IL98385A - Smoking composition - Google Patents

Info

Publication number

IL98385A

IL98385A IL9838591A IL9838591A IL98385A IL 98385 A IL98385 A IL 98385A IL 9838591 A IL9838591 A IL 9838591A IL 9838591 A IL9838591 A IL 9838591A IL 98385 A IL98385 A IL 98385A

Authority

IL

Israel

Prior art keywords

nicotine

smoking

inclusion complex

cyclodextrin

pct

Prior art date

1990-06-08

Links

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• Global Dossier
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• 230000000391 smoking effect Effects 0.000 title claims abstract description 20
• 239000000203 mixture Substances 0.000 title claims abstract description 14
• SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims abstract description 35
• 229960002715 nicotine Drugs 0.000 claims abstract description 35
• SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims abstract description 35
• 239000000463 material Substances 0.000 claims abstract description 13
• 229920001282 polysaccharide Polymers 0.000 claims abstract description 3
• 229920000858 Cyclodextrin Polymers 0.000 claims description 11
• 241000208125 Nicotiana Species 0.000 claims description 10
• 235000002637 Nicotiana tabacum Nutrition 0.000 claims description 10
• 150000001875 compounds Chemical class 0.000 claims description 5
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 4
• WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 3
• 238000000034 method Methods 0.000 claims description 3
• 229960004853 betadex Drugs 0.000 claims description 2
• 239000001116 FEMA 4028 Substances 0.000 claims 1
• 235000011175 beta-cyclodextrine Nutrition 0.000 claims 1
• -1 cyclodextrin compound Chemical class 0.000 claims 1
• 150000004676 glycans Chemical class 0.000 abstract description 2
• 239000005017 polysaccharide Substances 0.000 abstract description 2
• 235000019504 cigarettes Nutrition 0.000 description 7
• 238000002474 experimental method Methods 0.000 description 7
• 239000006049 herbal material Substances 0.000 description 7
• 239000000779 smoke Substances 0.000 description 3
• 239000000126 substance Substances 0.000 description 3
• 239000007864 aqueous solution Substances 0.000 description 2
• 229940097362 cyclodextrins Drugs 0.000 description 2
• LELOWRISYMNNSU-UHFFFAOYSA-N hydrogen cyanide Chemical compound N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 description 2
• 239000002245 particle Substances 0.000 description 2
• 239000000243 solution Substances 0.000 description 2
• 238000003756 stirring Methods 0.000 description 2
• 235000019505 tobacco product Nutrition 0.000 description 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
• UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
• NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
• 238000010521 absorption reaction Methods 0.000 description 1
• 239000000654 additive Substances 0.000 description 1
• 230000000996 additive effect Effects 0.000 description 1
• 150000001299 aldehydes Chemical class 0.000 description 1
• 229910002091 carbon monoxide Inorganic materials 0.000 description 1
• 238000006243 chemical reaction Methods 0.000 description 1
• 238000002485 combustion reaction Methods 0.000 description 1
• 230000001419 dependent effect Effects 0.000 description 1
• RUZYUOTYCVRMRZ-UHFFFAOYSA-N doxazosin Chemical compound C1OC2=CC=CC=C2OC1C(=O)N(CC1)CCN1C1=NC(N)=C(C=C(C(OC)=C2)OC)C2=N1 RUZYUOTYCVRMRZ-UHFFFAOYSA-N 0.000 description 1
• 238000001035 drying Methods 0.000 description 1
• GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 description 1
• 229940080345 gamma-cyclodextrin Drugs 0.000 description 1
• 230000005802 health problem Effects 0.000 description 1
• 238000002360 preparation method Methods 0.000 description 1
• 239000002904 solvent Substances 0.000 description 1