IL88375A - נוגדנים מונוקלונליים הקושרים ספציפית אינטרפרון- ביא 2 טבעי ורקומביננטי ושיטה לטיהור אינטרפרון-ביטא 2 טבעי ורקומביננטי ושיטה לטיהור אינ - Google Patents
נוגדנים מונוקלונליים הקושרים ספציפית אינטרפרון- ביא 2 טבעי ורקומביננטי ושיטה לטיהור אינטרפרון-ביטא 2 טבעי ורקומביננטי ושיטה לטיהור אינInfo
- Publication number
- IL88375A IL88375A IL8837588A IL8837588A IL88375A IL 88375 A IL88375 A IL 88375A IL 8837588 A IL8837588 A IL 8837588A IL 8837588 A IL8837588 A IL 8837588A IL 88375 A IL88375 A IL 88375A
- Authority
- IL
- Israel
- Prior art keywords
- ifn
- cells
- recombinant
- expressed
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL8837588A IL88375A (he) | 1988-11-14 | 1988-11-14 | נוגדנים מונוקלונליים הקושרים ספציפית אינטרפרון- ביא 2 טבעי ורקומביננטי ושיטה לטיהור אינטרפרון-ביטא 2 טבעי ורקומביננטי ושיטה לטיהור אינ |
CA000589005A CA1341588C (en) | 1988-01-26 | 1989-01-24 | Human ifn-beta2/i1-6, its purification and use |
CA000617131A CA1341253C (en) | 1988-01-26 | 1989-01-24 | Human ifn-.beta.2/il-6, its purification and use |
AU28813/89A AU621852B2 (en) | 1988-01-26 | 1989-01-25 | Human ifn-beta 2/il-6, its purification and use |
DE68928641T DE68928641T2 (de) | 1988-01-26 | 1989-01-25 | Menschliches IFN-beta2/IL-6, dessen Reinigung und Verwendungen |
ES89101295T ES2119735T3 (es) | 1988-01-26 | 1989-01-25 | Ifn-beta2/il-6 humano, su purificacion y sus utilizaciones. |
AT89101295T ATE165010T1 (de) | 1988-01-26 | 1989-01-25 | Menschliches ifn-beta2/il-6, dessen reinigung und verwendungen |
JP1016080A JP2725818B2 (ja) | 1988-01-26 | 1989-01-25 | ヒトインターフエロンベーター2、その精製法及びその用途 |
EP89101295A EP0326120B1 (en) | 1988-01-26 | 1989-01-25 | Human IFN-beta2/IL-6, its purification and uses |
US07/436,321 US5618700A (en) | 1988-11-14 | 1989-11-14 | IL-6 specific monoclonal antibodies, hybridomas therefor and methods of making and using same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL8837588A IL88375A (he) | 1988-11-14 | 1988-11-14 | נוגדנים מונוקלונליים הקושרים ספציפית אינטרפרון- ביא 2 טבעי ורקומביננטי ושיטה לטיהור אינטרפרון-ביטא 2 טבעי ורקומביננטי ושיטה לטיהור אינ |
Publications (2)
Publication Number | Publication Date |
---|---|
IL88375A0 IL88375A0 (en) | 1989-06-30 |
IL88375A true IL88375A (he) | 1995-07-31 |
Family
ID=11059415
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL8837588A IL88375A (he) | 1988-01-26 | 1988-11-14 | נוגדנים מונוקלונליים הקושרים ספציפית אינטרפרון- ביא 2 טבעי ורקומביננטי ושיטה לטיהור אינטרפרון-ביטא 2 טבעי ורקומביננטי ושיטה לטיהור אינ |
Country Status (2)
Country | Link |
---|---|
US (1) | US5618700A (he) |
IL (1) | IL88375A (he) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW458985B (en) * | 1993-05-31 | 2001-10-11 | Chugai Pharmaceutical Co Ltd | Reconstructed human antibody against human interleukin-6 |
EP2308888B1 (en) * | 2001-11-14 | 2017-03-01 | Janssen Biotech, Inc. | Anti-IL-6 antibodies, compositions, methods and uses |
US20050100550A1 (en) * | 2003-11-10 | 2005-05-12 | Mohit Trikha | Anti-angiogenic uses of IL-6 antagonists |
PE20061324A1 (es) | 2005-04-29 | 2007-01-15 | Centocor Inc | Anticuerpos anti-il-6, composiciones, metodos y usos |
KR101422523B1 (ko) * | 2005-12-09 | 2014-07-24 | 유씨비 파마, 에스.에이. | 사람 il6에 특이성을 지니는 항체 분자 |
US7919095B2 (en) * | 2006-08-03 | 2011-04-05 | Vaccinex, Inc. | Anti-IL-6 monoclonal antibodies |
US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
TWI609965B (zh) * | 2007-05-21 | 2018-01-01 | 艾爾德生物控股有限責任公司 | 新穎兔抗體人化方法以及經人化之兔抗體 |
US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
US8404235B2 (en) | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
NZ597767A (en) | 2007-05-21 | 2013-06-28 | Bristol Myers Squibb Co | Antibodies to IL-6 and use thereof |
US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
US7906117B2 (en) * | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
US20090238825A1 (en) * | 2007-05-21 | 2009-09-24 | Kovacevich Brian R | Novel rabbit antibody humanization methods and humanized rabbit antibodies |
US8252286B2 (en) | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
JP2011520898A (ja) * | 2008-05-13 | 2011-07-21 | ノビミューン エスアー | 抗il−6/il−6r抗体およびそれらの使用方法 |
US8188235B2 (en) * | 2008-06-18 | 2012-05-29 | Pfizer Inc. | Antibodies to IL-6 and their uses |
BRPI0921665A2 (pt) * | 2008-11-13 | 2019-04-16 | Femta Pharmaceuticals, Inc. | humanizado anti-il-6 anticorpos |
US8337847B2 (en) | 2008-11-25 | 2012-12-25 | Alderbio Holdings Llc | Methods of treating anemia using anti-IL-6 antibodies |
US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
US9452227B2 (en) | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
US8420089B2 (en) | 2008-11-25 | 2013-04-16 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
US8323649B2 (en) * | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
CN102740888B (zh) | 2009-11-24 | 2016-10-12 | 奥尔德生物制药公司 | Il-6抗体及其用途 |
US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
ES2847891T3 (es) | 2010-11-23 | 2021-08-04 | Vitaeris Inc | Anticuerpos anti-IL-6 para el tratamiento de la mucositis oral |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL58765A (en) * | 1979-11-21 | 1986-09-30 | Yeda Res & Dev | Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta |
JPS59172496A (ja) * | 1983-03-18 | 1984-09-29 | Kyowa Hakko Kogyo Co Ltd | モノクロ−ナル抗体 |
JP2598666B2 (ja) * | 1987-10-19 | 1997-04-09 | 忠三 岸本 | 抗ヒトbcdfモノクローナル抗体 |
-
1988
- 1988-11-14 IL IL8837588A patent/IL88375A/he not_active IP Right Cessation
-
1989
- 1989-11-14 US US07/436,321 patent/US5618700A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5618700A (en) | 1997-04-08 |
IL88375A0 (en) | 1989-06-30 |
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