IS8135A - Þríhringtengdar indólafleiður og notkun þeirra til að meðhöndla Alzheimers-sjúkdóm - Google Patents
Þríhringtengdar indólafleiður og notkun þeirra til að meðhöndla Alzheimers-sjúkdómInfo
- Publication number
- IS8135A IS8135A IS8135A IS8135A IS8135A IS 8135 A IS8135 A IS 8135A IS 8135 A IS8135 A IS 8135A IS 8135 A IS8135 A IS 8135A IS 8135 A IS8135 A IS 8135A
- Authority
- IS
- Iceland
- Prior art keywords
- alzheimer
- disease
- treatment
- indole derivatives
- tricyclic indole
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0309221.0A GB0309221D0 (en) | 2003-04-23 | 2003-04-23 | Novel compounds |
| PCT/EP2004/004244 WO2004094430A1 (en) | 2003-04-23 | 2004-04-21 | Tricyclic indole derivatives and their use in the treatment of alzheimer’s disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IS8135A true IS8135A (is) | 2005-11-21 |
Family
ID=9957152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS8135A IS8135A (is) | 2003-04-23 | 2005-11-21 | Þríhringtengdar indólafleiður og notkun þeirra til að meðhöndla Alzheimers-sjúkdóm |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20060229302A1 (https=) |
| EP (1) | EP1620438A1 (https=) |
| JP (1) | JP2006524206A (https=) |
| KR (1) | KR20050111797A (https=) |
| CN (1) | CN1809573A (https=) |
| BR (1) | BRPI0409622A (https=) |
| CA (1) | CA2523291A1 (https=) |
| CO (1) | CO5700829A2 (https=) |
| GB (1) | GB0309221D0 (https=) |
| IS (1) | IS8135A (https=) |
| MA (1) | MA27674A1 (https=) |
| MX (1) | MXPA05011365A (https=) |
| NO (1) | NO20055442L (https=) |
| RU (1) | RU2005136370A (https=) |
| WO (1) | WO2004094430A1 (https=) |
| ZA (1) | ZA200508041B (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7351738B2 (en) * | 2002-11-27 | 2008-04-01 | Elan Pharmaceuticals, Inc. | Substituted ureas and carbamates |
| GB0328900D0 (en) * | 2003-12-12 | 2004-01-14 | Glaxo Group Ltd | Novel compounds |
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| GB0411404D0 (en) * | 2004-05-21 | 2004-06-23 | Glaxo Group Ltd | Novel compounds |
| BRPI0515383A (pt) * | 2004-09-21 | 2008-07-22 | Pfizer Prod Inc | n-etil hidroxietilamina útil no tratamento de condições do snc |
| GB0422765D0 (en) * | 2004-10-13 | 2004-11-17 | Glaxo Group Ltd | Novel compounds |
| GB0422766D0 (en) * | 2004-10-13 | 2004-11-17 | Glaxo Group Ltd | Novel compounds |
| GB0422755D0 (en) * | 2004-10-13 | 2004-11-17 | Glaxo Group Ltd | Novel compounds |
| WO2006088705A1 (en) * | 2005-02-14 | 2006-08-24 | Wyeth | Terphenyl guanidines as [beta symbol] -secretase inhibitors |
| GB0506562D0 (en) * | 2005-03-31 | 2005-05-04 | Glaxo Group Ltd | Novel compounds |
| KR20080015079A (ko) | 2005-04-08 | 2008-02-18 | 코멘티스, 인코포레이티드 | 베타 세크레타제 활성을 억제하는 화합물 및 이것의 사용방법 |
| US20090170830A1 (en) * | 2005-08-03 | 2009-07-02 | Nantermet Philippe G | Tricyclic Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease |
| US7838676B2 (en) * | 2005-11-21 | 2010-11-23 | Amgen Inc. | Beta-secretase modulators and methods of use |
| WO2007061670A1 (en) * | 2005-11-21 | 2007-05-31 | Amgen Inc. | Beta-secretase modulators and methods of use |
| US7745484B2 (en) | 2005-11-21 | 2010-06-29 | Amgen Inc. | Beta-secretase modulators and methods of use |
| US7872009B2 (en) * | 2005-11-21 | 2011-01-18 | Amgen Inc. | Beta-Secretase modulators and methods of use |
| CA2687608C (en) | 2007-05-25 | 2013-07-02 | Amgen Inc. | Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use |
| US8163909B2 (en) | 2007-05-25 | 2012-04-24 | Amgen Inc. | Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use |
| FR2919285B1 (fr) | 2007-07-27 | 2012-08-31 | Sanofi Aventis | Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo- 1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique. |
| PT2185561E (pt) * | 2007-07-27 | 2011-09-07 | Sanofi Aventis | Derivados de 1,2,3,4-tetra-hidropirrolo(1,2-a)pirazina-6- carboxamidas e de 2,3,4,5-tetra-hidropirrolo(1,2-a)-diazepina-7- carboxamidas, sua preparação e sua aplicação em terapia |
| FR2919289B1 (fr) * | 2007-07-27 | 2009-09-04 | Sanofi Aventis Sa | Derives de 2,3,4,5-tetrahydropyrrolo[1,2-a][1,4]- diazepine-7-carboxamides, leur preparation et leur application en therapeutique. |
| FR2919288B1 (fr) * | 2007-07-27 | 2009-09-04 | Sanofi Aventis Sa | Derives de 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6- carboxamides, leur preparation et leur application en therapeutique. |
| FR2919286A1 (fr) | 2007-07-27 | 2009-01-30 | Sanofi Aventis Sa | Derives de derives de 1-oxo-1,2-dihydroisoquinoleine-5- carboxamides et de 4-oxo-3,4-dihydroquinazoline-8- carboxamides,leur preparation et leur application en therapeutique. |
| WO2013148130A1 (en) * | 2012-03-29 | 2013-10-03 | Oklahoma Medical Research Foundation | Inhibition of memapsin 1 cleavage in the treatment of diabetes |
| MX2020003242A (es) * | 2017-09-22 | 2020-09-18 | Jubilant Epipad LLC | Compuestos heterociclicos como inhibidores de pad. |
| WO2019075358A1 (en) * | 2017-10-13 | 2019-04-18 | Ghosh Arun K | BACE1 INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
| US12043631B2 (en) | 2017-10-13 | 2024-07-23 | Purdue Research Foundation | BACE1 inhibitors for the treatment of Alzheimer's disease |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2280096A1 (en) * | 1997-02-04 | 1998-08-06 | The Regents Of The University Of California | Nanomolar, non-peptide inhibitors of cathepsin d |
| US6207664B1 (en) * | 1998-11-25 | 2001-03-27 | Pfizer Inc. | Squalene synthetase inhibitor agents |
| EP1299352B1 (en) * | 2000-06-30 | 2005-12-28 | Elan Pharmaceuticals, Inc. | Compounds to treat alzheimer's disease |
-
2003
- 2003-04-23 GB GBGB0309221.0A patent/GB0309221D0/en not_active Ceased
-
2004
- 2004-04-21 MX MXPA05011365A patent/MXPA05011365A/es not_active Application Discontinuation
- 2004-04-21 JP JP2006505223A patent/JP2006524206A/ja not_active Withdrawn
- 2004-04-21 CN CNA2004800175617A patent/CN1809573A/zh active Pending
- 2004-04-21 US US10/553,878 patent/US20060229302A1/en not_active Abandoned
- 2004-04-21 KR KR1020057019979A patent/KR20050111797A/ko not_active Withdrawn
- 2004-04-21 CA CA002523291A patent/CA2523291A1/en not_active Abandoned
- 2004-04-21 BR BRPI0409622-3A patent/BRPI0409622A/pt not_active IP Right Cessation
- 2004-04-21 RU RU2005136370/04A patent/RU2005136370A/ru not_active Application Discontinuation
- 2004-04-21 EP EP04728567A patent/EP1620438A1/en not_active Withdrawn
- 2004-04-21 WO PCT/EP2004/004244 patent/WO2004094430A1/en not_active Ceased
-
2005
- 2005-10-05 ZA ZA200508041A patent/ZA200508041B/en unknown
- 2005-10-19 MA MA28563A patent/MA27674A1/fr unknown
- 2005-10-21 CO CO05107375A patent/CO5700829A2/es not_active Application Discontinuation
- 2005-11-17 NO NO20055442A patent/NO20055442L/no not_active Application Discontinuation
- 2005-11-21 IS IS8135A patent/IS8135A/is unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO5700829A2 (es) | 2006-11-30 |
| JP2006524206A (ja) | 2006-10-26 |
| MXPA05011365A (es) | 2005-11-28 |
| CA2523291A1 (en) | 2004-11-04 |
| GB0309221D0 (en) | 2003-06-04 |
| EP1620438A1 (en) | 2006-02-01 |
| MA27674A1 (fr) | 2005-12-01 |
| BRPI0409622A (pt) | 2006-04-18 |
| ZA200508041B (en) | 2007-02-28 |
| AU2004232475A1 (en) | 2004-11-04 |
| CN1809573A (zh) | 2006-07-26 |
| KR20050111797A (ko) | 2005-11-28 |
| NO20055442L (no) | 2005-11-17 |
| US20060229302A1 (en) | 2006-10-12 |
| RU2005136370A (ru) | 2006-05-27 |
| WO2004094430A1 (en) | 2004-11-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IS8135A (is) | Þríhringtengdar indólafleiður og notkun þeirra til að meðhöndla Alzheimers-sjúkdóm | |
| IS8134A (is) | Píperasínafleiður og notkun þeirra til að meðhöndla tauga- og geðsjúkdóma | |
| DK1334091T3 (da) | Thioflavinderivater og deres anvendelse til diagnose og terapi af Alzheimer's sygdom | |
| NO20053920D0 (no) | Preparat for og behandling av demyelineringssykdommer og paralyse ved administrering av remyelineringsmidler. | |
| IS8127A (is) | Aðferðir og samsetningar sem nýta ónæmistemprandiefnasambönd í meðferð og umönnun á krabba og öðrum sjúkdómum | |
| DE60216275D1 (de) | Verwendung von mit azetidinon substituierten derivaten bei der behandlung der alzheimer-krankheit | |
| ATE411801T1 (de) | Verwendung von oxindol-derivaten bei der behandlung von demenzbedingten krankheiten, alzheimer-krankheit und erkrankungen im zusammenhang mit glykogen-synthase-kinase-3 | |
| IS7348A (is) | N-pýrasínýl-fenýlsúlfónamíð og notkun þeirra til að meðhöndla flakkboðatengda sjúkdóma | |
| ES2414872T8 (es) | Terapia combinada para la prevención o tratamiento de la enfermedad de Alzheimer y kit correspondiente | |
| ATE389649T1 (de) | Substituierte amin-derivate und deren verwendung zur behandlung von angionese-bedingten erkrankungen | |
| DK1678194T3 (da) | Modulering af syntese og degradering af hyaluronan i behandlingen af sygdom | |
| PL1599467T3 (pl) | Nowe pochodne cyjanopirydyny użyteczne w leczeniu raka i innych zaburzeń | |
| NO20055204D0 (no) | Derivater av piperidinyl- og pipemzinylalkylkarbamater, fremgangsmater for fremstilling derav og anvendelse av de samme i terapi | |
| DK1212317T3 (da) | Indolderivater og anvendelse deraf til behandling af osteoporose blandt andre anvendelser | |
| IS6966A (is) | Cýanó-tengd díhýdrópýrimídín efnasambönd og notkun þeirra við meðhöndlun sjúkdóma | |
| IS7579A (is) | Píperasínýlasýlpíperidín afleiður, framleiðsla þeirra og meðferðar notkun þeirra | |
| IS6967A (is) | Ný cýanó-tengd díhýdrópýrimídín efnasambönd og notkun þeirra við meðhöndlun sjúkdóma | |
| IS7444A (is) | Morfólínýl-þvagefna afleiður til notkunar við meðhöndlun á bólguvaldandi sjúkdómum | |
| DK1590321T3 (da) | Arylalkylcarbamat-derivater, fremstilling og terapeutisk anvendelse deraf | |
| NO20041214L (no) | Substituerte benzimidazolforbindelser og deres anvendelse for behandling av cancer | |
| DK1556382T3 (da) | 3-Phenylpyridoindolderivater, fremstilling og terapeutisk anvendelse deraf | |
| NO20023448D0 (no) | Medikamentkombinasjon for behandling av depresjon og beslektede forstyrrelser omfattende mirtazapin | |
| ITMI20010957A0 (it) | Derivati dell'aoe-emodina e loro impiego nel trattamento di patologieneoplastiche | |
| NO20040659D0 (no) | Isoksazolopyridinoner og andvendelse derav ved behandling av Parkinsons sykdom | |
| NO20052699D0 (no) | 4(fenylpiperazinyl-metyl)benzamid-derivater og deres anvendelse ved behandling av smerte og gastrointestinale lidelser. |