IL90745A0 - Tissue plasminogen activator analogue and nucleic acid coding for it - Google Patents

Tissue plasminogen activator analogue and nucleic acid coding for it

Info

Publication number
IL90745A0
IL90745A0 IL90745A IL9074589A IL90745A0 IL 90745 A0 IL90745 A0 IL 90745A0 IL 90745 A IL90745 A IL 90745A IL 9074589 A IL9074589 A IL 9074589A IL 90745 A0 IL90745 A0 IL 90745A0
Authority
IL
Israel
Prior art keywords
nucleic acid
plasminogen activator
tissue plasminogen
acid coding
activator analogue
Prior art date
Application number
IL90745A
Other languages
English (en)
Original Assignee
British Bio Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Bio Technology filed Critical British Bio Technology
Priority to IL90745A priority Critical patent/IL90745A0/xx
Publication of IL90745A0 publication Critical patent/IL90745A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
    • C22B4/00—Electrothermal treatment of ores or metallurgical products for obtaining metals or alloys
    • C22B4/02—Light metals
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
    • C22B4/00—Electrothermal treatment of ores or metallurgical products for obtaining metals or alloys
    • C22B4/06—Alloys
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C1/00—Making non-ferrous alloys
    • C22C1/02—Making non-ferrous alloys by melting
    • C22C1/026—Alloys based on aluminium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P10/00—Technologies related to metal processing
    • Y02P10/20—Recycling

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Mechanical Engineering (AREA)
  • Biomedical Technology (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Geology (AREA)
  • Geochemistry & Mineralogy (AREA)
  • Environmental & Geological Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL90745A 1988-06-24 1989-06-25 Tissue plasminogen activator analogue and nucleic acid coding for it IL90745A0 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL90745A IL90745A0 (en) 1988-06-24 1989-06-25 Tissue plasminogen activator analogue and nucleic acid coding for it

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888815135A GB8815135D0 (en) 1988-06-24 1988-06-24 Proteins & nucleic acids
IL90745A IL90745A0 (en) 1988-06-24 1989-06-25 Tissue plasminogen activator analogue and nucleic acid coding for it

Publications (1)

Publication Number Publication Date
IL90745A0 true IL90745A0 (en) 1990-03-19

Family

ID=10639339

Family Applications (1)

Application Number Title Priority Date Filing Date
IL90745A IL90745A0 (en) 1988-06-24 1989-06-25 Tissue plasminogen activator analogue and nucleic acid coding for it

Country Status (15)

Country Link
US (1) US5232847A (pt)
EP (1) EP0352904A1 (pt)
JP (1) JPH03505524A (pt)
KR (1) KR900702018A (pt)
AU (1) AU627475B2 (pt)
DK (1) DK305490A (pt)
FI (1) FI906322A0 (pt)
GB (1) GB8815135D0 (pt)
HU (1) HUT61593A (pt)
IL (1) IL90745A0 (pt)
NO (1) NO905561L (pt)
NZ (1) NZ229691A (pt)
PT (1) PT90976A (pt)
WO (1) WO1989012681A1 (pt)
ZA (1) ZA894800B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
JPH0595786A (ja) * 1991-10-07 1993-04-20 Green Cross Corp:The 変異ヒトプロウロキナーゼ
AU664469B2 (en) * 1992-06-03 1995-11-16 Genentech Inc. Tissue plasminogen activator glycosylation variants with improved therapeutic properties
AU2660397A (en) * 1996-04-05 1997-10-29 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells
US6083715A (en) * 1997-06-09 2000-07-04 Board Of Regents, The University Of Texas System Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987004722A1 (en) * 1986-01-31 1987-08-13 Genetics Institute, Inc. Novel thrombolytic proteins
GB8608014D0 (en) * 1986-04-02 1986-05-08 Beecham Group Plc Compounds
PT84587B (pt) * 1986-04-02 1989-11-30 Beecham Group Plc Processo para preparacao de uma enzima fibrinolitica
PT84589B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
DK302388A (da) * 1987-06-04 1989-02-03 Zymogenetics Inc T-pa analoger med dodificeret vaekstfaktordomaene
AU613942B2 (en) * 1987-06-30 1991-08-15 Genentech Inc. Improved processes for the treatment of vascular disease
JPH03500002A (ja) * 1987-07-06 1991-01-10 ジェネティックス・インスチチュート・インコーポレーテッド 新規な血栓崩壊蛋白
US4963357A (en) * 1987-10-09 1990-10-16 Monsanto Company Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
JPH02273179A (ja) * 1988-12-12 1990-11-07 Yamanouchi Pharmaceut Co Ltd 新規な血栓溶解蛋白質，その製造法および該蛋白質からなる医薬

Also Published As

Publication number Publication date
WO1989012681A1 (en) 1989-12-28
HU893786D0 (en) 1991-05-28
NZ229691A (en) 1992-03-26
FI906322A0 (fi) 1990-12-20
HUT61593A (en) 1993-01-28
NO905561L (no) 1991-02-22
PT90976A (pt) 1989-12-29
ZA894800B (en) 1990-05-30
DK305490A (da) 1991-02-20
DK305490D0 (da) 1990-12-21
AU3838189A (en) 1990-01-12
EP0352904A1 (en) 1990-01-31
US5232847A (en) 1993-08-03
NO905561D0 (no) 1990-12-21
KR900702018A (ko) 1990-12-05
JPH03505524A (ja) 1991-12-05
GB8815135D0 (en) 1988-08-03
AU627475B2 (en) 1992-08-27

Similar Documents

Publication Publication Date Title
GB2179948B (en) Poly-kringle plasminogen activator
NZ215660A (en) Tissue plasminogen activator modified in the growth factor domain
NZ216306A (en) Pharmaceutical compositions containing tissue plasminogen activator
NZ216307A (en) Pharmaceutical compositions containing tissue plasminogen activator
AU6806487A (en) Tissue plasminogen activator
IL90745A0 (en) Tissue plasminogen activator analogue and nucleic acid coding for it
NZ217331A (en) Tissue plasminogen activator derivatives and genetically engineered product
IL86909A0 (en) Hybrid plasminogen activator,dna coding therefor,derivatives of said plasminogen activator and pharmaceutical compositions containing said plasminogen activator or said derivatives
IL91774A0 (en) Preparation of plasminogen activator expressed in prokaryotes
EP0225177A3 (en) Dna sequence coding for human tissue plasminogen activator
ZA863956B (en) Pharmaceutical formulations containing tissue plasminogen activator
GB2247031B (en) Reinforcement of tissue
IE870208L (en) Modified tissue plasminogen activator
GB8901422D0 (en) New tissue plasminogen activator
GB8815245D0 (en) New tissue plasminogen activator
AU7090787A (en) Tissue plasminogen activator
GB8726683D0 (en) Tissue plasminogen activator
GB8718298D0 (en) Tissue plasminogen activator
GB8725052D0 (en) Tissue plasminogen activator
GB8826692D0 (en) Tissue plasminogen activator
EP0358274A3 (en) Method for purifying tissue plasminogen activator
GB8815246D0 (en) New tissue plasminogen activator
GB8815247D0 (en) New tissue plasminogen activator
ZA862976B (en) Human tissue plasminogen activator mutants
IE861388L (en) Tissue plasminogen activator