IN2015DN02513A - - Google Patents
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- Publication number
- IN2015DN02513A IN2015DN02513A IN2513DEN2015A IN2015DN02513A IN 2015DN02513 A IN2015DN02513 A IN 2015DN02513A IN 2513DEN2015 A IN2513DEN2015 A IN 2513DEN2015A IN 2015DN02513 A IN2015DN02513 A IN 2015DN02513A
- Authority
- IN
- India
- Prior art keywords
- preparation
- compounds
- antibiotics
- ertapenem
- intermediates
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 229940088710 antibiotic agent Drugs 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- JUZNIMUFDBIJCM-ANEDZVCMSA-N Invanz Chemical compound O=C([C@H]1NC[C@H](C1)SC=1[C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)NC1=CC=CC(C(O)=O)=C1 JUZNIMUFDBIJCM-ANEDZVCMSA-N 0.000 abstract 1
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 abstract 1
- 229960002770 ertapenem Drugs 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
- C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
- C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12188351 | 2012-10-12 | ||
| PCT/EP2013/071252 WO2014057079A1 (en) | 2012-10-12 | 2013-10-11 | Preparation of ertapenem intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN02513A true IN2015DN02513A (enrdf_load_stackoverflow) | 2015-09-11 |
Family
ID=47022553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2513DEN2015 IN2015DN02513A (enrdf_load_stackoverflow) | 2012-10-12 | 2013-10-11 |
Country Status (9)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013328585A1 (en) * | 2012-10-12 | 2015-04-09 | Sandoz Ag | Preparation of ertapenem intermediates |
| CN113880839A (zh) * | 2021-11-01 | 2022-01-04 | 石药集团中诺药业（石家庄）有限公司 | 一种厄他培南钠粗品的合成新方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9202298D0 (en) * | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
| AR008255A1 (es) | 1996-07-12 | 1999-12-29 | Merck & Co Inc | Procedimiento para sintetizar antibioticos de carbapenem |
| SK179799A3 (en) | 1997-06-16 | 2000-09-12 | Merck & Co Inc | Stabilized carbapenem intermediates and synthetic use |
| US5872250A (en) * | 1997-07-30 | 1999-02-16 | Merck & Co., Inc. | Process for synthesizing carbapenem antibiotics |
| JP2005508321A (ja) | 2001-09-26 | 2005-03-31 | メルク エンド カムパニー インコーポレーテッド | 結晶形態のエルタペネムナトリウム |
| CN100457760C (zh) * | 2005-10-20 | 2009-02-04 | 上海交通大学 | 尔他培南钠盐的制备方法 |
| US8293894B2 (en) | 2006-11-20 | 2012-10-23 | Orchid Chemicals & Pharmaceuticals Limited | Process for the preparation of carbapenem antibiotic |
| CN101875665B (zh) * | 2009-04-30 | 2013-02-06 | 石药集团中奇制药技术（石家庄）有限公司 | 一种厄他培南中间体、含其的组合物及其制备方法 |
| US20110288289A1 (en) * | 2010-05-19 | 2011-11-24 | Savior Lifetec Corporation | Preparation of Carbapenem Intermediate and Their Use |
| US8729260B2 (en) * | 2010-05-19 | 2014-05-20 | Savior Lifetec Corporation | Process for the preparation of carbapenem using cabapenem intermediates and recovery of cabapenem |
| KR20120007331A (ko) * | 2010-07-14 | 2012-01-20 | 주식회사 경보제약 | 카르바페넴계 화합물들의 개선된 제조방법 |
| CN101935321A (zh) * | 2010-07-20 | 2011-01-05 | 深圳市海滨制药有限公司 | 1β甲基碳青霉烯类抗生素的合成方法 |
| CN102731502B (zh) * | 2011-04-13 | 2016-08-03 | 石药集团中奇制药技术（石家庄）有限公司 | 一种碳青霉烯抗生素的制备方法 |
| CN102351861A (zh) * | 2011-08-16 | 2012-02-15 | 湖南欧亚生物有限公司 | 一种厄他培南的工业化制备方法 |
| CN102432611B (zh) * | 2011-11-09 | 2013-11-20 | 上海希迈医药科技有限公司 | 一种双保护厄他培南结晶体及其制备方法 |
| CN102731508A (zh) * | 2012-07-03 | 2012-10-17 | 浙江海翔川南药业有限公司 | 一种晶体形式的厄他培南中间体及其制备方法和应用 |
| AU2013328585A1 (en) * | 2012-10-12 | 2015-04-09 | Sandoz Ag | Preparation of ertapenem intermediates |
-
2013
- 2013-10-11 AU AU2013328585A patent/AU2013328585A1/en not_active Abandoned
- 2013-10-11 EP EP13774444.7A patent/EP2906561A1/en not_active Withdrawn
- 2013-10-11 IN IN2513DEN2015 patent/IN2015DN02513A/en unknown
- 2013-10-11 KR KR1020157009049A patent/KR20150065176A/ko not_active Withdrawn
- 2013-10-11 WO PCT/EP2013/071252 patent/WO2014057079A1/en active Application Filing
- 2013-10-11 CA CA2887098A patent/CA2887098A1/en not_active Abandoned
- 2013-10-11 CN CN201380053067.5A patent/CN104703986A/zh active Pending
- 2013-10-11 US US14/434,550 patent/US9546171B2/en not_active Expired - Fee Related
- 2013-10-11 JP JP2015536143A patent/JP2015533142A/ja active Pending
-
2017
- 2017-01-17 US US15/407,741 patent/US20170166570A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20170166570A1 (en) | 2017-06-15 |
| CA2887098A1 (en) | 2014-04-17 |
| JP2015533142A (ja) | 2015-11-19 |
| US9546171B2 (en) | 2017-01-17 |
| AU2013328585A1 (en) | 2015-04-09 |
| CN104703986A (zh) | 2015-06-10 |
| EP2906561A1 (en) | 2015-08-19 |
| US20150274732A1 (en) | 2015-10-01 |
| WO2014057079A1 (en) | 2014-04-17 |
| KR20150065176A (ko) | 2015-06-12 |
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