IL97122A - 7-Transformed androstane-) or androstine- (3,71-dions, useful as aromatase inhibitors, and pharmaceuticals containing them - Google Patents

7-Transformed androstane-) or androstine- (3,71-dions, useful as aromatase inhibitors, and pharmaceuticals containing them

Info

Publication number
IL97122A
IL97122A IL9712291A IL9712291A IL97122A IL 97122 A IL97122 A IL 97122A IL 9712291 A IL9712291 A IL 9712291A IL 9712291 A IL9712291 A IL 9712291A IL 97122 A IL97122 A IL 97122A
Authority
IL
Israel
Prior art keywords
compound
pharmaceutical composition
aromatase
alkenyl
carrier
Prior art date
Application number
IL9712291A
Other languages
English (en)
Hebrew (he)
Other versions
IL97122A0 (en
Original Assignee
Endorecherche Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endorecherche Inc filed Critical Endorecherche Inc
Publication of IL97122A0 publication Critical patent/IL97122A0/xx
Publication of IL97122A publication Critical patent/IL97122A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL9712291A 1990-02-08 1991-02-01 7-Transformed androstane-) or androstine- (3,71-dions, useful as aromatase inhibitors, and pharmaceuticals containing them IL97122A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/477,024 US5227375A (en) 1990-02-08 1990-02-08 Aromatase inhibitors

Publications (2)

Publication Number Publication Date
IL97122A0 IL97122A0 (en) 1992-05-25
IL97122A true IL97122A (en) 1996-06-18

Family

ID=23894189

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9712291A IL97122A (en) 1990-02-08 1991-02-01 7-Transformed androstane-) or androstine- (3,71-dions, useful as aromatase inhibitors, and pharmaceuticals containing them

Country Status (10)

Country Link
US (1) US5227375A (zh)
AU (1) AU7150991A (zh)
GR (1) GR910100067A (zh)
IE (1) IE65269B1 (zh)
IL (1) IL97122A (zh)
MY (1) MY105479A (zh)
NZ (1) NZ236966A (zh)
TW (1) TW221418B (zh)
WO (1) WO1991012206A2 (zh)
ZA (1) ZA91604B (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0582713B1 (en) * 1991-03-28 1997-06-04 Teikoku Hormone Mfg. Co., Ltd. -New D-homo-17-oxa and D-homo-17-aza-androstane derivatives
DE69324595T2 (de) * 1992-09-30 1999-08-19 Teikoku Hormone Mfg. Co. 7-substituierte oxa-steroid verbindung
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
US5593987A (en) * 1993-12-21 1997-01-14 Eli Lilly And Company Methods of inhibiting breast disorders
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
WO1999007381A1 (en) * 1997-08-11 1999-02-18 Weider Nutrition International, Inc. Compositions and treatments to reduce side effects of administration of androgenic testosterone precursors
CN1429104A (zh) 1998-03-11 2003-07-09 内部研究股份有限公司 5型和3型17β－羟基类固醇脱氢酶的抑制剂及其用法
WO2001014406A1 (fr) * 1999-08-23 2001-03-01 Chugai Seiyaku Kabushiki Kaisha Agents anti-androgènes
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
US20040024202A1 (en) * 2002-03-22 2004-02-05 Pharmacia Corporation C-17 spirolactonization and 6,7 oxidation of steroids
MXPA05004024A (es) * 2002-11-07 2005-06-08 Pharmacia & Upjohn Co Llc Procedimientos para preparar esteroides c-7 sustituidos.
US8183401B2 (en) * 2004-01-16 2012-05-22 Cedarburg Pharmaceuticals, Inc. Exemestane and its intermediates and methods of making the same
AU2011256088B2 (en) * 2010-05-20 2015-03-26 University Of Saskatchewan Use of aromatase inhibitors for synchronizing ovulation, inducing superovulation or double ovulation and improving twinning and fertility in a mammal
US10004723B2 (en) 2013-04-19 2018-06-26 University Of Saskatchewan Aromatase inhibitor-releasing intravaginal device

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL125069C (zh) * 1963-12-24
US3380886A (en) * 1965-04-07 1968-04-30 Upjohn Co 7alpha-methyl-3beta-hydroxy-5-androstenes
US3591607A (en) * 1966-04-19 1971-07-06 Hoffmann La Roche Retrosteroid a-ring formation
US3766213A (en) * 1966-04-19 1973-10-16 Hoffmann La Roche Retrosteroid a ring formation
US3485828A (en) * 1967-04-10 1969-12-23 Syntex Corp 6,7-ethylene and 6,7-substituted ethylene derivatives of the pregnane series
US3952018A (en) * 1972-01-14 1976-04-20 Hoffmann-La Roche Inc. 15-Oxasteroids
DE2558088C2 (de) * 1975-12-19 1985-05-30 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur Herstellung von 4-Androsten-3,17-dion-Derivaten
DE3121153A1 (de) * 1981-05-22 1982-12-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen "verwendung von aromatase-hemmern zur prophylaxe und therapie der prostatahyperplasie"
US4451404A (en) * 1983-02-09 1984-05-29 The Upjohn Company 16β-Methyl steroid process
US4596796A (en) * 1983-09-12 1986-06-24 Sumitomo Chemical Company, Limited Dithiolphosphoric acid ester as a soil pesticide
DE3612632A1 (de) * 1986-04-11 1987-10-22 Schering Ag Verfahren zur herstellung von 7(alpha)-propylsteroiden
GB8617107D0 (en) * 1986-07-14 1986-08-20 Erba Farmitalia 6-/7-methylenandrosta-1 4-diene-3 17-dione derivatives
GB8622330D0 (en) * 1986-09-17 1986-10-22 Erba Farmitalia 4-substituted 6-alkylidenandrostene-3,17-dione derivatives

Also Published As

Publication number Publication date
AU7150991A (en) 1991-09-03
NZ236966A (en) 1993-11-25
US5227375A (en) 1993-07-13
ZA91604B (en) 1992-09-30
WO1991012206A2 (en) 1991-08-22
TW221418B (zh) 1994-03-01
WO1991012206A3 (en) 1991-11-28
GR910100067A (el) 1992-06-30
IE65269B1 (en) 1995-10-18
IL97122A0 (en) 1992-05-25
MY105479A (en) 1994-10-31
IE910263A1 (en) 1991-08-14

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees