IT1049348B - 1.N.AMINO HYDROXIACIL.4.6.DI.AMINOGLICOSIL.1.3.DIAMINOCYCLITLES METHOD FOR THEIR PREPARATION AND INTERMEDIATE PRODUCTS PARTIALLY N.PROTECTS - Google Patents

1.N.AMINO HYDROXIACIL.4.6.DI.AMINOGLICOSIL.1.3.DIAMINOCYCLITLES METHOD FOR THEIR PREPARATION AND INTERMEDIATE PRODUCTS PARTIALLY N.PROTECTS

Info

Publication number
IT1049348B
IT1049348B IT19435/75A IT1943575A IT1049348B IT 1049348 B IT1049348 B IT 1049348B IT 19435/75 A IT19435/75 A IT 19435/75A IT 1943575 A IT1943575 A IT 1943575A IT 1049348 B IT1049348 B IT 1049348B
Authority
IT
Italy
Prior art keywords
hydroxiacil
diaminocyclitles
aminoglicosil
protects
amino
Prior art date
Application number
IT19435/75A
Other languages
Italian (it)
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/452,586 external-priority patent/US4029882A/en
Application filed by Scherico Ltd filed Critical Scherico Ltd
Application granted granted Critical
Publication of IT1049348B publication Critical patent/IT1049348B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IT19435/75A 1974-03-19 1975-01-21 1.N.AMINO HYDROXIACIL.4.6.DI.AMINOGLICOSIL.1.3.DIAMINOCYCLITLES METHOD FOR THEIR PREPARATION AND INTERMEDIATE PRODUCTS PARTIALLY N.PROTECTS IT1049348B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45257174A 1974-03-19 1974-03-19
US05/452,586 US4029882A (en) 1974-03-19 1974-03-19 Selective acylation of the C-1 amino group of aminoglycoside antibiotics
CH1060174 1974-07-31

Publications (1)

Publication Number Publication Date
IT1049348B true IT1049348B (en) 1981-01-20

Family

ID=27176473

Family Applications (1)

Application Number Title Priority Date Filing Date
IT19435/75A IT1049348B (en) 1974-03-19 1975-01-21 1.N.AMINO HYDROXIACIL.4.6.DI.AMINOGLICOSIL.1.3.DIAMINOCYCLITLES METHOD FOR THEIR PREPARATION AND INTERMEDIATE PRODUCTS PARTIALLY N.PROTECTS

Country Status (11)

Country Link
JP (1) JPS5843398B2 (en)
AT (1) AT341088B (en)
DD (1) DD117871A5 (en)
DK (1) DK156070C (en)
ES (1) ES433990A1 (en)
FI (1) FI60714C (en)
HU (1) HU175673B (en)
IT (1) IT1049348B (en)
LU (1) LU71687A1 (en)
NL (1) NL183826C (en)
NO (1) NO140426C (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2007783B1 (en) 2006-04-03 2018-07-11 Technion Research & Development Foundation Ltd. Novel aminoglycosides and uses thereof in the treatment of genetic disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3780018A (en) * 1972-06-26 1973-12-18 Bristol Myers Co Derivatives of gentamicin c1
US3796698A (en) * 1972-10-18 1974-03-12 Bristol Myers Co Antibiotic derivatives of gentamicin c2
US3796699A (en) * 1972-11-06 1974-03-12 Bristol Myers Co Antibiotic derivatives of gentamicin c1a

Also Published As

Publication number Publication date
NL183826B (en) 1988-09-01
JPS5843398B2 (en) 1983-09-27
DK156070C (en) 1989-11-06
FI60714B (en) 1981-11-30
HU175673B (en) 1980-09-28
FI750141A (en) 1975-09-20
LU71687A1 (en) 1975-12-09
NL7500690A (en) 1975-09-23
NO750168L (en) 1975-09-22
FI60714C (en) 1982-03-10
DK18675A (en) 1975-09-20
NO140426C (en) 1979-08-29
ES433990A1 (en) 1977-03-01
NO140426B (en) 1979-05-21
AT341088B (en) 1978-01-25
JPS50126640A (en) 1975-10-04
NL183826C (en) 1989-02-01
DK156070B (en) 1989-06-19
ATA42975A (en) 1977-05-15
DD117871A5 (en) 1976-02-05

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