IN2014CH00247A - - Google Patents
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- Publication number
- IN2014CH00247A IN2014CH00247A IN247CH2014A IN2014CH00247A IN 2014CH00247 A IN2014CH00247 A IN 2014CH00247A IN 247CH2014 A IN247CH2014 A IN 247CH2014A IN 2014CH00247 A IN2014CH00247 A IN 2014CH00247A
- Authority
- IN
- India
- Prior art keywords
- novel
- dolutegravir
- preparation
- pharmaceutically acceptable
- acceptable salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/80—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms having carbon atoms of carboxamide groups and keto groups bound to the same carbon atom, e.g. acetoacetamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15740288.4A EP3096763B1 (en) | 2014-01-21 | 2015-01-20 | Novel process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof |
| US15/113,080 US9856271B2 (en) | 2014-01-21 | 2015-01-20 | Process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof |
| ES15740288T ES2770050T3 (es) | 2014-01-21 | 2015-01-20 | Nuevo procedimiento para la preparación de dolutegravir y sus sales farmacéuticamente aceptables |
| IN247CH2014 IN2014CH00247A (US07585860-20090908-C00154.png) | 2014-01-21 | 2015-01-20 | |
| PCT/IB2015/000048 WO2015110897A2 (en) | 2014-01-21 | 2015-01-20 | Novel process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof |
| PCT/IN2015/000040 WO2015111080A2 (en) | 2014-01-21 | 2015-01-21 | Novel process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof |
| US15/809,151 US10301321B2 (en) | 2014-01-21 | 2017-11-10 | Process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN247CH2014 IN2014CH00247A (US07585860-20090908-C00154.png) | 2014-01-21 | 2015-01-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014CH00247A true IN2014CH00247A (US07585860-20090908-C00154.png) | 2015-08-14 |
Family
ID=53682060
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN247CH2014 IN2014CH00247A (US07585860-20090908-C00154.png) | 2014-01-21 | 2015-01-20 |
Country Status (5)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10519168B2 (en) | 2014-06-20 | 2019-12-31 | Gilead Sciences, Inc. | Synthesis of polycyclic-carbamoylpyridone compounds |
| US11634431B2 (en) | 2018-07-12 | 2023-04-25 | Laurus Labs Limited | Process for purification of protected polycyclic carbamoylpyridone derivatives |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2926068T3 (es) | 2012-12-21 | 2022-10-21 | Gilead Sciences Inc | Compuestos de carbamoilpiridona policíclicos y su uso farmacéutico |
| NO2865735T3 (US07585860-20090908-C00154.png) | 2013-07-12 | 2018-07-21 | ||
| NO2717902T3 (US07585860-20090908-C00154.png) | 2014-06-20 | 2018-06-23 | ||
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| CZ201599A3 (cs) * | 2015-02-13 | 2016-08-24 | Zentiva, K.S. | Pevné formy solí dolutegraviru a způsob jejich přípravy |
| WO2017109649A1 (en) * | 2015-12-21 | 2017-06-29 | Lupin Limited | Process for the preparation of hiv integrase inhibitors |
| CN105699509B (zh) * | 2016-01-23 | 2018-08-31 | 河北科技大学 | 一种3-氨基丁醇对映异构体的分离检测方法 |
| CN106565747A (zh) * | 2016-11-10 | 2017-04-19 | 顾世海 | 一种制备度鲁特韦的新方法 |
| WO2019048808A1 (en) | 2017-09-07 | 2019-03-14 | Cipla Limited | NOVEL POLYMORPHS OF DOLUTÉGRAVIR SODIQUE |
| SG11202002789XA (en) | 2017-10-06 | 2020-04-29 | Shionogi & Co | Stereoselective process for preparing substituted polycyclic pyridone derivatives |
| CN107935881B (zh) * | 2017-12-11 | 2020-06-26 | 浙江朗华制药有限公司 | 一种n-[(2,4-二氟苯基)甲基]-4-甲氧基-3-氧代丁酰胺的制备方法 |
