IL88375A - נוגדנים מונוקלונליים הקושרים ספציפית אינטרפרון- ביא 2 טבעי ורקומביננטי ושיטה לטיהור אינטרפרון-ביטא 2 טבעי ורקומביננטי ושיטה לטיהור אינ - Google Patents

נוגדנים מונוקלונליים הקושרים ספציפית אינטרפרון- ביא 2 טבעי ורקומביננטי ושיטה לטיהור אינטרפרון-ביטא 2 טבעי ורקומביננטי ושיטה לטיהור אינ

Info

Publication number
IL88375A
IL88375A IL8837588A IL8837588A IL88375A IL 88375 A IL88375 A IL 88375A IL 8837588 A IL8837588 A IL 8837588A IL 8837588 A IL8837588 A IL 8837588A IL 88375 A IL88375 A IL 88375A
Authority
IL
Israel
Prior art keywords
ifn
cells
recombinant
expressed
protein
Prior art date
Application number
IL8837588A
Other languages
English (en)
Other versions
IL88375A0 (en
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Priority to IL8837588A priority Critical patent/IL88375A/he
Priority to CA000617131A priority patent/CA1341253C/en
Priority to CA000589005A priority patent/CA1341588C/en
Priority to DE68928641T priority patent/DE68928641T2/de
Priority to ES89101295T priority patent/ES2119735T3/es
Priority to JP1016080A priority patent/JP2725818B2/ja
Priority to EP89101295A priority patent/EP0326120B1/en
Priority to AT89101295T priority patent/ATE165010T1/de
Priority to AU28813/89A priority patent/AU621852B2/en
Publication of IL88375A0 publication Critical patent/IL88375A0/xx
Priority to US07/436,321 priority patent/US5618700A/en
Publication of IL88375A publication Critical patent/IL88375A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL8837588A 1988-01-26 1988-11-14 נוגדנים מונוקלונליים הקושרים ספציפית אינטרפרון- ביא 2 טבעי ורקומביננטי ושיטה לטיהור אינטרפרון-ביטא 2 טבעי ורקומביננטי ושיטה לטיהור אינ IL88375A (he)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IL8837588A IL88375A (he) 1988-11-14 1988-11-14 נוגדנים מונוקלונליים הקושרים ספציפית אינטרפרון- ביא 2 טבעי ורקומביננטי ושיטה לטיהור אינטרפרון-ביטא 2 טבעי ורקומביננטי ושיטה לטיהור אינ
CA000617131A CA1341253C (en) 1988-01-26 1989-01-24 Human ifn-.beta.2/il-6, its purification and use
CA000589005A CA1341588C (en) 1988-01-26 1989-01-24 Human ifn-beta2/i1-6, its purification and use
JP1016080A JP2725818B2 (ja) 1988-01-26 1989-01-25 ヒトインターフエロンベーター２、その精製法及びその用途
ES89101295T ES2119735T3 (es) 1988-01-26 1989-01-25 Ifn-beta2/il-6 humano, su purificacion y sus utilizaciones.
DE68928641T DE68928641T2 (de) 1988-01-26 1989-01-25 Menschliches IFN-beta2/IL-6, dessen Reinigung und Verwendungen
EP89101295A EP0326120B1 (en) 1988-01-26 1989-01-25 Human IFN-beta2/IL-6, its purification and uses
AT89101295T ATE165010T1 (de) 1988-01-26 1989-01-25 Menschliches ifn-beta2/il-6, dessen reinigung und verwendungen
AU28813/89A AU621852B2 (en) 1988-01-26 1989-01-25 Human ifn-beta 2/il-6, its purification and use
US07/436,321 US5618700A (en) 1988-11-14 1989-11-14 IL-6 specific monoclonal antibodies, hybridomas therefor and methods of making and using same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL8837588A IL88375A (he) 1988-11-14 1988-11-14 נוגדנים מונוקלונליים הקושרים ספציפית אינטרפרון- ביא 2 טבעי ורקומביננטי ושיטה לטיהור אינטרפרון-ביטא 2 טבעי ורקומביננטי ושיטה לטיהור אינ

Publications (2)

Publication Number Publication Date
IL88375A0 IL88375A0 (en) 1989-06-30
IL88375A true IL88375A (he) 1995-07-31

Family

ID=11059415

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8837588A IL88375A (he) 1988-01-26 1988-11-14 נוגדנים מונוקלונליים הקושרים ספציפית אינטרפרון- ביא 2 טבעי ורקומביננטי ושיטה לטיהור אינטרפרון-ביטא 2 טבעי ורקומביננטי ושיטה לטיהור אינ

Country Status (2)

