IN2014MN02228A - - Google Patents
Info
- Publication number
- IN2014MN02228A IN2014MN02228A IN2228MUN2014A IN2014MN02228A IN 2014MN02228 A IN2014MN02228 A IN 2014MN02228A IN 2228MUN2014 A IN2228MUN2014 A IN 2228MUN2014A IN 2014MN02228 A IN2014MN02228 A IN 2014MN02228A
- Authority
- IN
- India
- Prior art keywords
- jak2
- inden
- imidazo
- pyrazol
- pyridin
- Prior art date
Links
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Chemical compound C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 abstract 1
- GAMYYCRTACQSBR-UHFFFAOYSA-N 4-azabenzimidazole Chemical compound C1=CC=C2NC=NC2=N1 GAMYYCRTACQSBR-UHFFFAOYSA-N 0.000 abstract 1
- 101000997835 Homo sapiens Tyrosine-protein kinase JAK1 Proteins 0.000 abstract 1
- 101000997832 Homo sapiens Tyrosine-protein kinase JAK2 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 102100033438 Tyrosine-protein kinase JAK1 Human genes 0.000 abstract 1
- 102100033444 Tyrosine-protein kinase JAK2 Human genes 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- -1 amino pyrazole compound Chemical class 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004497 pyrazol-5-yl group Chemical group N1N=CC=C1* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261659679P | 2012-06-14 | 2012-06-14 | |
| PCT/US2013/044211 WO2013188184A1 (en) | 2012-06-14 | 2013-06-05 | Inhibitor of jak1 and jak2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014MN02228A true IN2014MN02228A (https=) | 2015-07-17 |
Family
ID=48626679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2228MUN2014 IN2014MN02228A (https=) | 2012-06-14 | 2013-06-05 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9062050B2 (https=) |
| EP (1) | EP2861231B1 (https=) |
| JP (1) | JP6092376B2 (https=) |
| KR (1) | KR20150008907A (https=) |
| CN (1) | CN104349775B (https=) |
| AU (1) | AU2013274641B2 (https=) |
| BR (1) | BR112014030651A2 (https=) |
| CA (1) | CA2871659C (https=) |
| EA (1) | EA201492104A1 (https=) |
| ES (1) | ES2605827T3 (https=) |
| IN (1) | IN2014MN02228A (https=) |
| MX (1) | MX2014015271A (https=) |
| WO (1) | WO2013188184A1 (https=) |
| ZA (1) | ZA201407940B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR105400A1 (es) * | 2015-08-04 | 2017-09-27 | Lilly Co Eli | Inhibidores de jak1 |
| US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| CN110229067A (zh) * | 2019-06-05 | 2019-09-13 | 南京焕然生物科技有限公司 | 一种2-氨基茚制备方法 |
| EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN115141195B (zh) * | 2021-03-03 | 2024-02-06 | 成都先导药物开发股份有限公司 | 一种nuak抑制剂及其用途 |
| TW202325289A (zh) | 2021-11-09 | 2023-07-01 | 美商雅捷可斯治療公司 | Ｊａｋ２抑制劑之形式及組合物 |
| CN116585312A (zh) * | 2023-04-30 | 2023-08-15 | 兰州大学第二医院 | 含苯氧基丙酸化合物的胰腺癌jak2和stat3双靶向抑制剂及应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1853588E (pt) | 2005-02-16 | 2008-08-25 | Astrazeneca Ab | Compostos químicos |
| TWI398252B (zh) * | 2006-05-26 | 2013-06-11 | 諾華公司 | 吡咯并嘧啶化合物及其用途 |
| WO2008129255A1 (en) * | 2007-04-18 | 2008-10-30 | Astrazeneca Ab | 5-aminopyrazol-3-yl-3h-imidazo [4,5-b] pyridine derivatives and their use for the treatment of cancer |
-
2013
- 2013-06-05 CA CA2871659A patent/CA2871659C/en not_active Expired - Fee Related
- 2013-06-05 IN IN2228MUN2014 patent/IN2014MN02228A/en unknown
- 2013-06-05 CN CN201380031385.1A patent/CN104349775B/zh not_active Expired - Fee Related
- 2013-06-05 JP JP2015517311A patent/JP6092376B2/ja not_active Expired - Fee Related
- 2013-06-05 EP EP13729215.7A patent/EP2861231B1/en not_active Not-in-force
- 2013-06-05 KR KR20147034683A patent/KR20150008907A/ko not_active Abandoned
