IT1116497B

IT1116497B - Acidi mercapto-acilamminici alogeno sostituiti e relativo procedimento di produzione

Acidi mercapto-acilamminici alogeno sostituiti e relativo procedimento di produzione

Info

Publication number: IT1116497B
Authority: IT; Italy
Prior art keywords: proline; halo; mercapto; hypotensive activity; pipecolic acid
Prior art date: 1978-09-01

Application number

IT4875579A

Other languages

English (en)

Other versions

IT7948755A0 (it

Original Assignee

Squibb & Sons Inc

Priority date

1978-09-01

Filing date

1979-04-17

Publication date

1986-02-10

1978-09-01 Priority claimed from US05/939,147 external-priority patent/US4154935A/en

1979-04-17 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1979-04-17 Publication of IT7948755A0 publication Critical patent/IT7948755A0/it

1986-02-10 Application granted granted Critical

1986-02-10 Publication of IT1116497B publication Critical patent/IT1116497B/it

Links

ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 title abstract 2
230000001077 hypotensive effect Effects 0.000 title abstract 2
102000015427 Angiotensins Human genes 0.000 title 1
108010064733 Angiotensins Proteins 0.000 title 1
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 title 1
HXEACLLIILLPRG-YFKPBYRVSA-N L-pipecolic acid Chemical compound [O-]C(=O)[C@@H]1CCCC[NH2+]1 HXEACLLIILLPRG-YFKPBYRVSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 title 1
125000001475 halogen functional group Chemical group 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 3
102000005862 Angiotensin II Human genes 0.000 abstract 1
101800000734 Angiotensin-1 Proteins 0.000 abstract 1
102400000344 Angiotensin-1 Human genes 0.000 abstract 1
101800000733 Angiotensin-2 Proteins 0.000 abstract 1
101100097467 Arabidopsis thaliana SYD gene Proteins 0.000 abstract 1
CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 abstract 1
101100495925 Schizosaccharomyces pombe (strain 972 / ATCC 24843) chr3 gene Proteins 0.000 abstract 1
235000001014 amino acid Nutrition 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
ORWYRWWVDCYOMK-HBZPZAIKSA-N angiotensin I Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 ORWYRWWVDCYOMK-HBZPZAIKSA-N 0.000 abstract 1
229950006323 angiotensin ii Drugs 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical compound O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1