IN2014MN02418A - - Google Patents

Download PDF

Info

Publication number
IN2014MN02418A
IN2014MN02418A IN2418MUN2014A IN2014MN02418A IN 2014MN02418 A IN2014MN02418 A IN 2014MN02418A IN 2418MUN2014 A IN2418MUN2014 A IN 2418MUN2014A IN 2014MN02418 A IN2014MN02418 A IN 2014MN02418A
Authority
IN
India
Prior art keywords
methods
breast cancer
subject
gene expression
evaluating
Prior art date
Application number
Inventor
Sean M Ferree
James Justin Storhoff
Joel S Parker
Charles M Perou
Matthew J Ellis
Philip S Bernard
Torsten O Nielsen
Original Assignee
Nanostring Technologies Inc
Univ North Carolina
Univ Utah Res Found
British Columbia Cancer Agency
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanostring Technologies Inc, Univ North Carolina, Univ Utah Res Found, British Columbia Cancer Agency, Univ Washington filed Critical Nanostring Technologies Inc
Publication of IN2014MN02418A publication Critical patent/IN2014MN02418A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides methods for classifying and for evaluating the prognosis of a subject having breast cancer are provided. The methods include prediction of breast cancer subtype using a supervised algorithm trained to stratify subjects on the basis of breast cancer intrinsic subtype. The prediction model is based on the gene expression profile of the intrinsic genes listed in Table 1. Further provided are compositions and methods for predicting outcome or response to therapy of a subject diagnosed with or suspected of having breast cancer. These methods are useful for guiding or determining treatment options for a subject afflicted with breast cancer. Methods of the invention further include means for evaluating gene expression profiles including microarrays and quantitative polymerase chain reaction assays as well as kits comprising reagents for practicing the methods of the invention.
IN2418MUN2014 2012-05-22 2013-05-22 IN2014MN02418A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261650209P 2012-05-22 2012-05-22
US201361753673P 2013-01-17 2013-01-17
PCT/US2013/042157 WO2013177245A2 (en) 2012-05-22 2013-05-22 Nano46 genes and methods to predict breast cancer outcome

Publications (1)

Publication Number Publication Date
IN2014MN02418A true IN2014MN02418A (en) 2015-08-14

Family

ID=49624503

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2418MUN2014 IN2014MN02418A (en) 2012-05-22 2013-05-22

Country Status (12)

