IN2012DN05125A - - Google Patents

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Publication number
IN2012DN05125A
IN2012DN05125A IN5125DEN2012A IN2012DN05125A IN 2012DN05125 A IN2012DN05125 A IN 2012DN05125A IN 5125DEN2012 A IN5125DEN2012 A IN 5125DEN2012A IN 2012DN05125 A IN2012DN05125 A IN 2012DN05125A
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India
Prior art keywords
sphingosine
modulators
pharmaceuticals
preparing
processes
Prior art date
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English (en)
Inventor
M Heidelbaugh Todd
X Nguyen Phong
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Allergan Inc
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Publication of IN2012DN05125A publication Critical patent/IN2012DN05125A/en

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    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140048874A (ko) * 2011-04-14 2014-04-24 알러간, 인코포레이티드 스핑고신-1 포스페이트 수용체 조절제로서의 페닐 이환식 메틸 아민 유도체
WO2013126381A1 (en) * 2012-02-21 2013-08-29 Allergan, Inc. Phenoxy-azetidine derivatives as sphingosine 1-phosphate (s1p) receptor modulators
US20140171393A1 (en) * 2012-12-13 2014-06-19 Allergan, Inc. Novel aromatic thio compounds as receptor modulators
PT2958913T (pt) 2013-02-20 2018-12-03 Lg Chemical Ltd Agonistas de recetores de esfingosina-1-fosfato, métodos para a sua preparação e composições farmacêuticas que os contêm como agente ativo
WO2014138075A1 (en) * 2013-03-07 2014-09-12 Allergan, Inc. Phosphonic acid compounds as sphingosine-1-phosphate receptor modulators
WO2015021109A1 (en) * 2013-08-08 2015-02-12 Allergan, Inc. Disubstituted aryl azetidine derivatives as sphingosine-1-phosphate receptors modulators
US20150045328A1 (en) * 2013-08-08 2015-02-12 Allergan, Inc. Disubstituted aryl oxy derivatives as sphingosine-1 phosphate receptors modulators
WO2015073547A1 (en) * 2013-11-13 2015-05-21 Allergan, Inc. Disubstituted phenoxy azetidine derivatives as sphingosine-1-phosphate (s1p) receptor modulators
KR20200116953A (ko) 2018-02-02 2020-10-13 고쿠리츠 다이가쿠 호진 교토 다이가쿠 안내 혈관 신생 및/또는 안내 혈관 투과성 항진을 수반하는 안과 질환의 예방 또는 치료를 위한 의약
CN117136183A (zh) * 2021-04-14 2023-11-28 株式会社Lg化学 制备鞘氨醇-1-磷酸酯受体激动剂的新方法
KR102802371B1 (ko) * 2021-04-14 2025-05-07 주식회사 엘지화학 스핑고신-1-인산 수용체 효능제의 신규한 제조방법
US20240217935A1 (en) * 2021-04-14 2024-07-04 Lg Chem, Ltd. Method for preparing intermediate for synthesis of sphingosine-1-phosphate receptor agonist

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0146810A3 (de) 1983-12-05 1987-05-13 Solco Basel AG Verfahren zur Herstellung von Sphingosinderivaten
US5110987A (en) 1988-06-17 1992-05-05 Emory University Method of preparing sphingosine derivatives
ZA902794B (en) 1989-04-18 1991-04-24 Duphar Int Res New 3-n substituted carbamoyl-indole derivatives
US5294722A (en) 1992-04-16 1994-03-15 E. R. Squibb & Sons, Inc. Process for the preparation of imidazoles useful in angiotensin II antagonism
US5403851A (en) 1994-04-05 1995-04-04 Interneuron Pharmaceuticals, Inc. Substituted tryptamines, phenalkylamines and related compounds
WO1998040349A1 (fr) 1997-03-12 1998-09-17 Takara Shuzo Co., Ltd. Analogues de sphingosine
KR100561890B1 (ko) 1997-09-11 2006-03-16 다카라 바이오 가부시키가이샤 스핑고신류 유도체 및 의약 조성물
DE10010067A1 (de) * 2000-03-02 2001-09-06 Bayer Ag Neue Imidazotriazinone und ihre Verwendung
US7074817B2 (en) 2001-06-20 2006-07-11 Wyeth Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
CA2472713C (en) * 2002-01-18 2011-07-19 Merck & Co., Inc. N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as edg receptor agonists
EP1470137B1 (en) * 2002-01-18 2009-09-02 Merck & Co., Inc. Edg receptor agonists
AU2003216054B2 (en) * 2002-01-18 2007-01-04 Merck & Co., Inc. Selective S1P1/Edg1 receptor agonists
SI1638551T1 (sl) * 2003-05-19 2012-04-30 Irm Llc Imunosupresivne spojine in sestavki
CN1874991A (zh) * 2003-08-29 2006-12-06 小野药品工业株式会社 能够结合s1p受体的化合物及其药物用途
WO2006018325A1 (en) * 2004-08-17 2006-02-23 Galderma Research & Development, S.N.C. Novel biaromatic compounds which activate receptors of ppar type and their use in cosmetic or pharmaceutical compositions
GB0612721D0 (en) * 2006-06-27 2006-08-09 Novartis Ag Organic compounds
WO2008030843A1 (en) * 2006-09-07 2008-03-13 Allergan, Inc. Heteroaromatic compounds having sphingosine-1-phosphate (s1p) receptor agonist and/or antagonist biological activity
EP2064183A2 (en) * 2006-09-07 2009-06-03 Allergan, Inc. Heteroaromatic compounds having sphingosine-1-phosphate (s1p) receptor agonist biological activity
US8444970B2 (en) * 2006-10-27 2013-05-21 Lpath, Inc. Compositions and methods for treating ocular diseases and conditions
TW200827346A (en) * 2006-11-03 2008-07-01 Astrazeneca Ab Chemical compounds
US8633245B2 (en) 2008-04-11 2014-01-21 Institute Of Medicinal Molecular Design, Inc. PAI-1 inhibitor

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CA2780908A1 (en) 2011-06-03
AU2010324988B2 (en) 2016-05-26
IN2012DN05171A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html) 2015-10-23
EP2504328A1 (en) 2012-10-03
BR112012012261A2 (pt) 2016-04-26
NZ599966A (en) 2014-09-26
RU2012122615A (ru) 2013-12-27
KR20120101686A (ko) 2012-09-14
CN102712618B (zh) 2014-11-26
JP5939158B2 (ja) 2016-06-22
US20110152241A1 (en) 2011-06-23
US8440644B2 (en) 2013-05-14
CL2012001352A1 (es) 2012-08-31
IL219758A0 (en) 2012-07-31
US8653062B2 (en) 2014-02-18
EP2504323B1 (en) 2017-03-15
RU2012125184A (ru) 2013-12-27
WO2011066184A1 (en) 2011-06-03
CA2780987C (en) 2018-03-06
BR112012012259A2 (pt) 2019-09-24
CN102712618A (zh) 2012-10-03
US20140107075A1 (en) 2014-04-17
MX2012006028A (es) 2012-06-19
JP2013512244A (ja) 2013-04-11
AU2010324983A1 (en) 2012-06-07
CA2780987A1 (en) 2011-06-03
ZA201203524B (en) 2013-01-30
EP2504323A1 (en) 2012-10-03
US8703745B1 (en) 2014-04-22
CN102712607B (zh) 2016-06-22
CN102712607A (zh) 2012-10-03
MX2012006022A (es) 2012-08-15
WO2011066179A1 (en) 2011-06-03
ZA201203523B (en) 2013-01-31
KR20120098796A (ko) 2012-09-05

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