IN2015DN01785A - - Google Patents
Info
- Publication number
- IN2015DN01785A IN2015DN01785A IN1785DEN2015A IN2015DN01785A IN 2015DN01785 A IN2015DN01785 A IN 2015DN01785A IN 1785DEN2015 A IN1785DEN2015 A IN 1785DEN2015A IN 2015DN01785 A IN2015DN01785 A IN 2015DN01785A
- Authority
- IN
- India
- Prior art keywords
- etip
- plant
- targeted
- crisprs
- tals
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 1
- 108091033409 CRISPR Proteins 0.000 abstract 1
- 238000010354 CRISPR gene editing Methods 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108700019146 Transgenes Proteins 0.000 abstract 1
- 108010017070 Zinc Finger Nucleases Proteins 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 230000010354 integration Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000010809 targeting technique Methods 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8209—Selection, visualisation of transformants, reporter constructs, e.g. antibiotic resistance markers
- C12N15/821—Non-antibiotic resistance markers, e.g. morphogenetic, metabolic markers
- C12N15/8212—Colour markers, e.g. beta-glucoronidase [GUS], green fluorescent protein [GFP], carotenoid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8213—Targeted insertion of genes into the plant genome by homologous recombination
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Botany (AREA)
- Physiology (AREA)
- Enzymes And Modification Thereof (AREA)
- Developmental Biology & Embryology (AREA)
- Environmental Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
Abstract
An Engineered Transgene Integration Platform (ETIP) is described that can be inserted randomly or at targeted locations in plant genomes to facilitate rapid selection and detection of a GOI that is perfectly targeted (both the 3? and 5? ends) at the ETIP genomic location. One element in the invention is the introduction of specific double stranded breaks within the ETIP. In some embodiments an ETIP is described using zinc finger nuclease binding sites but may utilize other targeting technologies such as meganucleases TALs CRISPRs or leucine zippers. Also described are compositions of and methods for producing transgenic plants wherein the donor or payload DNA expresses one or more products of an exogenous nucleic acid sequence (e.g. protein or RNA) that has been stably integrated into an ETIP in a plant cell. In embodiments the ETIP facilitates testing of gene candidates and plant expression vectors from ideation through Development phases.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261697890P | 2012-09-07 | 2012-09-07 | |
| US14/020,694 US20140075593A1 (en) | 2012-09-07 | 2013-09-06 | Fluorescence activated cell sorting (facs) enrichment to generate plants |
| PCT/US2013/058766 WO2014039970A1 (en) | 2012-09-07 | 2013-09-09 | Fluorescence activated cell sorting (facs) enrichment to generate plants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN01785A true IN2015DN01785A (en) | 2015-05-29 |
Family
ID=50234835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1785DEN2015 IN2015DN01785A (en) | 2012-09-07 | 2013-09-09 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20140075593A1 (en) |
| EP (1) | EP2893024B1 (en) |
| JP (1) | JP6362600B2 (en) |
| KR (1) | KR102219621B1 (en) |
| CN (2) | CN104736712A (en) |
| AR (1) | AR092482A1 (en) |
| AU (1) | AU2013312198B2 (en) |
| BR (1) | BR112015004864B8 (en) |
| CA (1) | CA2883800C (en) |
| HK (1) | HK1210220A1 (en) |
| IL (1) | IL237535B (en) |
| IN (1) | IN2015DN01785A (en) |
| MX (1) | MX367170B (en) |
| RU (1) | RU2679510C2 (en) |
| TW (1) | TWI670004B (en) |
| WO (1) | WO2014039970A1 (en) |
