-02 1985-06-08 川研フアインケミカル株式会社 Method for producing alkoxy aromatic compounds
US4071524A (en) * 1976-11-08 1978-01-31 Riker Laboratories, Inc. Derivatives of urea
US4097481A (en) * 1976-11-08 1978-06-27 Riker Laboratories, Inc. Tertiary amide derivatives of pyrrolidine and piperidine

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
US3719687A (en) * 1970-07-22 1973-03-06 Riker Laboratories Inc N-(2-dialkylaminoalkylene)amides of 1,1-dihydroperfluoroalkoxy-substituted aryl acids and salts thereof

Also Published As

Publication number Publication date
FR2468590A1 (en) 1981-05-08
SE8401554D0 (en) 1984-03-21
GB2045760A (en) 1980-11-05
FR2454438B1 (en) 1982-07-23
JPH01104045A (en) 1989-04-21
DK167062B1 (en) 1993-08-23
GB2097000A (en) 1982-10-27
SE447992B (en) 1987-01-12
FR2468570A1 (en) 1981-05-08
NL191486B (en) 1995-04-03
FR2468571B1 (en) 1983-03-11
GB2097000B (en) 1983-11-30
IL59623A0 (en) 1980-06-30
JPH01125342A (en) 1989-05-17
DK164857C (en) 1993-01-18
JPH0251906B2 (en) 1990-11-08
DK122290D0 (en) 1990-05-17
FR2468591A1 (en) 1981-05-08
ES489629A0 (en) 1981-04-01
FR2468576B1 (en) 1983-01-21
CA1137486A (en) 1982-12-14
IL59623A (en) 1983-07-31
FR2468569A1 (en) 1981-05-08
JPH0372212B2 (en) 1991-11-18
JPH01125344A (en) 1989-05-17
SE8901532D0 (en) 1989-04-27
DK164857B (en) 1992-08-31
CH643829A5 (en) 1984-06-29
DK79891A (en) 1991-04-30
FR2468576A1 (en) 1981-05-08
NL8001551A (en) 1980-09-23
SE8401555D0 (en) 1984-03-21
JPH01125339A (en) 1989-05-17
IT8020746A0 (en) 1980-03-18
JPH022870B2 (en) 1990-01-19
GB2045760B (en) 1983-05-11
SE463260B (en) 1990-10-29
FR2468590B1 (en) 1983-09-23
JPH01125341A (en) 1989-05-17
SE447993B (en) 1987-01-12
SE8401555L (en) 1984-03-21
FR2468569B1 (en) 1983-03-11
JPH0251907B2 (en) 1990-11-08
PT70967A (en) 1980-04-01
SE8401554L (en) 1984-03-21
DE3010195A1 (en) 1980-10-02
JPH0339498B2 (en) 1991-06-14
JPH01104043A (en) 1989-04-21
FR2468571A1 (en) 1981-05-08
DK112180A (en) 1980-09-20
FR2468570B1 (en) 1983-03-11
JPH01125343A (en) 1989-05-17
SE8901533D0 (en) 1989-04-27
DK79891D0 (en) 1991-04-30
SE8901532L (en) 1989-04-27
IE800549L (en) 1980-09-19
ES8104227A1 (en) 1981-04-01
DE3010195C2 (en) 1990-10-25
SE8002003L (en) 1980-09-20
DK122290A (en) 1990-05-17
FR2468591B1 (en) 1983-07-22
JPH0251908B2 (en) 1990-11-08
SE463418B (en) 1990-11-19
NL191486C (en) 1995-08-04
JPH01104044A (en) 1989-04-21
JPH022869B2 (en) 1990-01-19
IT1195262B (en) 1988-10-12
SE463419B (en) 1990-11-19
IE49558B1 (en) 1985-10-30
SE8901533L (en) 1989-04-27
JPH0149695B2 (en) 1989-10-25

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