IL98770A - Peptides, analogues and mixtures thereof, methods for the detection of I-VLTH and II-VLTH antiviral antibodies and pharmaceutical preparations containing them - Google Patents
Peptides, analogues and mixtures thereof, methods for the detection of I-VLTH and II-VLTH antiviral antibodies and pharmaceutical preparations containing themInfo
- Publication number
- IL98770A IL98770A IL9877091A IL9877091A IL98770A IL 98770 A IL98770 A IL 98770A IL 9877091 A IL9877091 A IL 9877091A IL 9877091 A IL9877091 A IL 9877091A IL 98770 A IL98770 A IL 98770A
- Authority
- IL
- Israel
- Prior art keywords
- htlv
- peptide
- bch
- amino acids
- immunogenic
- Prior art date
Links
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- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- IOPLHGOSNCJOOO-UHFFFAOYSA-N methyl 3,4-diaminobenzoate Chemical compound COC(=O)C1=CC=C(N)C(N)=C1 IOPLHGOSNCJOOO-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 229960003104 ornithine Drugs 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 108010091748 peptide A Proteins 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000006069 physical mixture Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 108700004029 pol Genes Proteins 0.000 description 1
- 101150088264 pol gene Proteins 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000005373 porous glass Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002953 preparative HPLC Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000001566 pro-viral effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 101150034499 rex2 gene Proteins 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- VUFNRPJNRFOTGK-UHFFFAOYSA-M sodium;1-[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]oxy-2,5-dioxopyrrolidine-3-sulfonate Chemical compound [Na+].O=C1C(S(=O)(=O)[O-])CC(=O)N1OC(=O)C1CCC(CN2C(C=CC2=O)=O)CC1 VUFNRPJNRFOTGK-UHFFFAOYSA-M 0.000 description 1
- 238000002764 solid phase assay Methods 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- ZERULLAPCVRMCO-UHFFFAOYSA-N sulfure de di n-propyle Natural products CCCSCCC ZERULLAPCVRMCO-UHFFFAOYSA-N 0.000 description 1
- 229940126577 synthetic vaccine Drugs 0.000 description 1
- 229960000814 tetanus toxoid Drugs 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
- 108091005703 transmembrane proteins Proteins 0.000 description 1
- 102000035160 transmembrane proteins Human genes 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 235000002374 tyrosine Nutrition 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/14011—Deltaretrovirus, e.g. bovine leukeamia virus
- C12N2740/14022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55425890A | 1990-07-18 | 1990-07-18 | |
| US07/672,483 US5359029A (en) | 1990-07-18 | 1991-03-20 | Peptides and analogues and mixtures thereof for detecting antibodies to HTLV-I and HTLV-II viruses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL98770A0 IL98770A0 (en) | 1992-07-15 |
| IL98770A true IL98770A (en) | 1996-10-16 |
Family
ID=27070535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9877091A IL98770A (en) | 1990-07-18 | 1991-07-09 | Peptides, analogues and mixtures thereof, methods for the detection of I-VLTH and II-VLTH antiviral antibodies and pharmaceutical preparations containing them |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0539405B1 (es) |
| JP (1) | JP3390002B2 (es) |
| AP (1) | AP9100296A0 (es) |
| AT (1) | ATE124419T1 (es) |
| AU (1) | AU658144B2 (es) |
| CA (1) | CA2087436C (es) |
| CS (1) | CS221391A3 (es) |
| DE (1) | DE69110891T2 (es) |
| ES (1) | ES2076538T3 (es) |
| IE (1) | IE912497A1 (es) |
| IL (1) | IL98770A (es) |
| MX (1) | MX9100257A (es) |
| NZ (1) | NZ238855A (es) |
| PT (1) | PT98356B (es) |
| WO (1) | WO1992001713A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04164097A (ja) * | 1990-10-24 | 1992-06-09 | Kuraray Co Ltd | ペプチドおよびその用途 |
| ATE180495T1 (de) * | 1991-07-10 | 1999-06-15 | Abbott Lab | Unterscheidung von htlv-i und htlv-ii unter verwendung von synthetischen peptiden |
| AU660752B2 (en) * | 1991-11-25 | 1995-07-06 | Dade International Inc. | Immunoassay using synthetic HTLV-11 peptides |
| JP3506252B2 (ja) * | 1992-02-24 | 2004-03-15 | ジェネラブス・テクノロジーズ・インコーポレイテッド | Ｈｔｌｖ−ｉ／ｈｔｌｖ−ｉｉの分析及び方法 |
| AU1880995A (en) * | 1994-03-02 | 1995-09-18 | Abbott Laboratories | Hiv immunoassay utilizing recombinant protein and synthetic peptide reagents |
| US5888763A (en) * | 1994-12-30 | 1999-03-30 | The Rockefeller University | Peptides specific for the first Crk-SH3 domain |
| WO2015068715A1 (ja) * | 2013-11-06 | 2015-05-14 | 富士レビオ株式会社 | 抗ｈｔｌｖ抗体の免疫測定における非特異反応の低減方法 |
| EP2913338A1 (en) * | 2014-02-28 | 2015-09-02 | Roche Diagniostics GmbH | Soluable and immunoreactive variants of HTLV capsid antigen p24 |
| CN110672844A (zh) * | 2019-10-29 | 2020-01-10 | 华中科技大学 | 一种新城疫病毒抗体磁免疫化学发光检测试剂盒及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3380564D1 (en) * | 1982-09-30 | 1989-10-19 | Japan Found Cancer | Human leukemia virus-related peptides, antibodies of the peptides and a process for production of the antibodies |
| US5017687A (en) * | 1988-03-10 | 1991-05-21 | Virovahl, S.A. | Peptides for the detection of HTLV-1 infection |
| DE69015708T2 (de) * | 1989-01-13 | 1995-06-08 | United Biomedical Inc., Lake Success, N.Y. | Künstliche peptid-zusammensetzungen mit immunoreaktiven antikörpern von htlv-1. |
| SE8900721D0 (sv) * | 1989-03-02 | 1989-03-02 | Blomberg Jonas | Methods for detection of antibodies to |
-
1991
- 1991-07-05 NZ NZ238855A patent/NZ238855A/en not_active IP Right Cessation
- 1991-07-09 IL IL9877091A patent/IL98770A/en not_active IP Right Cessation
- 1991-07-10 JP JP51159191A patent/JP3390002B2/ja not_active Expired - Fee Related
- 1991-07-10 AT AT91912338T patent/ATE124419T1/de not_active IP Right Cessation
- 1991-07-10 AU AU82119/91A patent/AU658144B2/en not_active Ceased
- 1991-07-10 EP EP91912338A patent/EP0539405B1/en not_active Expired - Lifetime
- 1991-07-10 WO PCT/CA1991/000238 patent/WO1992001713A1/en active IP Right Grant
- 1991-07-10 DE DE69110891T patent/DE69110891T2/de not_active Expired - Fee Related
- 1991-07-10 CA CA002087436A patent/CA2087436C/en not_active Expired - Lifetime
- 1991-07-10 ES ES91912338T patent/ES2076538T3/es not_active Expired - Lifetime
- 1991-07-17 AP APAP/P/1991/000296A patent/AP9100296A0/en unknown
- 1991-07-17 PT PT98356A patent/PT98356B/pt not_active IP Right Cessation
- 1991-07-17 IE IE249791A patent/IE912497A1/en unknown
- 1991-07-17 CS CS912213A patent/CS221391A3/cs unknown
- 1991-07-18 MX MX9100257A patent/MX9100257A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ238855A (en) | 1994-03-25 |
| IL98770A0 (en) | 1992-07-15 |
| WO1992001713A1 (en) | 1992-02-06 |
| CS221391A3 (en) | 1992-02-19 |
| AU8211991A (en) | 1992-02-18 |
| ES2076538T3 (es) | 1995-11-01 |
| JPH05508838A (ja) | 1993-12-09 |
| PT98356B (pt) | 1999-01-29 |
| CA2087436C (en) | 2001-04-17 |
| AU658144B2 (en) | 1995-04-06 |
| AP9100296A0 (en) | 1991-07-31 |
| EP0539405A1 (en) | 1993-05-05 |
| DE69110891D1 (de) | 1995-08-03 |
| ATE124419T1 (de) | 1995-07-15 |
| DE69110891T2 (de) | 1996-03-14 |
| PT98356A (pt) | 1992-06-30 |
| JP3390002B2 (ja) | 2003-03-24 |
| EP0539405B1 (en) | 1995-06-28 |
| CA2087436A1 (en) | 1992-01-19 |
| MX9100257A (es) | 1992-02-28 |
| IE912497A1 (en) | 1992-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| RH | Patent void | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |