IS4167A - 1-súbstitúeraðar ísatín- og oxindólafleiður sem blokka asetýlkólínesterasa - Google Patents
1-súbstitúeraðar ísatín- og oxindólafleiður sem blokka asetýlkólínesterasaInfo
- Publication number
- IS4167A IS4167A IS4167A IS4167A IS4167A IS 4167 A IS4167 A IS 4167A IS 4167 A IS4167 A IS 4167A IS 4167 A IS4167 A IS 4167A IS 4167 A IS4167 A IS 4167A
- Authority
- IS
- Iceland
- Prior art keywords
- acetylcholinesterase
- block
- oxindole derivatives
- substituted isatin
- isatin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE19939302080A SE9302080D0 (sv) | 1993-06-16 | 1993-06-16 | New compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
IS4167A true IS4167A (is) | 1994-12-17 |
Family
ID=20390305
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IS4167A IS4167A (is) | 1993-06-16 | 1994-05-18 | 1-súbstitúeraðar ísatín- og oxindólafleiður sem blokka asetýlkólínesterasa |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0703901A1 (sv) |
JP (1) | JPH08511515A (sv) |
AU (1) | AU7010894A (sv) |
CA (1) | CA2164119A1 (sv) |
FI (1) | FI956074A (sv) |
IS (1) | IS4167A (sv) |
NO (1) | NO955074L (sv) |
SE (1) | SE9302080D0 (sv) |
WO (1) | WO1994029272A1 (sv) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9103752D0 (sv) * | 1991-12-18 | 1991-12-18 | Astra Ab | New compounds |
DE69911380T2 (de) * | 1998-03-06 | 2004-07-01 | Astrazeneca Ab | Verwendung von isatin- und oxindolderivaten zur herstellung von arzeneimittel für die behandlung von mykobakteriellen erkrankungen |
US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
KR100648869B1 (ko) | 1998-09-30 | 2007-02-28 | 다케다 야쿠힌 고교 가부시키가이샤 | 방광 배출력 개선제 |
US6358947B1 (en) | 1999-05-04 | 2002-03-19 | American Home Products Corporation | Tetracyclic progesterone receptor modulator compounds and methods |
US6380178B1 (en) | 1999-05-04 | 2002-04-30 | American Home Products Corporation | Cyclic regimens using cyclocarbamate and cyclic amide derivatives |
US6399593B1 (en) | 1999-05-04 | 2002-06-04 | Wyeth | Cyclic regimens using cyclic urea and cyclic amide derivatives |
US6358948B1 (en) | 1999-05-04 | 2002-03-19 | American Home Products Corporation | Quinazolinone and benzoxazine derivatives as progesterone receptor modulators |
US6462032B1 (en) | 1999-05-04 | 2002-10-08 | Wyeth | Cyclic regimens utilizing indoline derivatives |
US6380235B1 (en) | 1999-05-04 | 2002-04-30 | American Home Products Corporation | Benzimidazolones and analogues |
US6423699B1 (en) | 1999-05-04 | 2002-07-23 | American Home Products Corporation | Combination therapies using benzimidazolones |
US6369056B1 (en) | 1999-05-04 | 2002-04-09 | American Home Products Corporation | Cyclic urea and cyclic amide derivatives |
US6498154B1 (en) | 1999-05-04 | 2002-12-24 | Wyeth | Cyclic regimens using quinazolinone and benzoxazine derivatives |
US6339098B1 (en) | 1999-05-04 | 2002-01-15 | American Home Products Corporation | 2,1-benzisothiazoline 2,2-dioxides |
US6407101B1 (en) | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
US6444668B1 (en) | 1999-05-04 | 2002-09-03 | Wyeth | Combination regimens using progesterone receptor modulators |
US6509334B1 (en) | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
US6306851B1 (en) | 1999-05-04 | 2001-10-23 | American Home Products Corporation | Cyclocarbamate and cyclic amide derivatives |
US6417214B1 (en) | 1999-05-04 | 2002-07-09 | Wyeth | 3,3-substituted indoline derivatives |
US6319912B1 (en) | 1999-05-04 | 2001-11-20 | American Home Products Corporation | Cyclic regimens using 2,1-benzisothiazoline 2,2-dioxides |
US6329416B1 (en) | 1999-05-04 | 2001-12-11 | American Home Products Corporation | Combination regimens using 3,3-substituted indoline derivatives |
US6391907B1 (en) | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
US6355648B1 (en) | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
UA73119C2 (en) | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
US7186745B2 (en) | 2001-03-06 | 2007-03-06 | Astrazeneca Ab | Indolone derivatives having vascular damaging activity |
TW200508197A (en) | 2003-03-31 | 2005-03-01 | Ucb Sa | Indolone-acetamide derivatives, processes for preparing them and their uses |
JP4914346B2 (ja) * | 2004-05-27 | 2012-04-11 | ユセベ ファルマ ソシエテ アノニム | ベンズオキサゾロン誘導体、その調製方法及びその使用 |
ATE482194T1 (de) | 2004-07-22 | 2010-10-15 | Ucb Pharma Sa | Indolonderivate, verfahren zu deren herstellung und deren anwendungen |
GT200500185A (es) | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
WO2010090680A1 (en) * | 2008-12-15 | 2010-08-12 | Wyeth Llc | Substituted oxindole cb2 agonists |
CA2789014C (en) | 2010-02-09 | 2019-01-15 | Michela Gallagher | Methods and compositions for improving cognitive function |
WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
UA114016C2 (xx) | 2012-12-13 | 2017-04-10 | Композиції, що містять вортіоксетин та донепезил | |
EP3827820A1 (en) | 2013-03-15 | 2021-06-02 | The Johns Hopkins University | Brivaracetam for improving cognitive function |
US11160785B2 (en) | 2013-03-15 | 2021-11-02 | Agenebio Inc. | Methods and compositions for improving cognitive function |
CN103242332B (zh) * | 2013-05-13 | 2015-11-04 | 江西科技师范大学 | 1-n酰基取代吲哚酮衍生物 |
CN104530065A (zh) * | 2013-05-13 | 2015-04-22 | 江西科技师范大学 | 1-n酰基取代吲哚酮衍生物的应用 |
BR112017025031B1 (pt) | 2015-05-22 | 2023-03-21 | Agenebio, Inc | Composições farmacêuticas de liberação prolongada de levetiracetam |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH491106A (de) * | 1964-06-11 | 1970-05-31 | Ciba Geigy | Verfahren zur Herstellung von neuen Thiosemicarbazonen |
-
1993
- 1993-06-16 SE SE19939302080A patent/SE9302080D0/sv unknown
-
1994
- 1994-05-13 AU AU70108/94A patent/AU7010894A/en not_active Abandoned
- 1994-05-13 WO PCT/SE1994/000448 patent/WO1994029272A1/en not_active Application Discontinuation
- 1994-05-13 JP JP7501642A patent/JPH08511515A/ja active Pending
- 1994-05-13 EP EP94919032A patent/EP0703901A1/en not_active Withdrawn
- 1994-05-13 CA CA002164119A patent/CA2164119A1/en not_active Abandoned
- 1994-05-18 IS IS4167A patent/IS4167A/is unknown
-
1995
- 1995-12-14 NO NO955074A patent/NO955074L/no unknown
- 1995-12-18 FI FI956074A patent/FI956074A/sv not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU7010894A (en) | 1995-01-03 |
EP0703901A1 (en) | 1996-04-03 |
SE9302080D0 (sv) | 1993-06-16 |
NO955074D0 (no) | 1995-12-14 |
JPH08511515A (ja) | 1996-12-03 |
NO955074L (no) | 1996-02-07 |
FI956074A0 (sv) | 1995-12-18 |
WO1994029272A1 (en) | 1994-12-22 |
CA2164119A1 (en) | 1994-12-22 |
FI956074A (sv) | 1995-12-18 |
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