IN2014DN09412A - - Google Patents

Info

Publication number
IN2014DN09412A
IN2014DN09412A IN9412DEN2014A IN2014DN09412A IN 2014DN09412 A IN2014DN09412 A IN 2014DN09412A IN 9412DEN2014 A IN9412DEN2014 A IN 9412DEN2014A IN 2014DN09412 A IN2014DN09412 A IN 2014DN09412A
Authority
IN
India
Prior art keywords
bacterial biofilm
composition
seaprose
disrupts
disrupting
Prior art date
Application number
Other languages
English (en)
Inventor
Lei Shi
Aleksa Jovanovic
Kar Catherine Van Der
Eric Roche
Original Assignee
Smith & Nephew Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith & Nephew Inc filed Critical Smith & Nephew Inc
Publication of IN2014DN09412A publication Critical patent/IN2014DN09412A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/082—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances in combination with specific enzymes
    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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    • A61L31/10—Macromolecular materials
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
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    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C12N9/62—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from Aspergillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21063—Oryzin (3.4.21.63)
    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/254—Enzymes, proenzymes
    • A—HUMAN NECESSITIES
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Materials Engineering (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
IN9412DEN2014 2012-05-11 2013-05-10 IN2014DN09412A (OSRAM)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261645815P 2012-05-11 2012-05-11
US201361820915P 2013-05-08 2013-05-08
PCT/US2013/040514 WO2013170128A1 (en) 2012-05-11 2013-05-10 Use of seaprose to remove bacterial biofilm

Publications (1)

Publication Number Publication Date
IN2014DN09412A true IN2014DN09412A (OSRAM) 2015-07-17

Family

ID=48468851

Family Applications (1)

Application Number Title Priority Date Filing Date
IN9412DEN2014 IN2014DN09412A (OSRAM) 2012-05-11 2013-05-10

Country Status (16)

Country Link
US (1) US11096992B2 (OSRAM)
EP (1) EP2849777B1 (OSRAM)
JP (3) JP2015523330A (OSRAM)
KR (1) KR20150013280A (OSRAM)
CN (1) CN104602700A (OSRAM)
AU (1) AU2013259360B2 (OSRAM)
BR (1) BR112014027995A2 (OSRAM)
CA (1) CA2872530A1 (OSRAM)
CL (1) CL2014003059A1 (OSRAM)
CO (1) CO7250444A2 (OSRAM)
IL (1) IL235617A0 (OSRAM)
IN (1) IN2014DN09412A (OSRAM)
MX (1) MX2014013745A (OSRAM)
NZ (1) NZ701623A (OSRAM)
RU (1) RU2014145270A (OSRAM)
WO (1) WO2013170128A1 (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101801521B (zh) 2007-05-14 2015-06-17 纽约州立大学研究基金会 生物膜中细菌细胞内的生理学分散响应诱导
CN104602700A (zh) 2012-05-11 2015-05-06 史密夫和内修公司 蜂蜜曲霉蛋白酶在用于去除细菌生物膜的用途
US11446364B2 (en) 2012-11-14 2022-09-20 Smith & Nephew, Inc. Stable thermolysin hydrogel
WO2014150857A1 (en) 2013-03-15 2014-09-25 Smith & Nephew, Inc. Dissolvable gel-forming film for delivery of active agents
EP2857025A1 (en) * 2013-10-02 2015-04-08 Special Water Patents B.V. Wound treatment composition
EP3120866A1 (en) 2015-07-24 2017-01-25 Zymetech ehf. Use of marine serine proteases for removal, prevention and inhibition of formation and growth of biofilms
WO2018020435A1 (en) 2016-07-27 2018-02-01 Smith & Nephew, Inc. Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces
WO2018071506A1 (en) * 2016-10-11 2018-04-19 Sharklet Technologies, Inc Composition for biofilm disruption, methods of manufacture thereof and articles comprising the same
US11413300B2 (en) 2017-01-30 2022-08-16 Smith & Nephew, Inc. Synergistic combination of thermolysin and an antibacterial agent to reduce or eliminate bacterial biofilms from surfaces
JP6955784B2 (ja) * 2017-07-04 2021-10-27 フルケム リミテッドＦｌｕｃｈｅｍ Ｌｔｄ 水溶解性が向上されたヨード剤及び塩化ナトリウムを含む固体組成物及びその水溶液を含む目、口腔用、鼻腔用又は吸入用抗ウイルス及び抗菌組成物
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
CN116057158A (zh) * 2020-07-27 2023-05-02 联合利华知识产权控股有限公司 酶和表面活性剂用于抑制微生物的用途

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4197291A (en) 1974-01-08 1980-04-08 Gerold K. V. Klein Hydrolytic enzyme material
JPS5692217A (en) 1979-12-26 1981-07-25 Kowa Co Easily absorbable enzyme preparation
IT1264322B (it) 1992-07-30 1996-09-23 Lanfranco Callegaro Esteri di gellano autoreticolato, procedimento di preparazione e loro applicazioni farmaceutiche e biomedico-sanitarie
CA2106609A1 (en) 1992-09-28 1994-03-29 Irene Yeatman Aldridge Proteases to inhibit and remove biofilm
US5902600A (en) 1992-12-21 1999-05-11 Healthpoint, Ltd. Hydrogel polymer wound dressing
US6395529B1 (en) 1998-11-10 2002-05-28 Novozymes Biotech, Inc. Polypeptides having lactonohydrolase activity and nucleic acids encoding same
US6548556B2 (en) 2000-12-27 2003-04-15 Healthpoint, Ltd. Stable enzymatic wound debrider
US6399092B1 (en) 2000-12-27 2002-06-04 Healthpoint, Ltd. Anhydrous, hydrophilic absorbent wound dressing (tube) with antimicrobials or other pharmaceutically active agents
US20030026794A1 (en) * 2001-07-31 2003-02-06 Howard Fein Selective enzyme treatment of skin conditions
US6479060B1 (en) 2001-09-04 2002-11-12 Healthpoint, Ltd. Elegant hydrogenated castor oil ointments
US20030198631A1 (en) 2002-04-18 2003-10-23 Healthpoint, Ltd. Thermolysin enzymatic wound debrider
KR20050052666A (ko) 2002-10-10 2005-06-03 다이버사 코포레이션 프로테아제, 이를 암호화하는 핵산, 및 이를 제조하고사용하는 방법
US20050079594A1 (en) 2002-10-31 2005-04-14 Karine Marion Method of removing a biofilm
EP2302031A1 (en) 2002-12-20 2011-03-30 The University of Medicine and Dentistry of New Jersey Compositions and methods for enzymatic detachment of bacterial and fungal biofilms
US8821862B2 (en) 2002-12-20 2014-09-02 Kane Biotech Inc. Soluble β-N-acetylglucosaminidase based antibiofilm compositions and uses thereof
US20100221237A1 (en) 2003-03-26 2010-09-02 Biosynexus Incorporated Enzyme disruption of bacterial biofilms
US7785584B2 (en) 2003-08-13 2010-08-31 Healthpoint, Ltd. Ointment wound spray
CA2544156C (en) * 2003-10-29 2012-07-10 Altus Pharmaceuticals Inc. Non-pancreatic proteases for controlling plasma cholecystokinin (cck) concentration and for treating pain
GB0326194D0 (en) 2003-11-10 2003-12-17 Univ Kent Canterbury Proteins involved in signal transduction
JP2007537200A (ja) 2004-05-14 2007-12-20 ハンス−ディートリヒ・ポラシェグ タウロリジン製剤及び投与：細菌マイクロフィルム形成に対する治療処置及び抗菌保護
EP1666075A1 (en) 2004-10-04 2006-06-07 Switch Biotech Aktiengesellschaft Wound dressing compositions, especially for delivery of protease inhibitors
IL165334A0 (en) 2004-11-22 2006-01-15 Mediwound Ltd Debriding composition from bromelain and methods of producing same
EP1942930A2 (en) * 2005-10-11 2008-07-16 Amano Enzyme USA., Ltd. Enzyme inhibitors of pai-1
WO2008021987A2 (en) 2006-08-10 2008-02-21 Jon Barron Proteolytic enzyme formulations
AT504159A1 (de) 2006-08-16 2008-03-15 Marlyn Nutraceuticals Inc Verwendung von proteasen
BRPI0809096A2 (pt) 2007-03-23 2014-09-09 Danisco Us Inc Genecor Division Produção aumentada de amilase através da adição n-terminal à proteína amilase madura
JP2008290966A (ja) 2007-05-24 2008-12-04 Michiharu Sasaki 養毛剤
CN104189908B (zh) 2007-11-27 2017-01-11 阿尔吉法玛公司 包含藻酸盐低聚物的产品、包含无生命表面的产品和清创组合物
AT506095A1 (de) * 2007-12-03 2009-06-15 Volopharm Gmbh Verwendung von proteasen
US8309081B2 (en) 2008-11-18 2012-11-13 Scarguard Labs, Llc. Composition and method for treatment of bruising
JP2010126710A (ja) 2008-12-01 2010-06-10 Kao Corp バイオフィルム除去剤組成物
WO2010079209A2 (en) * 2009-01-08 2010-07-15 Golub Alexandr A Compositions for treating wounds and skin conditions
GB0905451D0 (en) * 2009-03-31 2009-05-13 Novabiotics Ltd Biofilms
JP2013511555A (ja) * 2009-11-23 2013-04-04 スティーブン エフ オルムステッド 特定の症状に関連するバイオフィルムの抑制及び治療のための、セラチア・ペプチダーゼを含む組成物及び方法
BR112012013812A2 (pt) 2009-12-08 2018-05-29 Healthpoint Ltd "composições para desbridamento enzimático de feridas com atividade enzimática melhorada"
EP2707019B1 (en) 2011-05-12 2016-06-29 Smith & Nephew Orthopaedics AG Wound debridement compositions containing seaprose and methods of wound treatment using same
WO2013096337A1 (en) 2011-12-20 2013-06-27 Kci Licensing, Inc. Composition for enzymatic debridement
CN104602700A (zh) 2012-05-11 2015-05-06 史密夫和内修公司 蜂蜜曲霉蛋白酶在用于去除细菌生物膜的用途
US11446364B2 (en) 2012-11-14 2022-09-20 Smith & Nephew, Inc. Stable thermolysin hydrogel
WO2014150857A1 (en) 2013-03-15 2014-09-25 Smith & Nephew, Inc. Dissolvable gel-forming film for delivery of active agents
WO2014145037A1 (en) * 2013-03-15 2014-09-18 M. Alphabet 3, L.L.C. Methods and compositions for enhancing oxygen levels in tissues
WO2017035107A1 (en) 2015-08-24 2017-03-02 Smith & Nephew, Inc. Synergistic antibacterial activity of medium polarity oils in combination with antibacterial agents on bacterial biofilms

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AU2013259360B2 (en) 2017-07-13
CL2014003059A1 (es) 2015-03-06
US20150118219A1 (en) 2015-04-30
JP7118022B2 (ja) 2022-08-15
KR20150013280A (ko) 2015-02-04
IL235617A0 (en) 2015-01-29
CO7250444A2 (es) 2015-04-30
JP2019104757A (ja) 2019-06-27
WO2013170128A1 (en) 2013-11-14
JP2018083830A (ja) 2018-05-31
NZ701623A (en) 2016-12-23
US11096992B2 (en) 2021-08-24
EP2849777A1 (en) 2015-03-25
AU2013259360A1 (en) 2014-11-20
RU2014145270A (ru) 2016-07-10
CN104602700A (zh) 2015-05-06
EP2849777B1 (en) 2017-10-18
MX2014013745A (es) 2016-05-05
JP2015523330A (ja) 2015-08-13
CA2872530A1 (en) 2013-11-14

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