IT1158049B - Cefalosporine-betaine di isochinolinio - Google Patents

Cefalosporine-betaine di isochinolinio

Info

Publication number
IT1158049B
IT1158049B IT23151/82A IT2315182A IT1158049B IT 1158049 B IT1158049 B IT 1158049B IT 23151/82 A IT23151/82 A IT 23151/82A IT 2315182 A IT2315182 A IT 2315182A IT 1158049 B IT1158049 B IT 1158049B
Authority
IT
Italy
Prior art keywords
isokinolinium
cephalosporine
betaine
isokinolinium cephalosporine
Prior art date
Application number
IT23151/82A
Other languages
English (en)
Other versions
IT8223151A0 (it
Inventor
William Henry Walker Lunn
John Kevin Shadle
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IT8223151A0 publication Critical patent/IT8223151A0/it
Application granted granted Critical
Publication of IT1158049B publication Critical patent/IT1158049B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT23151/82A 1981-09-08 1982-09-07 Cefalosporine-betaine di isochinolinio IT1158049B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/300,100 US4396619A (en) 1981-09-08 1981-09-08 Cephalosporin betaines

Publications (2)

Publication Number Publication Date
IT8223151A0 IT8223151A0 (it) 1982-09-07
IT1158049B true IT1158049B (it) 1987-02-18

Family

ID=23157706

Family Applications (1)

Application Number Title Priority Date Filing Date
IT23151/82A IT1158049B (it) 1981-09-08 1982-09-07 Cefalosporine-betaine di isochinolinio

Country Status (11)

Country Link
US (1) US4396619A (it)
JP (1) JPS5857386A (it)
AU (1) AU8808982A (it)
BE (1) BE894333A (it)
DE (1) DE3233377A1 (it)
FR (1) FR2512448B1 (it)
GB (1) GB2105334B (it)
IL (1) IL66727A0 (it)
IT (1) IT1158049B (it)
NL (1) NL8203481A (it)
ZA (1) ZA826539B (it)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1582884A (en) * 1977-05-19 1981-01-14 Beecham Group Ltd Clavulanic acid derivatives their preparation and use
DK330880A (da) * 1979-08-03 1981-02-04 Beecham Group Ltd Fremgangsmaade til fremstilling af clavulansyrederivater
NZ199061A (en) * 1980-12-09 1984-10-19 Beecham Group Ltd 9-(n-tetrazolyl)-deoxyclavulanic acids,salts,esters,and pharmaceutical compositions
NZ199200A (en) * 1980-12-23 1984-07-31 Beecham Group Ltd Clavulanic acid derivatives and pharmaceutical compositions
DE3207840A1 (de) * 1982-03-04 1983-09-15 Hoechst Ag, 6230 Frankfurt "cephalosporinderivate und verfahren zu ihrer herstellung"
DE3247614A1 (de) * 1982-12-23 1984-07-05 Hoechst Ag, 6230 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
DE3316797A1 (de) * 1983-05-07 1984-11-08 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von cephemverbindungen
DE3316798A1 (de) * 1983-05-07 1984-11-08 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von cephemverbindungen
FR2546520B1 (fr) * 1983-05-27 1985-08-30 Sanofi Sa Nouveaux composes antibiotiques derives des cephalosporines
EP0452987B1 (en) * 1984-12-27 1995-03-01 Banyu Pharmaceutical Co., Ltd. Isoindoline derivatives
JPS61186253A (ja) * 1985-02-14 1986-08-19 電気化学工業株式会社 高強度水中モルタル・コンクリ−ト組成物
US4703118A (en) * 1985-04-08 1987-10-27 Eli Lilly And Company Synthesis of 3-iodomethyl cephalosporins
ZA863170B (en) 1985-04-30 1987-12-30 Lilly Co Eli 7-substituted bicyclic pyrazolidinones
JPS61281057A (ja) * 1985-06-06 1986-12-11 日鐵セメント株式会社 高強度・高耐久性モルタル・コンクリ−ト用組成物
CA1296012C (en) * 1986-03-19 1992-02-18 Susumu Nakagawa 6,7-dihydroxy-isoquinoline derivatives
US4814328A (en) * 1986-03-19 1989-03-21 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives, and antibacterial agents
US5019571A (en) * 1988-01-25 1991-05-28 Eli Lilly And Company 1-carbacephalosporin antibiotics
DE3910421A1 (de) * 1989-03-31 1990-10-04 Hoechst Ag Polare cephalosporinderivate und verfahren zu ihrer herstellung

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4160830A (en) * 1971-07-17 1979-07-10 Takeda Chemical Industries, Ltd. Cephalosporins
BE786271A (fr) * 1971-07-17 1973-01-15 Takeda Chemical Industries Ltd Cephalosporines
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
JPS6011713B2 (ja) * 1976-09-08 1985-03-27 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
JPS609719B2 (ja) * 1977-08-06 1985-03-12 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
FR2410655A1 (fr) * 1977-12-05 1979-06-29 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments

Also Published As

Publication number Publication date
NL8203481A (nl) 1983-04-05
GB2105334B (en) 1985-05-01
ZA826539B (en) 1984-04-25
IL66727A0 (en) 1982-12-31
JPS5857386A (ja) 1983-04-05
BE894333A (fr) 1983-03-07
IT8223151A0 (it) 1982-09-07
GB2105334A (en) 1983-03-23
FR2512448A1 (fr) 1983-03-11
AU8808982A (en) 1983-03-17
FR2512448B1 (fr) 1986-02-21
DE3233377A1 (de) 1983-03-24
US4396619A (en) 1983-08-02

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