ES433990A1 - Procedure for the preparation of diaminociclitol derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of diaminociclitol derivatives. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES433990A1
ES433990A1 ES433990A ES433990A ES433990A1 ES 433990 A1 ES433990 A1 ES 433990A1 ES 433990 A ES433990 A ES 433990A ES 433990 A ES433990 A ES 433990A ES 433990 A1 ES433990 A1 ES 433990A1
Authority
ES
Spain
Prior art keywords
gentamicin
antibiotic
amino
derivatives
translation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES433990A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scherico Ltd
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/452,586 external-priority patent/US4029882A/en
Application filed by Scherico Ltd filed Critical Scherico Ltd
Publication of ES433990A1 publication Critical patent/ES433990A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Procedure for the preparation of diaminocyclitole derivatives, specifically 1-N substituted derivatives of 4,6-di- (aminoglycosyl) -1,3-diaminocyclitols gentamicin A, gentamicin B, gentamicin B1 gentamicin C1, gentamicin Cla, gentamicin C2, Gentamicin C2a, Gentamicin X2, Sisomycin, Verdamicin, Antibiotic G-418, Antibiotic 66-40B, Antibiotic 66-40D, Antibiotic JI-20B, and Antibiotic G-52 where the substituent on 1-N is designated by X, which represents: S-3-amino-2-hydroxypropionyl or S-4-amino-2-hydroxybutyryl with the proviso that, in the case of C1 gentamicin, Cla gentamicin and C2 gentamicin, X is S-3- amino-2-hydroxypropionyl; and its pharmaceutically acceptable acid addition salts; comprising treating one of the aforementioned 4,6-di- (aminoglycosyl) -l, 3-diaminocyclitols which may have amino group protecting groups at any position other than position 1 with an acid of the formula HO - X' wherein X is a group as defined for X above, wherein the amino group and/or the hydroxy group may be protected, in the presence of a carbodiimide, or with a reactive derivative of said above acid, removing all protecting groups present in the molecule and isolating the derivative as such or as a pharmaceutically acceptable acid addition salt. (Machine-translation by Google Translate, not legally binding)
ES433990A 1974-03-19 1975-01-21 Procedure for the preparation of diaminociclitol derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES433990A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45257174A 1974-03-19 1974-03-19
US05/452,586 US4029882A (en) 1974-03-19 1974-03-19 Selective acylation of the C-1 amino group of aminoglycoside antibiotics
CH1060174 1974-07-31

Publications (1)

Publication Number Publication Date
ES433990A1 true ES433990A1 (en) 1977-03-01

Family

ID=27176473

Family Applications (1)

Application Number Title Priority Date Filing Date
ES433990A Expired ES433990A1 (en) 1974-03-19 1975-01-21 Procedure for the preparation of diaminociclitol derivatives. (Machine-translation by Google Translate, not legally binding)

Country Status (11)

Country Link
JP (1) JPS5843398B2 (en)
AT (1) AT341088B (en)
DD (1) DD117871A5 (en)
DK (1) DK156070C (en)
ES (1) ES433990A1 (en)
FI (1) FI60714C (en)
HU (1) HU175673B (en)
IT (1) IT1049348B (en)
LU (1) LU71687A1 (en)
NL (1) NL183826C (en)
NO (1) NO140426C (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007113841A2 (en) 2006-04-03 2007-10-11 Technion Research & Development Foundation Ltd. Novel aminoglycosides and uses thereof in the treatment of genetic disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3780018A (en) * 1972-06-26 1973-12-18 Bristol Myers Co Derivatives of gentamicin c1
US3796698A (en) * 1972-10-18 1974-03-12 Bristol Myers Co Antibiotic derivatives of gentamicin c2
US3796699A (en) * 1972-11-06 1974-03-12 Bristol Myers Co Antibiotic derivatives of gentamicin c1a

Also Published As

Publication number Publication date
NL7500690A (en) 1975-09-23
HU175673B (en) 1980-09-28
NL183826B (en) 1988-09-01
NL183826C (en) 1989-02-01
FI60714C (en) 1982-03-10
NO140426C (en) 1979-08-29
AT341088B (en) 1978-01-25
FI750141A (en) 1975-09-20
JPS5843398B2 (en) 1983-09-27
DK156070C (en) 1989-11-06
IT1049348B (en) 1981-01-20
DK18675A (en) 1975-09-20
NO750168L (en) 1975-09-22
ATA42975A (en) 1977-05-15
FI60714B (en) 1981-11-30
DD117871A5 (en) 1976-02-05
JPS50126640A (en) 1975-10-04
NO140426B (en) 1979-05-21
DK156070B (en) 1989-06-19
LU71687A1 (en) 1975-12-09

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