GB2019411A - Peptides Related to Somatostatin - Google Patents

Peptides Related to Somatostatin

Info

Publication number
GB2019411A
GB2019411A GB7913871A GB7913871A GB2019411A GB 2019411 A GB2019411 A GB 2019411A GB 7913871 A GB7913871 A GB 7913871A GB 7913871 A GB7913871 A GB 7913871A GB 2019411 A GB2019411 A GB 2019411A
Authority
GB
United Kingdom
Prior art keywords
trp
gly
ala
image
residue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7913871A
Other versions
GB2019411B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Priority to IE81279A priority Critical patent/IE48500B1/en
Publication of GB2019411A publication Critical patent/GB2019411A/en
Application granted granted Critical
Publication of GB2019411B publication Critical patent/GB2019411B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Peptides of the formula: <IMAGE> wherein: x is H, -NH2, -NH-Gly-Ala, -NH-D-Ala-Ala, -NH-Gly-Gly- Gly, -NH-acetyl, or -NH-benzoyl; X1 is His or Arg; X2 is His, Glu, Tyr, Trp or Phe; X3 is Trp, D-Trp, or 6-F-D-Trp; X4 is a D- alpha -amino acid; the residue <IMAGE> has the L-configuration and the residue <IMAGE> has the L or D-configuration or the reduced, linear form thereof, or a non-toxic, pharmaceutically acceptable acid addition salt thereof which inhibit the release of growth hormone, insulin and glucagon; and show prolonged inhibition activity.
GB7913871A 1978-04-24 1979-04-20 Peptides related to somatostatin Expired GB2019411B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IE81279A IE48500B1 (en) 1978-04-24 1979-08-08 Peptides related to somatostatin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89943878A 1978-04-24 1978-04-24

Publications (2)

Publication Number Publication Date
GB2019411A true GB2019411A (en) 1979-10-31
GB2019411B GB2019411B (en) 1982-06-16

Family

ID=25410973

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7913871A Expired GB2019411B (en) 1978-04-24 1979-04-20 Peptides related to somatostatin

Country Status (2)

Country Link
BE (1) BE875817A (en)
GB (1) GB2019411B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4316890A (en) * 1979-03-16 1982-02-23 Ciba-Geigy Corporation Peptides and processes for the manufacture thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4316890A (en) * 1979-03-16 1982-02-23 Ciba-Geigy Corporation Peptides and processes for the manufacture thereof

Also Published As

Publication number Publication date
BE875817A (en) 1979-10-24
GB2019411B (en) 1982-06-16

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee