IN2015KN00073A - - Google Patents

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Publication number
IN2015KN00073A
IN2015KN00073A IN73KON2015A IN2015KN00073A IN 2015KN00073 A IN2015KN00073 A IN 2015KN00073A IN 73KON2015 A IN73KON2015 A IN 73KON2015A IN 2015KN00073 A IN2015KN00073 A IN 2015KN00073A
Authority
IN
India
Prior art keywords
relates
present
rna molecule
individual cells
molecule expressed
Prior art date
Application number
Other languages
English (en)
Inventor
Yuri Bushkin
Maria Laura Gennaro
Sanjay Tyagi
Richard Pine
Original Assignee
Univ Rutgers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rutgers filed Critical Univ Rutgers
Publication of IN2015KN00073A publication Critical patent/IN2015KN00073A/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6841In situ hybridisation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404Handling flow, e.g. hydrodynamic focusing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6866Interferon
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869Interleukin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/107Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IN73KON2015 2012-06-27 2013-06-26 IN2015KN00073A (enrdf_load_html_response)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261665231P 2012-06-27 2012-06-27
US201361784802P 2013-03-14 2013-03-14
PCT/US2013/047774 WO2014004609A2 (en) 2012-06-27 2013-06-26 Rapid assays for t-cell activation by rna measurements using flow cytometry

Publications (1)

Publication Number Publication Date
IN2015KN00073A true IN2015KN00073A (enrdf_load_html_response) 2015-07-31

Family

ID=49784002

Family Applications (1)

Application Number Title Priority Date Filing Date
IN73KON2015 IN2015KN00073A (enrdf_load_html_response) 2012-06-27 2013-06-26

Country Status (12)

Country Link
US (2) US10900072B2 (enrdf_load_html_response)
EP (2) EP3828278A1 (enrdf_load_html_response)
JP (1) JP6464081B2 (enrdf_load_html_response)
KR (1) KR20150036186A (enrdf_load_html_response)
CN (2) CN104662170A (enrdf_load_html_response)
AU (2) AU2013280416B2 (enrdf_load_html_response)
BR (1) BR112014032677A2 (enrdf_load_html_response)
CA (1) CA2877933A1 (enrdf_load_html_response)
IN (1) IN2015KN00073A (enrdf_load_html_response)
RU (1) RU2671707C2 (enrdf_load_html_response)
WO (1) WO2014004609A2 (enrdf_load_html_response)
ZA (1) ZA201500239B (enrdf_load_html_response)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014019168B1 (pt) 2012-02-03 2021-10-05 California Institute Of Technology Método capaz de detectar de forma não degenerada presença ou ausência de analitos em um único volume de amostra e método de detecção da presença ou ausência de cada analito dentre uma pluralidade de analitos
EP3901243A1 (en) 2012-08-03 2021-10-27 California Institute of Technology Multiplexing and quantification in pcr with reduced hardware and requirements
CN106198358B (zh) * 2016-06-24 2019-02-15 北京大学 基于"石英杯中激发型"流式细胞分选仪的染色体分选方法
CN108732082A (zh) * 2018-06-07 2018-11-02 北京唯公医疗技术有限公司 细胞分群方法
US12203129B2 (en) * 2018-07-03 2025-01-21 ChromaCode, Inc. Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays
JP7457572B2 (ja) * 2019-05-27 2024-03-28 住友化学株式会社 光学フィルムの反りの測定方法、及び、測定装置
US20220308061A1 (en) * 2019-09-03 2022-09-29 The Regents Of The University Of California Method to sequence mrna in single cells in parallel with quantification of intracellular phenotype
WO2021083807A1 (en) * 2019-10-29 2021-05-06 Universitaet Heidelberg Artificial antigen presenting molecules and their uses
CN111999235A (zh) * 2020-07-03 2020-11-27 青岛农业大学 一种利用流式细胞术快速检测有活力的食用菌原生质体数量的方法
RU2766781C1 (ru) * 2021-03-03 2022-03-15 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр кардиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ кардиологии" Минздрава России) Способ выявления поражения сосудистого эндотелия
WO2022271272A1 (en) * 2021-06-22 2022-12-29 Nantcell, Inc. Rapid test for patient cd8 t-cell activation, systems and methods

Family Cites Families (23)

