IL86299A - Manganese (ii) chelates of n, n) -dipyridoxyldiamine- n-acetic (or n,n)-diacetic)- acid derivatives and their use as nmri contrast agents - Google Patents

Manganese (ii) chelates of n, n) -dipyridoxyldiamine- n-acetic (or n,n)-diacetic)- acid derivatives and their use as nmri contrast agents

Info

Publication number
IL86299A
IL86299A IL86299A IL8629988A IL86299A IL 86299 A IL86299 A IL 86299A IL 86299 A IL86299 A IL 86299A IL 8629988 A IL8629988 A IL 8629988A IL 86299 A IL86299 A IL 86299A
Authority
IL
Israel
Prior art keywords
dipyridoxyldiamine
diacetic
chelates
manganese
acetic
Prior art date
Application number
IL86299A
Other languages
English (en)
Other versions
IL86299A0 (en
Original Assignee
Salutar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salutar Inc filed Critical Salutar Inc
Publication of IL86299A0 publication Critical patent/IL86299A0/xx
Publication of IL86299A publication Critical patent/IL86299A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL86299A 1987-05-08 1988-05-06 Manganese (ii) chelates of n, n) -dipyridoxyldiamine- n-acetic (or n,n)-diacetic)- acid derivatives and their use as nmri contrast agents IL86299A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/047,584 US4935518A (en) 1987-05-08 1987-05-08 Manganese(II), chelate contrast agents derived from N,N'-bis-(pyridoxal ethylene diamine-N,N')-diacetic acid and derivatives thereof

Publications (2)

Publication Number Publication Date
IL86299A0 IL86299A0 (en) 1988-11-15
IL86299A true IL86299A (en) 1993-01-14

Family

ID=21949817

Family Applications (1)

Application Number Title Priority Date Filing Date
IL86299A IL86299A (en) 1987-05-08 1988-05-06 Manganese (ii) chelates of n, n) -dipyridoxyldiamine- n-acetic (or n,n)-diacetic)- acid derivatives and their use as nmri contrast agents

Country Status (14)

Country Link
US (1) US4935518A (no)
EP (1) EP0292761B1 (no)
JP (1) JP2773870B2 (no)
AR (1) AR244208A1 (no)
AT (1) ATE101158T1 (no)
CA (1) CA1312867C (no)
DE (1) DE3887566T2 (no)
DK (1) DK251588A (no)
ES (1) ES2061546T3 (no)
FI (1) FI88032C (no)
IE (1) IE63425B1 (no)
IL (1) IL86299A (no)
NO (1) NO174710C (no)
NZ (1) NZ224531A (no)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250285A (en) * 1985-05-08 1993-10-05 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US5422096A (en) * 1985-05-08 1995-06-06 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
AR246956A1 (es) 1987-05-08 1994-10-31 Salutar Inc Compuesto quelante, un intermediario para preparar el mismo, y un procedimiento para preparar una composicion de medio de contraste.
US5130437A (en) * 1987-05-08 1992-07-14 Salutar, Inc. N,N'-bis-(pyridoxal)ethylenediamine-N,N'-diacetic acid derivatives
ES2033433T3 (es) * 1987-07-16 1993-03-16 Nycomed As Procedimiento para preparar acidos aminopolicarboxilicos y sus derivados.
US5531978A (en) * 1987-07-16 1996-07-02 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
US4889931A (en) * 1988-09-27 1989-12-26 Salutar, Inc. Manganese (II) chelate manufacture
US5155224A (en) * 1988-09-27 1992-10-13 Salutar, Inc. Manganese (II) chelates
EP0498380A1 (de) * 1991-02-08 1992-08-12 Byk Gulden Lomberg Chemische Fabrik Gmbh Komplexbildner
DE4107570A1 (de) * 1991-03-07 1992-11-19 Diagnostikforschung Inst Chelate, deren metallkomplexe sowie ihre verwendung in diagnostik und therapie
US5463030A (en) * 1991-05-03 1995-10-31 Research Foundation Of The State Of New York Metal chelating agents for medical application
WO1992021017A1 (en) * 1991-05-23 1992-11-26 Unger Evan C Liposoluble compounds for magnetic resonance imaging
US5385719A (en) * 1991-09-24 1995-01-31 Unger; Evan C. Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications
EP0648209A1 (de) * 1992-07-01 1995-04-19 Byk Gulden Lomberg Chemische Fabrik GmbH Kontrastmittel für die mr diagnostik
US5364953A (en) * 1992-11-05 1994-11-15 Mallinckrodt Medical, Inc. High relaxivity, paramagnetic, metal clusters for magnetic resonance imaging
US5330743A (en) * 1992-11-12 1994-07-19 Magnetic Research, Inc. Aminosaccharide contrast agents for magnetic resonance images
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
TW319763B (no) 1995-02-01 1997-11-11 Epix Medical Inc
GB9613182D0 (en) * 1996-06-24 1996-08-28 Nycomed Imaging As Method
GB9727224D0 (en) * 1997-12-23 1998-02-25 Nycomed Imaging As Method
ATE277038T1 (de) * 1997-12-23 2004-10-15 Amersham Health As Stickstoffoxid freisetzende chelatbildner und ihre therapeutische verwendung
GB2333704A (en) * 1998-01-31 1999-08-04 Procter & Gamble Contrasting compositions for magnetic resonance imaging comprising a complex of ethylene diamine disuccinic acid and one or more paramagnetic metal ions
WO2010133907A1 (en) * 2009-05-18 2010-11-25 Carlo Ghisalberti Hexadentate chelators in inflammatory bowel disease
US20150313921A1 (en) * 2012-11-02 2015-11-05 Pledpharma Ab Cancer Treatment Methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322361A (en) * 1980-03-03 1982-03-30 The Dow Chemical Company Method of preparing a manganese chelate having improved properties
GB8413849D0 (en) * 1984-05-31 1984-07-04 Amersham Int Plc Nmr contrast agents

Also Published As

Publication number Publication date
JPS63287791A (ja) 1988-11-24
US4935518A (en) 1990-06-19
DK251588A (da) 1988-11-09
FI88032C (fi) 1993-03-25
DE3887566D1 (de) 1994-03-17
ATE101158T1 (de) 1994-02-15
NO174710C (no) 1994-06-22
FI882126A (fi) 1988-11-09
AU1568188A (en) 1989-11-09
FI88032B (fi) 1992-12-15
EP0292761B1 (en) 1994-02-02
EP0292761A3 (en) 1991-01-30
NZ224531A (en) 1993-05-26
IE881367L (en) 1988-11-08
NO882003D0 (no) 1988-05-06
NO882003L (no) 1988-11-09
AU612647B2 (en) 1991-07-18
CA1312867C (en) 1993-01-19
JP2773870B2 (ja) 1998-07-09
AR244208A1 (es) 1993-10-29
FI882126A0 (fi) 1988-05-06
DE3887566T2 (de) 1994-05-11
ES2061546T3 (es) 1994-12-16
IL86299A0 (en) 1988-11-15
EP0292761A2 (en) 1988-11-30
DK251588D0 (da) 1988-05-06
IE63425B1 (en) 1995-04-19
NO174710B (no) 1994-03-14

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