IN176618B - - Google Patents

Info

Publication number
IN176618B
IN176618B IN504CA1993A IN176618B IN 176618 B IN176618 B IN 176618B IN 504CA1993 A IN504CA1993 A IN 504CA1993A IN 176618 B IN176618 B IN 176618B
Authority
IN
India
Prior art keywords
obtainable
thioctic acid
new morphology
recrystallisation process
recrystallisation
Prior art date
Application number
Other languages
English (en)
Inventor
Thomas Beisswenger
Horst Bethge
Frank Huebner
Joachim Goede
Klaus Huthmacher
Herbert Klenk
Roland Moeller
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6471240&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN176618(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Priority to IN504CA1993 priority Critical patent/IN176618B/en
Publication of IN176618B publication Critical patent/IN176618B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
IN504CA1993 1992-10-23 1993-09-01 IN176618B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IN504CA1993 IN176618B (zh) 1992-10-23 1993-09-01

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4235912A DE4235912C2 (de) 1992-10-23 1992-10-23 Verfahren zur Herstellung kristalliner Thioctsäure und deren Verwendung
IN504CA1993 IN176618B (zh) 1992-10-23 1993-09-01

Publications (1)

Publication Number Publication Date
IN176618B true IN176618B (zh) 1996-08-10

Family

ID=6471240

Family Applications (1)

Application Number Title Priority Date Filing Date
IN504CA1993 IN176618B (zh) 1992-10-23 1993-09-01

Country Status (11)

Country Link
US (1) US5455264A (zh)
EP (1) EP0593896B2 (zh)
JP (1) JPH06228130A (zh)
AT (1) ATE157093T1 (zh)
CA (1) CA2109050C (zh)
DE (2) DE4235912C2 (zh)
DK (1) DK0593896T4 (zh)
ES (1) ES2106236T5 (zh)
GR (1) GR3024746T3 (zh)
IN (1) IN176618B (zh)
MX (1) MX9306571A (zh)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19510130C1 (de) * 1995-03-21 1996-11-21 Asta Medica Ag Verfahren zur Herstellung rieselfähiger R,S-Thioctsäure, R,S-Thioctsäure sowie deren Verwendung
DE19705555A1 (de) * 1997-02-13 1998-08-20 Ulrich Dr Posanski Pharmazeutische Präparate der Thioctsäure zur oralen Anwendung
DE19726519A1 (de) * 1997-06-23 1998-12-24 Asta Medica Ag Verfahren zur Herstellung trockener Thioctsäure
DE19810336A1 (de) * 1998-03-11 1999-09-23 Asta Medica Ag Alpha-Liponsäure mit neuartiger Modifikation
US6197340B1 (en) * 1998-05-28 2001-03-06 Medical Research Institute Controlled release lipoic acid
US20050085498A1 (en) * 1998-05-28 2005-04-21 Byrd Edward A. Oral formulation of lipid soluble thiamine, lipoic acid, creatine derivative, and L-arginine alpha-ketoglutarate
US20040259895A1 (en) * 1998-05-28 2004-12-23 Medical Research Institute Oral formulation of lipid soluble thiamine and lipoic acid
US6191162B1 (en) 1998-05-28 2001-02-20 Medical Research Institute Method of reducing serum glucose levels
US6905707B2 (en) * 1998-05-28 2005-06-14 Medical Research Institute Controlled release arginine alpha ketoglutarate
DE19834608A1 (de) * 1998-07-31 2000-02-03 Basf Ag Kristallmodifikation der Liponsäure
DE10137381A1 (de) * 2001-07-31 2003-02-13 Viatris Gmbh Neue Modifikationen des Trometamolsalzes der R-Thioctsäure sowie Verfahren zu ihrer Herstellung
DE10223882A1 (de) * 2002-05-29 2003-12-18 Degussa Fliessfähige, pulverförmige Liponsäure(-Derivate) enthaltende Zusammensetzung
RU2432159C2 (ru) * 2004-11-24 2011-10-27 Хилл'С Пет Ньютришн, Инк. Способы для улучшения обезвреживания печенью ксенобиотических веществ у животных
US20090176864A1 (en) * 2004-11-24 2009-07-09 Hill's Pet Nutrition, Inc. Methods For Improving Hepatic and Immune Function In An Animal
AU2005322887B2 (en) * 2004-12-30 2010-03-11 Hill's Pet Nutrition, Inc. Methods for enhancing the quality of life of a senior animal
US8252742B2 (en) 2004-12-30 2012-08-28 Hill's Pet Nutrition, Inc. Methods for enhancing the quality of life of a senior animal
RU2011124739A (ru) * 2008-12-01 2013-01-10 Инваск Терапьютикс, Инк. Композиции, содержащие ингибиторы системы ренин-ангиотензин альдостерона и соединения липоевой кислоты, и их применение для лечения заболеваний, связанных с системой ренин-ангиотензин альдостерона
US7928067B2 (en) 2009-05-14 2011-04-19 Ischemix Llc Compositions and methods for treating ischemia and ischemia-reperfusion injury
ITMI20111286A1 (it) * 2011-07-11 2013-01-12 Laboratorio Chimico Int Spa Nuova forma cristallina
CN110913851B (zh) 2017-04-25 2023-08-25 伊斯切米克斯公司 治疗外伤性脑损伤的组合物和方法
CN107652264A (zh) * 2017-09-25 2018-02-02 苏州华诺医药有限公司 硫辛酸杂质a的制备方法
CN108484570B (zh) * 2018-05-15 2021-05-04 苏州富士莱医药股份有限公司 一种制备硫辛酸颗粒的方法及设备

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3049549A (en) * 1954-03-22 1962-08-14 Research Corp Lipoic acid and derivatives
US2933430A (en) * 1959-01-22 1960-04-19 Du Pont Lipoic acid compositions
DE3629116A1 (de) * 1986-08-27 1988-03-10 Asta Pharma Ag Verfahren zur herstellung enantiomerenreiner r-(+)-(alpha)-liponsaeure und s-(-)-(alpha)-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer
DE4035442B4 (de) * 1989-11-09 2010-04-29 Evonik Degussa Gmbh Arzneimittel enthaltend als Wirkstoff R-α-Liponsäure
DE4137773A1 (de) * 1991-11-16 1993-05-19 Degussa Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure

Also Published As

Publication number Publication date
MX9306571A (es) 1994-05-31
DE4235912C2 (de) 2002-12-05
DE4235912A1 (de) 1994-04-28
EP0593896A1 (de) 1994-04-27
CA2109050C (en) 2002-04-23
ES2106236T3 (es) 1997-11-01
EP0593896B2 (de) 2005-03-02
JPH06228130A (ja) 1994-08-16
ATE157093T1 (de) 1997-09-15
CA2109050A1 (en) 1994-04-24
DK0593896T4 (da) 2005-06-20
GR3024746T3 (en) 1997-12-31
DE59307160D1 (de) 1997-09-25
ES2106236T5 (es) 2005-09-16
EP0593896B1 (de) 1997-08-20
US5455264A (en) 1995-10-03
DK0593896T3 (da) 1998-03-02

Similar Documents

Publication Publication Date Title
GR3024746T3 (en) Rs-thioctic acid with a new morphology
DK0559413T3 (zh)
UA35592C2 (uk) Похідні оцтової кислоти
EP0742209A3 (en) Process for the preparation of an optically active quinoline demevalonolacton and process for the preparation of a salt of an optically active quinoline demevalolon
HU9302462D0 (en) Pesticidal preparatives containing fluorine-alkenyl compounds
TW198026B (zh)
HU9904356D0 (en) Process for producing alfa,alfa-difuoro-beta-silyloxy-1,3-dioxolane-4-propanoic acid esters
HUT65526A (en) Process for producing mono-n-substituted tetraaza-macrocycles
ES2087129T3 (es) Sintesis enantioselectiva de antifoliatos.
TW231256B (zh)
GR3004968T3 (zh)
IL101357A0 (en) Preparation of hindered amine light stabilizers
AU9148882A (en) Preparation of 2-exo-hydroxy-7-oxabicyclo(2,2,1)heptanes, and intermediated in their syntheses
IE882475L (en) C.12 modified erythromycin a derivatives
JPS6431777A (en) Manufacture of thiophene derivative
EP0448544A3 (en) Process for preparation of fluoromethyl-substituted piperidine carbodithioates
EP0367598A3 (en) Novel process for the production of 4,6-dimethyl-7-hydroxynonan-3-one
HUT33992A (en) Process for preparing 2,3,5,6-tetrasubstituted p- benzoquinones
GR3015020T3 (en) Purification process for N,N-diethylmandelamide.
EP0317394A3 (fr) Procédé de préparation d'anhydrides d'acide
EP0659752A4 (zh)
IE872279L (en) Crystalline n-(s-3-methylheptanoyl)-d-gamma-glutamyl-glycyl¹-d-alanine.
GR3025084T3 (en) Acrylic derivatives of 2-thiazolypyrroles having a fungicidal activity
HU9400864D0 (en) Process for increase of "pot life" of elektrolyte solutions with diminetion of organic contaminable matters