IL94981A - פפטידים אנטי-נגיפיים בעלי שרשרת צדדית של 2-אוקסואלקיל, הכנתם ותכשירי רוקחות המכילים אותם - Google Patents

פפטידים אנטי-נגיפיים בעלי שרשרת צדדית של 2-אוקסואלקיל, הכנתם ותכשירי רוקחות המכילים אותם

Info

Publication number
IL94981A
IL94981A IL9498190A IL9498190A IL94981A IL 94981 A IL94981 A IL 94981A IL 9498190 A IL9498190 A IL 9498190A IL 9498190 A IL9498190 A IL 9498190A IL 94981 A IL94981 A IL 94981A
Authority
IL
Israel
Prior art keywords
alkyl
hydrogen
peptide
lower alkyl
phenyl
Prior art date
Application number
IL9498190A
Other languages
English (en)
Other versions
IL94981A0 (en
Original Assignee
Bio Mega Boehringer Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Mega Boehringer Ingelheim filed Critical Bio Mega Boehringer Ingelheim
Publication of IL94981A0 publication Critical patent/IL94981A0/xx
Publication of IL94981A publication Critical patent/IL94981A/he

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1005Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
IL9498190A 1989-07-07 1990-07-05 פפטידים אנטי-נגיפיים בעלי שרשרת צדדית של 2-אוקסואלקיל, הכנתם ותכשירי רוקחות המכילים אותם IL94981A (he)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA000605062A CA1340682C (en) 1989-07-07 1989-07-07 Antiviral peptides having a 2-oxoalkyl amino acid side chain

Publications (2)

Publication Number Publication Date
IL94981A0 IL94981A0 (en) 1991-06-10
IL94981A true IL94981A (he) 1995-03-15

Family

ID=4140313

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9498190A IL94981A (he) 1989-07-07 1990-07-05 פפטידים אנטי-נגיפיים בעלי שרשרת צדדית של 2-אוקסואלקיל, הכנתם ותכשירי רוקחות המכילים אותם

Country Status (8)

Country Link
US (1) US5700780A (he)
EP (1) EP0411332B1 (he)
JP (1) JP2877910B2 (he)
AT (1) ATE131174T1 (he)
AU (1) AU643448B2 (he)
CA (1) CA1340682C (he)
DE (1) DE69023977T2 (he)
IL (1) IL94981A (he)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU643636B2 (en) * 1989-07-07 1993-11-18 Bio-Mega/Boehringer Ingelheim Research Inc. Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain
EP0411333B1 (en) * 1989-07-07 1995-05-31 Bio-Mega/Boehringer Ingelheim Research Inc. Antiherpes tetrapeptide derivatives having a substituted aspartic acid side chain
CA1340681C (en) * 1989-07-07 1999-07-27 Robert Deziel Antiherpes tetrapeptides having a substituted aspartic acid side chain
US5846941A (en) * 1992-03-12 1998-12-08 Boehringer Ingelheim (Canada) Ltd. Isosteric antiherpes peptide derivatives II
ATE169931T1 (de) 1992-03-12 1998-09-15 Boehringer Ingelheim Ca Ltd Isosterische peptidderivate gegen herpes
US6465612B1 (en) * 1998-09-23 2002-10-15 The Regents Of The University Of California Synthetic peptides, conjugation reagents and methods
WO2001057072A2 (en) 2000-02-07 2001-08-09 Wisconsin Alumni Research Foundation Pharmacologically active antiviral peptides and methods of their use
WO2005060541A2 (en) * 2003-12-01 2005-07-07 Wisconsin Alumni Research Foundation Peptides and methods for inducing cellular resistance to infection

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795740A (en) * 1986-05-20 1989-01-03 Cohen Eric A Antiviral peptides and means for treating herpes infections
EP0292255A3 (en) * 1987-05-22 1990-08-22 Merck & Co. Inc. Inhibitor of ribonucleotide reductase
US4845195A (en) * 1987-05-22 1989-07-04 Merck & Co., Inc. Inhibitor of ribonucleotide reductase
US4814432A (en) * 1987-05-22 1989-03-21 Merck & Co., Inc. Inhibitor of ribonucleotide reductase
US4837304A (en) * 1987-05-22 1989-06-06 Merck & Co., Inc. Inhibitor of ribonucleotide reductase
IL90872A0 (en) * 1988-07-08 1990-02-09 Smithkline Beckman Corp Retroviral protease binding peptides
EP0357332A3 (en) * 1988-08-24 1991-07-31 Merck & Co. Inc. Renin inhibitors useful for the treatment of aids by inhibition of hiv protease
EP0374097A3 (de) * 1988-12-15 1991-06-12 Ciba-Geigy Ag Verwendung von Peptidisosteren als retrovirale Proteasehemmer
AU643636B2 (en) * 1989-07-07 1993-11-18 Bio-Mega/Boehringer Ingelheim Research Inc. Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain
EP0411333B1 (en) * 1989-07-07 1995-05-31 Bio-Mega/Boehringer Ingelheim Research Inc. Antiherpes tetrapeptide derivatives having a substituted aspartic acid side chain
CA1340684C (en) * 1989-07-07 1999-07-27 Pierre Louis Beaulieu Antiherpes pentapeptides
CA1340683C (en) * 1989-07-07 1999-07-27 Pierre Louis Beaulieu Antiherpes pentapeptides having a substituted aspartic acid side chain

Also Published As

Publication number Publication date
DE69023977D1 (de) 1996-01-18
DE69023977T2 (de) 1996-05-15
EP0411332A1 (en) 1991-02-06
EP0411332B1 (en) 1995-12-06
JP2877910B2 (ja) 1999-04-05
AU643448B2 (en) 1993-11-18
ATE131174T1 (de) 1995-12-15
AU5877790A (en) 1991-01-10
US5700780A (en) 1997-12-23
IL94981A0 (en) 1991-06-10
CA1340682C (en) 1999-07-27
JPH03115296A (ja) 1991-05-16

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