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US4994369A (en) * 1987-12-15 1991-02-19 The Board Of Trustees Of The Leland Stanford Jr. Univ. T-cell activation related gene
US5866331A (en) 1995-10-20 1999-02-02 University Of Massachusetts Single molecule detection by in situ hybridization
EA199900349A1 (ru) * 1996-10-01 2000-06-26 Джерон Корпорейшн Каталитическая субъединица теломеразы человека
US6610839B1 (en) * 1997-08-14 2003-08-26 Geron Corporation Promoter for telomerase reverse transcriptase
US7514232B2 (en) * 1996-12-06 2009-04-07 Becton, Dickinson And Company Method for detecting T cell response to specific antigens in whole blood
RU2258710C2 (ru) 1999-03-09 2005-08-20 Займодженетикс, Инк. Новый цитокин zalpha11-лиганд
RU2346951C2 (ru) 1999-03-09 2009-02-20 Займодженетикс, Инк. Выделенный полипептид, связывающий рецептор zalpha11-лиганда (варианты), кодирующий его полинуклеотид (варианты), вектор экспрессии (варианты) и клетка-хозяин (варианты)
AU2003228591A1 (en) * 2002-04-19 2003-11-03 The Scripps Research Institute Compositions and methods relating to endothelial cell signaling using the protease activated receptor (par1)
EP1546719B1 (en) * 2002-08-08 2015-04-01 Baylor College Of Medicine Isolation and identification of t cells
JP5070045B2 (ja) * 2004-05-27 2012-11-07 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 新規人工抗原提示細胞およびそれらの用途
DE102005020754B3 (de) 2005-05-02 2007-01-11 Altana Pharma Ag Zelluläres Assayverfahren zur Identifizierung von PKCtheta-Inhibitoren
US20090081688A1 (en) * 2005-06-20 2009-03-26 Advanced Cell Diagnostics Methods of detecting nucleic acids in individual cells and of identifying rare cells from large heterogeneous cell populations
EP2460893B1 (en) 2005-06-20 2013-08-28 Advanced Cell Diagnostics, Inc. Multiplex detection of nucleic acids
SI1760089T1 (sl) 2005-09-05 2009-12-31 Immatics Biotechnologies Gmbh S tumorjem povezani peptidi, ki se veĹľejo na molekule humanega levkocitnega antigena (HLA) razreda I ali II in ustrezno cepivo proti raku
US8114982B2 (en) * 2006-12-06 2012-02-14 Albert Einstein College Of Medicine Of Yeshiva University Multi-microRNA methods and compositions
WO2009003493A2 (en) 2007-07-03 2009-01-08 Dako Denmark A/S Mhc multimers, methods for their generation, labeling and use
JP2010004750A (ja) * 2008-06-24 2010-01-14 Institute For Rheumatic Diseases Co Ltd 自己免疫疾患による組織傷害の発症または発症可能性の診断方法、およびその利用
EP2186827A1 (en) * 2008-11-14 2010-05-19 HS LifeSciences Ltd. Surrogate marker directed cDNA cloning of selectively induced mRNAs
ES2363545B2 (es) * 2010-01-26 2012-04-18 Universidade De Santiago De Compostela Método para identificar y purificar células t reguladoras naturales humanas (ntreg).
DE102010037622B4 (de) * 2010-09-17 2012-07-12 Lophius Biosciences Gmbh Verfahren zum Nachweis, Differenzieren und Quantifizieren von T-Zellpopulationen mittels der Reverse Transkription quantitativen Real-Time PCR (RT-qPCR) Technologie
US20120171161A1 (en) * 2010-12-30 2012-07-05 Sascha Abramson Compositions comprising placental stem cells and platelet rich plasma, and methods of use thereof
WO2012162779A1 (en) * 2011-05-27 2012-12-06 The University Of British Columbia Microfluidic cell trap and assay apparatus for high-throughput analysis
JP5344007B2 (ja) * 2011-06-30 2013-11-20 株式会社デンソー 近距離無線通信装置

Also Published As

Publication number Publication date
WO2014004609A2 (en) 2014-01-03
CN108624654A (zh) 2018-10-09
US11767551B2 (en) 2023-09-26
JP2015522284A (ja) 2015-08-06
AU2017228677A1 (en) 2017-10-05
AU2017228677B2 (en) 2019-02-14
AU2013280416B2 (en) 2017-06-15
US20160201122A1 (en) 2016-07-14
WO2014004609A3 (en) 2014-02-27
CN104662170A (zh) 2015-05-27
ZA201500239B (en) 2015-12-23
EP2867374B1 (en) 2020-10-28
AU2013280416A1 (en) 2015-02-05
CA2877933A1 (en) 2014-01-03
BR112014032677A2 (pt) 2019-01-15
RU2671707C2 (ru) 2018-11-06
EP2867374A4 (en) 2016-05-11
JP6464081B2 (ja) 2019-02-06
RU2015102447A (ru) 2016-08-20
US20210139965A1 (en) 2021-05-13
EP3828278A1 (en) 2021-06-02
KR20150036186A (ko) 2015-04-07
US10900072B2 (en) 2021-01-26
EP2867374A2 (en) 2015-05-06

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