IL92958A - Purified human sciatic nerve ciliary neurotrophic factor and methods for the preparation thereof - Google Patents

Purified human sciatic nerve ciliary neurotrophic factor and methods for the preparation thereof

Info

Publication number
IL92958A
IL92958A IL92958A IL9295890A IL92958A IL 92958 A IL92958 A IL 92958A IL 92958 A IL92958 A IL 92958A IL 9295890 A IL9295890 A IL 9295890A IL 92958 A IL92958 A IL 92958A
Authority
IL
Israel
Prior art keywords
preparation
methods
neurotrophic factor
sciatic nerve
purified human
Prior art date
Application number
IL92958A
Other languages
English (en)
Other versions
IL92958A0 (en
Inventor
Franklin D Collins
Leu-Fen Lin
Drzislav Mismer
Christine Ko
Original Assignee
Synergen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/293,851 external-priority patent/US5011914A/en
Priority claimed from US07/404,533 external-priority patent/US4997929A/en
Application filed by Synergen Inc filed Critical Synergen Inc
Publication of IL92958A0 publication Critical patent/IL92958A0/xx
Publication of IL92958A publication Critical patent/IL92958A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
IL92958A 1989-01-05 1990-01-03 Purified human sciatic nerve ciliary neurotrophic factor and methods for the preparation thereof IL92958A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/293,851 US5011914A (en) 1989-01-05 1989-01-05 Purified ciliary neurotrophic factor
US07/404,533 US4997929A (en) 1989-01-05 1989-09-08 Purified ciliary neurotrophic factor
US07/458,564 US5141856A (en) 1989-01-05 1989-12-28 Expression of purified ciliary neurotrophic factor

Publications (2)

Publication Number Publication Date
IL92958A0 IL92958A0 (en) 1990-09-17
IL92958A true IL92958A (en) 1997-09-30

Family

ID=27404236

Family Applications (1)

Application Number Title Priority Date Filing Date
IL92958A IL92958A (en) 1989-01-05 1990-01-03 Purified human sciatic nerve ciliary neurotrophic factor and methods for the preparation thereof

Country Status (21)

Country Link
US (2) US5141856A (ja)
EP (1) EP0385060B1 (ja)
JP (2) JPH0768270B2 (ja)
KR (1) KR930012105B1 (ja)
AU (1) AU7032496A (ja)
BR (1) BR9006996A (ja)
CH (1) CH681426A5 (ja)
DD (1) DD299318A5 (ja)
DE (1) DE4090006C2 (ja)
DK (1) DK131391A (ja)
ES (1) ES2091768T3 (ja)
FI (1) FI104375B (ja)
GB (1) GB2246132B (ja)
GR (1) GR3021705T3 (ja)
HU (2) HUT58792A (ja)
IE (1) IE81151B1 (ja)
IL (1) IL92958A (ja)
NL (1) NL9020024A (ja)
NZ (1) NZ231985A (ja)
SE (1) SE513358C2 (ja)
WO (1) WO1990007341A1 (ja)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328988A (en) * 1987-10-26 1994-07-12 Immunex Corporation Interleukin-7
US5714585A (en) * 1987-10-26 1998-02-03 Sterling Winthrop, Inc. Antibodies that are immunoreactive with interleukin-7
US5141856A (en) * 1989-01-05 1992-08-25 Synergen, Inc. Expression of purified ciliary neurotrophic factor
IE903130A1 (en) * 1989-09-15 1991-03-27 Regeneron Pharma Ciliary neurotrophic factor
HUT62033A (en) * 1990-03-14 1993-03-29 Fidia Spa Process for producing human ciliary body neuronotropic factor
US6511823B1 (en) * 1990-08-20 2003-01-28 American Cyanamid Corporation Heparin binding neurotrophic factor gene sequence
IT1247150B (it) * 1991-01-21 1994-12-12 Fidia Spa Processo per la sintesi e la purificazione del fattore neuronotroficociliare umano (cntf) da escherichia coli.
US5593857A (en) * 1991-08-23 1997-01-14 Scios Inc. Production of homogeneous truncated CNTF
EP0668911A1 (en) * 1991-11-11 1995-08-30 FIDIA S.p.A. Synthesis and purification of truncated and mutein forms of human ciliary neuronotrophic factor
US5360740A (en) * 1992-07-02 1994-11-01 Regeneron Pharmaceuticals, Inc. Assay system for degenerative muscle disease
AU6130094A (en) * 1993-01-29 1994-08-15 Regeneron Pharmaceuticals, Inc. Methods of treatment using ciliary neurotrophic factor
EP0632008B1 (en) * 1993-06-01 1998-02-04 Ono Pharmaceutical Co., Ltd. Pentanoic acid derivatives
WO1995022560A1 (en) * 1994-02-22 1995-08-24 The Syntex-Synergen Neuroscience Joint Venture Pharmaceutical formulations of cntf
US5534615A (en) * 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
US6472585B1 (en) 1994-04-25 2002-10-29 Genentech, Inc. Cardiotrophin-1 defective mouse
ES2276393T3 (es) * 1994-04-25 2007-06-16 Genentech, Inc. Cardiotrofina y sus usos.
US7258983B2 (en) * 1994-04-25 2007-08-21 Genentech, Inc. Cardiotrophin-1 compositions and methods for the treatment of tumor
US5739307A (en) 1995-08-28 1998-04-14 Washington University Polynucleotide encoding neurturin neurotrophic factor
US6743628B1 (en) 1995-08-28 2004-06-01 Washington University Method of cell culture using neurturin
DE69732350T2 (de) 1996-03-14 2005-12-22 Washington University Persephin und verwandte wachstumsfaktoren
US6716600B1 (en) 1996-03-14 2004-04-06 Washington University Persephin and related growth factors
US6222022B1 (en) 1996-03-14 2001-04-24 Washington University Persephin and related growth factors
US6299895B1 (en) 1997-03-24 2001-10-09 Neurotech S.A. Device and method for treating ophthalmic diseases
IT1288388B1 (it) 1996-11-19 1998-09-22 Angeletti P Ist Richerche Bio Uso di sostanze che attivano il recettore del cntf ( fattore neurotrofico ciliare) per la preparazione di farmaci per la terapia
US6042579A (en) * 1997-04-30 2000-03-28 Medtronic, Inc. Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain
US6689573B1 (en) * 1999-05-24 2004-02-10 New England Biolabs, Inc. Method for screening restriction endonucleases
CA2409190A1 (en) 2000-04-14 2001-10-25 The Uab Research Foundation Poliovirus replicons encoding therapeutic agents and uses thereof
US20050064555A1 (en) * 2003-07-09 2005-03-24 Xencor, Inc. Ciliary neurotrophic factor variants
WO2008054786A2 (en) * 2006-10-31 2008-05-08 The Ohio State University Research Foundation Methods and compositions for inhibiting gsk-3 in glial cell related disorders
JP2014506119A (ja) 2010-12-02 2014-03-13 ニューロテック ユーエスエー， インコーポレイテッド 抗血管新生抗体足場および可溶性受容体を分泌する細胞株およびその使用
CA2986769A1 (en) 2015-05-27 2016-12-01 Neurotech Usa, Inc. Use of encapsulated cell therapy for treatment of ophthalmic disorders

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US404533A (en) * 1889-06-04 Signments
US293851A (en) * 1884-02-19 de castro
US408172A (en) * 1889-07-30 Steam-boiler house
US429517A (en) * 1890-06-03 Packing-box
US570651A (en) * 1896-11-03 Motor-driven fan
US458564A (en) * 1891-09-01 Ring-gage
US4399216A (en) * 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4923696A (en) * 1987-05-04 1990-05-08 Baylor College Of Medicine Method to prepare a neurotrophic composition
US5028622A (en) * 1988-05-06 1991-07-02 Ajinomoto Company, Inc. Administration of amino acids as treatment for neurodegenerative disorders
US5141856A (en) * 1989-01-05 1992-08-25 Synergen, Inc. Expression of purified ciliary neurotrophic factor
US4997929A (en) * 1989-01-05 1991-03-05 Synergen, Inc. Purified ciliary neurotrophic factor
US5011914A (en) * 1989-01-05 1991-04-30 Collins Franklin D Purified ciliary neurotrophic factor
EP0463082A1 (en) * 1989-03-15 1992-01-02 The Regents Of The University Of California Purified ciliary neurotrophic factor
FI912358A0 (fi) * 1989-09-15 1991-05-15 Max Planck Gesellschaft Neurotrofisk faktor av ciliar ganglion.
IE903130A1 (en) * 1989-09-15 1991-03-27 Regeneron Pharma Ciliary neurotrophic factor
US5349056A (en) * 1992-10-09 1994-09-20 Regeneron Pharmaceuticals Modified ciliary neurotrophic factors

