IL87150A - 8,9-anellated-1,2,3,4 - tetrahydro-'-carboline derivatives, their preparation and pharmaceutical compositions containing them - Google Patents
8,9-anellated-1,2,3,4 - tetrahydro-'-carboline derivatives, their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL87150A IL87150A IL87150A IL8715088A IL87150A IL 87150 A IL87150 A IL 87150A IL 87150 A IL87150 A IL 87150A IL 8715088 A IL8715088 A IL 8715088A IL 87150 A IL87150 A IL 87150A
- Authority
- IL
- Israel
- Prior art keywords
- atoms
- group
- groups
- alkyl
- substituted
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 59
- 125000000217 alkyl group Chemical group 0.000 abstract 29
- 125000003545 alkoxy group Chemical group 0.000 abstract 18
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 9
- 125000001153 fluoro group Chemical group F* 0.000 abstract 8
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 6
- 125000006413 ring segment Chemical group 0.000 abstract 6
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000004414 alkyl thio group Chemical group 0.000 abstract 4
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 4
- 125000005842 heteroatom Chemical group 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- RAHZWNYVWXNFOC-UHFFFAOYSA-N sulfur dioxide Inorganic materials O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 3
- 125000002837 carbocyclic group Chemical group 0.000 abstract 2
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 2
- 125000005366 cycloalkylthio group Chemical group 0.000 abstract 2
- 230000003480 fibrinolytic effect Effects 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical group O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 229910019950 S—O Inorganic materials 0.000 abstract 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
- 125000005079 alkoxycarbonylmethyl group Chemical group 0.000 abstract 1
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8701709 | 1987-07-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL87150A0 IL87150A0 (en) | 1988-12-30 |
| IL87150A true IL87150A (en) | 1992-12-01 |
Family
ID=19850345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL87150A IL87150A (en) | 1987-07-20 | 1988-07-18 | 8,9-anellated-1,2,3,4 - tetrahydro-'-carboline derivatives, their preparation and pharmaceutical compositions containing them |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5100884A (de) |
| EP (1) | EP0300541B1 (de) |
| JP (1) | JPS6434984A (de) |
| AT (1) | ATE136032T1 (de) |
| AU (1) | AU613059B2 (de) |
| CA (1) | CA1338189C (de) |
| DE (1) | DE3855147D1 (de) |
| DK (1) | DK395888A (de) |
| IL (1) | IL87150A (de) |
| NZ (1) | NZ225421A (de) |
| ZA (1) | ZA885146B (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0347980A1 (de) * | 1988-06-20 | 1989-12-27 | Duphar International Research B.V | 8,9-Anellierte B-Carboline und 8,9-anellierte 3,4-dihydro-B-Carboline |
| EP0357122A3 (de) * | 1988-08-29 | 1991-10-23 | Duphar International Research B.V | Verwendung von Beta-Carbolinen und deren bio-isosterischen Benzofuran- und Benzothiophenanalogen zur Herstellung eines Arzneimittels mit cytostatischer Wirkung |
| EP0377238A1 (de) * | 1988-12-22 | 1990-07-11 | Duphar International Research B.V | Annelierte Indolo(3,2-c)-lactame |
| EP0380155A1 (de) * | 1989-01-19 | 1990-08-01 | Duphar International Research B.V | 8,9-Annelierte-1,2,3,4-tetrahydro-beta-carboline-Derivate |
| FR2663935A1 (fr) * | 1990-06-27 | 1992-01-03 | Adir | Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| NZ314105A (en) * | 1996-02-02 | 1997-12-19 | Sumitomo Pharma | Guanidine derivative substituted with a substituted indole which is peri condensed with a heterocyclic ring |
| MXPA01012969A (es) * | 1999-06-15 | 2003-10-14 | Bristol Myers Squibb Pharma Co | Gamma-carbolinas fusionadas de heterociclo sustituido. |
| US7071186B2 (en) | 1999-06-15 | 2006-07-04 | Bristol-Myers Squibb Pharma Co. | Substituted heterocycle fused gamma-carbolines |
| US6713471B1 (en) | 1999-06-15 | 2004-03-30 | Bristol-Myers Squibb Pharma Company | Substituted heterocycle fused gamma-carbolines |
| HK1049157A1 (zh) * | 1999-06-30 | 2003-05-02 | 持田制药株式会社 | 具有螺接的三环化合物 |
| US6858599B2 (en) | 1999-06-30 | 2005-02-22 | Mochida Pharmaceutical Co., Ltd. | Tricyclic compound having spiro union |
| UA74826C2 (en) | 2000-05-17 | 2006-02-15 | Ortho Mcneil Pharm Inc | ?-carboline derivatives as phosphodiesterase inhibitors |
| US6849619B2 (en) * | 2000-12-20 | 2005-02-01 | Bristol-Myers Squibb Company | Substituted pyridoindoles as serotonin agonists and antagonists |
| PL366233A1 (en) | 2000-12-20 | 2005-01-24 | Bristol-Myers Squibb Company | Substituted pyridoindoles as serotonin agonists and antagonists |
| CN1910183A (zh) | 2004-01-23 | 2007-02-07 | 希龙公司 | 四氢咔啉化合物作为抗癌药 |
| US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
| US7767689B2 (en) | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
| MXPA06010543A (es) | 2004-03-15 | 2007-03-26 | Ptc Therapeutics Inc | Derivados de carbolina utiles en la inhibicion de la angiogenesis. |
| US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
| WO2011082266A2 (en) | 2009-12-30 | 2011-07-07 | Arqule, Inc. | Substituted heterocyclic compounds |
| DE102019128072B4 (de) | 2019-10-17 | 2021-11-18 | Infineon Technologies Ag | Transistorbauelement mit einem variierenden flächenbezogenen spezifischen gaterunnerwiderstand |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3299078A (en) * | 1962-10-01 | 1967-01-17 | Smith Kline French Lab | Pyrido [3', 4': 4, 5] pyrrolo [3, 2, 1-hi] indoles and-[3, 2, 1-ij] quinolines |
| DK72180A (da) * | 1979-04-10 | 1980-10-11 | Ciba Geigy Ag | Fremgangsmaade til fremstilling af diazatricycler samt salte deraf |
| EP0185429A1 (de) * | 1984-12-21 | 1986-06-25 | Duphar International Research B.V | Bizyklische Piperazine |
| DK686688A (da) * | 1987-12-14 | 1989-06-15 | Duphar Int Res | 8,9-annelerede beta-carboliner, deres fremstilling og laegemidler indeholdende forbindelserne |
| EP0357122A3 (de) * | 1988-08-29 | 1991-10-23 | Duphar International Research B.V | Verwendung von Beta-Carbolinen und deren bio-isosterischen Benzofuran- und Benzothiophenanalogen zur Herstellung eines Arzneimittels mit cytostatischer Wirkung |
-
1988
- 1988-07-07 EP EP88201418A patent/EP0300541B1/de not_active Expired - Lifetime
- 1988-07-07 AT AT88201418T patent/ATE136032T1/de not_active IP Right Cessation
- 1988-07-07 DE DE3855147T patent/DE3855147D1/de not_active Expired - Lifetime
- 1988-07-15 CA CA000572113A patent/CA1338189C/en not_active Expired - Fee Related
- 1988-07-15 ZA ZA885146A patent/ZA885146B/xx unknown
- 1988-07-15 NZ NZ225421A patent/NZ225421A/en unknown
- 1988-07-15 DK DK395888A patent/DK395888A/da not_active Application Discontinuation
- 1988-07-18 IL IL87150A patent/IL87150A/xx not_active IP Right Cessation
- 1988-07-18 AU AU19152/88A patent/AU613059B2/en not_active Ceased
- 1988-07-18 JP JP63177252A patent/JPS6434984A/ja active Pending
-
1989
- 1989-10-30 US US07/428,481 patent/US5100884A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0300541A1 (de) | 1989-01-25 |
| IL87150A0 (en) | 1988-12-30 |
| CA1338189C (en) | 1996-03-26 |
| DK395888A (da) | 1989-01-21 |
| ATE136032T1 (de) | 1996-04-15 |
| US5100884A (en) | 1992-03-31 |
| AU1915288A (en) | 1989-01-27 |
| EP0300541B1 (de) | 1996-03-27 |
| JPS6434984A (en) | 1989-02-06 |
| DE3855147D1 (de) | 1996-05-02 |
| NZ225421A (en) | 1991-03-26 |
| ZA885146B (en) | 1989-03-29 |
| AU613059B2 (en) | 1991-07-25 |
| DK395888D0 (da) | 1988-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RH | Patent void |