IL94379A - Conjugates of anthracycline linked to a ligand by an acylhydrazone linkage their production and pharmaceutical compositions containing them - Google Patents
Conjugates of anthracycline linked to a ligand by an acylhydrazone linkage their production and pharmaceutical compositions containing themInfo
- Publication number
- IL94379A IL94379A IL9437990A IL9437990A IL94379A IL 94379 A IL94379 A IL 94379A IL 9437990 A IL9437990 A IL 9437990A IL 9437990 A IL9437990 A IL 9437990A IL 94379 A IL94379 A IL 94379A
- Authority
- IL
- Israel
- Prior art keywords
- anthracycline
- ligand
- conjugates
- pharmaceutical compositions
- production
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/353,729 US5122368A (en) | 1988-02-11 | 1989-05-17 | Anthracycline conjugates having a novel linker and methods for their production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL94379A0 IL94379A0 (en) | 1991-03-10 |
| IL94379A true IL94379A (en) | 1997-02-18 |
Family
ID=23390328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9437990A IL94379A (en) | 1989-05-17 | 1990-05-14 | Conjugates of anthracycline linked to a ligand by an acylhydrazone linkage their production and pharmaceutical compositions containing them |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0398305B1 (de) |
| JP (1) | JP3062696B2 (de) |
| KR (1) | KR0136899B1 (de) |
| AT (1) | ATE150321T1 (de) |
| AU (1) | AU631638B2 (de) |
| CA (1) | CA2016584C (de) |
| DE (1) | DE69030213T2 (de) |
| DK (1) | DK0398305T3 (de) |
| ES (1) | ES2099075T3 (de) |
| FI (1) | FI102356B (de) |
| GR (1) | GR3023784T3 (de) |
| HK (1) | HK1005018A1 (de) |
| IE (1) | IE81109B1 (de) |
| IL (1) | IL94379A (de) |
| MY (1) | MY131039A (de) |
| NO (1) | NO300691B1 (de) |
| NZ (1) | NZ233696A (de) |
| PT (1) | PT94064B (de) |
| ZA (1) | ZA903757B (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU638971B2 (en) * | 1990-02-14 | 1993-07-15 | Bristol-Myers Squibb Company | Anthracycline immunoconjugates having a novel linker and methods for their production |
| CA2048089A1 (en) * | 1990-09-17 | 1992-03-18 | Wolfgang A. Wrasidlo | Chemical conjugation of morpholino anthracyclines to antibodies |
| US5622929A (en) * | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
| RU2119354C1 (ru) * | 1996-01-05 | 1998-09-27 | Виктор Савельевич Гуревич | Способ направленного транспорта фармакологических препаратов путем их конъюгации с аргинил-глицил-аспартил (rgd) содержащими пептидами |
| US7033765B1 (en) | 1997-02-20 | 2006-04-25 | Toronto Research Chemicals, Inc. | Site-specific drug delivery |
| EP0966304B1 (de) * | 1997-02-20 | 2005-05-25 | David S. Dime | Ortsspezifische arzneimittel verabreichung |
| GB9724838D0 (en) * | 1997-11-26 | 1998-01-21 | Franks Christopher R | Compositions |
| CA2414401A1 (en) * | 2000-06-28 | 2002-01-03 | Ward Page Faulk | Targeted delivery of cytotoxic drugs a) to activated lymphocytes in patients with transplanted organs, b) as radiosensitizers to cancer cells in patients undergoing radiation therapy, and c) in vitamin-binding proteins as drug carriers in the diagnosis and treatment of cancer |
| EP1343531A2 (de) * | 2000-12-21 | 2003-09-17 | McGILL UNIVERSITY | Konjugate von antikörpern und antikrebsmitteln |
| NZ511705A (en) * | 2001-05-14 | 2004-03-26 | Horticulture & Food Res Inst | Methods and rapid immunoassay device for detecting progesterone and other steroids |
| KR100507968B1 (ko) | 2001-08-18 | 2005-08-17 | 한국과학기술연구원 | 자기집합체를 형성하는 항암제-키토산 복합체 및 그의제조방법 |
| CA2523197C (en) * | 2003-04-22 | 2016-05-24 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Peptide vectors |
| US9011880B2 (en) | 2003-10-21 | 2015-04-21 | Igf Oncology, Llc | Compounds and methods for treating cancer |
| WO2005041865A2 (en) * | 2003-10-21 | 2005-05-12 | Igf Oncology, Llc | Compounds and method for treating cancer |
| CA2558399C (en) * | 2004-03-02 | 2015-05-19 | Seattle Genetics, Inc. | Partially loaded antibodies and methods of their conjugation |
| EP1695717A1 (de) * | 2005-02-23 | 2006-08-30 | Ludwig-Maximilians-Universität | Transport Nano- und Makromolecularer Strukturen ins Zytoplasma und in den Zellkern |
| WO2010009124A2 (en) | 2008-07-15 | 2010-01-21 | Genentech, Inc. | Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds |
| WO2015106224A2 (en) | 2014-01-12 | 2015-07-16 | Hugh Mctavish | Fusion proteins containing insulin-like growth factor-1 and epidermal growth factor and variants thereof and uses thereof |
| US10149913B2 (en) * | 2014-09-12 | 2018-12-11 | Genentech, Inc. | Anthracycline disulfide intermediates, antibody-drug conjugates and methods |
| CA3059593A1 (en) | 2017-05-21 | 2018-11-29 | Igf Oncology, Llc | An insulin-like growth factor-chemotherapeputic conjugate for treating myelodysplastic syndrome |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3957755A (en) * | 1967-10-18 | 1976-05-18 | Rhone-Poulenc S.A. | Naphthacene derivatives |
| US4112217A (en) * | 1977-09-02 | 1978-09-05 | Sri International | Bis-hydrazones of daunomycin and adriamycin |
| US4263428A (en) * | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| US4950738A (en) * | 1984-09-13 | 1990-08-21 | Cytogen Corporation | Amine derivatives of anthracycline antibiotics |
| US5162512A (en) * | 1982-03-09 | 1992-11-10 | Cytogen Corporation | Amine derivatives of anthracycline antibodies |
| GB8610551D0 (en) * | 1986-04-30 | 1986-06-04 | Hoffmann La Roche | Polypeptide & protein derivatives |
| FI102355B1 (fi) | 1988-02-11 | 1998-11-30 | Bristol Myers Squibb Co | Menetelmä yhdistävän välikappaleen omaavien antrasykliini-immunokonjugaattien valmistamiseksi |
| AU638971B2 (en) * | 1990-02-14 | 1993-07-15 | Bristol-Myers Squibb Company | Anthracycline immunoconjugates having a novel linker and methods for their production |
-
1990
- 1990-05-11 CA CA002016584A patent/CA2016584C/en not_active Expired - Lifetime
- 1990-05-14 IL IL9437990A patent/IL94379A/xx not_active IP Right Cessation
- 1990-05-14 FI FI902387A patent/FI102356B/fi active IP Right Grant
- 1990-05-15 NZ NZ233696A patent/NZ233696A/en unknown
- 1990-05-16 DE DE69030213T patent/DE69030213T2/de not_active Expired - Lifetime
- 1990-05-16 EP EP90109268A patent/EP0398305B1/de not_active Expired - Lifetime
- 1990-05-16 DK DK90109268.4T patent/DK0398305T3/da active
- 1990-05-16 ZA ZA903757A patent/ZA903757B/xx unknown
- 1990-05-16 AT AT90109268T patent/ATE150321T1/de not_active IP Right Cessation
- 1990-05-16 AU AU55117/90A patent/AU631638B2/en not_active Expired
- 1990-05-16 IE IE176490A patent/IE81109B1/en not_active IP Right Cessation
- 1990-05-16 PT PT94064A patent/PT94064B/pt not_active IP Right Cessation
- 1990-05-16 NO NO902197A patent/NO300691B1/no not_active IP Right Cessation
- 1990-05-16 ES ES90109268T patent/ES2099075T3/es not_active Expired - Lifetime
- 1990-05-17 MY MYPI90000790A patent/MY131039A/en unknown
- 1990-05-17 KR KR1019900007085A patent/KR0136899B1/ko not_active Expired - Fee Related
- 1990-05-17 JP JP2125629A patent/JP3062696B2/ja not_active Expired - Lifetime
-
1997
- 1997-06-13 GR GR970401423T patent/GR3023784T3/el unknown
-
1998
- 1998-05-15 HK HK98104210A patent/HK1005018A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GR3023784T3 (en) | 1997-09-30 |
| NZ233696A (en) | 1992-04-28 |
| KR0136899B1 (ko) | 1998-04-25 |
| IL94379A0 (en) | 1991-03-10 |
| NO300691B1 (no) | 1997-07-07 |
| JP3062696B2 (ja) | 2000-07-12 |
| PT94064A (pt) | 1991-01-08 |
| FI902387A0 (fi) | 1990-05-14 |
| JPH0327321A (ja) | 1991-02-05 |
| NO902197D0 (no) | 1990-05-16 |
| ES2099075T3 (es) | 1997-05-16 |
| KR900017597A (ko) | 1990-12-19 |
| IE901764L (en) | 1990-11-17 |
| CA2016584A1 (en) | 1990-11-17 |
| DE69030213D1 (de) | 1997-04-24 |
| ATE150321T1 (de) | 1997-04-15 |
| DE69030213T2 (de) | 1997-10-16 |
| EP0398305B1 (de) | 1997-03-19 |
| AU631638B2 (en) | 1992-12-03 |
| CA2016584C (en) | 1999-06-29 |
| EP0398305A2 (de) | 1990-11-22 |
| ZA903757B (en) | 1992-01-29 |
| PT94064B (pt) | 1997-07-31 |
| FI102356B1 (fi) | 1998-11-30 |
| FI102356B (fi) | 1998-11-30 |
| IE81109B1 (en) | 2000-03-08 |
| DK0398305T3 (da) | 1997-06-23 |
| EP0398305A3 (de) | 1991-03-20 |
| HK1005018A1 (en) | 1998-12-18 |
| NO902197L (no) | 1990-11-19 |
| AU5511790A (en) | 1990-11-22 |
| MY131039A (en) | 2007-07-31 |
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| US5137877B1 (en) | Bifunctional linking compounds conjugates and methods for their production | |
| HK1005018B (en) | Anthracycline conjugates having a novel linker and methods for their production | |
| WO1993025228A1 (en) | Cytotoxins specific for gm-csf receptor-bearing cells | |
| CA2010164A1 (en) | Anthracycline immunoconjugates having a novel linker and methods for their production |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |