IL94379A - Conjugates of anthracycline linked to a ligand by an acylhydrazone linkage their production and pharmaceutical compositions containing them - Google Patents

Conjugates of anthracycline linked to a ligand by an acylhydrazone linkage their production and pharmaceutical compositions containing them

Info

Publication number
IL94379A
IL94379A IL9437990A IL9437990A IL94379A IL 94379 A IL94379 A IL 94379A IL 9437990 A IL9437990 A IL 9437990A IL 9437990 A IL9437990 A IL 9437990A IL 94379 A IL94379 A IL 94379A
Authority
IL
Israel
Prior art keywords
anthracycline
ligand
conjugates
pharmaceutical compositions
production
Prior art date
Application number
IL9437990A
Other languages
English (en)
Other versions
IL94379A0 (en
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/353,729 external-priority patent/US5122368A/en
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL94379A0 publication Critical patent/IL94379A0/xx
Publication of IL94379A publication Critical patent/IL94379A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL9437990A 1989-05-17 1990-05-14 Conjugates of anthracycline linked to a ligand by an acylhydrazone linkage their production and pharmaceutical compositions containing them IL94379A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/353,729 US5122368A (en) 1988-02-11 1989-05-17 Anthracycline conjugates having a novel linker and methods for their production

Publications (2)

Publication Number Publication Date
IL94379A0 IL94379A0 (en) 1991-03-10
IL94379A true IL94379A (en) 1997-02-18

Family

ID=23390328

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9437990A IL94379A (en) 1989-05-17 1990-05-14 Conjugates of anthracycline linked to a ligand by an acylhydrazone linkage their production and pharmaceutical compositions containing them

Country Status (19)

Country Link
EP (1) EP0398305B1 (de)
JP (1) JP3062696B2 (de)
KR (1) KR0136899B1 (de)
AT (1) ATE150321T1 (de)
AU (1) AU631638B2 (de)
CA (1) CA2016584C (de)
DE (1) DE69030213T2 (de)
DK (1) DK0398305T3 (de)
ES (1) ES2099075T3 (de)
FI (1) FI102356B1 (de)
GR (1) GR3023784T3 (de)
HK (1) HK1005018A1 (de)
IE (1) IE81109B1 (de)
IL (1) IL94379A (de)
MY (1) MY131039A (de)
NO (1) NO300691B1 (de)
NZ (1) NZ233696A (de)
PT (1) PT94064B (de)
ZA (1) ZA903757B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU638971B2 (en) * 1990-02-14 1993-07-15 Bristol-Myers Squibb Company Anthracycline immunoconjugates having a novel linker and methods for their production
CA2048089A1 (en) * 1990-09-17 1992-03-18 Wolfgang A. Wrasidlo Chemical conjugation of morpholino anthracyclines to antibodies
US5622929A (en) * 1992-01-23 1997-04-22 Bristol-Myers Squibb Company Thioether conjugates
RU2119354C1 (ru) * 1996-01-05 1998-09-27 Виктор Савельевич Гуревич Способ направленного транспорта фармакологических препаратов путем их конъюгации с аргинил-глицил-аспартил (rgd) содержащими пептидами
DE69830305T2 (de) * 1997-02-20 2006-02-02 Dime, David S., Toronto Ortsspezifische arzneimittel verabreichung
US7033765B1 (en) 1997-02-20 2006-04-25 Toronto Research Chemicals, Inc. Site-specific drug delivery
GB9724838D0 (en) * 1997-11-26 1998-01-21 Franks Christopher R Compositions
WO2002000170A2 (en) * 2000-06-28 2002-01-03 Ward Page Faulk Targeted delivery of cytotoxic drugs a) to activated lymphocytes in patients with transplanted organs, b) as radiosensitizers to cancer cells in patients undergoing radiation therapy, and c) in vitamin-binding proteins as drug carriers in the diagnosis and treatment of cancer
EP1343531A2 (de) * 2000-12-21 2003-09-17 McGILL UNIVERSITY Konjugate von antikörpern und antikrebsmitteln
NZ511705A (en) * 2001-05-14 2004-03-26 Horticulture & Food Res Inst Methods and rapid immunoassay device for detecting progesterone and other steroids
KR100507968B1 (ko) * 2001-08-18 2005-08-17 한국과학기술연구원 자기집합체를 형성하는 항암제-키토산 복합체 및 그의제조방법
NZ564694A (en) * 2003-04-22 2009-11-27 Sod Conseils Rech Applic Peptide vectors
EP1680073B1 (de) * 2003-10-21 2013-01-02 IGF Oncology, LLC Verbindungen und verfahren zur behandlung von krebs
US9011880B2 (en) 2003-10-21 2015-04-21 Igf Oncology, Llc Compounds and methods for treating cancer
AU2005218642B2 (en) * 2004-03-02 2011-04-28 Seagen Inc. Partially loaded antibodies and methods of their conjugation
EP1695717A1 (de) * 2005-02-23 2006-08-30 Ludwig-Maximilians-Universität Transport Nano- und Makromolecularer Strukturen ins Zytoplasma und in den Zellkern
CN102159248B (zh) * 2008-07-15 2013-09-11 健泰科生物技术公司 蒽环类衍生物缀合物、它们的制备方法以及它们作为抗肿瘤化合物的用途
JP6835590B2 (ja) 2014-01-12 2021-02-24 アイジーエフ オンコロジー、 エルエルシー インスリン様成長因子−１および上皮増殖因子を含む融合タンパク質およびそのバリアントならびにその使用
WO2016040825A1 (en) * 2014-09-12 2016-03-17 Genentech, Inc. Anthracycline disulfide intermediates, antibody-drug conjugates and methods
WO2018217669A1 (en) 2017-05-21 2018-11-29 Igf Oncology, Llc An insulin-like growth factor-chemotherapeputic conjugate for treating myelodysplastic syndrome

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957755A (en) * 1967-10-18 1976-05-18 Rhone-Poulenc S.A. Naphthacene derivatives
US4112217A (en) * 1977-09-02 1978-09-05 Sri International Bis-hydrazones of daunomycin and adriamycin
US4263428A (en) * 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
US5162512A (en) * 1982-03-09 1992-11-10 Cytogen Corporation Amine derivatives of anthracycline antibodies
US4950738A (en) * 1984-09-13 1990-08-21 Cytogen Corporation Amine derivatives of anthracycline antibiotics
GB8610551D0 (en) * 1986-04-30 1986-06-04 Hoffmann La Roche Polypeptide & protein derivatives
IL106992A (en) 1988-02-11 1994-06-24 Bristol Myers Squibb Co Acylhydrazone derivatives of anthracycline and methods for their preparation
AU638971B2 (en) * 1990-02-14 1993-07-15 Bristol-Myers Squibb Company Anthracycline immunoconjugates having a novel linker and methods for their production

Also Published As

Publication number Publication date
NZ233696A (en) 1992-04-28
GR3023784T3 (en) 1997-09-30
IE81109B1 (en) 2000-03-08
NO902197L (no) 1990-11-19
KR0136899B1 (ko) 1998-04-25
EP0398305A3 (de) 1991-03-20
ES2099075T3 (es) 1997-05-16
IL94379A0 (en) 1991-03-10
HK1005018A1 (en) 1998-12-18
ZA903757B (en) 1992-01-29
EP0398305B1 (de) 1997-03-19
FI102356B (fi) 1998-11-30
PT94064A (pt) 1991-01-08
AU5511790A (en) 1990-11-22
AU631638B2 (en) 1992-12-03
JP3062696B2 (ja) 2000-07-12
DK0398305T3 (da) 1997-06-23
DE69030213T2 (de) 1997-10-16
JPH0327321A (ja) 1991-02-05
KR900017597A (ko) 1990-12-19
EP0398305A2 (de) 1990-11-22
CA2016584C (en) 1999-06-29
NO902197D0 (no) 1990-05-16
NO300691B1 (no) 1997-07-07
FI102356B1 (fi) 1998-11-30
MY131039A (en) 2007-07-31
CA2016584A1 (en) 1990-11-17
PT94064B (pt) 1997-07-31
FI902387A0 (fi) 1990-05-14
DE69030213D1 (de) 1997-04-24
ATE150321T1 (de) 1997-04-15
IE901764L (en) 1990-11-17

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