IN2014KN01030A - - Google Patents

Info

Publication number
IN2014KN01030A
IN2014KN01030A IN1030KON2014A IN2014KN01030A IN 2014KN01030 A IN2014KN01030 A IN 2014KN01030A IN 1030KON2014 A IN1030KON2014 A IN 1030KON2014A IN 2014KN01030 A IN2014KN01030 A IN 2014KN01030A
Authority
IN
India
Prior art keywords
12the
carbamoyl
cyano
denotes
general formula
Prior art date
Application number
Inventor
Luthra Parven Kumar
Sachin Bhuta
Chandrakant Pise Abhinay
N Chavan Dattatraya
D Metkar Shashikant
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of IN2014KN01030A publication Critical patent/IN2014KN01030A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

12The present invention relates to a process for preparing silodosin with high optical purity up to 99.9% enantiomeric excess (e.e.) or above. The process makes use of a method step in which the enantiomers contained in a racemic mixture of a compound represented by the general formula V: wherein * denotes the asymmetric center R is a protecting group and R is cyano or carbamoyl are separated.
IN1030KON2014 2011-10-21 2012-10-19 IN2014KN01030A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161549800P 2011-10-21 2011-10-21
EP11008484 2011-10-21
PCT/EP2012/004378 WO2013056842A1 (en) 2011-10-21 2012-10-19 Method for preparing silodosin

Publications (1)

Publication Number Publication Date
IN2014KN01030A true IN2014KN01030A (en) 2015-10-09

Family

ID=48140363

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1030KON2014 IN2014KN01030A (en) 2011-10-21 2012-10-19

Country Status (6)

Country Link
US (2) US20150038727A1 (en)
EP (1) EP2768806B1 (en)
CN (1) CN104302621A (en)
ES (1) ES2639196T3 (en)
IN (1) IN2014KN01030A (en)
WO (1) WO2013056842A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101447574B1 (en) * 2013-11-29 2014-10-07 동국제약 주식회사 Method for preparing silodosin using new intermediates
KR102114323B1 (en) * 2013-12-09 2020-05-22 이니스트에스티 주식회사 Method of preparing 1-(indolin-5-yl)propan-2-ol derivatives
KR101628946B1 (en) * 2014-07-09 2016-06-09 동방에프티엘(주) Improved Process of Silodosin
WO2016189552A2 (en) * 2015-05-26 2016-12-01 Ipca Laboratories Limited Novel recovery and recycling process of unwanted enantiomers of 2-aminopropyl indoline derivatives
ES2607639B1 (en) * 2015-09-30 2018-02-28 Urquima, S.A Maleic acid salt of a silodosin intermediate
CN106995399A (en) * 2016-01-25 2017-08-01 北京天泰恒华医药技术有限公司 A kind of method for preparing Silodosin
CN106083689B (en) * 2016-06-14 2020-07-31 齐鲁制药有限公司 Preparation method of silodosin compound
CN106380438B (en) * 2016-08-30 2019-07-30 江苏宇田医药有限公司 A kind of preparation method of indoline derivative for synthesizing silodosin
CN106496092B (en) * 2016-08-30 2019-03-29 江苏宇田医药有限公司 A kind of preparation method of intermediate for synthesizing silodosin
CN106928118B (en) * 2017-04-11 2022-08-23 常州瑞明药业有限公司 Method for preparing silodosin intermediate
EP3892615A1 (en) 2020-04-09 2021-10-13 Minakem Process for the preparation of silodosin

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69319551T2 (en) 1992-12-02 1998-10-29 Kissei Pharmaceutical Indoline compounds used to treat dysurias
JP4634560B2 (en) 2000-01-14 2011-02-16 キッセイ薬品工業株式会社 Process for producing optically active indoline derivative and production intermediate thereof
JP4921646B2 (en) 2001-03-08 2012-04-25 キッセイ薬品工業株式会社 1- (3-Benzyloxypropyl) -5- (2-substituted propyl) indoline derivatives and methods of use thereof
MX2007005126A (en) 2004-10-27 2007-07-04 Kissei Pharmaceutical Indoline compound and process for producing the same.
JP2006188470A (en) * 2005-01-07 2006-07-20 Kissei Pharmaceut Co Ltd Indoline derivative and method for producing the same
CN101993405B (en) * 2009-08-27 2014-01-15 浙江华海药业股份有限公司 Indoline derivatives, preparation methods and uses thereof
CN101993406B (en) * 2009-08-27 2014-01-15 浙江华海药业股份有限公司 Optically active indoline compound and its preparation method
CN101993407B (en) * 2009-08-27 2014-01-29 浙江华海药业股份有限公司 Indoline compound for preparing silodosin and preparation method thereof
JP5661773B2 (en) * 2009-09-12 2015-01-28 サンド・アクチエンゲゼルシヤフト Process for the preparation of indoline derivatives and intermediates thereof
CN101759627A (en) * 2009-09-15 2010-06-30 傅军 Novel preparation method of silodosin
WO2011124704A1 (en) * 2010-04-09 2011-10-13 Ratiopharm Gmbh Process for preparing an intermediate for silodosin
WO2012131710A2 (en) * 2011-03-30 2012-10-04 Panacea Biotec Ltd Novel process for the synthesis of indoline derivatives

Also Published As

Publication number Publication date
EP2768806B1 (en) 2017-05-31
EP2768806A1 (en) 2014-08-27
US20150038727A1 (en) 2015-02-05
WO2013056842A1 (en) 2013-04-25
US20160176818A1 (en) 2016-06-23
CN104302621A (en) 2015-01-21
US9938239B2 (en) 2018-04-10
ES2639196T3 (en) 2017-10-25

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