IT1045256B - 1,6-dimethyl-8-acyloxymethyl-10-methoxyergolines - with adrenolytic, hypotensive sedative and antiserotonin activity - Google Patents
1,6-dimethyl-8-acyloxymethyl-10-methoxyergolines - with adrenolytic, hypotensive sedative and antiserotonin activityInfo
- Publication number
- IT1045256B IT1045256B IT3105971A IT3105971A IT1045256B IT 1045256 B IT1045256 B IT 1045256B IT 3105971 A IT3105971 A IT 3105971A IT 3105971 A IT3105971 A IT 3105971A IT 1045256 B IT1045256 B IT 1045256B
- Authority
- IT
- Italy
- Prior art keywords
- methoxyergolines
- adrenolytic
- acyloxymethyl
- hypotensive
- sedative
- Prior art date
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Title cpds. of formula (I): (where R is 2-furanoyl or a pyrroyl residue of the formula: in which Y is H, 1-6C alkyl or phenyl; R1 is H, CH3 or carbonyl; R2 is H, CH3, halogen or carbonyl, and R3 and R4 are H, halogen, alkyl, 1-6C alkoxy or carbethoxy) and their pharmaceutically acceptable acid addn. salts with an org. acid are prepd. by reacting 1-methyl-lumilysergol 10-methyl ether with the chloride or bromide of an aryl- or alkylsulphonic acid in the presence of the chloride or bromide of a tertiary amine, reacting the resulting 1-methyl-8beta-halomethyl-10alpha-methylergoline with a salt of R-OH in a polar aprotic solvent for 3-10 hrs. at 40-150 degrees C, and isolating and purifying the resulting (I).
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT3105971A IT1045256B (en) | 1971-11-13 | 1971-11-13 | 1,6-dimethyl-8-acyloxymethyl-10-methoxyergolines - with adrenolytic, hypotensive sedative and antiserotonin activity |
NL7202845.A NL159384B (en) | 1971-03-13 | 1972-03-03 | PROCEDURE FOR PREPARING A MEDICINAL PRODUCT WITH AN ADRENOLYTIC ACTIVITY, AS WELL AS A PROCEDURE FOR PREPARING AN ESTER OF 1-METHYL-10-METHOXYLUMILYSERGOL. |
US05/232,605 US3966739A (en) | 1971-03-13 | 1972-03-07 | Pyrrole-carboxylic acids lumilysergol esters |
CA136,871A CA967958A (en) | 1971-03-13 | 1972-03-08 | Lumilysergol derivatives and process for preparing them |
IE293/72A IE36207B1 (en) | 1971-03-13 | 1972-03-08 | Lumilysergol derivatives |
IL38936A IL38936A (en) | 1971-03-13 | 1972-03-08 | 1,6-dimethyl-10alpha-methoxy-8beta-pyrroyloxymethyl-ergolines |
GB1069872A GB1333024A (en) | 1971-03-13 | 1972-03-08 | Lumilysergol derivatives |
DE2211397A DE2211397B2 (en) | 1971-03-13 | 1972-03-09 | 1,6-Dünethyl-10 a-methoxy-ergoline, their production and medicinal products containing them |
FR7208204A FR2130140B1 (en) | 1971-03-13 | 1972-03-09 | |
AU39871/72A AU461957B2 (en) | 1971-03-13 | 1972-03-10 | Lumilysergol derivatives |
DK111172AA DK140479B (en) | 1971-03-13 | 1972-03-10 | Analogous process for the preparation of lumilysergol esters or pharmaceutically acceptable addition salts thereof with organic acids. |
CH358172A CH567505A5 (en) | 1971-03-13 | 1972-03-10 | |
NO00773/72*[A NO127920B (en) | 1971-03-13 | 1972-03-10 | |
BE780473A BE780473A (en) | 1971-03-13 | 1972-03-10 | LUMILYSERGOL DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS AS MEDICINAL PRODUCTS, IN PARTICULAR ADRENOLYTICS |
AT202072A AT322119B (en) | 1971-03-13 | 1972-03-10 | PROCESS FOR PRODUCING NEW ESTERS OF 1-METHYL-LUMILYSERGOL-10-METHYL ETHER |
SE7203051A SE394281B (en) | 1971-03-13 | 1972-03-10 | METHOD OF PREPARING ESTERS OF 1-METHYLLUMILYSERGOL-10-METHYLETHER |
ES400683A ES400683A1 (en) | 1971-03-13 | 1972-03-11 | Pyrrole-carboxylic acids lumilysergol esters |
HUFA905A HU163400B (en) | 1971-03-13 | 1972-03-11 | |
JP47024431A JPS5133920B1 (en) | 1971-03-13 | 1972-03-11 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT3105971A IT1045256B (en) | 1971-11-13 | 1971-11-13 | 1,6-dimethyl-8-acyloxymethyl-10-methoxyergolines - with adrenolytic, hypotensive sedative and antiserotonin activity |
Publications (1)
Publication Number | Publication Date |
---|---|
IT1045256B true IT1045256B (en) | 1980-05-10 |
Family
ID=11233032
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT3105971A IT1045256B (en) | 1971-03-13 | 1971-11-13 | 1,6-dimethyl-8-acyloxymethyl-10-methoxyergolines - with adrenolytic, hypotensive sedative and antiserotonin activity |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1045256B (en) |
-
1971
- 1971-11-13 IT IT3105971A patent/IT1045256B/en active
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