| EP3866803A1 (en) * | 2018-10-19 | 2021-08-25 | Virginia Commonwealth University | Novel pyrrole and pyridone derivatives and uses thereof |
| US11248005B2 (en) | 2019-07-08 | 2022-02-15 | Lupin Limited | Process for preparation of intermediates used for the synthesis of HIV integrase inhibitor |
| CN110294705A (zh) * | 2019-07-25 | 2019-10-01 | 浙江沙星科技有限公司 | 一种度鲁特韦关键中间体的合成方法 |
| CN111620891B (zh) * | 2020-05-27 | 2023-07-14 | 上海启讯医药科技有限公司 | 一种多替拉韦关键中间体溶剂化物多晶型物及其制备方法和用途 |
| JPWO2022107755A1 (US07585860-20090908-C00154.png) | 2020-11-17 | 2022-05-27 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2567197T3 (es) | 2005-04-28 | 2016-04-20 | Viiv Healthcare Company | Derivado de carbamoilpiridona policíclico que tiene actividad inhibidora de la integrasa del VIH |
| WO2010011819A1 (en) * | 2008-07-25 | 2010-01-28 | Smithkline Beecham Corporation | Chemical compounds |
| PT2320908E (pt) * | 2008-07-25 | 2014-03-06 | Shionogi & Co | Pró-fármacos de dolutegravir |
| ES2964383T3 (es) | 2008-12-11 | 2024-04-05 | Viiv Healthcare Co | Procesos e intermedios para inhibidores de la integrasa del VIH de carbamoilpiridona |
| MX2011006241A (es) * | 2008-12-11 | 2011-06-28 | Shionogi & Co | Sintesis de inhibidores de integrasa de vih de carbamoil-piridona e intermediarios. |
| TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Ｖｉｉｖ醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
| CN103154004B (zh) | 2010-08-05 | 2016-07-06 | 盐野义制药株式会社 | 具有hiv整合酶抑制活性的化合物的制造方法 |
| WO2015001572A2 (en) | 2013-07-04 | 2015-01-08 | Hetero Research Foundation | Process for the preparation of intermediate of dolutegravir |
| WO2015177537A1 (en) | 2014-05-20 | 2015-11-26 | Cipla Limited | Process for preparing polycyclic carbamoyl pyridone derivatives and intermediates thereof |
| TWI677489B (zh) | 2014-06-20 | 2019-11-21 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
| WO2016092527A1 (en) | 2014-12-12 | 2016-06-16 | Sun Pharmaceutical Industries Limited | A process for the preparation of dolutegravir |
-
2015
- 2015-01-20 US US15/113,080 patent/US9856271B2/en active Active
- 2015-01-20 EP EP15740288.4A patent/EP3096763B1/en active Active
- 2015-01-20 IN IN247CH2014 patent/IN2014CH00247A/en unknown
- 2015-01-20 ES ES15740288T patent/ES2770050T3/es active Active
- 2015-01-20 WO PCT/IB2015/000048 patent/WO2015110897A2/en active Application Filing
- 2015-01-21 WO PCT/IN2015/000040 patent/WO2015111080A2/en active Application Filing
-
2017
- 2017-11-10 US US15/809,151 patent/US10301321B2/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10519168B2 (en) | 2014-06-20 | 2019-12-31 | Gilead Sciences, Inc. | Synthesis of polycyclic-carbamoylpyridone compounds |
| US10975096B2 (en) | 2014-06-20 | 2021-04-13 | Gilead Sciences, Inc. | Synthesis of polycyclic-carbamoylpyridone compounds |
| US11634431B2 (en) | 2018-07-12 | 2023-04-25 | Laurus Labs Limited | Process for purification of protected polycyclic carbamoylpyridone derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| US10301321B2 (en) | 2019-05-28 |
| US20160333026A1 (en) | 2016-11-17 |
| ES2770050T3 (es) | 2020-06-30 |
| WO2015111080A2 (en) | 2015-07-30 |
| US20180155364A1 (en) | 2018-06-07 |
| EP3096763B1 (en) | 2019-12-25 |
| WO2015110897A3 (en) | 2015-12-03 |
| WO2015110897A2 (en) | 2015-07-30 |
| EP3096763A2 (en) | 2016-11-30 |
| US9856271B2 (en) | 2018-01-02 |
| EP3096763A4 (en) | 2017-06-28 |
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