| ZA (1) | ZA201501736B (en) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3613852A3 (en) | 2011-07-22 | 2020-04-22 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| CA2884162C (en) | 2012-09-07 | 2020-12-29 | Dow Agrosciences Llc | Fad3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks |
| UA119135C2 (en) * | 2012-09-07 | 2019-05-10 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Engineered transgene integration platform (etip) for gene targeting and trait stacking |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| AU2014346559B2 (en) | 2013-11-07 | 2020-07-09 | Editas Medicine,Inc. | CRISPR-related methods and compositions with governing gRNAs |
| US20150166982A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting pi3k point mutations |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| EP3227447B1 (en) | 2014-12-03 | 2024-04-24 | Agilent Technologies, Inc. | Guide rna with chemical modifications |
| JP6873911B2 (en) | 2015-04-06 | 2021-05-19 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | In vitro methods to induce gene regulation of target nucleic acids in primary cells |
| IL294014B1 (en) | 2015-10-23 | 2024-03-01 | Harvard College | Nucleobase editors and uses thereof |
| US10767175B2 (en) | 2016-06-08 | 2020-09-08 | Agilent Technologies, Inc. | High specificity genome editing using chemically modified guide RNAs |
| CN106198358B (en) * | 2016-06-24 | 2019-02-15 | 北京大学 | Chromosome sorting method based on " excitated type in quartz curette " flow cell sorter |
| AU2017306676B2 (en) | 2016-08-03 | 2024-02-22 | President And Fellows Of Harvard College | Adenosine nucleobase editors and uses thereof |
| CA3033327A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| CN110214180A (en) | 2016-10-14 | 2019-09-06 | 哈佛大学的校长及成员们 | The AAV of nucleobase editing machine is delivered |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| JP2020510439A (en) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Base-editing factor from cytosine to guanine |
| KR20190130613A (en) | 2017-03-23 | 2019-11-22 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | Nucleobase edits comprising nucleic acid programmable DNA binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| EP3630973A1 (en) | 2017-05-31 | 2020-04-08 | Tropic Biosciences UK Limited | Methods of selecting cells comprising genome editing events |
| GB201708662D0 (en) | 2017-05-31 | 2017-07-12 | Tropic Biosciences Uk Ltd | Compositions and methods for increasing shelf-life of banana |
| WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
| US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
| US11795443B2 (en) | 2017-10-16 | 2023-10-24 | The Broad Institute, Inc. | Uses of adenosine base editors |
| EP3942040A1 (en) | 2019-03-19 | 2022-01-26 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| GB201905542D0 (en) * | 2019-04-18 | 2019-06-05 | Phytoform Labs Ltd | Methods, systems and apparatus for plant material screening and propagation |
| WO2021067394A1 (en) * | 2019-09-30 | 2021-04-08 | Calyxt, Inc. | Gene editing using a messenger ribonucleic acid construct |
| MX2022014008A (en) | 2020-05-08 | 2023-02-09 | Broad Inst Inc | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence. |
| CA3230927A1 (en) | 2021-09-10 | 2023-03-16 | Agilent Technologies, Inc. | Guide rnas with chemical modification for prime editing |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4727028A (en) | 1981-06-22 | 1988-02-23 | Eli Lilly And Company | Recombinant DNA cloning vectors and the eukaryotic and prokaryotic transformants thereof |
| US4762785A (en) | 1982-08-12 | 1988-08-09 | Calgene, Inc. | Novel method and compositions for introducting alien DNA in vivo |
| EP0116718B2 (en) | 1983-01-13 | 1996-05-08 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Process for the introduction of expressible genes into plant cell genomes and agrobacterium strains carrying hybrid Ti plasmid vectors useful for this process |
| WO1984002919A1 (en) | 1983-01-17 | 1984-08-02 | Monsanto Co | Plasmids for transforming plant cells |
| NL8300698A (en) | 1983-02-24 | 1984-09-17 | Univ Leiden | METHOD FOR BUILDING FOREIGN DNA INTO THE NAME OF DIABIC LOBAL PLANTS; AGROBACTERIUM TUMEFACIENS BACTERIA AND METHOD FOR PRODUCTION THEREOF; PLANTS AND PLANT CELLS WITH CHANGED GENETIC PROPERTIES; PROCESS FOR PREPARING CHEMICAL AND / OR PHARMACEUTICAL PRODUCTS. |
| NL8300699A (en) | 1983-02-24 | 1984-09-17 | Univ Leiden | METHOD FOR BUILDING FOREIGN DNA INTO THE NAME OF DIABIC LOBAL PLANTS; METHOD FOR PRODUCING AGROBACTERIUM TUMEFACIENS BACTERIEN; STABLE COINTEGRATE PLASMIDS; PLANTS AND PLANT CELLS WITH CHANGED GENETIC PROPERTIES; PROCESS FOR PREPARING CHEMICAL AND / OR PHARMACEUTICAL PRODUCTS. |
| US5428147A (en) | 1983-04-15 | 1995-06-27 | Mycogen Plant Science, Inc. | Octopine T-DNA promoters |
| US5231019A (en) | 1984-05-11 | 1993-07-27 | Ciba-Geigy Corporation | Transformation of hereditary material of plants |
| US5149645A (en) | 1984-06-04 | 1992-09-22 | Rijksuniversiteit Leiden | Process for introducing foreign DNA into the genome of plants |
| NL8401780A (en) | 1984-06-04 | 1986-01-02 | Rijksuniversiteit Leiden En Pr | METHOD FOR BUILDING FOREIGN DNA INTO THE GENOMES OF PLANTS |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| CA1288073C (en) | 1985-03-07 | 1991-08-27 | Paul G. Ahlquist | Rna transformation vector |
| US5569597A (en) | 1985-05-13 | 1996-10-29 | Ciba Geigy Corp. | Methods of inserting viral DNA into plant material |
| AU7360087A (en) | 1986-04-30 | 1987-11-24 | Boyce Thompson Institute For Plant Research Inc. | Electric field mediated dna transformation of plant cells and organelles |
| US5188958A (en) | 1986-05-29 | 1993-02-23 | Calgene, Inc. | Transformation and foreign gene expression in brassica species |
| US5177010A (en) | 1986-06-30 | 1993-01-05 | University Of Toledo | Process for transforming corn and the products thereof |
| EP0267159A3 (en) | 1986-11-07 | 1990-05-02 | Ciba-Geigy Ag | Process for the genetic modification of monocotyledonous plants |
| SE455438B (en) | 1986-11-24 | 1988-07-11 | Aga Ab | SET TO REDUCE A BURNER'S FLAME TEMPERATURE AND BURNER WITH THE OXYGEN RESP FUEL NOZZLE |
| US5004863B2 (en) | 1986-12-03 | 2000-10-17 | Agracetus | Genetic engineering of cotton plants and lines |
| ES2074999T3 (en) | 1987-05-20 | 1995-10-01 | Ciba Geigy Ag | ZEA MAYS PLANTS AND TRANSGENIC PLANTS REGENERATED FROM PROTOPLASTS OR CELLS DERIVED FROM PROTOPLASTS. |
| US5316931A (en) | 1988-02-26 | 1994-05-31 | Biosource Genetics Corp. | Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes |
| US5302523A (en) | 1989-06-21 | 1994-04-12 | Zeneca Limited | Transformation of plant cells |
| US5141131A (en) | 1989-06-30 | 1992-08-25 | Dowelanco | Method and apparatus for the acceleration of a propellable matter |
| WO1992009696A1 (en) | 1990-11-23 | 1992-06-11 | Plant Genetic Systems, N.V. | Process for transforming monocotyledonous plants |
| US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
| JPH05130861A (en) * | 1991-11-06 | 1993-05-28 | Hitachi Chem Co Ltd | Production of clone cell from protoplast |
| US5679558A (en) | 1992-04-15 | 1997-10-21 | Plant Genetic Systems, N.V. | Transformation of monocot cells |