Also Published As

Publication number Publication date
SE513358C2 (sv) 2000-08-28
IE900020L (en) 1990-07-05
JPH0768270B2 (ja) 1995-07-26
DD299318A5 (de) 1992-04-09
EP0385060A2 (en) 1990-09-05
GB2246132A8 (en) 2001-05-22
AU4838190A (en) 1990-08-01
HU211933A9 (en) 1996-01-29
NZ231985A (en) 1992-12-23
EP0385060B1 (en) 1996-08-28
GB2246132B (en) 1993-09-15
KR930012105B1 (ko) 1993-12-24
SE9102079D0 (sv) 1991-07-03
GB9113704D0 (en) 1991-08-21
JPH1129598A (ja) 1999-02-02
DK131391A (da) 1991-09-05
EP0385060A3 (en) 1991-04-03
CH681426A5 (ja) 1993-03-31
IL92958A0 (en) 1990-09-17
AU642858B2 (en) 1993-11-04
HUT58792A (en) 1992-03-30
JPH04502916A (ja) 1992-05-28
DE4090006C2 (de) 1996-09-19
ES2091768T3 (es) 1996-11-16
BR9006996A (pt) 1991-11-12
FI104375B (fi) 2000-01-14
SE9102079L (sv) 1991-07-03
NL9020024A (nl) 1991-10-01
IE81151B1 (en) 2000-05-03
GR3021705T3 (en) 1997-02-28
DK131391D0 (da) 1991-07-05
WO1990007341A1 (en) 1990-07-12
GB2246132A (en) 1992-01-22
US5141856A (en) 1992-08-25
KR910700068A (ko) 1991-03-13
AU7032496A (en) 1997-01-16
FI913251A0 (fi) 1991-07-04
US5780600A (en) 1998-07-14

Similar Documents

Publication Publication Date Title
IL92958A (en) Purified human sciatic nerve ciliary neurotrophic factor and methods for the preparation thereof
GB2239260B (en) Oxygen-generating electrode and method for the preparation thereof
ZA906926B (en) Brain derived neurotrophic factor
AP9000234A0 (en) Therapeutic nucleocides
LTIP785A (en) Stimulating preparation with nicotine
IL96258A0 (en) Adjustable seating
AR244967A1 (es) Silla.
ZA9081B (en) Purified ciliary neurotrophic factor
GB8728550D0 (en) Adjustable chair
EP0405542A3 (en) Wheelchair
GB8926580D0 (en) Demountable railing panels
IL91671A (en) Opaliform porcellanite and process for the preparation thereof
EP0257361A3 (en) 5-fluorouridine derivative and preparation of the same
GB8917406D0 (en) Therapeutic aid
EP0414003A3 (en) Electronically controlled wheelchair
GB8716041D0 (en) Adjustable chair
EP0427942A3 (en) Process for the preparation of s-triazine-sulfenimides and their use
ZA907303B (en) Ciliary neurotrophic factor
HRP931137A2 (en) Process for the preparation of human stephine b and the mutants thereof
GB9027635D0 (en) Adjustable seating
EP0373919A3 (en) Process for the preparation of 2'-deoxy-beta-adenosine
GB8918243D0 (en) Therapeutic preparation
GB8728713D0 (en) Temporary adjustable door frame
IL108464A0 (en) Methods of treatment using ciliary neurotrophic factor
HU895837D0 (en) Process for the preparation of ortho-nitro-aniline and ortho-phenylen-diamine

Legal Events

Date Code Title Description
CB Opposition filed against grant of patent
KB Patent renewed
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired