IN167562B - - Google Patents

Info

Publication number
IN167562B
IN167562B IN560/CAL/87A IN560CA1987A IN167562B IN 167562 B IN167562 B IN 167562B IN 560CA1987 A IN560CA1987 A IN 560CA1987A IN 167562 B IN167562 B IN 167562B
Authority
IN
India
Prior art keywords
sulphone
ring
substituted
diaminodiphenyl
benzylpyrimidines
Prior art date
Application number
IN560/CAL/87A
Other languages
English (en)
Inventor
Joachim K Dr Seydel
Manfred Kansy
Gerd Hachtel
Rolf Eugen Dr Haller
Original Assignee
Saarstickstoff Fatol Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Saarstickstoff Fatol Gmbh filed Critical Saarstickstoff Fatol Gmbh
Priority to IN312/CAL/90A priority Critical patent/IN170675B/en
Publication of IN167562B publication Critical patent/IN167562B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IN560/CAL/87A 1986-02-06 1987-07-21 IN167562B (OSRAM)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IN312/CAL/90A IN170675B (OSRAM) 1986-02-06 1990-04-17

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863603577 DE3603577A1 (de) 1986-02-06 1986-02-06 Neue substituierte 2,4-diamino-5-benzylpyrimidine, deren herstellung und deren verwendung als arzneimittel mit antibakterieller wirksamkeit

Publications (1)

Publication Number Publication Date
IN167562B true IN167562B (OSRAM) 1990-11-17

Family

ID=6293457

Family Applications (1)

Application Number Title Priority Date Filing Date
IN560/CAL/87A IN167562B (OSRAM) 1986-02-06 1987-07-21

Country Status (6)

Country Link
US (1) US4912112A (OSRAM)
EP (1) EP0231888B1 (OSRAM)
JP (1) JPH0826007B2 (OSRAM)
AT (1) ATE84029T1 (OSRAM)
DE (2) DE3603577A1 (OSRAM)
IN (1) IN167562B (OSRAM)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3831445C2 (de) * 1988-09-13 1998-09-10 Joachim K Prof Dr Seydel Verwendung von substituierten 2,4-Diamino-5-benzylpyrimidinen gegebenenfalls in Kombination mit 4,4'-Diaminodiphenylsulfonen zur Behandlung von Malaria
US5622954A (en) * 1994-05-11 1997-04-22 Fmc Corporation 5[W(substituted aryl)alkenylene and alkynylene]-2,4-diaminopyrimidines as pesticides
US20030157036A1 (en) * 2002-02-20 2003-08-21 Osborne David W. Topical dapsone for the treatment of acne
NZ515598A (en) 1999-05-24 2004-05-28 Sankyo Co Synergistic medicinal compositions containing anti-Fas antibody and a compound having a folate antagonistic activity or a dihydrofolate reductase inhibiting activity
CA2557372C (en) * 2004-03-05 2013-01-08 F. Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 antagonists
CN1938307B (zh) 2004-03-26 2010-06-16 大日本住友制药株式会社 9-取代的8-氧代腺嘌呤
EP1924564B1 (en) * 2005-09-01 2016-11-09 F.Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 modulators
KR101025381B1 (ko) * 2005-09-01 2011-03-28 에프. 호프만-라 로슈 아게 Ｐ2ｘ3 및 ｐ2ｘ2/3 조정자로서의 다이아미노피리미딘
ES2562056T3 (es) * 2005-09-01 2016-03-02 F. Hoffmann-La Roche Ag Diaminopirimidinas como moduladores P2X3 y P2X2/3
CA2640304A1 (en) * 2006-02-13 2007-08-23 Laboratoires Serono S.A. Sulfonamide derivatives for the treatment of bacterial infections
EP2041135A4 (en) * 2006-07-05 2010-12-01 Astrazeneca Ab As TLR7 MODULATORS, 8-OXOADENINE DERIVATIVES WORK
TW200831105A (en) * 2006-12-14 2008-08-01 Astrazeneca Ab Novel compounds
DK2132209T3 (da) * 2007-03-19 2014-04-14 Astrazeneca Ab 9-substituerede 8-oxo-adeninforbindelser som modulatorer af tlr7 (toll-like receptor 7)
ATE530549T1 (de) * 2007-03-19 2011-11-15 Astrazeneca Ab 9-substituierte 8-oxoadeninverbindungen als modulatoren des toll-like-receptor (tlr7)
EP2138497A4 (en) * 2007-03-20 2012-01-04 Dainippon Sumitomo Pharma Co NEW ADENINE CONNECTION
PE20091236A1 (es) * 2007-11-22 2009-09-16 Astrazeneca Ab Derivados de pirimidina como immunomoduladores de tlr7
PE20091156A1 (es) 2007-12-17 2009-09-03 Astrazeneca Ab Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo
WO2009108147A1 (en) 2008-02-27 2009-09-03 Qlt Usa, Inc. Dapsone to treat rosascea
GB0908772D0 (en) * 2009-05-21 2009-07-01 Astrazeneca Ab New salts 756
KR20120030436A (ko) 2009-05-21 2012-03-28 아스트라제네카 아베 신규한 피리미딘 유도체 및 암 및 추가의 질병의 치료에서의 이의 용도
WO2012080728A1 (en) 2010-12-16 2012-06-21 Astrazeneca Ab Imidazo [4, 5 -c] quinolin- 1 -yl derivative useful in therapy
WO2012080730A1 (en) 2010-12-17 2012-06-21 Astrazeneca Ab Purine derivatives
TWI619704B (zh) 2012-05-18 2018-04-01 大日本住友製藥股份有限公司 羧酸化合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB920412A (en) * 1958-04-18 1963-03-06 Wellcome Found Pyrimidine derivatives and the manufacture thereof
DE1303727B (de) * 1959-09-03 1976-02-05 Ausscheidung aus: 14 45 176 The Wellcome Foundation Ltd., London Alpha-Arylidensubstituierte Propioni-Irile
FR94837E (fr) * 1966-02-19 1969-11-28 Wellcome Found Procédé de préparation de dérivés de la pyrimidine.
GB1261455A (en) * 1969-03-06 1972-01-26 Burroughs Wellcome Co Improvements in or relating to substituted acrylonitriles
US4143227A (en) * 1973-02-26 1979-03-06 Hoffmann-La Roche Inc. Process for substituted 5-benzyl-2,4-diamino-pyrimidines
US4515948A (en) * 1973-09-12 1985-05-07 Hoffmann-La Roche Inc. 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines
US4115650A (en) * 1976-11-17 1978-09-19 Hoffmann-La Roche Inc. Process for preparing 2,4-diamino-5-(substituted benzyl)-pyrimidines
DE2720771C3 (de) * 1977-05-09 1979-11-29 Ludwig Heumann & Co Gmbh, 8500 Nuernberg 2,4-Diamino-5-(33-dimethoxy-4thioalkyl-benzyD-pyrimidine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
GR71725B (OSRAM) * 1977-11-10 1983-06-22 Hoffmann La Roche
US4258045A (en) * 1979-11-30 1981-03-24 Merck & Co., Inc. Inhibitor of dihydrofolate reductase
DE3174994D1 (de) * 1980-11-27 1986-08-28 Wellcome Found Antibacterial benzylpyrimidines

Also Published As

Publication number Publication date
DE3603577A1 (de) 1987-08-13
EP0231888A2 (de) 1987-08-12
EP0231888A3 (en) 1988-10-19
US4912112A (en) 1990-03-27
ATE84029T1 (de) 1993-01-15
EP0231888B1 (de) 1992-12-30
JPS62265272A (ja) 1987-11-18
JPH0826007B2 (ja) 1996-03-13
DE3783238D1 (de) 1993-02-11

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