IN2014CN02963A - - Google Patents

Info

Publication number
IN2014CN02963A
IN2014CN02963A IN2963CHN2014A IN2014CN02963A IN 2014CN02963 A IN2014CN02963 A IN 2014CN02963A IN 2963CHN2014 A IN2963CHN2014 A IN 2963CHN2014A IN 2014CN02963 A IN2014CN02963 A IN 2014CN02963A
Authority
IN
India
Prior art keywords
strains
generating
methods
host cells
relates
Prior art date
Application number
Other languages
English (en)
Inventor
Bo Jiang
Rebecca D Argyros
Stephanie Nelson
Robert C Davidson
Ronghua Chen
Jun Zhuang
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of IN2014CN02963A publication Critical patent/IN2014CN02963A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IN2963CHN2014 2011-10-28 2012-10-23 IN2014CN02963A (cs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161552674P 2011-10-28 2011-10-28
PCT/US2012/061432 WO2013062940A1 (en) 2011-10-28 2012-10-23 Engineered lower eukaryotic host strains for recombinant protein expression

Publications (1)

Publication Number Publication Date
IN2014CN02963A true IN2014CN02963A (cs) 2015-07-03

Family

ID=48168381

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2963CHN2014 IN2014CN02963A (cs) 2011-10-28 2012-10-23

Country Status (9)

Country Link
US (1) US9328367B2 (cs)
EP (1) EP2771461B1 (cs)
JP (1) JP2014532406A (cs)
KR (1) KR20140091018A (cs)
CN (1) CN104024409A (cs)
AU (1) AU2012329091A1 (cs)
CA (1) CA2853341A1 (cs)
IN (1) IN2014CN02963A (cs)
WO (1) WO2013062940A1 (cs)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6294585B2 (ja) 2009-09-03 2018-03-20 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. 抗gitr抗体
IN2014CN02963A (cs) 2011-10-28 2015-07-03 Merck Sharp & Dohme
EP2814943A4 (en) * 2012-02-16 2015-08-19 Merck Sharp & Dohme PROCESS FOR REDUCING MANNOSYL TRANSFERASE ACTIVITY IN YEAST
KR102134936B1 (ko) * 2012-10-22 2020-07-16 머크 샤프 앤드 돔 코포레이션 Crz1 돌연변이체 진균 세포
SG11201707056UA (en) * 2015-03-03 2017-09-28 Sandoz Ag Constitutive yeast LLP promoter-based expression system
EP3455635A1 (en) * 2016-05-13 2019-03-20 The University of Copenhagen A cell-based array platform
JP2018038286A (ja) * 2016-09-05 2018-03-15 国立大学法人神戸大学 新規宿主細胞及びそれを用いた目的タンパク質の製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060148000A1 (en) * 1999-04-21 2006-07-06 Wyeth Methods for identifying modulators of N-type ion channel inactivation
WO2000063667A2 (en) * 1999-04-21 2000-10-26 American Home Products Corporation Methods for identifying modulators of n-type ion channel inactivation
JP2004527204A (ja) * 2000-04-24 2004-09-09 ワイエス ペプチド結合対の特異的相互作用を有する新規な細胞系
ES2328106T3 (es) 2000-05-17 2009-11-10 Mitsubishi Tanabe Pharma Corporation Procedimiento para producir proteina con reduccion de fosfato de manosa en la cadena de azucar y glicoproteina prducida con el mismo.
US7795002B2 (en) 2000-06-28 2010-09-14 Glycofi, Inc. Production of galactosylated glycoproteins in lower eukaryotes
WO2002000879A2 (en) 2000-06-28 2002-01-03 Glycofi, Inc. Methods for producing modified glycoproteins
US7259007B2 (en) 2003-12-24 2007-08-21 Glycofi, Inc. Methods for eliminating mannosylphosphorylation of glycans in the production of glycoproteins
CN101084233B (zh) * 2004-04-29 2012-08-15 格利科菲公司 用于在糖蛋白产生中减少或消除α-甘露糖苷酶抗性聚糖的方法
CN101606769A (zh) 2009-07-15 2009-12-23 陈德芳 一种宝石连接结构
AR087433A1 (es) * 2011-08-08 2014-03-26 Merck Sharp & Dohme Analogos de insulina n-glicosilados
IN2014CN02963A (cs) 2011-10-28 2015-07-03 Merck Sharp & Dohme

Also Published As

Publication number Publication date
EP2771461A1 (en) 2014-09-03
US20140302557A1 (en) 2014-10-09
EP2771461A4 (en) 2015-06-17
KR20140091018A (ko) 2014-07-18
CA2853341A1 (en) 2013-05-02
JP2014532406A (ja) 2014-12-08
CN104024409A (zh) 2014-09-03
AU2012329091A1 (en) 2014-05-01
EP2771461B1 (en) 2019-12-04
US9328367B2 (en) 2016-05-03
WO2013062940A1 (en) 2013-05-02

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