- 2013-06-05 AU AU2013274641A patent/AU2013274641B2/en not_active Ceased
- 2013-06-05 ES ES13729215.7T patent/ES2605827T3/es active Active
- 2013-06-05 EA EA201492104A patent/EA201492104A1/ru unknown
- 2013-06-05 US US14/402,146 patent/US9062050B2/en not_active Expired - Fee Related
- 2013-06-05 BR BR112014030651A patent/BR112014030651A2/pt not_active IP Right Cessation
- 2013-06-05 MX MX2014015271A patent/MX2014015271A/es unknown
- 2013-06-05 WO PCT/US2013/044211 patent/WO2013188184A1/en not_active Ceased
-
2014
- 2014-10-30 ZA ZA2014/07940A patent/ZA201407940B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20150008907A (ko) | 2015-01-23 |
| CN104349775A (zh) | 2015-02-11 |
| ZA201407940B (en) | 2016-05-25 |
| EP2861231A1 (en) | 2015-04-22 |
| EP2861231B1 (en) | 2016-08-31 |
| CA2871659A1 (en) | 2013-12-19 |
| JP2015519396A (ja) | 2015-07-09 |
| EA201492104A1 (ru) | 2015-06-30 |
| JP6092376B2 (ja) | 2017-03-08 |
| MX2014015271A (es) | 2015-03-05 |
| US20150133490A1 (en) | 2015-05-14 |
| BR112014030651A2 (pt) | 2017-06-27 |
| CN104349775B (zh) | 2017-06-06 |
| ES2605827T3 (es) | 2017-03-16 |
| CA2871659C (en) | 2017-04-04 |
| AU2013274641B2 (en) | 2015-09-24 |
| AU2013274641A1 (en) | 2014-11-20 |
| WO2013188184A1 (en) | 2013-12-19 |
| US9062050B2 (en) | 2015-06-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IN2014MN02228A (https=) | ||
| PH12014501986A1 (en) | 2-amino, 6-phenyl substituted pyrido [2,3-d] pyrimidine derivatives useful as raf kinase inhibitors | |
| IL266170A (en) | A process for the preparation of pyrazolo[1,5-a]pyrimidines and their salts | |
| IL266305B (en) | History of [4,2,1]triazolo[5,1-a]pyrimidine as pde2 inhibitors | |
| MX370814B (es) | Pirazolo[3,4-d]pirimidinas sustituidas y usos de las mismas. | |
| SG11201907095UA (en) | DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO [1,2-a]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS | |
| PH12018502604A1 (en) | 1h-pyrazolo[4,3-b]pyridines as pde1 inhibitors | |
| NZ744349A (en) | Pyrazolo[1,5-a]pyrazin-4-yl derivatives as jak-inhibitors | |
| SMT202300157T1 (it) | Pirazolo [1,5-a] pirimidine utili come inibitori dell'atr chinasi per il trattamento di malattie del cancro | |
| MX2018003861A (es) | Nuevos derivados de pirrolo[2,3-d]pirimidina, un proceso para su preparacion y composiciones farmaceuticas que los contienen. | |
| MX2012009074A (es) | Compuestos de urea pirrolo [2, 3-d] pirimidina como inhibidores de janus quinasa. | |
| PH12019501022A1 (en) | Pyrazolopyrimidine compounds and methods of use thereof | |
| IL268923A (en) | History of alicyclic-converted pyrazolo[5,1-a]pyrimidine pharmacological activity | |
| IL262673A (en) | A pyrazolo[5,1-a]pyrimidine compound | |
| IL290419B (en) | Imidazo[a-1,5]pyrazine derivatives as inhibitors of pi3k delta | |
| IL280513A (en) | Imidazo[2,1-B]pyridazines as TRK inhibitors | |
| SG11202001286SA (en) | IMIDAZO[1,5-A]PYRAZINE DERIVATIVES AS PI3Kdelta INHIBITORS | |
| HUE056561T2 (hu) | Gyógyászatilag hatékony aril-szubsztituált pirazolo[1,5-a]pirimidin származékok | |
| IL280122A (en) | Imidazo[2,1-B]pyridazine derivatives as TRK inhibitors | |
| PL3621966T3 (pl) | Pochodne pirazolo[1,5-a]pirymidyny jako inhibitory kinazy JAK | |
| LV14663A (lv) | Pirolo[1,2-a]hinazolīna atvasinājumu sintēze no N-antranilskābes hidrazīdiem un alfa-ketoskābēm | |
| UA84238U (en) | 3-(31,51-ditertbutyl-41-hydroxyphenyl)-6,7-dihydro-5h-pyrrolo[1,2-a]imidazole hydrochloride exhibiting antitumor properties |