ATE84029T1 - Substituierte 2,4-diamino-5-benzylpyrimidine, deren herstellung und deren verwendung als arzneimittel mit antimikrobieller wirksamkeit. - Google Patents

Substituierte 2,4-diamino-5-benzylpyrimidine, deren herstellung und deren verwendung als arzneimittel mit antimikrobieller wirksamkeit.

Info

Publication number
ATE84029T1
ATE84029T1 AT87101246T AT87101246T ATE84029T1 AT E84029 T1 ATE84029 T1 AT E84029T1 AT 87101246 T AT87101246 T AT 87101246T AT 87101246 T AT87101246 T AT 87101246T AT E84029 T1 ATE84029 T1 AT E84029T1
Authority
AT
Austria
Prior art keywords
substituted
benzylpyrimidines
diamino
antimicrobial activity
medications
Prior art date
Application number
AT87101246T
Other languages
German (de)
English (en)
Inventor
Joachim K Prof Dr Seydel
Rolf Prof Dr Haller
Manfred Kansy
Gerd Hachtel
Original Assignee
Fatol Arzneimittel Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fatol Arzneimittel Gmbh filed Critical Fatol Arzneimittel Gmbh
Application granted granted Critical
Publication of ATE84029T1 publication Critical patent/ATE84029T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT87101246T 1986-02-06 1987-01-29 Substituierte 2,4-diamino-5-benzylpyrimidine, deren herstellung und deren verwendung als arzneimittel mit antimikrobieller wirksamkeit. ATE84029T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863603577 DE3603577A1 (de) 1986-02-06 1986-02-06 Neue substituierte 2,4-diamino-5-benzylpyrimidine, deren herstellung und deren verwendung als arzneimittel mit antibakterieller wirksamkeit
EP87101246A EP0231888B1 (de) 1986-02-06 1987-01-29 Substituierte 2,4-Diamino-5-benzylpyrimidine, deren Herstellung und deren Verwendung als Arzneimittel mit antimikrobieller Wirksamkeit

Publications (1)

Publication Number Publication Date
ATE84029T1 true ATE84029T1 (de) 1993-01-15

Family

ID=6293457

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87101246T ATE84029T1 (de) 1986-02-06 1987-01-29 Substituierte 2,4-diamino-5-benzylpyrimidine, deren herstellung und deren verwendung als arzneimittel mit antimikrobieller wirksamkeit.

Country Status (6)

Country Link
US (1) US4912112A (OSRAM)
EP (1) EP0231888B1 (OSRAM)
JP (1) JPH0826007B2 (OSRAM)
AT (1) ATE84029T1 (OSRAM)
DE (2) DE3603577A1 (OSRAM)
IN (1) IN167562B (OSRAM)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3831445C2 (de) * 1988-09-13 1998-09-10 Joachim K Prof Dr Seydel Verwendung von substituierten 2,4-Diamino-5-benzylpyrimidinen gegebenenfalls in Kombination mit 4,4'-Diaminodiphenylsulfonen zur Behandlung von Malaria
US5622954A (en) * 1994-05-11 1997-04-22 Fmc Corporation 5[W(substituted aryl)alkenylene and alkynylene]-2,4-diaminopyrimidines as pesticides
US20030157036A1 (en) * 2002-02-20 2003-08-21 Osborne David W. Topical dapsone for the treatment of acne
WO2000071160A1 (fr) 1999-05-24 2000-11-30 Sankyo Company, Limited Compositions medicinales contenant un anticorps anti-fas
JP4717876B2 (ja) 2004-03-05 2011-07-06 エフ．ホフマン−ラ ロシュ アーゲー Ｐ２ｘ３およびｐ２ｘ２／３アンタゴニストとしてのジアミノピリミジン
UA86798C2 (en) 2004-03-26 2009-05-25 ДАЙНИППОН СУМИТОМО ФАРМА Ко., ЛТД. 9-substituted 8-oxoadenine compound
CA2619919C (en) * 2005-09-01 2014-04-01 F. Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 modulators
EP1924565B1 (en) * 2005-09-01 2016-09-14 F.Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p3x2/3 modulators
EP1924566B1 (en) * 2005-09-01 2016-01-13 F.Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 modulators
JP2009526773A (ja) * 2006-02-13 2009-07-23 ラボラトワール セローノ ソシエテ アノニム 細菌感染症治療のためのスルホンアミド誘導体
WO2008004948A1 (en) * 2006-07-05 2008-01-10 Astrazeneca Ab 8-oxoadenine derivatives acting as modulators of tlr7
TW200831105A (en) * 2006-12-14 2008-08-01 Astrazeneca Ab Novel compounds
EP2139894B1 (en) * 2007-03-19 2011-10-26 AstraZeneca AB 9-substituted-8-oxo-adenine compounds as toll-like receptor (tlr7) modulators
DK2132209T3 (da) * 2007-03-19 2014-04-14 Astrazeneca Ab 9-substituerede 8-oxo-adeninforbindelser som modulatorer af tlr7 (toll-like receptor 7)
JPWO2008114819A1 (ja) * 2007-03-20 2010-07-08 大日本住友製薬株式会社 新規アデニン化合物
PE20091236A1 (es) * 2007-11-22 2009-09-16 Astrazeneca Ab Derivados de pirimidina como immunomoduladores de tlr7
PE20091156A1 (es) 2007-12-17 2009-09-03 Astrazeneca Ab Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo
AU2008351422A1 (en) 2008-02-27 2009-09-03 Allergan, Inc. Dapsone to treat rosascea
GB0908772D0 (en) * 2009-05-21 2009-07-01 Astrazeneca Ab New salts 756
BRPI1010937A2 (pt) 2009-05-21 2019-09-24 Astrazeneca Ab composto, uso de um composto, e, método para tratar câncer
JP5978225B2 (ja) 2010-12-16 2016-08-24 大日本住友製薬株式会社 治療に有用なイミダゾ［４，５−ｃ］キノリン−１−イル誘導体
DK2651943T3 (en) 2010-12-17 2017-06-06 Sumitomo Dainippon Pharma Co Ltd purine derivatives
AU2013261267B2 (en) 2012-05-18 2017-06-29 Sumitomo Pharma Co., Ltd. Carboxylic acid compounds

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB920412A (en) * 1958-04-18 1963-03-06 Wellcome Found Pyrimidine derivatives and the manufacture thereof
DE1303727B (de) * 1959-09-03 1976-02-05 Ausscheidung aus: 14 45 176 The Wellcome Foundation Ltd., London Alpha-Arylidensubstituierte Propioni-Irile
DE1720031A1 (de) * 1966-02-19 1972-08-03 Wellcome Found Biologisch wirksame 5-Benzylpyrimidin-Derivate und Verfahren zu ihrer Herstellung
GB1261455A (en) * 1969-03-06 1972-01-26 Burroughs Wellcome Co Improvements in or relating to substituted acrylonitriles
US4143227A (en) * 1973-02-26 1979-03-06 Hoffmann-La Roche Inc. Process for substituted 5-benzyl-2,4-diamino-pyrimidines
US4515948A (en) * 1973-09-12 1985-05-07 Hoffmann-La Roche Inc. 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines
US4115650A (en) * 1976-11-17 1978-09-19 Hoffmann-La Roche Inc. Process for preparing 2,4-diamino-5-(substituted benzyl)-pyrimidines
DE2720771C3 (de) * 1977-05-09 1979-11-29 Ludwig Heumann & Co Gmbh, 8500 Nuernberg 2,4-Diamino-5-(33-dimethoxy-4thioalkyl-benzyD-pyrimidine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
GR71725B (OSRAM) * 1977-11-10 1983-06-22 Hoffmann La Roche
US4258045A (en) * 1979-11-30 1981-03-24 Merck & Co., Inc. Inhibitor of dihydrofolate reductase
JPS57116050A (en) * 1980-11-27 1982-07-19 Wellcome Found 2,4-diamino-5-benzylpyrimidine

Also Published As

Publication number Publication date
EP0231888A3 (en) 1988-10-19
JPH0826007B2 (ja) 1996-03-13
DE3783238D1 (de) 1993-02-11
EP0231888A2 (de) 1987-08-12
US4912112A (en) 1990-03-27
EP0231888B1 (de) 1992-12-30
DE3603577A1 (de) 1987-08-13
JPS62265272A (ja) 1987-11-18
IN167562B (OSRAM) 1990-11-17

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