IL85724A - Immunogenic polypeptides containing an amino acid sequence derived from plasmodium falciparum p190 merozoite antigen, their preparation and their use - Google Patents
Immunogenic polypeptides containing an amino acid sequence derived from plasmodium falciparum p190 merozoite antigen, their preparation and their useInfo
- Publication number
- IL85724A IL85724A IL8572488A IL8572488A IL85724A IL 85724 A IL85724 A IL 85724A IL 8572488 A IL8572488 A IL 8572488A IL 8572488 A IL8572488 A IL 8572488A IL 85724 A IL85724 A IL 85724A
- Authority
- IL
- Israel
- Prior art keywords
- polypeptide
- dna
- aaa
- gaa
- polypeptides
- Prior art date
Links
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- 239000000312 peanut oil Substances 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
- 238000002135 phase contrast microscopy Methods 0.000 description 1
- 150000004713 phosphodiesters Chemical class 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000447 polyanionic polymer Polymers 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000008057 potassium phosphate buffer Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 239000012146 running buffer Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000012134 supernatant fraction Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000037369 susceptibility to malaria Diseases 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229960000814 tetanus toxoid Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- IESDGNYHXIOKRW-LEOABGAYSA-N tuftsin Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](CCCNC(N)=N)C(O)=O IESDGNYHXIOKRW-LEOABGAYSA-N 0.000 description 1
- 229940035670 tuftsin Drugs 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- NLIVDORGVGAOOJ-MAHBNPEESA-M xylene cyanol Chemical compound [Na+].C1=C(C)C(NCC)=CC=C1C(\C=1C(=CC(OS([O-])=O)=CC=1)OS([O-])=O)=C\1C=C(C)\C(=[NH+]/CC)\C=C/1 NLIVDORGVGAOOJ-MAHBNPEESA-M 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878706599A GB8706599D0 (en) | 1987-03-19 | 1987-03-19 | Plasmodium falciparum merozoite antigen peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL85724A0 IL85724A0 (en) | 1988-08-31 |
| IL85724A true IL85724A (en) | 1994-11-28 |
Family
ID=10614280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL8572488A IL85724A (en) | 1987-03-19 | 1988-03-14 | Immunogenic polypeptides containing an amino acid sequence derived from plasmodium falciparum p190 merozoite antigen, their preparation and their use |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5238836A (hu) |
| EP (1) | EP0283829B1 (hu) |
| JP (1) | JP2567024B2 (hu) |
| AT (1) | ATE92526T1 (hu) |
| AU (1) | AU613344B2 (hu) |
| DE (1) | DE3882755D1 (hu) |
| DK (1) | DK84388A (hu) |
| ES (1) | ES2058156T3 (hu) |
| GB (1) | GB8706599D0 (hu) |
| HU (1) | HU211581A9 (hu) |
| IE (1) | IE62252B1 (hu) |
| IL (1) | IL85724A (hu) |
| MY (1) | MY103217A (hu) |
| NZ (1) | NZ223860A (hu) |
| PH (1) | PH25320A (hu) |
| PT (1) | PT87022B (hu) |
| ZA (1) | ZA881775B (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0309746A1 (de) * | 1987-09-08 | 1989-04-05 | F. Hoffmann-La Roche Ag | Antimalaria-Vakzine |
| US5225534A (en) * | 1987-09-08 | 1993-07-06 | Hoffmann-La Roche Inc. | Recombinant malarial polypeptides |
| GB9002512D0 (en) * | 1990-02-05 | 1990-04-04 | 3I Res Expl Ltd | Polypeptides and dna encoding same |
| AUPO517897A0 (en) * | 1997-02-19 | 1997-04-11 | Csl Limited | Chelating immunostimulating complexes |
| ZA981370B (en) * | 1997-02-20 | 1998-09-07 | Cerberus Developments Bv | Method and apparatus for continuous flow isoelectric focusing for purifying biological substances |
| EP1754717A1 (en) * | 2005-08-19 | 2007-02-21 | Université de Lausanne | Antigenic peptides and their use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0154454B1 (en) * | 1984-02-22 | 1991-07-03 | The Wellcome Foundation Limited | Cloning of dna for protozoal antigens |
| US4569794A (en) * | 1984-12-05 | 1986-02-11 | Eli Lilly And Company | Process for purifying proteins and compounds useful in such process |
| EP0254862A1 (en) * | 1986-06-26 | 1988-02-03 | BEHRINGWERKE Aktiengesellschaft | Vaccines against protozoan parasites |
| US4735799A (en) * | 1987-01-14 | 1988-04-05 | Patarroyo Manuel E | Malaria vaccine |
| CA1340522C (en) * | 1987-03-10 | 1999-05-04 | Heinz Dobeli | Fusion proteins containing neighbouring histidines for improved purification |
-
1987
- 1987-03-19 GB GB878706599A patent/GB8706599D0/en active Pending
-
1988
- 1988-02-18 DK DK084388A patent/DK84388A/da not_active Application Discontinuation
- 1988-02-25 MY MYPI88000191A patent/MY103217A/en unknown
- 1988-03-08 ES ES88103564T patent/ES2058156T3/es not_active Expired - Lifetime
- 1988-03-08 EP EP88103564A patent/EP0283829B1/de not_active Expired - Lifetime
- 1988-03-08 DE DE8888103564T patent/DE3882755D1/de not_active Expired - Fee Related
- 1988-03-08 AT AT88103564T patent/ATE92526T1/de not_active IP Right Cessation
- 1988-03-11 NZ NZ223860A patent/NZ223860A/en unknown
- 1988-03-11 ZA ZA881775A patent/ZA881775B/xx unknown
- 1988-03-14 US US07/167,811 patent/US5238836A/en not_active Expired - Fee Related
- 1988-03-14 AU AU13077/88A patent/AU613344B2/en not_active Ceased
- 1988-03-14 IL IL8572488A patent/IL85724A/en not_active IP Right Cessation
- 1988-03-16 PH PH36643A patent/PH25320A/en unknown
- 1988-03-18 PT PT87022A patent/PT87022B/pt not_active IP Right Cessation
- 1988-03-18 JP JP63063786A patent/JP2567024B2/ja not_active Expired - Lifetime
- 1988-03-18 IE IE80988A patent/IE62252B1/en not_active IP Right Cessation
-
1995
- 1995-06-20 HU HU95P/P00264P patent/HU211581A9/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK84388D0 (da) | 1988-02-18 |
| IE62252B1 (en) | 1995-01-11 |
| AU613344B2 (en) | 1991-08-01 |
| US5238836A (en) | 1993-08-24 |
| JP2567024B2 (ja) | 1996-12-25 |
| EP0283829B1 (de) | 1993-08-04 |
| GB8706599D0 (en) | 1987-04-23 |
| DK84388A (da) | 1988-09-20 |
| PT87022B (pt) | 1992-06-30 |
| MY103217A (en) | 1993-05-29 |
| AU1307788A (en) | 1988-09-22 |
| PT87022A (pt) | 1988-04-01 |
| DE3882755D1 (de) | 1993-09-09 |
| EP0283829A1 (de) | 1988-09-28 |
| IE880809L (en) | 1988-09-19 |
| ATE92526T1 (de) | 1993-08-15 |
| PH25320A (en) | 1991-04-30 |
| IL85724A0 (en) | 1988-08-31 |
| NZ223860A (en) | 1991-05-28 |
| ZA881775B (en) | 1988-09-19 |
| ES2058156T3 (es) | 1994-11-01 |
| HU211581A9 (en) | 1995-12-28 |
| JPS63275599A (ja) | 1988-11-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RH | Patent void |