IT1049348B - 1.n.aminoidrossiacil.4.6.di.aminoglicosil.1.3.diaminociclitoli metodo per la loro preparazione e prodotti intermedi parzialmente n.protetti - Google Patents

1.n.aminoidrossiacil.4.6.di.aminoglicosil.1.3.diaminociclitoli metodo per la loro preparazione e prodotti intermedi parzialmente n.protetti

Info

Publication number
IT1049348B
IT1049348B IT19435/75A IT1943575A IT1049348B IT 1049348 B IT1049348 B IT 1049348B IT 19435/75 A IT19435/75 A IT 19435/75A IT 1943575 A IT1943575 A IT 1943575A IT 1049348 B IT1049348 B IT 1049348B
Authority
IT
Italy
Prior art keywords
hydroxiacil
diaminocyclitles
aminoglicosil
protects
amino
Prior art date
Application number
IT19435/75A
Other languages
English (en)
Italian (it)
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/452,586 external-priority patent/US4029882A/en
Application filed by Scherico Ltd filed Critical Scherico Ltd
Application granted granted Critical
Publication of IT1049348B publication Critical patent/IT1049348B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IT19435/75A 1974-03-19 1975-01-21 1.n.aminoidrossiacil.4.6.di.aminoglicosil.1.3.diaminociclitoli metodo per la loro preparazione e prodotti intermedi parzialmente n.protetti IT1049348B (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45257174A 1974-03-19 1974-03-19
US05/452,586 US4029882A (en) 1974-03-19 1974-03-19 Selective acylation of the C-1 amino group of aminoglycoside antibiotics
CH1060174 1974-07-31

Publications (1)

Publication Number Publication Date
IT1049348B true IT1049348B (it) 1981-01-20

Family

ID=27176473

Family Applications (1)

Application Number Title Priority Date Filing Date
IT19435/75A IT1049348B (it) 1974-03-19 1975-01-21 1.n.aminoidrossiacil.4.6.di.aminoglicosil.1.3.diaminociclitoli metodo per la loro preparazione e prodotti intermedi parzialmente n.protetti

Country Status (11)

Country Link
JP (1) JPS5843398B2 (enrdf_load_stackoverflow)
AT (1) AT341088B (enrdf_load_stackoverflow)
DD (1) DD117871A5 (enrdf_load_stackoverflow)
DK (1) DK156070C (enrdf_load_stackoverflow)
ES (1) ES433990A1 (enrdf_load_stackoverflow)
FI (1) FI60714C (enrdf_load_stackoverflow)
HU (1) HU175673B (enrdf_load_stackoverflow)
IT (1) IT1049348B (enrdf_load_stackoverflow)
LU (1) LU71687A1 (enrdf_load_stackoverflow)
NL (1) NL183826C (enrdf_load_stackoverflow)
NO (1) NO140426C (enrdf_load_stackoverflow)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2007783B1 (en) * 2006-04-03 2018-07-11 Technion Research & Development Foundation Ltd. Novel aminoglycosides and uses thereof in the treatment of genetic disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3780018A (en) * 1972-06-26 1973-12-18 Bristol Myers Co Derivatives of gentamicin c1
US3796698A (en) * 1972-10-18 1974-03-12 Bristol Myers Co Antibiotic derivatives of gentamicin c2
US3796699A (en) * 1972-11-06 1974-03-12 Bristol Myers Co Antibiotic derivatives of gentamicin c1a

Also Published As

Publication number Publication date
DK156070B (da) 1989-06-19
JPS50126640A (enrdf_load_stackoverflow) 1975-10-04
NO140426C (no) 1979-08-29
NL183826C (nl) 1989-02-01
HU175673B (hu) 1980-09-28
NL183826B (nl) 1988-09-01
DK18675A (enrdf_load_stackoverflow) 1975-09-20
FI750141A7 (enrdf_load_stackoverflow) 1975-09-20
ES433990A1 (es) 1977-03-01
JPS5843398B2 (ja) 1983-09-27
FI60714C (fi) 1982-03-10
LU71687A1 (enrdf_load_stackoverflow) 1975-12-09
ATA42975A (de) 1977-05-15
NO750168L (enrdf_load_stackoverflow) 1975-09-22
NO140426B (no) 1979-05-21
FI60714B (fi) 1981-11-30
AT341088B (de) 1978-01-25
DK156070C (da) 1989-11-06
NL7500690A (nl) 1975-09-23
DD117871A5 (enrdf_load_stackoverflow) 1976-02-05

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