IT1156749B - Amino-alkyl substd. thiophene derivs. - selective blockers of histamine H2 receptors, e.g. for treating gastric hypersecretion - Google Patents

Amino-alkyl substd. thiophene derivs. - selective blockers of histamine H2 receptors, e.g. for treating gastric hypersecretion

Info

Publication number
IT1156749B
IT1156749B IT4940378A IT4940378A IT1156749B IT 1156749 B IT1156749 B IT 1156749B IT 4940378 A IT4940378 A IT 4940378A IT 4940378 A IT4940378 A IT 4940378A IT 1156749 B IT1156749 B IT 1156749B
Authority
IT
Italy
Prior art keywords
histamine
receptors
formula
opt
lower alkyl
Prior art date
Application number
IT4940378A
Other languages
Italian (it)
Other versions
IT7849403A0 (en
Original Assignee
Allen & Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB20659/77A external-priority patent/GB1601459A/en
Application filed by Allen & Hanburys Ltd filed Critical Allen & Hanburys Ltd
Publication of IT7849403A0 publication Critical patent/IT7849403A0/en
Application granted granted Critical
Publication of IT1156749B publication Critical patent/IT1156749B/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Thiophene derivs. of formula (I), their physiologically acceptable salts, hydrates and in vivo precursors are new: In the formula, R1 and R2 = H, lower alkyl, cycloalkyl, aralkyl or alkenyl, the alkyl groups opt. interrupted by O or NR4; or R1R2N is a heterocycle opt. contg. other O or NR4 functions; R4 = H, lower alkyl, alkenyl or alkoxyalkyl; X is O,S or CH2; Y is S,O=NR5 or =CHR6; R5 = H, NO2, CN, lower alkyl, aryl, alkylsulphonyl or arylsulphonyl; R6 = NO2, alkylsulphonyl or arylsulphonyl; m=2-4, n = 1 or 2; or can also be O when X is S or CH2; and alk = 1-6C opt. branched alkenylene (sic). Also new are intermediates of formula (II). (I) selectively block the histamine H2 receptors so are useful in treatment of hypersecretion of gastric acid; allergic states in which histamine is a mediator, and allergic-inflammatory conditions such as urticaria. The usual oral dose is 0.1-2g/day; they can also be given topically or parenterally.
IT4940378A 1977-05-17 1978-05-16 Amino-alkyl substd. thiophene derivs. - selective blockers of histamine H2 receptors, e.g. for treating gastric hypersecretion IT1156749B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB20659/77A GB1601459A (en) 1977-05-17 1977-05-17 Aminoalkyl thiophene derivatives
IE853/78A IE46811B1 (en) 1977-05-17 1978-04-28 Aminoalkyl thiophene derivatives

Publications (2)

Publication Number Publication Date
IT7849403A0 IT7849403A0 (en) 1978-05-16
IT1156749B true IT1156749B (en) 1987-02-04

Family

ID=26254808

Family Applications (1)

Application Number Title Priority Date Filing Date
IT4940378A IT1156749B (en) 1977-05-17 1978-05-16 Amino-alkyl substd. thiophene derivs. - selective blockers of histamine H2 receptors, e.g. for treating gastric hypersecretion

Country Status (1)

Country Link
IT (1) IT1156749B (en)

Also Published As

Publication number Publication date
IT7849403A0 (en) 1978-05-16

Similar Documents

Publication Publication Date Title
EP0176927A3 (en) Diazepine-containing pharmaceutical compositions having a platelet activating factor (paf)-antagonist action
DE3681517D1 (en) THIAZOLIDE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF.
DE69005248D1 (en) Compositions containing 2-aminopyrimidine-3-oxide derivatives for use in reducing hair loss and for inducing and stimulating hair growth, and new compounds derived from 2-aminopyrimidine-3-oxide.
PE20001063A1 (en) NEW ANTIBACTERIAL AGENTS OF ISOXAZOLINONE
ES469952A1 (en) Pharmacologically active compounds
ES2124545T3 (en) AZOLIDINDIONAS AS ANTI-HYPERGLYCEMIC AGENTS.
IE780940L (en) Pharmacologically active compounds.
ATE181114T1 (en) METHOD FOR PRODUCING PHARMACEUTICALLY ACTIVE THIAZOLIDINE OR OXAZOLIDINE COMPOUNDS USING A YEAST REDUCTASE
ES2087950T3 (en) DERIVATIVES OF BENZOFENONA OXIMA, PHARMACEUTICAL COMPOSITION AND ITS USE.
HUP9900501A2 (en) Oxa- and thia-diazole derivatives as muscarinic receptor antagonists, intermediates, preparation and use thereof, pharmaceutical compositions containing these compounds
AR241422A1 (en) N-substituted diphenyl piperidines
IT1156749B (en) Amino-alkyl substd. thiophene derivs. - selective blockers of histamine H2 receptors, e.g. for treating gastric hypersecretion
ATE67199T1 (en) BENZOXAZINE DERIVATIVES AND PROCESS FOR THEIR MANUFACTURE.
ES486071A1 (en) Amine derivatives
AR040123A1 (en) THIOPHEN, ANTIHELMINTIC AND INSECTICIDE COMPOUNDS
IE41273B1 (en) 7-aminoalkoxy substituted benzopyrans, benzo thiopyrans and naphthalenes
ES2013322A6 (en) Derivatives of 2,3,4,5,6,7-hexahydro-2,7-methano-1,5-benzoxazonines and -1,4-benzoxazonines, processes for their production and their use as pharmaceuticals
GB1087174A (en) Piperidine derivatives
ATE5586T1 (en) NEW AMINOPROPANOL DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND MEDICATIONS CONTAINING THESE COMPOUNDS.
ATE148682T1 (en) USE OF AGENTS TO ACCELERATE THE CURING RATE OF CEMENT, MORTAR AND CONCRETE, WHILE MAINTAINING THEIR WORKABILITY.
FR2313064A1 (en) Antidepressant 2-indenyloxymethyl-morpholine derivs - prepd. by acylation and cyclization of 1-indenyloxy-2-amino-propanol derivs
IT1214660B (en) Aminoalkyl-furan derivs.
ATE3977T1 (en) NOVEL AMINOPROPANOL DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS.
ATE4639T1 (en) NEW 1-(ACYLAMINO-ARYLOXY-)2-HYDROXY-3-ALKINYLAMINOPROPANES AND PROCESS FOR THEIR PRODUCTION.
ATE4704T1 (en) NEW 1-(ACYLAMINO-ARYLOXY-)2-HYDROXY-3-ALKINYLAMINOPROPANES AND PROCESS FOR THEIR PRODUCTION.