| US5591616A (en) | 1992-07-07 | 1997-01-07 | Japan Tobacco, Inc. | Method for transforming monocotyledons |
| US5469976A (en) | 1993-04-30 | 1995-11-28 | Burchell; James R. | Shelf allocation and management system |
| EP0627752B1 (en) | 1993-06-04 | 1997-07-23 | CAVIS S.r.l. | An inertia device for interrupting the electrical circuit of a vehicle with an internal combustion engine |
| ES2330168T3 (en) | 1995-10-13 | 2009-12-04 | Dow Agrosciences Llc | MOPDIFIED GENE OF BACILLUS THURINGIENSIS TO COMBAT LEPIDOPTERS IN PLANTS. |
| US5783431A (en) * | 1996-04-24 | 1998-07-21 | Chromaxome Corporation | Methods for generating and screening novel metabolic pathways |
| US20030219763A1 (en) * | 1996-12-13 | 2003-11-27 | Jen Sheen | Plant protoplast gene expression systems and uses thereof |
| WO2000034468A2 (en) | 1998-12-11 | 2000-06-15 | Biomira Inc. | Muc-1 antagonists and methods of treating immune disorders |
| EP1130093A1 (en) | 1999-01-19 | 2001-09-05 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| ATE538205T1 (en) | 1999-11-29 | 2012-01-15 | Midwest Oilseeds Inc | METHOD, MEDIA AND DEVICE FOR INTRODUCING MOLECULES INTO PLANT CELLS AND BACTERIA USING AEROSOL JETS |
| JP3780333B2 (en) * | 2000-09-22 | 2006-05-31 | 国立大学法人大阪大学 | A novel method for introducing foreign genetic material or physiologically active substance into cells |
| US7022826B2 (en) | 2001-02-26 | 2006-04-04 | The Regents Of The University Of California | Non-oligomerizing fluorescent proteins |
| US20030232410A1 (en) | 2002-03-21 | 2003-12-18 | Monika Liljedahl | Methods and compositions for using zinc finger endonucleases to enhance homologous recombination |
| JP4022614B2 (en) * | 2002-03-25 | 2007-12-19 | 国立大学法人大阪大学 | New biobead manufacturing method |
| US7179965B2 (en) | 2004-03-26 | 2007-02-20 | Dow Agrosciences Llc | Cry1F and Cry1Ac transgenic cotton lines and event-specific identification thereof |
| CN105296527B (en) * | 2006-08-11 | 2020-11-27 | 陶氏益农公司 | Zinc finger nuclease-mediated homologous recombination |
| JP5632610B2 (en) | 2006-12-14 | 2014-11-26 | ダウ アグロサイエンシィズ エルエルシー | Optimized non-canonical zinc finger protein |
| WO2009042163A2 (en) | 2007-09-27 | 2009-04-02 | Sangamo Biosciences, Inc. | Rapid in vivo identification of biologically active nucleases |
| EP2455454A1 (en) * | 2010-11-19 | 2012-05-23 | Albert-Ludwigs-Universität Freiburg | Method for introducing a polynucleotide into plant protoplast cells |
| CN103596423B (en) * | 2011-06-07 | 2017-05-24 | 弗劳恩霍夫应用研究促进协会 | Method for the generation of a monoclonal plant cell line |
-
2013
- 2013-09-06 US US14/020,694 patent/US20140075593A1/en not_active Abandoned
- 2013-09-06 TW TW102132254A patent/TWI670004B/en active
- 2013-09-06 AR ARP130103193A patent/AR092482A1/en unknown
- 2013-09-09 CA CA2883800A patent/CA2883800C/en active Active
- 2013-09-09 RU RU2015112573A patent/RU2679510C2/en active
- 2013-09-09 BR BR112015004864A patent/BR112015004864B8/en active IP Right Grant
- 2013-09-09 JP JP2015531282A patent/JP6362600B2/en active Active
- 2013-09-09 EP EP13835630.8A patent/EP2893024B1/en active Active
- 2013-09-09 MX MX2015002964A patent/MX367170B/en active IP Right Grant
- 2013-09-09 KR KR1020157008557A patent/KR102219621B1/en active IP Right Grant
- 2013-09-09 CN CN201380054087.4A patent/CN104736712A/en active Pending
- 2013-09-09 AU AU2013312198A patent/AU2013312198B2/en active Active
- 2013-09-09 IN IN1785DEN2015 patent/IN2015DN01785A/en unknown
- 2013-09-09 WO PCT/US2013/058766 patent/WO2014039970A1/en active Application Filing
- 2013-09-09 CN CN201910796679.2A patent/CN111118100A/en active Pending
-
2015
