IT1186788B - Eteri sostituiti con bicicloeptano ad attivita' farmaceutica - Google Patents

Eteri sostituiti con bicicloeptano ad attivita' farmaceutica

Info

Publication number
IT1186788B
IT1186788B IT22744/85A IT2274485A IT1186788B IT 1186788 B IT1186788 B IT 1186788B IT 22744/85 A IT22744/85 A IT 22744/85A IT 2274485 A IT2274485 A IT 2274485A IT 1186788 B IT1186788 B IT 1186788B
Authority
IT
Italy
Prior art keywords
bicycloeptane
ethers
replaced
pharmaceutical activities
activities
Prior art date
Application number
IT22744/85A
Other languages
English (en)
Other versions
IT8522744A0 (it
Inventor
Melanie J Locts
Steven E Hall
Peter W Sprague
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of IT8522744A0 publication Critical patent/IT8522744A0/it
Application granted granted Critical
Publication of IT1186788B publication Critical patent/IT1186788B/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/53Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/21Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a non-condensed ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0091Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is bridged condensed
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/125Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
    • C07C59/13Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups containing rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/58Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/62Unsaturated compounds containing ether groups, groups, groups, or groups containing rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/36Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT22744/85A 1984-11-08 1985-11-07 Eteri sostituiti con bicicloeptano ad attivita' farmaceutica IT1186788B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/669,568 US4647585A (en) 1984-11-08 1984-11-08 Bicycloheptane substituted ethers

Publications (2)

Publication Number Publication Date
IT8522744A0 IT8522744A0 (it) 1985-11-07
IT1186788B true IT1186788B (it) 1987-12-16

Family

ID=24686841

Family Applications (1)

Application Number Title Priority Date Filing Date
IT22744/85A IT1186788B (it) 1984-11-08 1985-11-07 Eteri sostituiti con bicicloeptano ad attivita' farmaceutica

Country Status (7)

Country Link
US (1) US4647585A (it)
JP (1) JPS61115051A (it)
CA (1) CA1253493A (it)
DE (1) DE3539218A1 (it)
FR (1) FR2572725B1 (it)
GB (1) GB2166733B (it)
IT (1) IT1186788B (it)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1278577C (en) * 1985-11-18 1991-01-02 Tatsuo Tsuri Bicyclic sulfonamide derivatives
US4734424A (en) * 1986-09-24 1988-03-29 E. R. Squibb & Sons, Inc. Bicycloheptane substituted diamide and its congener prostaglandin analogs
DE3928707A1 (de) * 1989-08-30 1991-03-07 Henkel Kgaa Entzuendungshemmende wirkstoffe fuer kosmetische praeparate
US6623724B2 (en) 1996-09-18 2003-09-23 Applied Genetics Incorporated Dermatics Dermatological compositions and methods
US6214888B1 (en) 1996-09-18 2001-04-10 Applied Genetics Incorporated Dermatological compounds
ATE301459T1 (de) 1996-09-18 2005-08-15 Applied Genetics Inc Dermatics Norbornen- und norbornandiolen zur behandlung von pigmentierungsstörungen, neurodegenerativen erkrankungen oder proliferativen hauterkrankungen
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US20050119725A1 (en) * 2003-04-08 2005-06-02 Xingwu Wang Energetically controlled delivery of biologically active material from an implanted medical device
US20050155779A1 (en) * 2003-04-08 2005-07-21 Xingwu Wang Coated substrate assembly
US20060118758A1 (en) * 2004-09-15 2006-06-08 Xingwu Wang Material to enable magnetic resonance imaging of implantable medical devices
WO2006116718A2 (en) 2005-04-28 2006-11-02 Proteus Biomedical, Inc. Pharma-informatics system
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質(rap)結合体の投与による肝障害の処置
WO2010068581A1 (en) 2008-12-08 2010-06-17 Glaxosmithkline Llc Novel compounds
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
EA024559B1 (ru) 2009-05-06 2016-09-30 Лаборэтори Скин Кэа, Инк. Композиции для нанесения на кератинизированную поверхность кожи млекопитающего и способ доставки
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4073933A (en) * 1975-06-27 1978-02-14 Sumitomo Chemical Company, Limited Novel bicycloheptene derivatives
US4143054A (en) * 1977-11-04 1979-03-06 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane- and 7-oxabicycloheptene compounds
WO1980001381A1 (en) * 1979-01-05 1980-07-10 R Jones Substituted bicyclo (2,2,1) heptanes and hept-2-enes
US4351949A (en) * 1981-02-05 1982-09-28 Iowa State University Research Foundation, Inc. Bicyclic prostaglandin analogs and method of synthesis
US4436934A (en) * 1981-02-05 1984-03-13 Iowa State University Research Foundation, Inc. Bicyclic prostaglandin analogs and method of synthesis
JPS57139060A (en) * 1981-02-20 1982-08-27 Sendai Fukusokan Kagaku Kenkyusho Prostaglandin derivative and its preparation

Also Published As

Publication number Publication date
IT8522744A0 (it) 1985-11-07
CA1253493A (en) 1989-05-02
FR2572725B1 (fr) 1989-01-20
GB8525533D0 (en) 1985-11-20
GB2166733A (en) 1986-05-14
FR2572725A1 (fr) 1986-05-09
US4647585A (en) 1987-03-03
GB2166733B (en) 1988-03-16
JPS61115051A (ja) 1986-06-02
DE3539218A1 (de) 1986-05-07

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