IT1045256B - 1,6-dimethyl-8-acyloxymethyl-10-methoxyergolines - with adrenolytic, hypotensive sedative and antiserotonin activity - Google Patents

1,6-dimethyl-8-acyloxymethyl-10-methoxyergolines - with adrenolytic, hypotensive sedative and antiserotonin activity

Info

Publication number
IT1045256B
IT1045256B IT3105971A IT3105971A IT1045256B IT 1045256 B IT1045256 B IT 1045256B IT 3105971 A IT3105971 A IT 3105971A IT 3105971 A IT3105971 A IT 3105971A IT 1045256 B IT1045256 B IT 1045256B
Authority
IT
Italy
Prior art keywords
methoxyergolines
adrenolytic
acyloxymethyl
hypotensive
sedative
Prior art date
Application number
IT3105971A
Other languages
Italian (it)
Inventor
L Bernardi
G Fregnan
G Bosisio
Original Assignee
Farmaceutici Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia filed Critical Farmaceutici Italia
Priority to IT3105971A priority Critical patent/IT1045256B/en
Priority to NL7202845.A priority patent/NL159384B/en
Priority to US05/232,605 priority patent/US3966739A/en
Priority to GB1069872A priority patent/GB1333024A/en
Priority to CA136,871A priority patent/CA967958A/en
Priority to IE293/72A priority patent/IE36207B1/en
Priority to IL38936A priority patent/IL38936A/en
Priority to FR7208204A priority patent/FR2130140B1/fr
Priority to DE2211397A priority patent/DE2211397B2/en
Priority to BE780473A priority patent/BE780473A/en
Priority to AU39871/72A priority patent/AU461957B2/en
Priority to DK111172AA priority patent/DK140479B/en
Priority to CH358172A priority patent/CH567505A5/xx
Priority to NO00773/72*[A priority patent/NO127920B/no
Priority to AT202072A priority patent/AT322119B/en
Priority to SE7203051A priority patent/SE394281B/en
Priority to ES400683A priority patent/ES400683A1/en
Priority to HUFA905A priority patent/HU163400B/hu
Priority to JP47024431A priority patent/JPS5133920B1/ja
Application granted granted Critical
Publication of IT1045256B publication Critical patent/IT1045256B/en

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  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Title cpds. of formula (I): (where R is 2-furanoyl or a pyrroyl residue of the formula: in which Y is H, 1-6C alkyl or phenyl; R1 is H, CH3 or carbonyl; R2 is H, CH3, halogen or carbonyl, and R3 and R4 are H, halogen, alkyl, 1-6C alkoxy or carbethoxy) and their pharmaceutically acceptable acid addn. salts with an org. acid are prepd. by reacting 1-methyl-lumilysergol 10-methyl ether with the chloride or bromide of an aryl- or alkylsulphonic acid in the presence of the chloride or bromide of a tertiary amine, reacting the resulting 1-methyl-8beta-halomethyl-10alpha-methylergoline with a salt of R-OH in a polar aprotic solvent for 3-10 hrs. at 40-150 degrees C, and isolating and purifying the resulting (I).
IT3105971A 1971-03-13 1971-11-13 1,6-dimethyl-8-acyloxymethyl-10-methoxyergolines - with adrenolytic, hypotensive sedative and antiserotonin activity IT1045256B (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
IT3105971A IT1045256B (en) 1971-11-13 1971-11-13 1,6-dimethyl-8-acyloxymethyl-10-methoxyergolines - with adrenolytic, hypotensive sedative and antiserotonin activity
NL7202845.A NL159384B (en) 1971-03-13 1972-03-03 PROCEDURE FOR PREPARING A MEDICINAL PRODUCT WITH AN ADRENOLYTIC ACTIVITY, AS WELL AS A PROCEDURE FOR PREPARING AN ESTER OF 1-METHYL-10-METHOXYLUMILYSERGOL.
US05/232,605 US3966739A (en) 1971-03-13 1972-03-07 Pyrrole-carboxylic acids lumilysergol esters
CA136,871A CA967958A (en) 1971-03-13 1972-03-08 Lumilysergol derivatives and process for preparing them
IE293/72A IE36207B1 (en) 1971-03-13 1972-03-08 Lumilysergol derivatives
IL38936A IL38936A (en) 1971-03-13 1972-03-08 1,6-dimethyl-10alpha-methoxy-8beta-pyrroyloxymethyl-ergolines
GB1069872A GB1333024A (en) 1971-03-13 1972-03-08 Lumilysergol derivatives
DE2211397A DE2211397B2 (en) 1971-03-13 1972-03-09 1,6-Dünethyl-10 a-methoxy-ergoline, their production and medicinal products containing them
FR7208204A FR2130140B1 (en) 1971-03-13 1972-03-09
AU39871/72A AU461957B2 (en) 1971-03-13 1972-03-10 Lumilysergol derivatives
DK111172AA DK140479B (en) 1971-03-13 1972-03-10 Analogous process for the preparation of lumilysergol esters or pharmaceutically acceptable addition salts thereof with organic acids.
CH358172A CH567505A5 (en) 1971-03-13 1972-03-10
NO00773/72*[A NO127920B (en) 1971-03-13 1972-03-10
BE780473A BE780473A (en) 1971-03-13 1972-03-10 LUMILYSERGOL DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS AS MEDICINAL PRODUCTS, IN PARTICULAR ADRENOLYTICS
AT202072A AT322119B (en) 1971-03-13 1972-03-10 PROCESS FOR PRODUCING NEW ESTERS OF 1-METHYL-LUMILYSERGOL-10-METHYL ETHER
SE7203051A SE394281B (en) 1971-03-13 1972-03-10 METHOD OF PREPARING ESTERS OF 1-METHYLLUMILYSERGOL-10-METHYLETHER
ES400683A ES400683A1 (en) 1971-03-13 1972-03-11 Pyrrole-carboxylic acids lumilysergol esters
HUFA905A HU163400B (en) 1971-03-13 1972-03-11
JP47024431A JPS5133920B1 (en) 1971-03-13 1972-03-11

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT3105971A IT1045256B (en) 1971-11-13 1971-11-13 1,6-dimethyl-8-acyloxymethyl-10-methoxyergolines - with adrenolytic, hypotensive sedative and antiserotonin activity

Publications (1)

Publication Number Publication Date
IT1045256B true IT1045256B (en) 1980-05-10

Family

ID=11233032

Family Applications (1)

Application Number Title Priority Date Filing Date
IT3105971A IT1045256B (en) 1971-03-13 1971-11-13 1,6-dimethyl-8-acyloxymethyl-10-methoxyergolines - with adrenolytic, hypotensive sedative and antiserotonin activity

Country Status (1)

Country Link
IT (1) IT1045256B (en)

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