- 2015-03-03 IL IL23753515A patent/IL237535B/en active IP Right Grant
- 2015-03-13 ZA ZA2015/01736A patent/ZA201501736B/en unknown
- 2015-11-09 HK HK15111003.5A patent/HK1210220A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2893024A1 (en) | 2015-07-15 |
| CA2883800C (en) | 2021-07-13 |
| US20140075593A1 (en) | 2014-03-13 |
| IL237535A0 (en) | 2015-04-30 |
| CN104736712A (en) | 2015-06-24 |
| RU2015112573A (en) | 2016-10-27 |
| KR20150052241A (en) | 2015-05-13 |
| BR112015004864B1 (en) | 2022-10-25 |
| MX2015002964A (en) | 2015-06-05 |
| BR112015004864A2 (en) | 2017-11-21 |
| CN111118100A (en) | 2020-05-08 |
| TWI670004B (en) | 2019-09-01 |
| AU2013312198B2 (en) | 2018-11-08 |
| TW201424578A (en) | 2014-07-01 |
| WO2014039970A1 (en) | 2014-03-13 |
| AR092482A1 (en) | 2015-04-22 |
| HK1210220A1 (en) | 2016-04-15 |
| RU2679510C2 (en) | 2019-02-11 |
| ZA201501736B (en) | 2016-10-26 |
| JP6362600B2 (en) | 2018-07-25 |
| WO2014039970A9 (en) | 2014-10-09 |
| IL237535B (en) | 2019-11-28 |
| AU2013312198A1 (en) | 2015-03-19 |
| EP2893024A4 (en) | 2016-03-30 |
| JP2015527085A (en) | 2015-09-17 |
| BR112015004864B8 (en) | 2023-05-16 |
| KR102219621B1 (en) | 2021-02-24 |
| EP2893024B1 (en) | 2019-12-04 |
| MX367170B (en) | 2019-08-07 |
| CA2883800A1 (en) | 2014-03-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IN2015DN01785A (en) | ||
| NZ705675A (en) | Engineered transgene integration platform (etip) for gene targeting and trait stacking | |
| WO2014172489A3 (en) | Targeted modification of rat genome | |
| MX2017005267A (en) | Methods and compositions for targeted nucleic acid sequencing. | |
| CA3062698A1 (en) | Nucleic acid molecules encoding an engineered antigen receptor and an inhibitory nucleic acid molecule and methods of use thereof | |
| EP3845640A3 (en) | Modified tranposases for improved insertion sequence bias and increased dna input tolerence | |
| TN2014000493A1 (en) | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription | |
| UA116205C2 (en) | Compositions and methods for quantifying a nucleic acid sequence in a sample | |
| WO2014165612A3 (en) | Methods and compositions for integration of an exogenous sequence within the genome of plants | |
| NZ705745A (en) | Fad3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks | |
| NZ705742A (en) | Fad2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks | |
| MX347575B (en) | Methods and means to modify a plant genome at a nucleotide sequence commonly used in plant genome engineering. | |
| SG11201809242VA (en) | Method for increasing mutation introduction efficiency in genome sequence modification technique, and molecular complex to be used therefor | |
| WO2012017329A8 (en) | Method for targeted genomic events in algae | |
| MX2009006681A (en) | Compositions and methods for the expression of nucleic acids. | |
| WO2014146181A3 (en) | Specific leaf promoter, chimeric gene, recombinant vector, transformed plant or plant part and methods using specific leaf promoter to modify the expression of genes of interest in plants | |
| WO2012012412A3 (en) | Glyphosate-inducible promoter its use | |
| BR112015026422A2 (en) | dual construct system for expressing the coding sequence of a gene of interest in a host cell, dual viral vector system, host cell, pharmaceutical composition, method for treating and / or preventing a condition or disease, nucleic acid and method for induce genetic recombination | |
| WO2012032287A3 (en) | Gene regulation by dna methylation | |
| NZ730667A (en) | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription | |
| MX2015007370A (en) | Recovery of genomic dna from remnant extracted seed samples. |