Country Link
US (3) US20130337444A1 (en)
EP (1) EP2852689B1 (en)
JP (1) JP6325530B2 (en)
CN (2) CN104704128A (en)
AU (1) AU2013266419B2 (en)
BR (1) BR112014029300A2 (en)
CA (1) CA2874492C (en)
ES (1) ES2763931T3 (en)
IL (1) IL235795B (en)
IN (1) IN2014MN02418A (en)
MX (1) MX369628B (en)
WO (1) WO2013177245A2 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2457534T3 (en) 2008-05-30 2014-04-28 The University Of North Carolina At Chapel Hill Gene expression profiles to predict outcomes in breast cancer
EP2685988A4 (en) 2011-03-15 2014-08-20 Univ North Carolina METHODS OF TREATING BREAST CANCER WITH ANTHRACYCLINE THERAPY
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
JP6144695B2 (en) 2011-11-30 2017-06-07 ユニバーシティー オブ ノースカロライナ アット チャペル ヒル How to treat breast cancer with taxane therapy
EP4592400A3 (en) 2012-10-17 2025-10-29 10x Genomics Sweden AB Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
JP2016519935A (en) * 2013-05-13 2016-07-11 ナノストリング テクノロジーズ，インコーポレイティド A method to predict the risk of recurrence in nodule-positive early breast cancer
CA2916662C (en) 2013-06-25 2022-03-08 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
CA2923166A1 (en) * 2013-09-09 2015-03-12 British Columbia Cancer Agency Branch Methods and kits for predicting outcome and methods and kits for treating breast cancer with radiation therapy
WO2016081740A1 (en) 2014-11-21 2016-05-26 Nanostring Technologies, Inc. Enzyme- and amplification-free sequencing
KR102602507B1 (en) * 2014-11-24 2023-11-14 나노스트링 테크놀로지스, 인크. Methods and apparatuses for gene purification and imaging
CA2969163A1 (en) * 2014-12-09 2016-06-16 King's College London Breast cancer treatment with taxane therapy
EP3901282B1 (en) 2015-04-10 2023-06-28 Spatial Transcriptomics AB Spatially distinguished, multiplex nucleic acid analysis of biological specimens
WO2017014694A1 (en) * 2015-07-23 2017-01-26 National University Of Singapore Wbp2 as a co-prognostic factor with her2 for stratification of patients for treatment
CN116200462B (en) 2016-05-16 2025-10-03 布鲁克空间生物学公司 Method for detecting target nucleic acid in a sample
US11352667B2 (en) 2016-06-21 2022-06-07 10X Genomics, Inc. Nucleic acid sequencing
WO2018074865A2 (en) * 2016-10-21 2018-04-26 서울대학교병원 Composition and method for breast cancer prognosis prediction
EP4556575A3 (en) 2016-11-21 2025-10-08 Bruker Spatial Biology, Inc. A method for sequencing nucleic acids
KR101950717B1 (en) * 2016-11-23 2019-02-21 주식회사 젠큐릭스 Methods for predicting effectiveness of chemotherapy for breast cancer patients
WO2018144782A1 (en) * 2017-02-01 2018-08-09 The Translational Genomics Research Institute Methods of detecting somatic and germline variants in impure tumors
CN120210336A (en) 2017-10-06 2025-06-27 10X基因组学有限公司 RNA templated ligation
KR102071491B1 (en) * 2017-11-10 2020-01-30 주식회사 디시젠 Breast cancer prognosis prediction method and system based on machine learning using next generation sequencing
EP3794146B1 (en) 2018-05-14 2025-12-10 Bruker Spatial Biology, Inc. Method for identifying a predetermined nucleotide sequence
US20210371936A1 (en) * 2018-11-05 2021-12-02 Biontech Diagnostics Gmbh Predictive methods in breast cancer
CN119220641A (en) 2019-05-31 2024-12-31 10X基因组学有限公司 Method for detecting target nucleic acid molecules
JP7352937B2 (en) * 2019-07-19 2023-09-29 公立大学法人福島県立医科大学 Differential marker gene set, method and kit for differentiating or classifying breast cancer subtypes
GB201919032D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
EP4484571A3 (en) 2020-02-21 2025-03-19 10X Genomics, Inc. Methods and compositions for integrated in situ spatial assay
US12209273B2 (en) 2020-06-12 2025-01-28 10X Genomics, Inc. Nucleic acid assays using click chemistry bioconjugation
EP3945136A1 (en) * 2020-07-28 2022-02-02 Hospital Clínic de Barcelona In vitro method for the prognosis of patients suffering from her2-positive breast cancer
US12297499B2 (en) 2020-08-17 2025-05-13 10X Genomics, Inc. Multicomponent nucleic acid probes for sample analysis
US12509717B2 (en) 2020-12-11 2025-12-30 10X Genomics, Inc. Methods and compositions for multimodal in situ analysis
US12060603B2 (en) 2021-01-19 2024-08-13 10X Genomics, Inc. Methods for internally controlled in situ assays using padlock probes
AU2022419002A1 (en) * 2021-12-20 2024-08-01 Fundació De Recerca Clínic Barcelona-Institut D’Investigacions Biomèdiques August Pi I Sunyer Development and validation of an in vitro method for the prognosis of patients suffering from her2-positive breast cancer
CN117965734B (en) * 2024-02-02 2024-09-24 奥明星程(杭州)生物科技有限公司 Gene marker for detecting hard fibroid, kit, detection method and application

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5770358A (en) 1991-09-18 1998-06-23 Affymax Technologies N.V. Tagged synthetic oligomer libraries
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
CA2124087C (en) 1991-11-22 2002-10-01 James L. Winkler Combinatorial strategies for polymer synthesis
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
EP0880598A4 (en) 1996-01-23 2005-02-23 Affymetrix Inc Nucleic acid analysis techniques
DE69829402T2 (en) 1997-10-31 2006-04-13 Affymetrix, Inc. (a Delaware Corp.), Santa Clara EXPRESSION PROFILES IN ADULTS AND FOLDS ORGANS
US6020135A (en) 1998-03-27 2000-02-01 Affymetrix, Inc. P53-regulated genes
US6750015B2 (en) * 2000-06-28 2004-06-15 Kathryn B. Horwitz Progesterone receptor-regulated gene expression and methods related thereto
US20020168639A1 (en) * 2000-09-22 2002-11-14 Muraca Patrick J. Profile array substrates
HUE050365T2 (en) 2003-06-24 2022-09-28 Genomic Health Inc Prediction of likelihood of cancer recurrence
US20050071087A1 (en) * 2003-09-29 2005-03-31 Anderson Glenda G. Systems and methods for detecting biological features
US20080032293A1 (en) 2004-07-15 2008-02-07 The University Of North Carolina At Chapel Hill Housekeeping Genes And Methods For Identifying Same
CN101057144A (en) * 2004-09-22 2007-10-17 三路影像公司 Methods and compositions for evaluating breast cancer prognosis
EP1954708A4 (en) 2005-11-23 2009-05-13 Univ Utah Res Found METHODS AND COMPOSITIONS IN WHICH INTRINSIC GENES ARE USED
WO2007076128A2 (en) 2005-12-23 2007-07-05 Nanostring Technologies, Inc. Nanoreporters and methods of manufacturing and use thereof
JP5700911B2 (en) 2005-12-23 2015-04-15 ナノストリング テクノロジーズ，インコーポレーテッド Composition comprising oriented and immobilized macromolecules and method for producing the same
CA2687292C (en) 2007-04-10 2017-07-04 Nanostring Technologies, Inc. Methods and computer systems for identifying target-specific sequences for use in nanoreporters
WO2008150512A2 (en) * 2007-06-04 2008-12-11 University Of Louisville Research Foundation, Inc. Methods for identifying an increased likelihood of recurrence of breast cancer
JP2010538609A (en) * 2007-09-06 2010-12-16 バイオセラノスティクス，インコーポレイティド Tumor grade classification and cancer prognosis
ES2457534T3 (en) 2008-05-30 2014-04-28 The University Of North Carolina At Chapel Hill Gene expression profiles to predict outcomes in breast cancer
US8519115B2 (en) 2008-08-14 2013-08-27 Nanostring Technologies, Inc. Stable nanoreporters
EP2845911B1 (en) * 2010-03-31 2016-05-18 Sividon Diagnostics GmbH Method for breast cancer recurrence prediction under endocrine treatment

