IL96239A0 - Novel insulin derivatives,process for their preparation,their use and pharmaceutical preparations containing them - Google Patents

Novel insulin derivatives,process for their preparation,their use and pharmaceutical preparations containing them

Info

Publication number
IL96239A0
IL96239A0 IL96239A IL9623990A IL96239A0 IL 96239 A0 IL96239 A0 IL 96239A0 IL 96239 A IL96239 A IL 96239A IL 9623990 A IL9623990 A IL 9623990A IL 96239 A0 IL96239 A0 IL 96239A0
Authority
IL
Israel
Prior art keywords
insulin derivatives
preparation
residue
atoms
chain
Prior art date
Application number
IL96239A
Other languages
English (en)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL96239A0 publication Critical patent/IL96239A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Emergency Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL96239A 1989-11-06 1990-11-05 Novel insulin derivatives,process for their preparation,their use and pharmaceutical preparations containing them IL96239A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3936876A DE3936876A1 (de) 1989-11-06 1989-11-06 Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung

Publications (1)

Publication Number Publication Date
IL96239A0 true IL96239A0 (en) 1991-08-16

Family

ID=6392948

Family Applications (1)

Application Number Title Priority Date Filing Date
IL96239A IL96239A0 (en) 1989-11-06 1990-11-05 Novel insulin derivatives,process for their preparation,their use and pharmaceutical preparations containing them

Country Status (18)

Country Link
US (1) US5149716A (fr)
EP (1) EP0427162B1 (fr)
JP (1) JP3131215B2 (fr)
KR (1) KR910009930A (fr)
AT (1) ATE137765T1 (fr)
AU (1) AU6577290A (fr)
CA (1) CA2029289A1 (fr)
DE (2) DE3936876A1 (fr)
DK (1) DK0427162T3 (fr)
ES (1) ES2087879T3 (fr)
FI (1) FI905439A0 (fr)
GR (1) GR3020095T3 (fr)
HU (1) HU205773B (fr)
IE (1) IE903978A1 (fr)
IL (1) IL96239A0 (fr)
NO (1) NO904808L (fr)
PT (1) PT95788A (fr)
ZA (1) ZA908842B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6875589B1 (en) * 1988-06-23 2005-04-05 Hoechst Aktiengesellschaft Mini-proinsulin, its preparation and use
CZ342492A3 (en) * 1991-11-26 1993-06-16 Lilly Co Eli Derivatives of tri-arginine insulin, process of their preparation and a pharmaceutical composition in which said derivatives are comprised
JP3406244B2 (ja) * 1999-04-30 2003-05-12 伊藤ハム株式会社 新規な融合蛋白質からの組み換えインスリンの製造方法
IL161848A0 (en) * 2001-12-20 2005-11-20 Lilly Co Eli Insulin moldecule having protracted time action
WO2004096854A2 (fr) * 2003-04-29 2004-11-11 Eli Lilly And Company Analogues de l'insuline ayant une action prolongee
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
WO2007081824A2 (fr) * 2006-01-06 2007-07-19 Case Western Reserve University Protéines résistantes à la fibrillation
EP2074140B8 (fr) * 2006-10-04 2015-10-28 Case Western Reserve University Insuline et analogues de l'insuline résistants à la fibrillation
US8993516B2 (en) * 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
BRPI0911571A2 (pt) * 2008-04-22 2018-04-03 Univ Case Western Reserve método para tratar um mamífero, análogo de insulina, ácido nucléico e célula hospedeira
US9200053B2 (en) 2008-07-31 2015-12-01 Case Western Reserve University Insulin analogues containing penta-fluoro-Phenylalanine at position B24
KR20120129875A (ko) 2008-07-31 2012-11-28 케이스 웨스턴 리저브 유니버시티 염소화 아미노산을 갖는 인슐린 유사체
US8399407B2 (en) * 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
US9079975B2 (en) 2009-12-11 2015-07-14 Case Western Reserve University Insulin analogues with chlorinated amino acids
RU2447149C1 (ru) * 2011-03-24 2012-04-10 Винсорт Менеджемент Инк РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pMSIN4, КОДИРУЮЩАЯ ГИБРИДНЫЙ ПОЛИПЕПТИД - ПРЕДШЕСТВЕННИК ИНСУЛИНА ЧЕЛОВЕКА, ШТАММ BL21(DE3)/pMSIN4-ПРОДУЦЕНТ РЕКОМБИНАНТНОГО ИНСУЛИНА ЧЕЛОВЕКА, СПОСОБ ПОЛУЧЕНИЯ РЕКОМБИНАНТНОГО ИНСУЛИНА ЧЕЛОВЕКА
ES2709339T3 (es) 2013-04-03 2019-04-16 Sanofi Sa Tratamiento de la diabetes mellitus mediante formulaciones de insulinas de acción prolongada
CN107108716A (zh) 2014-10-06 2017-08-29 卡斯西部储备大学 双相性单链胰岛素类似物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3326473A1 (de) * 1983-07-22 1985-01-31 Hoechst Ag, 6230 Frankfurt Pharmazeutisches mittel zur behandlung des diabetes mellitus
DE3327928A1 (de) * 1983-08-03 1985-02-21 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DK113585D0 (da) * 1985-03-12 1985-03-12 Novo Industri As Nye peptider
DK347086D0 (da) * 1986-07-21 1986-07-21 Novo Industri As Novel peptides
DE3837273A1 (de) * 1987-05-05 1990-05-10 Hoechst Ag Verfahren zur herstellung eines insulin-vorprodukts in streptomyceten
DE3714866A1 (de) * 1987-05-05 1988-11-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
DE3844211A1 (de) * 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung

Also Published As

Publication number Publication date
AU6577290A (en) 1991-05-09
HU907026D0 (en) 1991-05-28
NO904808D0 (no) 1990-11-05
US5149716A (en) 1992-09-22
ATE137765T1 (de) 1996-05-15
HUT55804A (en) 1991-06-28
FI905439A0 (fi) 1990-11-02
GR3020095T3 (en) 1996-08-31
DE59010316D1 (de) 1996-06-13
DK0427162T3 (da) 1996-09-16
EP0427162B1 (fr) 1996-05-08
PT95788A (pt) 1991-09-13
IE903978A1 (en) 1991-05-08
EP0427162A1 (fr) 1991-05-15
ES2087879T3 (es) 1996-08-01
CA2029289A1 (fr) 1991-05-07
JP3131215B2 (ja) 2001-01-31
JPH03169895A (ja) 1991-07-23
DE3936876A1 (de) 1991-05-23
ZA908842B (en) 1991-08-28
NO904808L (no) 1991-05-07
KR910009930A (ko) 1991-06-28
HU205773B (en) 1992-06-29

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