IT1137485B - Mercaptoacil propioniammidi n-sostituite inibitrici del collagenasi mammifero e procedimento per la loro produzione - Google Patents
Mercaptoacil propioniammidi n-sostituite inibitrici del collagenasi mammifero e procedimento per la loro produzioneInfo
- Publication number
- IT1137485B IT1137485B IT21951/81A IT2195181A IT1137485B IT 1137485 B IT1137485 B IT 1137485B IT 21951/81 A IT21951/81 A IT 21951/81A IT 2195181 A IT2195181 A IT 2195181A IT 1137485 B IT1137485 B IT 1137485B
- Authority
- IT
- Italy
- Prior art keywords
- propioniammidi
- mercaptoacil
- collagenase
- mammal
- procedure
- Prior art date
Links
- 102000029816 Collagenase Human genes 0.000 title 1
- 108060005980 Collagenase Proteins 0.000 title 1
- 241000124008 Mammalia Species 0.000 title 1
- 229960002424 collagenase Drugs 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/154,748 US4263293A (en) | 1980-05-30 | 1980-05-30 | Heterocyclic containing amides as inhibitors of mammalian collagenase |
| US06/168,933 US4327111A (en) | 1980-07-14 | 1980-07-14 | N-Substituted mercaptoacyl pripionamides |
| US20299880A | 1980-11-03 | 1980-11-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8121951A0 IT8121951A0 (it) | 1981-05-26 |
| IT1137485B true IT1137485B (it) | 1986-09-10 |
Family
ID=27387632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT21951/81A IT1137485B (it) | 1980-05-30 | 1981-05-26 | Mercaptoacil propioniammidi n-sostituite inibitrici del collagenasi mammifero e procedimento per la loro produzione |
Country Status (5)
| Country | Link |
|---|---|
| CA (1) | CA1182818A (enrdf_load_stackoverflow) |
| DE (1) | DE3121189A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2483411A1 (enrdf_load_stackoverflow) |
| GB (1) | GB2076809B (enrdf_load_stackoverflow) |
| IT (1) | IT1137485B (enrdf_load_stackoverflow) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2540495B1 (fr) * | 1983-02-07 | 1986-02-14 | Roussel Uclaf | Nouveaux derives de o-mercaptopropanamide et de ses homologues, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus |
| FR2559770B1 (fr) * | 1984-02-20 | 1986-10-24 | Roussel Uclaf | Nouveaux derives de n-alkyl-o-mercaptopropanamide, leurs procedes de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus |
| FR2562068B1 (fr) * | 1984-03-29 | 1987-07-17 | Roussel Uclaf | Nouveaux derives de l'o-mercaptopropanamide et de ses homologues, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus |
| ATE30415T1 (de) * | 1984-04-02 | 1987-11-15 | Squibb & Sons Inc | Enkephalinas-inhibitoren. |
| FR2589468B1 (fr) * | 1985-07-30 | 1987-12-31 | Roussel Uclaf | Nouveaux derives du 2-acylamino ethanethiol 2-substitue, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4113715A (en) * | 1977-01-17 | 1978-09-12 | E. R. Squibb & Sons, Inc. | Amino acid derivatives |
| US4235885A (en) * | 1979-06-25 | 1980-11-25 | E. R. Squibb & Sons, Inc. | Inhibitors of mammalian collagenase |
-
1981
- 1981-04-28 CA CA000376389A patent/CA1182818A/en not_active Expired
- 1981-04-28 GB GB8113036A patent/GB2076809B/en not_active Expired
- 1981-05-20 FR FR8110073A patent/FR2483411A1/fr active Granted
- 1981-05-26 IT IT21951/81A patent/IT1137485B/it active
- 1981-05-27 DE DE3121189A patent/DE3121189A1/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| FR2483411A1 (fr) | 1981-12-04 |
| FR2483411B1 (enrdf_load_stackoverflow) | 1983-05-13 |
| IT8121951A0 (it) | 1981-05-26 |
| GB2076809A (en) | 1981-12-09 |
| GB2076809B (en) | 1984-03-14 |
| DE3121189A1 (de) | 1982-02-25 |
| CA1182818A (en) | 1985-02-19 |
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