Country Link
US (1) US5618700A (he)
IL (1) IL88375A (he)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856135A (en) * 1993-05-31 1999-01-05 Chugai Seiyaku Kabushiki Kaisha Reshaped human antibody to human interleukin-6
BRPI0214168B8 (pt) * 2001-11-14 2021-05-25 Centocor Inc anticorpos anti-il-6, moléculas de ácido nucleico codificando os mesmos, vetores compreendendo as referidas moléculas, composições e formulações compreendendo os referidos anticorpos, bem como métodos de produção dos mesmos
US20050100550A1 (en) * 2003-11-10 2005-05-12 Mohit Trikha Anti-angiogenic uses of IL-6 antagonists
PE20061324A1 (es) 2005-04-29 2007-01-15 Centocor Inc Anticuerpos anti-il-6, composiciones, metodos y usos
EP2336181A1 (en) * 2005-12-09 2011-06-22 UCB Pharma, S.A. Antibody molecules having specificity for human IL-6
MX2009001110A (es) * 2006-08-03 2009-05-11 Vaccinex Inc Anticuerpos monoclonales anti-il-6 y usos de los mismos.
US8062864B2 (en) 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
US7906117B2 (en) * 2007-05-21 2011-03-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
US8404235B2 (en) * 2007-05-21 2013-03-26 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US8178101B2 (en) 2007-05-21 2012-05-15 Alderbio Holdings Inc. Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
US9701747B2 (en) 2007-05-21 2017-07-11 Alderbio Holdings Llc Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
KR20170036814A (ko) * 2007-05-21 2017-04-03 앨더바이오 홀딩스 엘엘씨 신규한 래빗 항체 인간화 방법 및 인간화된 래빗 항체
US20090238825A1 (en) * 2007-05-21 2009-09-24 Kovacevich Brian R Novel rabbit antibody humanization methods and humanized rabbit antibodies
US8252286B2 (en) 2007-05-21 2012-08-28 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
HUE032563T2 (en) 2007-05-21 2017-09-28 Alderbio Holdings Llc Antibodies to IL-6 and their use
WO2009140348A2 (en) 2008-05-13 2009-11-19 Novimmune Sa Anti-il-6/il-6r antibodies and methods of use thereof
US8188235B2 (en) * 2008-06-18 2012-05-29 Pfizer Inc. Antibodies to IL-6 and their uses
CA2742786A1 (en) * 2008-11-13 2010-05-20 Femta Pharmaceuticals, Inc. Humanized anti-il-6 antibodies
US8337847B2 (en) 2008-11-25 2012-12-25 Alderbio Holdings Llc Methods of treating anemia using anti-IL-6 antibodies
US8992920B2 (en) 2008-11-25 2015-03-31 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of arthritis
US9452227B2 (en) 2008-11-25 2016-09-27 Alderbio Holdings Llc Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
US8323649B2 (en) 2008-11-25 2012-12-04 Alderbio Holdings Llc Antibodies to IL-6 and use thereof
US8420089B2 (en) 2008-11-25 2013-04-16 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US9212223B2 (en) 2008-11-25 2015-12-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
WO2011066374A2 (en) 2009-11-24 2011-06-03 Alder Biopharmaceuticals, Inc. Antagonists of il-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
US9775921B2 (en) 2009-11-24 2017-10-03 Alderbio Holdings Llc Subcutaneously administrable composition containing anti-IL-6 antibody
US9304134B2 (en) 2010-11-23 2016-04-05 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of anemia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58765A (en) * 1979-11-21 1986-09-30 Yeda Res & Dev Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
JPS59172496A (ja) * 1983-03-18 1984-09-29 Kyowa Hakko Kogyo Co Ltd モノクロ−ナル抗体
JP2598666B2 (ja) * 1987-10-19 1997-04-09 忠三 岸本 抗ヒトｂｃｄｆモノクローナル抗体

Also Published As

Publication number Publication date
IL88375A0 (en) 1989-06-30
US5618700A (en) 1997-04-08

Similar Documents

Publication Publication Date Title
US5618700A (en) IL-6 specific monoclonal antibodies, hybridomas therefor and methods of making and using same
KR920002267B1 (ko) 하이브리드 인터페론의 제조방법
JP2725818B2 (ja) ヒトインターフエロンベーター２、その精製法及びその用途
Brakenhoff et al. Structure-function analysis of human IL-6. Epitope mapping of neutralizing monoclonal antibodies with amino-and carboxyl-terminal deletion mutants.
US5011912A (en) Hybridoma and monoclonal antibody for use in an immunoaffinity purification system
AU643189B2 (en) Production of chimeric mouse-human antibodies with specificity to human tumor antigens
CA1335653C (en) Monoclonal antibodies against human interleukin-4 and hybridomas producing the same
EP0262192A1 (en) PROCESS AND MEANS FOR PRODUCING A PROTEIN HAVING THE SAME SPECIFICITY FOR IgG AS PROTEIN G.
Kasahara et al. Preparation and characterization of polyclonal and monoclonal antibodies against human interleukin 1 alpha (IL 1 alpha).
US4599306A (en) Monoclonal antibodies which specifically bind to human immune interferon
US4845198A (en) Hybridoma antibody which binds IL-2 receptor
JP3104187B2 (ja) インターフエロン―ガンマ結合蛋白
US5644035A (en) Method for purifying secreted Mac-2-binding glycoprotein
US4959457A (en) Anti-lymphotoxin
Berg Identification, production, and characterization of murine monoclonal antibody (LO-22) recognizing 12 native species of human alpha interferon
Novick et al. Monoclonal antibodies for affinity purification of IL-6/IFN-β2 and for neutralization of HGF activity
KR100382628B1 (ko) 인터페론α/β결합단백질과이의제조및용도
Sugasawara Hybridoma growth factors
Sugi et al. Monoclonal antibody to human β interferon: Characterization and application
Conlon et al. Generation of anti-peptide monoclonal antibodies which recognize mature CSF-2 alpha (IL 3) protein.
AU651139B2 (en) Human IFN-beta 2/IL-6, its purification and use
CA1341253C (en) Human ifn-.beta.2/il-6, its purification and use
Giles et al. Intrasubunit homogeneity in heterogeneous IgM antibodies to the DNP moiety derived from a murine hybridoma cell line
Tsukui et al. Two monoclonal antibodies distinguish between human recombinant interferon-α5s produced by Escherichia coli and by mouse cells
KR19980701550A (ko) 항-트롬보포이에틴 단일클론 항체(anti-tpo monoclonal antibodies)

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired