IN2014DN09922A - - Google Patents
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- Publication number
- IN2014DN09922A IN2014DN09922A IN9922DEN2014A IN2014DN09922A IN 2014DN09922 A IN2014DN09922 A IN 2014DN09922A IN 9922DEN2014 A IN9922DEN2014 A IN 9922DEN2014A IN 2014DN09922 A IN2014DN09922 A IN 2014DN09922A
- Authority
- IN
- India
- Prior art keywords
- bcn
- amino acid
- relates
- group
- ylmethanol
- Prior art date
Links
- NSVXZMGWYBICRW-UHFFFAOYSA-N 9-bicyclo[6.1.0]non-4-ynylmethanol Chemical compound C1CC#CCCC2C(CO)C21 NSVXZMGWYBICRW-UHFFFAOYSA-N 0.000 abstract 9
- 150000001413 amino acids Chemical class 0.000 abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 2
- 239000004472 Lysine Substances 0.000 abstract 2
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 abstract 1
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 abstract 1
- -1 lysine amino acid Chemical class 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 108040001032 pyrrolysyl-tRNA synthetase activity proteins Proteins 0.000 abstract 1
- 0 CC(c1ccc(CNC(*2C=CC(C(OC3(c(ccc(OC(C)=O)c4)c4Oc4c5)c4ccc5OC(C)=O)=O)=C3C=C2)=O)cc1)=NN=CN=C* Chemical compound CC(c1ccc(CNC(*2C=CC(C(OC3(c(ccc(OC(C)=O)c4)c4Oc4c5)c4ccc5OC(C)=O)=O)=C3C=C2)=O)cc1)=NN=CN=C* 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/13—Labelling of peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y601/00—Ligases forming carbon-oxygen bonds (6.1)
- C12Y601/01—Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
- C12Y601/01026—Pyrrolysine-tRNAPyl ligase (6.1.1.26)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1208875.3A GB201208875D0 (en) | 2012-05-18 | 2012-05-18 | Methods |
| GBGB1210303.2A GB201210303D0 (en) | 2012-06-08 | 2012-06-08 | Polypeptides and methods |
| PCT/GB2013/051249 WO2013171485A1 (en) | 2012-05-18 | 2013-05-15 | Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN09922A true IN2014DN09922A (enrdf_load_stackoverflow) | 2015-08-14 |
Family
ID=48748281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN9922DEN2014 IN2014DN09922A (enrdf_load_stackoverflow) | 2012-05-18 | 2013-05-15 |
Country Status (8)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6343604B2 (ja) * | 2012-05-18 | 2018-06-13 | メディカル リサーチ カウンシル | ＢＣＮ基を含むアミノ酸をコードする直交性コドンと、直交性ＰｙｌＲＳ合成酵素とを使用して、ＢＣＮ基を含むアミノ酸をポリペプチドに取り込む方法 |
| CN104744293B (zh) * | 2013-12-31 | 2016-08-17 | 深圳先进技术研究院 | 胆碱类似物及其制备方法和应用、由染料分子标记的四嗪探针及其制备方法和应用 |
| GB2528227A (en) | 2014-03-14 | 2016-01-20 | Medical Res Council | Cyclopropene amino acids and methods |
| WO2016176689A1 (en) * | 2015-04-30 | 2016-11-03 | Oregon State University | Reagents and methods for bioorthogonal labeling of biomolecules in living cells |
| EP3360960A4 (en) * | 2015-08-19 | 2019-03-20 | Riken | ANTIBODIES WITH INGREDIENTS OF NON-NATURAL AMINO ACID |
| CN105254655B (zh) * | 2015-11-20 | 2017-03-22 | 江汉大学 | 一种基于bodipy的荧光氨基酸及其合成方法与应用 |
| CN106565762B (zh) * | 2016-11-17 | 2018-10-23 | 陕西师范大学 | 一种原位产生近红外荧光的bodipy类染料及其制备和应用 |
| AR111190A1 (es) | 2017-03-22 | 2019-06-12 | Genentech Inc | Composiciones en hidrogel de prodrogas entrecruzadas de ácido hialurónico y métodos relacionados |
| JOP20190245A1 (ar) | 2017-04-20 | 2019-10-15 | Novartis Ag | أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط |
| US11560384B2 (en) | 2017-05-04 | 2023-01-24 | University Of Utah Research Foundation | Benzonorbornadiene derivatives and reactions thereof |
| AR111963A1 (es) * | 2017-05-26 | 2019-09-04 | Univ California | Método y moléculas |
| AR116566A1 (es) | 2018-10-03 | 2021-05-19 | Novartis Ag | Administración sostenida de polipéptidos similares a la angiopoyetina 3 |
| GB201817444D0 (en) | 2018-10-26 | 2018-12-12 | Res & Innovation Uk | Methods and compositions |
| CN111849929B (zh) * | 2019-04-30 | 2021-05-11 | 苏州鲲鹏生物技术有限公司 | 高效引入赖氨酸衍生物的氨酰基—tRNA合成酶 |
| GB201906775D0 (en) | 2019-05-14 | 2019-06-26 | Res & Innovation Uk | Synthetic genome |
| IL267744A (en) * | 2019-06-30 | 2019-08-29 | Nat Inst Biotechnology Negev Ltd | Labelling molecules and methods of use thereof |
| CN115701451B (zh) * | 2021-08-02 | 2023-08-01 | 宁波鲲鹏生物科技有限公司 | 高效引入赖氨酸衍生物的氨酰基-tRNA合成酶及其应用 |
| WO2024223923A1 (en) | 2023-04-28 | 2024-10-31 | United Kingdom Research And Innovation | tRNA-BASED METHODS AND RELATED COMPOSITIONS |
| GB202307998D0 (en) | 2023-05-29 | 2023-07-12 | Res & Innovation Uk | Aminoacyl-irna synthetase sets |
| CN119613545A (zh) * | 2024-12-16 | 2025-03-14 | 天津大学 | 非天然氨基酸修饰的抗ccl5纳米抗体 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040029129A1 (en) * | 2001-10-25 | 2004-02-12 | Liangsu Wang | Identification of essential genes in microorganisms |
| JP5275566B2 (ja) | 2003-06-18 | 2013-08-28 | ザ スクリプス リサーチ インスティチュート | 反応性非天然アミノ酸遺伝コード付加 |
| ATE471385T1 (de) * | 2003-07-07 | 2010-07-15 | Scripps Research Inst | Zusammensetzungen aus orthogonalen lysyl-trna- und aminoacyl-trna-synthetasepaaren und deren verwendung |
| US7709604B2 (en) | 2003-12-18 | 2010-05-04 | The Scripps Research Institute | Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells |
| CA2580840A1 (en) | 2004-09-21 | 2006-03-30 | The Scripps Research Institute | In vivo incorporation of alkynyl amino acids into proteins in eubacteria |
| EP2383340B1 (en) | 2004-10-27 | 2014-07-16 | The Scripps Research Institute | Orthogonal translation components for the in vivo incorporation of unnatural amino acids |
| US8431558B2 (en) * | 2004-11-01 | 2013-04-30 | The Regents Of The University Of California | Compositions and methods for modification of biomolecules |
| JP2007037445A (ja) | 2005-08-02 | 2007-02-15 | Institute Of Physical & Chemical Research | ｔＲＮＡ合成方法、核酸、アミノアシルｔＲＮＡ合成方法及び非天然型アミノ酸組み込み蛋白質の製造方法 |
| US20090081669A1 (en) | 2006-02-01 | 2009-03-26 | Encode Bio, Inc. | Fluorescent Assays Using Orthogonal tRNA - Aminoacyl Synthetase Pairs |
| US20080096819A1 (en) | 2006-05-02 | 2008-04-24 | Allozyne, Inc. | Amino acid substituted molecules |
| JP2010526091A (ja) | 2007-04-30 | 2010-07-29 | インテザイン テクノロジーズ， インコーポレイテッド | 癌の処置のための生物学的な標的基の改変 |
| JP5590649B2 (ja) * | 2007-09-20 | 2014-09-17 | 独立行政法人理化学研究所 | 変異体ピロリジル−ｔＲＮＡ合成酵素及びこれを用いる非天然アミノ酸組み込みタンパク質の製造方法 |
| GB0721291D0 (en) | 2007-10-30 | 2007-12-12 | Medical Res Council | Methods and compositions |
| PE20120616A1 (es) * | 2009-02-25 | 2012-05-26 | Bigtec Private Ltd | Sondas y cebadores para la deteccion de chikungunya |
| GB2470770A (en) | 2009-06-04 | 2010-12-08 | Medical Res Council | Incorporation of unnatural amino acids having an orthogonal functional group into polypeptides using orthogonal tRNA/tRNA synthetase pairs |
| GB0917240D0 (en) * | 2009-10-01 | 2009-11-18 | Medical Res Council | Incorporation of methyl lysine into poiypeptide |
| GB0917242D0 (en) * | 2009-10-01 | 2009-11-18 | Medical Res Council | Acetyl lysine incorporation with tRNA synthetase |
| KR101687054B1 (ko) | 2010-04-15 | 2016-12-15 | 메디뮨 리미티드 | 증식성 질환 치료용 피롤로벤조디아제핀 |
| DK2563753T6 (en) * | 2010-04-27 | 2016-04-04 | Synaffix Bv | Fused cyclooctynforbindelser and their use in metal-free click-reactions |
| US20120077186A1 (en) | 2010-05-07 | 2012-03-29 | Oregon Health & Science University | Use of cysteine-derived suppressor trnas for non-native amino acid incorporation |
| WO2011156686A2 (en) | 2010-06-11 | 2011-12-15 | The Regents Of The University Of Colorado, A Body Corporate | Method for synthesizing a cyclic multivalent peptide using a thiol-mediated reaction |
| DK2670767T3 (en) | 2011-02-03 | 2018-03-26 | European Molecular Biology Laboratory | Non-naturally occurring amino acids comprising a cyclooctynyl or transcyclooctynyl analog group and uses thereof |
| GB201110815D0 (en) * | 2011-06-24 | 2011-08-10 | Medical Res Council | Incorporation of subtituted lysines into polypeptides |
| EP2753607B1 (en) * | 2011-09-09 | 2016-04-13 | Berry And Associates, Inc. | Bicyclo[6.1.0]non-4-yne reagents for chemical modification of oligonucleotides |
| GB201201100D0 (en) | 2012-01-20 | 2012-03-07 | Medical Res Council | Polypeptides and methods |
| JP6343604B2 (ja) * | 2012-05-18 | 2018-06-13 | メディカル リサーチ カウンシル | ＢＣＮ基を含むアミノ酸をコードする直交性コドンと、直交性ＰｙｌＲＳ合成酵素とを使用して、ＢＣＮ基を含むアミノ酸をポリペプチドに取り込む方法 |
| AU2013308494B2 (en) | 2012-08-31 | 2018-03-01 | Sutro Biopharma, Inc. | Modified amino acids comprising an azido group |
| SG11201502216UA (en) | 2012-09-24 | 2015-04-29 | Medimmune Ltd | Cell lines |
| GB2528227A (en) | 2014-03-14 | 2016-01-20 | Medical Res Council | Cyclopropene amino acids and methods |
| GB201419109D0 (en) | 2014-10-27 | 2014-12-10 | Medical Res Council | Incorporation of unnatural amino acids into proteins |
| EP3274459A4 (en) * | 2015-03-27 | 2018-08-22 | The University of Queensland | Platform for non-natural amino acid incorporation into proteins |
| GB201817444D0 (en) | 2018-10-26 | 2018-12-12 | Res & Innovation Uk | Methods and compositions |
| EP3868882A1 (en) * | 2020-02-21 | 2021-08-25 | European Molecular Biology Laboratory | Archaeal pyrrolysyl trna synthetases for orthogonal use |
-
2013
- 2013-05-15 JP JP2015512124A patent/JP6343604B2/ja active Active
- 2013-05-15 CN CN201380037290.0A patent/CN104718285A/zh active Pending
- 2013-05-15 CA CA2873793A patent/CA2873793C/en active Active
- 2013-05-15 BR BR112014028588-8A patent/BR112014028588B1/pt active IP Right Grant
- 2013-05-15 WO PCT/GB2013/051249 patent/WO2013171485A1/en active Application Filing
- 2013-05-15 EP EP13734818.1A patent/EP2852664B1/en active Active
- 2013-05-15 IN IN9922DEN2014 patent/IN2014DN09922A/en unknown
- 2013-05-15 CN CN201810228028.9A patent/CN108410827B/zh active Active
- 2013-05-15 US US14/401,803 patent/US20150148525A1/en not_active Abandoned
-
2020
- 2020-05-12 US US16/872,826 patent/US11732001B2/en active Active
-
2023
- 2023-05-16 US US18/198,205 patent/US20230340013A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112014028588B1 (pt) | 2023-03-21 |
| US11732001B2 (en) | 2023-08-22 |
| BR112014028588A2 (pt) | 2017-06-27 |
| JP2015523965A (ja) | 2015-08-20 |
| CA2873793A1 (en) | 2013-11-21 |
| BR112014028588A8 (pt) | 2021-06-29 |
| CN104718285A (zh) | 2015-06-17 |
| CA2873793C (en) | 2022-02-22 |
| US20230340013A1 (en) | 2023-10-26 |
| US20200271658A1 (en) | 2020-08-27 |
| WO2013171485A1 (en) | 2013-11-21 |
| CN108410827B (zh) | 2023-05-09 |
| HK1208704A1 (en) | 2016-03-11 |
| EP2852664A1 (en) | 2015-04-01 |
| CN108410827A (zh) | 2018-08-17 |
| JP6343604B2 (ja) | 2018-06-13 |
| US20150148525A1 (en) | 2015-05-28 |
| EP2852664B1 (en) | 2017-09-06 |
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