Also Published As

Publication number Publication date
AU2013266419A1 (en) 2014-12-11
CN111500718A (en) 2020-08-07
BR112014029300A2 (en) 2017-07-25
CA2874492C (en) 2021-10-19
EP2852689A4 (en) 2016-05-11
US20200332368A1 (en) 2020-10-22
ES2763931T3 (en) 2020-06-01
MX369628B (en) 2019-11-14
EP2852689A2 (en) 2015-04-01
AU2013266419B2 (en) 2018-09-27
JP6325530B2 (en) 2018-05-16
WO2013177245A3 (en) 2015-01-29
CN104704128A (en) 2015-06-10
CA2874492A1 (en) 2013-11-28
IL235795A0 (en) 2015-01-29
IL235795B (en) 2020-02-27
US20230272476A1 (en) 2023-08-31
US20130337444A1 (en) 2013-12-19
MX2014014275A (en) 2015-07-06
JP2015518724A (en) 2015-07-06
EP2852689B1 (en) 2019-12-11
WO2013177245A2 (en) 2013-11-28

Similar Documents

Publication Publication Date Title
IN2014MN02418A (en)
CY1114993T1 (en) Gene Expression Profile To Predict Breast Cancer Outcomes
MX2019007814A (en) Gene expression profile algorithm and test for determining prognosis of prostate cancer.
EP2663656A1 (en) Genetic variants as markers for use in urinary bladder cancer risk assessment, diagnosis, prognosis and treatment
EA201370063A1 (en) PHOSPHOLYPIDE CANCER
NZ621638A (en) Dna methylation in colorectal and breast cancer diagnostic methods
NZ709167A (en) Compositions and methods for diagnosing thyroid tumors
NZ599194A (en) Methods to predict clinical outcome of cancer
WO2010051314A3 (en) Genomic classification of non-small cell lung carcinoma based on patterns of gene copy number alterations
NZ701652A (en) Breast cancer prognosis, prediction of progesterone receptor subtype and|prediction of response to antiprogestin treatment based on gene expression
WO2009009752A3 (en) Genetic models for stratification of cancer risk
HK1222888A1 (en) Methods to predict risk of recurrence in node-positive early breast cancer
WO2019089858A3 (en) Methods of assessing or monitoring a response to a cell therapy
RU2010149541A (en) METHOD FOR FORECASTING THE DEVELOPMENT OF METABOLIC SYNDROME IN A PATIENT WITH ABDOMINAL OBESITY
MX360225B (en) Steroid receptor assays for detecting tumor cells.
MX2017004816A (en) Methods for predicting clinical outcomes in subjects afflicted with ulcerative colitis.
Eapen Relapsed acute lymphoblastic leukemia: Is it crucial to achieve molecular remission prior to transplant?
GB201001950D0 (en) Infection prognostic assay
RU2011134465A (en) A METHOD FOR EVALUATING A PERSONAL PREPARATION FOR ONCOLOGICAL DISEASES BASED ON SIGNIFICANT POLYMORPHISMS OF SINGLE NUCLEOTIDES
WO2011133500A3 (en) Detection and analysis of epigenetic and genetic changes in tumor tissue
HK1199097A1 (en) Predictors for cancer treatment
UA108260U (en) METHOD OF FORECASTING OSTEOPOROSIS DEVELOPMENT
UA95616U (en) METHOD OF FORECASTING FRAGMENT FRAGMENT
UA59264U (en) Method for prediction of individual susceptibility to development of preeclampsia in pregnant
Brennan Quantifying Biomarker Risks and Benefits