IT1214660B - Aminoalkyl-furan derivs. - Google Patents
Aminoalkyl-furan derivs.Info
- Publication number
- IT1214660B IT1214660B IT8548436A IT4843685A IT1214660B IT 1214660 B IT1214660 B IT 1214660B IT 8548436 A IT8548436 A IT 8548436A IT 4843685 A IT4843685 A IT 4843685A IT 1214660 B IT1214660 B IT 1214660B
- Authority
- IT
- Italy
- Prior art keywords
- lower alkyl
- histamine
- derivs
- furan
- arylsulphonyl
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract 4
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 2
- 229960001340 histamine Drugs 0.000 abstract 2
- 101100244083 Arabidopsis thaliana PKL gene Proteins 0.000 abstract 1
- 229940122957 Histamine H2 receptor antagonist Drugs 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 208000024780 Urticaria Diseases 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 230000008602 contraction Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000003485 histamine H2 receptor antagonist Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Furan Compounds (AREA)
Abstract
New furan derivs. of formula (I), and their N-oxides, hydrates and salts: (where R1 andR2 are H, lower alkyl, cycloalkyl, lower alkenyl, aralkyl, or a lower alkyl gp. interrupted by O or NR4, or NR1R2 is a heterocyclic ring opt. contg. an O atom or NR4 gp; A is 1-6C alkylene; R3 is H, lower alkyl, lower alkenyl or alkoxyalkyl; R4 is H or lower alkyl; X is CH2, O or S; Y is S, O, NR5 or CHR6; R5 is H, NO21 CN, lower alkyl, aryl, alkylsulphonyl or arylsulphonyl; R6 is NO2, arylsulphonyl or alkylsulphonyl; m = 2-4, n = 1 or 2 or can be O when X is S or CH2). (I) are histamine H2 receptor antagonists. They inhibit histamine-induced gastric hypersecretion without affecting smoth-muscle contraction induced by histamine. They can also be used to treat allergic symptoms, e.g. urticaria.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB32465/76A GB1565966A (en) | 1976-08-04 | 1976-08-04 | Aminoalkyl furan derivatives |
| GB5068576 | 1976-12-06 | ||
| GB2018777 | 1977-05-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8548436A0 IT8548436A0 (en) | 1985-08-01 |
| IT1214660B true IT1214660B (en) | 1990-01-18 |
Family
ID=27257844
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT8548438A IT1214661B (en) | 1976-08-04 | 1985-08-01 | TIOLI AS INTERMEDIATES IN THE PREPARATION OF SELECTIVE AGENTS ON HISTAMINE RECEPTORS AND PROCEDURE FOR THE PRODUCTION OF THESE TIOLI |
| IT8548436A IT1214660B (en) | 1976-08-04 | 1985-08-01 | Aminoalkyl-furan derivs. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT8548438A IT1214661B (en) | 1976-08-04 | 1985-08-01 | TIOLI AS INTERMEDIATES IN THE PREPARATION OF SELECTIVE AGENTS ON HISTAMINE RECEPTORS AND PROCEDURE FOR THE PRODUCTION OF THESE TIOLI |
Country Status (4)
| Country | Link |
|---|---|
| HU (1) | HU185001B (en) |
| IL (1) | IL52604A (en) |
| IT (2) | IT1214661B (en) |
| NO (1) | NO149546C (en) |
-
1977
- 1977-07-26 IL IL52604A patent/IL52604A/en unknown
- 1977-08-01 NO NO772715A patent/NO149546C/en unknown
- 1977-08-03 HU HUAE000503 patent/HU185001B/en unknown
-
1985
- 1985-08-01 IT IT8548438A patent/IT1214661B/en active
- 1985-08-01 IT IT8548436A patent/IT1214660B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| IL52604A0 (en) | 1977-10-31 |
| NO149546B (en) | 1984-01-30 |
| IT8548438A0 (en) | 1985-08-01 |
| NO149546C (en) | 1984-05-09 |
| HU185001B (en) | 1984-11-28 |
| NO772715L (en) | 1978-02-07 |
| IT8548436A0 (en) | 1985-08-01 |
| IT1214661B (en) | 1990-01-18 |
| IL52604A (en) | 1981-09-13 |
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