DK395888A - 8,9-anelleret-1,2,3,4-tetrahydro-beta-carbolinderivater og deres salte og prolaegemidler, og farmaceutiske kompositioner indeholdende forbindelserne - Google Patents

8,9-anelleret-1,2,3,4-tetrahydro-beta-carbolinderivater og deres salte og prolaegemidler, og farmaceutiske kompositioner indeholdende forbindelserne

Info

Publication number
DK395888A
DK395888A DK395888A DK395888A DK395888A DK 395888 A DK395888 A DK 395888A DK 395888 A DK395888 A DK 395888A DK 395888 A DK395888 A DK 395888A DK 395888 A DK395888 A DK 395888A
Authority
DK
Denmark
Prior art keywords
atoms
group
groups
alkyl
substituted
Prior art date
Application number
DK395888A
Other languages
English (en)
Other versions
DK395888D0 (da
Inventor
Derk Hamminga
Ineke Van Wijngaarden
Johannes Wilhelmus Cath Jansen
Original Assignee
Duphar Int Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar Int Res filed Critical Duphar Int Res
Publication of DK395888D0 publication Critical patent/DK395888D0/da
Publication of DK395888A publication Critical patent/DK395888A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK395888A 1987-07-20 1988-07-15 8,9-anelleret-1,2,3,4-tetrahydro-beta-carbolinderivater og deres salte og prolaegemidler, og farmaceutiske kompositioner indeholdende forbindelserne DK395888A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8701709 1987-07-20

Publications (2)

Publication Number Publication Date
DK395888D0 DK395888D0 (da) 1988-07-15
DK395888A true DK395888A (da) 1989-01-21

Family

ID=19850345

Family Applications (1)

Application Number Title Priority Date Filing Date
DK395888A DK395888A (da) 1987-07-20 1988-07-15 8,9-anelleret-1,2,3,4-tetrahydro-beta-carbolinderivater og deres salte og prolaegemidler, og farmaceutiske kompositioner indeholdende forbindelserne

Country Status (11)

Country Link
US (1) US5100884A (da)
EP (1) EP0300541B1 (da)
JP (1) JPS6434984A (da)
AT (1) ATE136032T1 (da)
AU (1) AU613059B2 (da)
CA (1) CA1338189C (da)
DE (1) DE3855147D1 (da)
DK (1) DK395888A (da)
IL (1) IL87150A (da)
NZ (1) NZ225421A (da)
ZA (1) ZA885146B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0347980A1 (en) * 1988-06-20 1989-12-27 Duphar International Research B.V 8,9-Annelated beta-carbolines and 8,9-anelated-3,4-dihydro-beta-carbolines
EP0357122A3 (en) * 1988-08-29 1991-10-23 Duphar International Research B.V Use of beta-carbolines, their bio-isosteric benzofuran and benzothiophene analogues for the manufacture of a medicament having cytostatic properties
EP0377238A1 (en) * 1988-12-22 1990-07-11 Duphar International Research B.V New annelated indolo (3,2-c)-lactams
EP0380155A1 (en) * 1989-01-19 1990-08-01 Duphar International Research B.V 8,9-Annelated-1,2,3,4-tetrahydro-beta-carboline derivatives
FR2663935A1 (fr) * 1990-06-27 1992-01-03 Adir Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
CA2195697A1 (en) * 1996-02-02 1997-08-03 Masahumi Kitano Novel substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof
US6713471B1 (en) 1999-06-15 2004-03-30 Bristol-Myers Squibb Pharma Company Substituted heterocycle fused gamma-carbolines
MXPA01012969A (es) 1999-06-15 2003-10-14 Bristol Myers Squibb Pharma Co Gamma-carbolinas fusionadas de heterociclo sustituido.
US7071186B2 (en) 1999-06-15 2006-07-04 Bristol-Myers Squibb Pharma Co. Substituted heterocycle fused gamma-carbolines
DE60015541T2 (de) * 1999-06-30 2005-12-08 Mochida Pharmaceutical Co. Ltd. Trizyklische verbindungen mit einer spiro-einheit
US6858599B2 (en) 1999-06-30 2005-02-22 Mochida Pharmaceutical Co., Ltd. Tricyclic compound having spiro union
UA74826C2 (en) 2000-05-17 2006-02-15 Ortho Mcneil Pharm Inc ?-carboline derivatives as phosphodiesterase inhibitors
US6699852B2 (en) 2000-12-20 2004-03-02 Bristol-Myers Squibb Pharma Company Substituted pyridoindoles as serotonin agonists and antagonists
US6849619B2 (en) * 2000-12-20 2005-02-01 Bristol-Myers Squibb Company Substituted pyridoindoles as serotonin agonists and antagonists
CN1910183A (zh) 2004-01-23 2007-02-07 希龙公司 四氢咔啉化合物作为抗癌药
UA92317C2 (ru) 2004-03-15 2010-10-25 Пи-Ти-Си ТЕРАПЬЮТИКС, ИНК. Производные карболина, пригодные для ингибирования развития кровеносных сосудов
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US8563567B2 (en) 2009-12-30 2013-10-22 Arqule, Inc. Substituted heterocyclic compounds
DE102019128072B4 (de) 2019-10-17 2021-11-18 Infineon Technologies Ag Transistorbauelement mit einem variierenden flächenbezogenen spezifischen gaterunnerwiderstand

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3299078A (en) * 1962-10-01 1967-01-17 Smith Kline French Lab Pyrido [3', 4': 4, 5] pyrrolo [3, 2, 1-hi] indoles and-[3, 2, 1-ij] quinolines
EP0017727A1 (de) * 1979-04-10 1980-10-29 Ciba-Geigy Ag Polysubstituierte Diazatricyclen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
ATE44528T1 (de) * 1984-12-21 1989-07-15 Duphar Int Res Arzneimittel mit antipsychotischer wirkung.
ZA889251B (en) * 1987-12-14 1989-08-30 Duphar Int Res 8,9-annelated-beta-carbolines and 8,9-annelated-3,4-dihydro-beta-carbolines
EP0357122A3 (en) * 1988-08-29 1991-10-23 Duphar International Research B.V Use of beta-carbolines, their bio-isosteric benzofuran and benzothiophene analogues for the manufacture of a medicament having cytostatic properties

Also Published As

Publication number Publication date
NZ225421A (en) 1991-03-26
EP0300541A1 (en) 1989-01-25
ATE136032T1 (de) 1996-04-15
EP0300541B1 (en) 1996-03-27
CA1338189C (en) 1996-03-26
IL87150A0 (en) 1988-12-30
AU1915288A (en) 1989-01-27
IL87150A (en) 1992-12-01
DK395888D0 (da) 1988-07-15
JPS6434984A (en) 1989-02-06
AU613059B2 (en) 1991-07-25
ZA885146B (en) 1989-03-29
DE3855147D1 (de) 1996-05-02
US5100884A (en) 1992-03-31

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