IL87150A - 8,9-anellated-1,2,3,4 - tetrahydro-'-carboline derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

8,9-anellated-1,2,3,4 - tetrahydro-'-carboline derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL87150A
IL87150A IL87150A IL8715088A IL87150A IL 87150 A IL87150 A IL 87150A IL 87150 A IL87150 A IL 87150A IL 8715088 A IL8715088 A IL 8715088A IL 87150 A IL87150 A IL 87150A
Authority
IL
Israel
Prior art keywords
atoms
group
groups
alkyl
substituted
Prior art date
Application number
IL87150A
Other languages
English (en)
Other versions
IL87150A0 (en
Original Assignee
Duphar Int Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar Int Res filed Critical Duphar Int Res
Publication of IL87150A0 publication Critical patent/IL87150A0/xx
Publication of IL87150A publication Critical patent/IL87150A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
IL87150A 1987-07-20 1988-07-18 8,9-anellated-1,2,3,4 - tetrahydro-'-carboline derivatives, their preparation and pharmaceutical compositions containing them IL87150A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8701709 1987-07-20

Publications (2)

Publication Number Publication Date
IL87150A0 IL87150A0 (en) 1988-12-30
IL87150A true IL87150A (en) 1992-12-01

Family

ID=19850345

Family Applications (1)

Application Number Title Priority Date Filing Date
IL87150A IL87150A (en) 1987-07-20 1988-07-18 8,9-anellated-1,2,3,4 - tetrahydro-'-carboline derivatives, their preparation and pharmaceutical compositions containing them

Country Status (11)

Country Link
US (1) US5100884A (de)
EP (1) EP0300541B1 (de)
JP (1) JPS6434984A (de)
AT (1) ATE136032T1 (de)
AU (1) AU613059B2 (de)
CA (1) CA1338189C (de)
DE (1) DE3855147D1 (de)
DK (1) DK395888A (de)
IL (1) IL87150A (de)
NZ (1) NZ225421A (de)
ZA (1) ZA885146B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0347980A1 (de) * 1988-06-20 1989-12-27 Duphar International Research B.V 8,9-Anellierte B-Carboline und 8,9-anellierte 3,4-dihydro-B-Carboline
EP0357122A3 (de) * 1988-08-29 1991-10-23 Duphar International Research B.V Verwendung von Beta-Carbolinen und deren bio-isosterischen Benzofuran- und Benzothiophenanalogen zur Herstellung eines Arzneimittels mit cytostatischer Wirkung
EP0377238A1 (de) * 1988-12-22 1990-07-11 Duphar International Research B.V Annelierte Indolo(3,2-c)-lactame
EP0380155A1 (de) * 1989-01-19 1990-08-01 Duphar International Research B.V 8,9-Annelierte-1,2,3,4-tetrahydro-beta-carboline-Derivate
FR2663935A1 (fr) * 1990-06-27 1992-01-03 Adir Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
CA2195697A1 (en) * 1996-02-02 1997-08-03 Masahumi Kitano Novel substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof
US6713471B1 (en) 1999-06-15 2004-03-30 Bristol-Myers Squibb Pharma Company Substituted heterocycle fused gamma-carbolines
US7071186B2 (en) 1999-06-15 2006-07-04 Bristol-Myers Squibb Pharma Co. Substituted heterocycle fused gamma-carbolines
IL145998A0 (en) * 1999-06-15 2002-07-25 Du Pont Pharm Co Substituted heterocycle fused gamma-carbolines
AU774397B2 (en) * 1999-06-30 2004-06-24 Mochida Pharmaceutical Co., Ltd. Tricyclic compounds having spiro union
US6858599B2 (en) 1999-06-30 2005-02-22 Mochida Pharmaceutical Co., Ltd. Tricyclic compound having spiro union
UA74826C2 (en) 2000-05-17 2006-02-15 Ortho Mcneil Pharm Inc ?-carboline derivatives as phosphodiesterase inhibitors
US6849619B2 (en) * 2000-12-20 2005-02-01 Bristol-Myers Squibb Company Substituted pyridoindoles as serotonin agonists and antagonists
EP1343791A2 (de) 2000-12-20 2003-09-17 Bristol-Myers Squibb Company Substituierte tetrazyklische pyridoindole als serotonin agonisten und antagonisten
EP1706404A2 (de) 2004-01-23 2006-10-04 Chiron Corporation Tetrahydrocarbolinverbindungen als antikrebsmittel
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
EP1737461B1 (de) 2004-03-15 2012-12-12 PTC Therapeutics, Inc. Carbolin-derivate zur hemmung der angiogenese
US8563567B2 (en) 2009-12-30 2013-10-22 Arqule, Inc. Substituted heterocyclic compounds
DE102019128072B4 (de) 2019-10-17 2021-11-18 Infineon Technologies Ag Transistorbauelement mit einem variierenden flächenbezogenen spezifischen gaterunnerwiderstand

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3299078A (en) * 1962-10-01 1967-01-17 Smith Kline French Lab Pyrido [3', 4': 4, 5] pyrrolo [3, 2, 1-hi] indoles and-[3, 2, 1-ij] quinolines
EP0017727A1 (de) * 1979-04-10 1980-10-29 Ciba-Geigy Ag Polysubstituierte Diazatricyclen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
EP0185429A1 (de) * 1984-12-21 1986-06-25 Duphar International Research B.V Bizyklische Piperazine
DK686688A (da) * 1987-12-14 1989-06-15 Duphar Int Res 8,9-annelerede beta-carboliner, deres fremstilling og laegemidler indeholdende forbindelserne
EP0357122A3 (de) * 1988-08-29 1991-10-23 Duphar International Research B.V Verwendung von Beta-Carbolinen und deren bio-isosterischen Benzofuran- und Benzothiophenanalogen zur Herstellung eines Arzneimittels mit cytostatischer Wirkung

Also Published As

Publication number Publication date
NZ225421A (en) 1991-03-26
IL87150A0 (en) 1988-12-30
JPS6434984A (en) 1989-02-06
AU613059B2 (en) 1991-07-25
EP0300541A1 (de) 1989-01-25
DK395888A (da) 1989-01-21
DE3855147D1 (de) 1996-05-02
CA1338189C (en) 1996-03-26
AU1915288A (en) 1989-01-27
ATE136032T1 (de) 1996-04-15
US5100884A (en) 1992-03-31
DK395888D0 (da) 1988-07-15
ZA885146B (en) 1989-03-29
EP0300541B1 (de) 1996-03-27

Similar Documents

Publication Publication Date Title
IL87150A (en) 8,9-anellated-1,2,3,4 - tetrahydro-'-carboline derivatives, their preparation and pharmaceutical compositions containing them
DE2966954D1 (en) Alkyl derivatives of c-076 compounds, their preparation and their use as antiparasitic agents
KR890001553A (ko) 약학적 조성물
DE2966344D1 (en) Xanthone and thioxanthone derivatives, their preparation and pharmaceutical compositions containing them
ES2051814T3 (es) Proceso de preparacion de compuestos para la induccion de la produccion de citocinas in vivo e in vitro.
IL95321A0 (en) 2-oxo-1-oxa-8-azaspiro(4,5)decane derivatives,their preparation and pharmaceutical compositions containing them
PT88991A (pt) Processo para a preparacao de analogos de avermectinas e milbemicinas
PT91607A (pt) Process for the preparation of substituted beta-diketones and of pharmaceutical compositions containing them
ES8703409A1 (es) Un metodo para preparar un derivado de urea sustituido con aminoalquilo
KR910000725A (ko) 아졸 유도체와 그의 약제학적으로 허용가능한 염
ATE269329T1 (de) Neue basische derivate von benz(e)isoindol-1-onen und pyrrolo(3,4-c)chinolin-1-onen mit 5-ht3- antagonistischer aktivität, ihre herstellung und ihre therapeutische verwendung
AU4024989A (en) Sulphonamidocycloalkane compounds, processes for the preparation thereof and pharmaceutical compositions containing them
ES476241A1 (es) Procedimiento para la preparacion de derivados de tetraciclonomano.
YU158385A (en) Process for obtaining derivatives of 2-pyridine thioles
IL85253A0 (en) Ergoline derivatives,their preparation and pharmaceutical compositions containing them
ES473775A1 (es) Perfeccionamientos en o relacionados con compuestos organi- cos
ES8105319A1 (es) Procedimiento de preparacion de derivados pirazolo (1,5-c) quinazolinos y de sus sales de adicion acidas
HUT60261A (en) Process for producing piperazine derivatives and pharmaceutical compositions comprising same
ES8307498A1 (es) "procedimiento para la obtencion de un agente antihelmintico".
GR3023066T3 (en) Organosilane derivatives, pharmaceutical compositions containing them and process for preparing same
NZ218034A (en) Benzopyrando(2,3-c)pyrrole derivatives, intermediates and pharmaceutical compositions
IE800588L (en) Piperidinothiazolidines
JPS5610191A (en) Clavulanic acid derivative* its manufacture and composition
MY101771A (en) Antiparasitic agents and process for their preparation.

Legal Events

Date Code Title Description
RH Patent void