IN2014DN10328A - - Google Patents

Download PDF

Info

Publication number
IN2014DN10328A
IN2014DN10328A IN10328DEN2014A IN2014DN10328A IN 2014DN10328 A IN2014DN10328 A IN 2014DN10328A IN 10328DEN2014 A IN10328DEN2014 A IN 10328DEN2014A IN 2014DN10328 A IN2014DN10328 A IN 2014DN10328A
Authority
IN
India
Prior art keywords
telaprevir
boceprevir
peptides
synthetic routes
preparing
Prior art date
Application number
Other languages
English (en)
Inventor
PRANTZ Kathrin HOEFERL
Wolfgang Felzmann
Thorsten Wilhelm
GARAGORRI David BENITO
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of IN2014DN10328A publication Critical patent/IN2014DN10328A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/02—Formation of carboxyl groups in compounds containing amino groups, e.g. by oxidation of amino alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
IN10328DEN2014 2012-06-20 2013-06-19 IN2014DN10328A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12172775 2012-06-20
PCT/EP2013/062737 WO2013189980A1 (fr) 2012-06-20 2013-06-19 Synthèse de télaprévir et de bocéprévir, ou de sels ou de solvates pharmaceutiquement acceptables de ceux-ci et produits intermédiaires correspondants, notamment des acides ss-aminés, préparés par addition aldolique de mukaiyama

Publications (1)

Publication Number Publication Date
IN2014DN10328A true IN2014DN10328A (fr) 2015-08-07

Family

ID=48652093

Family Applications (1)

Application Number Title Priority Date Filing Date
IN10328DEN2014 IN2014DN10328A (fr) 2012-06-20 2013-06-19

Country Status (6)

Country Link
US (1) US9346853B2 (fr)
EP (1) EP2864321A1 (fr)
CN (1) CN104470914A (fr)
IN (1) IN2014DN10328A (fr)
RU (1) RU2014151613A (fr)
WO (1) WO2013189980A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105085310B (zh) * 2014-05-15 2017-05-10 重庆汇智药物研究院有限公司 一种替拉瑞韦中间体的合成新方法
WO2024015574A1 (fr) * 2022-07-14 2024-01-18 Jnana Therapeutics Inc. Inhibiteurs à petites molécules de la fonction slc6a19 de mammifère

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR044694A1 (es) * 2003-06-17 2005-09-21 Schering Corp Proceso y compuestos intermedios para la preparacion de (1r, 2s,5s) - 3 azabiciclo [3,1,0] hexano-2- carboxamida, n- [3- amino-1- (ciclobutilmetil) - 2, 3 - dioxopropil] -3- [ (2s) - 2 - [[ [ 1,1- dimetiletil] amino] carbonilamino] -3,3-dimetil -1- oxobutil]-6,6 dimetilo
JP5203203B2 (ja) 2005-08-19 2013-06-05 バーテックス ファーマシューティカルズ インコーポレイテッド 製造工程および中間体
CA2646123A1 (fr) 2006-03-16 2007-09-27 Vertex Pharmaceuticals Incorporated Procedes et intermediaires pour la synthese de composes steriques
WO2007138928A1 (fr) 2006-05-26 2007-12-06 Kaneka Corporation Procédé de production de dérivés optiquement actifs de cyclopropylamide d'acide 3-amino-2-hydroxypropionique et de leurs sels
WO2009114633A1 (fr) 2008-03-12 2009-09-17 Virobay, Inc. Procédé de préparation de dérivés de (3s)-3-amino-n-cyclopropyl-2-hydroxyalcanamide
US8143448B2 (en) 2008-06-13 2012-03-27 Virobay, Inc. Process for the preparation of (3S)-3-amino-N-cyclopropyl-2-hydroxyalkanamide derivatives

Also Published As

Publication number Publication date
WO2013189980A1 (fr) 2013-12-27
RU2014151613A (ru) 2016-08-10
US9346853B2 (en) 2016-05-24
CN104470914A (zh) 2015-03-25
EP2864321A1 (fr) 2015-04-29
US20150183824A1 (en) 2015-07-02

Similar Documents

Publication Publication Date Title
SG10201900948PA (en) Modified nucleotide linkers
CL2016000460A1 (es) Proteínas de unión al antígeno gitr
SG10201902924RA (en) Antibodies that bind ebola glycoprotein and uses thereof
MX2018010572A (es) Inmunoglobulinas heterodimericas.
MX2011011925A (es) Anticuerpos triespecificos o tetraespecificos.
PH12014501427B1 (en) Anti-phf-tau antibodies and their uses
NZ726859A (en) Synthesis of polycyclic-carbamoylpyridone compounds
WO2013138793A3 (fr) Réactifs d'affinité pour la purification de protéines
MX347454B (es) Anticuerpos monoclonales inhibidores anti-factor xii-xiia.
UA111827C2 (uk) Спосіб отримання інгенол-3-ангелату
MX346500B (es) Metodos y composiciones para inmunoterapia para enfermedad neural.
IN2012MU03723A (fr)
MX2017007381A (es) Miembros de union para homologo del oncogen de fibrosarcoma musculoadoneurotico (c-maf) humano.
AU2014324499A8 (en) Novel synthesis routes for prostaglandins and prostaglandin intermediates using metathesis
MX369662B (es) Granulos de harina de microalgas y proceso de preparacion de estos.
JO3771B1 (ar) متوسطات لتحضير ساكوبيتريل وتحضيرها
MY176465A (en) Synthetic route to 2?-deoxy-2?,2?-difluorotetrahydrouridines
IN2014DN09450A (fr)
IN2014DN07983A (fr)
IN2013MN00733A (fr)
MY175464A (en) Synthesis of trans-8-chloro-5-methyl-1-[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulene and crytalline forms thereof
PH12016501201A1 (en) Synthesis of ent-progesterone and intermediates thereof
IN2014DN10328A (fr)
PH12017500499A1 (en) Synthesis of ent-progesterone and intermediates thereof
EA201590778A1 (ru) ОЧИСТКА КОМБИНИРОВАННОЙ ГАЛАКТОЦЕРЕБРОЗИД-β-ГАЛАКТОЗИДАЗЫ ЧЕЛОВЕКА (rhGALC)