IN2014MU00203A - - Google Patents
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- Publication number
- IN2014MU00203A IN2014MU00203A IN203MU2014A IN2014MU00203A IN 2014MU00203 A IN2014MU00203 A IN 2014MU00203A IN 203MU2014 A IN203MU2014 A IN 203MU2014A IN 2014MU00203 A IN2014MU00203 A IN 2014MU00203A
- Authority
- IN
- India
- Prior art keywords
- compound
- trazodone
- preparation
- provides
- hydrochloride
- Prior art date
Links
- 238000000034 method Methods 0.000 abstract 5
- 238000002360 preparation method Methods 0.000 abstract 3
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000012535 impurity Substances 0.000 abstract 2
- PHLBKPHSAVXXEF-UHFFFAOYSA-N trazodone Chemical compound ClC1=CC=CC(N2CCN(CCCN3C(N4C=CC=CC4=N3)=O)CC2)=C1 PHLBKPHSAVXXEF-UHFFFAOYSA-N 0.000 abstract 2
- 229960002301 trazodone hydrochloride Drugs 0.000 abstract 2
- OHHDIOKRWWOXMT-UHFFFAOYSA-N trazodone hydrochloride Chemical compound [H+].[Cl-].ClC1=CC=CC(N2CCN(CCCN3C(N4C=CC=CC4=N3)=O)CC2)=C1 OHHDIOKRWWOXMT-UHFFFAOYSA-N 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- 230000002152 alkylating effect Effects 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229960003991 trazodone Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2937417A CA2937417C (en) | 2014-01-21 | 2014-12-12 | An improved process for the preparation of trazodone and hydrochloride salt thereof |
| EP14879353.2A EP3097099A4 (en) | 2014-01-21 | 2014-12-12 | An improved process for the preparation of trazodone and hydrochloride salt thereof |
| PCT/IB2014/066841 WO2015110883A1 (en) | 2014-01-21 | 2014-12-12 | An improved process for the preparation of trazodone and hydrochloride salt thereof |
| JP2016547540A JP2017505302A (ja) | 2014-01-21 | 2014-12-12 | トラゾドンおよびその塩酸塩を製造するための改良法 |
| IN203MU2014 IN2014MU00203A (enrdf_load_stackoverflow) | 2014-01-21 | 2014-12-12 | |
| IL246835A IL246835A0 (en) | 2014-01-21 | 2016-07-19 | Improved process for the preparation of trazodone and its hydrochloride salt |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN203MU2014 IN2014MU00203A (enrdf_load_stackoverflow) | 2014-01-21 | 2014-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014MU00203A true IN2014MU00203A (enrdf_load_stackoverflow) | 2015-09-25 |
Family
ID=53680891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN203MU2014 IN2014MU00203A (enrdf_load_stackoverflow) | 2014-01-21 | 2014-12-12 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP3097099A4 (enrdf_load_stackoverflow) |
| JP (1) | JP2017505302A (enrdf_load_stackoverflow) |
| CA (1) | CA2937417C (enrdf_load_stackoverflow) |
| IL (1) | IL246835A0 (enrdf_load_stackoverflow) |
| IN (1) | IN2014MU00203A (enrdf_load_stackoverflow) |
| WO (1) | WO2015110883A1 (enrdf_load_stackoverflow) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL234822B1 (pl) | 2017-03-14 | 2020-04-30 | Politechnika Krakowska Im Tadeusza Kosciuszki | Sposób otrzymywania trazodonu |
| CN117517545A (zh) * | 2023-12-08 | 2024-02-06 | 重庆锐恩医药有限公司 | 一种盐酸曲唑酮有关物质检测方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1066857B (it) * | 1965-12-15 | 1985-03-12 | Acraf | Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione |
| US4252806A (en) * | 1979-09-24 | 1981-02-24 | Mead Johnson & Company | Triazoloquinolones |
| HU201324B (en) * | 1988-07-29 | 1990-10-28 | Egyt Gyogyszervegyeszeti Gyar | New process for production of substituated 1,2,4-triasole (4,3-a)-piridin-2 (2h)-on |
| ITMI20071603A1 (it) * | 2007-08-03 | 2009-02-04 | Acraf | Trazodone e trazodone cloridrato in forma purificata |
| US20090209550A1 (en) * | 2008-02-20 | 2009-08-20 | Auspex Pharmaceuticals, Inc. | Substituted triazolopyridines |
-
2014
- 2014-12-12 IN IN203MU2014 patent/IN2014MU00203A/en unknown
- 2014-12-12 EP EP14879353.2A patent/EP3097099A4/en not_active Ceased
- 2014-12-12 JP JP2016547540A patent/JP2017505302A/ja active Pending
- 2014-12-12 CA CA2937417A patent/CA2937417C/en active Active
- 2014-12-12 WO PCT/IB2014/066841 patent/WO2015110883A1/en active Application Filing
-
2016
- 2016-07-19 IL IL246835A patent/IL246835A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL246835A0 (en) | 2016-08-31 |
| JP2017505302A (ja) | 2017-02-16 |
| CA2937417A1 (en) | 2015-07-30 |
| EP3097099A1 (en) | 2016-11-30 |
| CA2937417C (en) | 2022-04-12 |
| EP3097099A4 (en) | 2017-08-23 |
| WO2015110883A1 (en) | 2015-07-30 |
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