IL89491A0 - Bifunctional chimeric antibodies - Google Patents
Bifunctional chimeric antibodiesInfo
- Publication number
- IL89491A0 IL89491A0 IL89491A IL8949189A IL89491A0 IL 89491 A0 IL89491 A0 IL 89491A0 IL 89491 A IL89491 A IL 89491A IL 8949189 A IL8949189 A IL 8949189A IL 89491 A0 IL89491 A0 IL 89491A0
- Authority
- IL
- Israel
- Prior art keywords
- chimeric antibodies
- bifunctional chimeric
- bifunctional
- antibodies
- chimeric
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL106427A IL106427A0 (en) | 1988-11-17 | 1993-07-20 | Bifunctional chimeric antibodies |
IL106429A IL106429A0 (en) | 1988-11-17 | 1993-07-20 | Bifunctional chimeric antibodies |
IL106428A IL106428A0 (en) | 1988-11-17 | 1993-07-20 | A host cell which secretes bifunctional chimeric cem/cha |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27410588A | 1988-11-17 | 1988-11-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL89491A0 true IL89491A0 (en) | 1989-09-10 |
Family
ID=23046793
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL89491A IL89491A0 (en) | 1988-11-17 | 1989-03-06 | Bifunctional chimeric antibodies |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0369566A3 (de) |
JP (1) | JPH02145187A (de) |
AU (1) | AU618324B2 (de) |
DK (1) | DK108189A (de) |
IL (1) | IL89491A0 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL89489A0 (en) * | 1988-03-09 | 1989-09-10 | Hybritech Inc | Chimeric antibodies directed against human carcinoembryonic antigen |
IL89490A0 (en) * | 1988-11-17 | 1989-09-10 | Hybritech Inc | Chimeric antibodies directed against metal chelates |
IL89491A0 (en) * | 1988-11-17 | 1989-09-10 | Hybritech Inc | Bifunctional chimeric antibodies |
DE3920358A1 (de) * | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
US5582996A (en) * | 1990-12-04 | 1996-12-10 | The Wistar Institute Of Anatomy & Biology | Bifunctional antibodies and method of preparing same |
CA2097060A1 (en) * | 1990-12-04 | 1992-06-05 | Peter J. Curtis | Bifunctional antibodies and method of preparing same |
JPH0576385A (ja) * | 1990-12-18 | 1993-03-30 | Takeda Chem Ind Ltd | キメラ抗体およびその用途 |
ZA938243B (en) * | 1992-11-12 | 1995-05-04 | Hybritech Inc | Altered affinity polypeptides of metal chelate binding antibodies |
US5532136A (en) * | 1993-06-22 | 1996-07-02 | Bionebraska, Inc. | Monoclonal antibody assay and kit for detecting metal cations in body fluids |
GB9819411D0 (en) * | 1998-09-04 | 1998-10-28 | Ks Biomedix Ltd | Antibodies |
WO2005035754A1 (ja) | 2003-10-14 | 2005-04-21 | Chugai Seiyaku Kabushiki Kaisha | 機能蛋白質を代替する二重特異性抗体 |
AU2003271174A1 (en) | 2003-10-10 | 2005-04-27 | Chugai Seiyaku Kabushiki Kaisha | Double specific antibodies substituting for functional protein |
KR101374454B1 (ko) | 2005-03-31 | 2014-03-17 | 추가이 세이야쿠 가부시키가이샤 | 회합제어에 의한 폴리펩티드 제조방법 |
EP2006381B1 (de) | 2006-03-31 | 2016-02-03 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur kontrolle der blut-pharmakokinetik von antikörpern |
EP4218801A3 (de) | 2006-03-31 | 2023-08-23 | Chugai Seiyaku Kabushiki Kaisha | Antikörpermodifizierungsverfahren zur reinigung eines bispezifischen antikörpers |
PL2202245T3 (pl) | 2007-09-26 | 2017-02-28 | Chugai Seiyaku Kabushiki Kaisha | Sposób modyfikowania punktu izoelektrycznego przeciwciała poprzez podstawienie aminokwasu w cdr |
MY166429A (en) | 2010-11-17 | 2018-06-26 | Chugai Pharmaceutical Co Ltd | Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor viii |
JP6534615B2 (ja) | 2013-09-27 | 2019-06-26 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
TWI701435B (zh) | 2014-09-26 | 2020-08-11 | 日商中外製藥股份有限公司 | 測定fviii的反應性之方法 |
MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
TWI700300B (zh) | 2014-09-26 | 2020-08-01 | 日商中外製藥股份有限公司 | 中和具有第viii凝血因子(fviii)機能替代活性的物質之抗體 |
US11142587B2 (en) | 2015-04-01 | 2021-10-12 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide hetero-oligomer |
EP3398965A4 (de) | 2015-12-28 | 2019-09-18 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur förderung der effizienz der reinigung von polypeptid mit fc-region |
CN109661241A (zh) | 2016-09-06 | 2019-04-19 | 中外制药株式会社 | 使用识别凝血因子ix和/或活化凝血因子ix以及凝血因子x和/或活化凝血因子x的双特异性抗体的方法 |
CN108220281A (zh) * | 2017-09-25 | 2018-06-29 | 天津强微特生物科技有限公司 | 一种含有结合核酸的磁珠在生物样品保存液的制备和运用 |
AU2018338859A1 (en) | 2017-09-29 | 2020-02-06 | Chugai Seiyaku Kabushiki Kaisha | Multispecific antigen-binding molecule having blood coagulation factor VIII (FVIII) cofactor function-substituting activity, and pharmaceutical formulation containing said molecule as active ingredient |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1339445C (en) * | 1986-11-12 | 1997-09-09 | The General Hospital Corporation | Recombinant hybrid immunoglobulin molecules and method of use |
DE3853779T2 (de) * | 1987-05-29 | 1995-09-07 | Baylor College Medicine | Hiv-1 neutralisierende monoklonale antikörper. |
AU625613B2 (en) * | 1988-01-05 | 1992-07-16 | Novartis Ag | Novel chimeric antibodies |
IL89489A0 (en) * | 1988-03-09 | 1989-09-10 | Hybritech Inc | Chimeric antibodies directed against human carcinoembryonic antigen |
IL89491A0 (en) * | 1988-11-17 | 1989-09-10 | Hybritech Inc | Bifunctional chimeric antibodies |
IL89490A0 (en) * | 1988-11-17 | 1989-09-10 | Hybritech Inc | Chimeric antibodies directed against metal chelates |
-
1989
- 1989-03-06 IL IL89491A patent/IL89491A0/xx unknown
- 1989-03-07 DK DK108189A patent/DK108189A/da not_active Application Discontinuation
- 1989-03-07 AU AU31074/89A patent/AU618324B2/en not_active Ceased
- 1989-03-08 JP JP1057675A patent/JPH02145187A/ja active Pending
- 1989-03-08 EP EP19890302313 patent/EP0369566A3/de not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP0369566A3 (de) | 1991-10-16 |
EP0369566A2 (de) | 1990-05-23 |
AU3107489A (en) | 1990-05-24 |
DK108189A (da) | 1990-05-18 |
AU618324B2 (en) | 1991-12-19 |
DK108189D0 (da) | 1989-03-07 |
JPH02145187A (ja) | 1990-06-04 |
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