IT1157194B - Procedimento per la produzione di nuovi ciclopeptidi e prodotti cosi' ottenuti - Google Patents

Info

Publication number

IT1157194B

IT1157194B IT5126178A IT5126178A IT1157194B IT 1157194 B IT1157194 B IT 1157194B IT 5126178 A IT5126178 A IT 5126178A IT 5126178 A IT5126178 A IT 5126178A IT 1157194 B IT1157194 B IT 1157194B

Authority

IT

Italy

Prior art keywords

somatostatin

trp

glucagon

sulphur

growth hormone

Prior art date

1977-09-28

Links

• Espacenet
• Global Dossier
• Discuss

• NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title abstract 3
• 102000001189 Cyclic Peptides Human genes 0.000 title abstract 2
• 108010069514 Cyclic Peptides Proteins 0.000 title abstract 2
• 108060003199 Glucagon Proteins 0.000 title abstract 2
• 102000018997 Growth Hormone Human genes 0.000 title abstract 2
• 108010051696 Growth Hormone Proteins 0.000 title abstract 2
• MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title abstract 2
• 229960004666 glucagon Drugs 0.000 title abstract 2
• 239000000122 growth hormone Substances 0.000 title abstract 2
• 230000028327 secretion Effects 0.000 title abstract 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
• 102000051325 Glucagon Human genes 0.000 title 1
• 102000004877 Insulin Human genes 0.000 title 1
• 108090001061 Insulin Proteins 0.000 title 1
• 229940125396 insulin Drugs 0.000 title 1
• 229940075620 somatostatin analogue Drugs 0.000 title 1
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 2
• 102000005157 Somatostatin Human genes 0.000 abstract 2
• 108010056088 Somatostatin Proteins 0.000 abstract 2
• 239000002253 acid Substances 0.000 abstract 2
• 229940024606 amino acid Drugs 0.000 abstract 2
• 235000001014 amino acid Nutrition 0.000 abstract 2
• 125000000539 amino acid group Chemical group 0.000 abstract 2
• 150000001413 amino acids Chemical class 0.000 abstract 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
• 150000003839 salts Chemical class 0.000 abstract 2
• 229960000553 somatostatin Drugs 0.000 abstract 2
• 206010000599 Acromegaly Diseases 0.000 abstract 1
• 125000002698 D-tryptophano group Chemical group C(=O)(O)[C@@H](CC1=CNC2=CC=CC=C12)N* 0.000 abstract 1
• 102400000321 Glucagon Human genes 0.000 abstract 1
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
• OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
• 230000015572 biosynthetic process Effects 0.000 abstract 1
• 201000010099 disease Diseases 0.000 abstract 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
• 230000000694 effects Effects 0.000 abstract 1
• 229910052736 halogen Inorganic materials 0.000 abstract 1
• 125000001475 halogen functional group Chemical group 0.000 abstract 1
• 150000002367 halogens Chemical class 0.000 abstract 1
• 238000002347 injection Methods 0.000 abstract 1
• 239000007924 injection Substances 0.000 abstract 1
• 239000000543 intermediate Substances 0.000 abstract 1
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
• 229960005190 phenylalanine Drugs 0.000 abstract 1
• 230000001766 physiological effect Effects 0.000 abstract 1
• 238000002360 preparation method Methods 0.000 abstract 1
• 230000003294 somatostatinlike Effects 0.000 abstract 1
• 125000001424 substituent group Chemical group 0.000 abstract 1
• 238000003786 synthesis reaction Methods 0.000 abstract 1