IN2014DN06662A - - Google Patents
Info
- Publication number
- IN2014DN06662A IN2014DN06662A IN6662DEN2014A IN2014DN06662A IN 2014DN06662 A IN2014DN06662 A IN 2014DN06662A IN 6662DEN2014 A IN6662DEN2014 A IN 6662DEN2014A IN 2014DN06662 A IN2014DN06662 A IN 2014DN06662A
- Authority
- IN
- India
- Prior art keywords
- disease
- inflammatory
- intestinal diseases
- inflammatory bowel
- bowel disease
- Prior art date
Links
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 3
- 208000012258 Diverticular disease Diseases 0.000 abstract 2
- 206010013554 Diverticulum Diseases 0.000 abstract 2
- 230000002757 inflammatory effect Effects 0.000 abstract 2
- 208000028774 intestinal disease Diseases 0.000 abstract 2
- VOVIALXJUBGFJZ-AMTWPJRWSA-N ac1l1y6y Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3O[C@H](CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-AMTWPJRWSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/606—Salicylic acid; Derivatives thereof having amino groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261598308P | 2012-02-13 | 2012-02-13 | |
| PCT/EP2013/052838 WO2013120881A1 (en) | 2012-02-13 | 2013-02-13 | Method for treating intestinal diseases presenting at least one inflammatory component |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN06662A true IN2014DN06662A (pt) | 2015-05-22 |
Family
ID=47722264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN6662DEN2014 IN2014DN06662A (pt) | 2012-02-13 | 2013-02-13 |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US20150017239A1 (pt) |
| EP (1) | EP2814495B1 (pt) |
| JP (2) | JP2015506999A (pt) |
| CN (2) | CN104220076A (pt) |
| AU (1) | AU2013220464A1 (pt) |
| BR (1) | BR112014020095A8 (pt) |
| CA (1) | CA2864065A1 (pt) |
| DK (1) | DK2814495T3 (pt) |
| ES (1) | ES2882880T3 (pt) |
| HK (1) | HK1204927A1 (pt) |
| IL (1) | IL234054A0 (pt) |
| IN (1) | IN2014DN06662A (pt) |
| PT (1) | PT2814495T (pt) |
| RU (1) | RU2649807C2 (pt) |
| WO (1) | WO2013120881A1 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2974864B1 (fr) * | 2011-05-04 | 2016-05-27 | Snecma | Rotor de turbomachine avec moyen de retenue axiale des aubes |
| WO2014176646A1 (en) * | 2013-05-01 | 2014-11-06 | 3 Electric Sheep Pty Ltd | Event notification systems and methods |
| WO2015071812A1 (en) * | 2013-11-18 | 2015-05-21 | Wockhardt Limited | Solid oral modified-release composition comprising budesonide or salt thereof |
| US10327034B2 (en) * | 2014-03-27 | 2019-06-18 | Tvu Networks Corporation | Methods, apparatus and systems for exchange of video content |
| BR112020009171A2 (pt) * | 2017-11-10 | 2020-11-03 | Cosmo Technologies Ltd. | composições orais de rifamicina sv |
| CN110585164A (zh) * | 2019-10-08 | 2019-12-20 | 苏州弘森药业股份有限公司 | 一种艾司奥美拉唑镁碳酸氢钠胶囊的制作方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2274943A1 (en) * | 1998-06-17 | 1999-12-17 | Stephen L. Wolman | Compositions for the treatment and prevention of inflammatory diseases of the gastrointestinal tract and methods and uses thereof |
| DE19849737A1 (de) * | 1998-10-28 | 2000-05-04 | Falk Pharma Gmbh | Kombinationsmittel zur Behandlung entzündlicher Darmerkrankungen |
| US8895064B2 (en) * | 1999-06-14 | 2014-11-25 | Cosmo Technologies Limited | Controlled release and taste masking oral pharmaceutical composition |
| DK1183014T3 (da) | 1999-06-14 | 2004-02-09 | Cosmo Spa | Smagsmaskerede orale farmaceutiske sammensætninger med kontrolleret frigivelse |
| US20060188563A1 (en) * | 2003-03-27 | 2006-08-24 | Hisamitsu Pharmaceutical Co., Inc. | Medicinal oral preparations for colon delivery, medicinal oral preparations for treating colon cancer and medicinal oral preparations for treating colitis |
| BRPI0622008A2 (pt) * | 2006-09-13 | 2011-12-20 | Procter & Gamble | métodos de tratamento para colite ulcerativa |
| MX2009013683A (es) * | 2007-06-13 | 2010-04-07 | Jay Pravda | Materiales y metodos para el tratamiento y diagnostico de trastornos asociados con estres oxidativo. |
| EP2298321A1 (en) * | 2009-08-26 | 2011-03-23 | Nordic Pharma | Novel pharmaceutical compositions for treating IBD |
-
2013
- 2013-02-13 DK DK13704767.6T patent/DK2814495T3/da active
- 2013-02-13 IN IN6662DEN2014 patent/IN2014DN06662A/en unknown
- 2013-02-13 AU AU2013220464A patent/AU2013220464A1/en not_active Abandoned
- 2013-02-13 RU RU2014137128A patent/RU2649807C2/ru active
- 2013-02-13 US US14/378,114 patent/US20150017239A1/en not_active Abandoned
- 2013-02-13 US US13/766,167 patent/US20130209559A1/en not_active Abandoned
- 2013-02-13 PT PT137047676T patent/PT2814495T/pt unknown
- 2013-02-13 WO PCT/EP2013/052838 patent/WO2013120881A1/en active Application Filing
- 2013-02-13 CA CA2864065A patent/CA2864065A1/en not_active Abandoned
- 2013-02-13 CN CN201380017800.8A patent/CN104220076A/zh active Pending
- 2013-02-13 CN CN201910974077.1A patent/CN110693890A/zh active Pending
- 2013-02-13 BR BR112014020095A patent/BR112014020095A8/pt not_active IP Right Cessation
- 2013-02-13 JP JP2014557019A patent/JP2015506999A/ja active Pending
- 2013-02-13 EP EP13704767.6A patent/EP2814495B1/en active Active
- 2013-02-13 ES ES13704767T patent/ES2882880T3/es active Active
- 2013-04-05 US US13/857,295 patent/US20130225537A1/en not_active Abandoned
-
2014
- 2014-03-05 US US14/197,849 patent/US20140187517A1/en not_active Abandoned
- 2014-08-11 IL IL234054A patent/IL234054A0/en unknown
-
2015
- 2015-06-10 HK HK15105498.9A patent/HK1204927A1/xx unknown
-
2017
- 2017-07-14 JP JP2017138019A patent/JP6472063B2/ja not_active Expired - Fee Related
-
2019
- 2019-08-06 US US16/532,699 patent/US20200163888A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN110693890A (zh) | 2020-01-17 |
| HK1204927A1 (en) | 2015-12-11 |
| BR112014020095A2 (pt) | 2017-06-20 |
| US20150017239A1 (en) | 2015-01-15 |
| AU2013220464A1 (en) | 2014-09-04 |
| EP2814495A1 (en) | 2014-12-24 |
| PT2814495T (pt) | 2021-08-19 |
| ES2882880T3 (es) | 2021-12-03 |
| WO2013120881A1 (en) | 2013-08-22 |
| US20140187517A1 (en) | 2014-07-03 |
| US20130225537A1 (en) | 2013-08-29 |
| IL234054A0 (en) | 2014-09-30 |
| US20130209559A1 (en) | 2013-08-15 |
| CN104220076A (zh) | 2014-12-17 |
| EP2814495B1 (en) | 2021-07-07 |
| CA2864065A1 (en) | 2013-08-22 |
| US20200163888A1 (en) | 2020-05-28 |
| BR112014020095A8 (pt) | 2017-07-11 |
| RU2649807C2 (ru) | 2018-04-04 |
| JP2017210476A (ja) | 2017-11-30 |
| JP6472063B2 (ja) | 2019-02-20 |
| DK2814495T3 (da) | 2021-08-23 |
| RU2014137128A (ru) | 2016-04-10 |
| JP2015506999A (ja) | 2015-03-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12019502809A1 (en) | Substituted tricyclic compounds as fgfr inhibitors | |
| PH12017500941A1 (en) | Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof | |
| MX2017006302A (es) | Derivados de adenina que son utiles en el tratamiento de enfermedades alergicas u otras afecciones inflamatorias. | |
| MY192717A (en) | Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof | |
| HK1201274A1 (en) | 3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof 33- 19- | |
| PH12014502010A1 (en) | Bispecific antibodies against human tweak and human il17 and uses thereof | |
| MX357261B (es) | Inhibidores de la proteina cinasa dependiente de acido desoxirribonucleico (adn-pk). | |
| MX2015012401A (es) | Composiciones y metodos de alterar niveles de colesterol. | |
| MX2017001971A (es) | Composiciones antimetanogenicas y sus usos. | |
| MX2018009945A (es) | Composiciones y metodos novedosos para el tratamiento de las enfermedades relacionadas con la inmunidad. | |
| MX2015015784A (es) | Metodos para diagnosticar y tratar enfermedad inflamatoria de intestino. | |
| IN2014DN06662A (pt) | ||
| WO2015092393A3 (en) | Ligands specifically binding to human targets of interest | |
| NZ707035A (en) | Gene signatures of inflammatory disorders that relate to the liver | |
| EA201790885A1 (ru) | 6α-АЛКИЛ-6,7-ДИОНОВЫЕ СТЕРОИДЫ В КАЧЕСТВЕ ПРОМЕЖУТОЧНЫХ СОЕДИНЕНИЙ ДЛЯ ПОЛУЧЕНИЯ СТЕРОИДНЫХ МОДУЛЯТОРОВ FXR | |
| EA201790881A1 (ru) | 5-бета-6-алкил-7-гидрокси-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr | |
| EA201790879A1 (ru) | 6-альфа-алкил-3,7-дионовые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr | |
| EP2852570A4 (en) | Compositions and methods for the treatment of inflammatory bowel disease | |
| IN2015DN03229A (pt) | ||
| BR112017014107A2 (pt) | composição nutricional útil no tratamento de pacientes com ibd | |
| IN2013MU03373A (pt) | ||
| MY180844A (en) | Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions | |
| NZ738100A (en) | Igfbp3 and uses thereof | |
| IN2015KN00492A (pt) | ||
| WO2013052108A3 (en) | Methods and compositions for the treatment and diagnosis of ovarian cancer |