ES2058156T3 - Peptidos del antigeno de merozoitos del plasmodium falciparum. - Google Patents

Peptidos del antigeno de merozoitos del plasmodium falciparum.

Info

Publication number
ES2058156T3
ES2058156T3 ES88103564T ES88103564T ES2058156T3 ES 2058156 T3 ES2058156 T3 ES 2058156T3 ES 88103564 T ES88103564 T ES 88103564T ES 88103564 T ES88103564 T ES 88103564T ES 2058156 T3 ES2058156 T3 ES 2058156T3
Authority
ES
Spain
Prior art keywords
polypeptide
plasmodium falciparum
immunological composition
polypeptides
merozoites
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88103564T
Other languages
English (en)
Inventor
Ulrich Dr Certa
Reiner Dr Gentz
Bela Dr Takacs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2058156T3 publication Critical patent/ES2058156T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

EL INVENTO SE REFIERE A UN POLIPEPTIDO CON UNA SECUENCIA AMINOACIDO DEL 190 KD QUE SE DERIVA DE UNA PRECURSOR DE ANTIGENO NUROCOICO SUPERFICIAL DE LOS K1 AISLANTES DE PLASMODIUM FALCIPARUM. ESTOS POLIPEPTIDOS SON CAPACES DE DAR RESPUESTAS INMUNES CONTRA AISLANTES DIFERENTES DEL PLASMODIUM FALCIPARUM. EL INVENTO SE REFIERE A DEMAS A UNA COMPOSICION INMUNOLOGICO Y VACUNA QUE CONTIENE EN U MAYOR PARTE EL POLIPEPTIDO DESCRITO. LA SECUENCIA DE DNA DEL POLIPEPTIDO ORIGINA ANTICUERPOS QUE CODIFICAN EN SU POLIPEPTIDO VECTORES MICROBIALES REPLICABLES QUE CONTIENEN LA SECUENCIA DNA Y UN MICROORGGANISMO QU SON TRANSFORMADOS POR UN VECTOR. ADEMAS EL INVENTO TRATA DE UN PROCEDIMIENTO PARA PREPARACION DE POLIPEPTIDOS, LA COMPOSICION INMUNOLOGICA, DE LOS MICROORGANISMOS Y LOS ANTICUERPOS DEL CONTEXTO ASI COMO LA APLICACION DE ESTE POLIPEPTIDO, COMPOSICION INMUNOLOGICA PARA INMUNIZAR LACTANTES CONTRA LA MALARIA.
ES88103564T 1987-03-19 1988-03-08 Peptidos del antigeno de merozoitos del plasmodium falciparum. Expired - Lifetime ES2058156T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878706599A GB8706599D0 (en) 1987-03-19 1987-03-19 Plasmodium falciparum merozoite antigen peptides

Publications (1)

Publication Number Publication Date
ES2058156T3 true ES2058156T3 (es) 1994-11-01

Family

ID=10614280

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88103564T Expired - Lifetime ES2058156T3 (es) 1987-03-19 1988-03-08 Peptidos del antigeno de merozoitos del plasmodium falciparum.

Country Status (17)

Country Link
US (1) US5238836A (es)
EP (1) EP0283829B1 (es)
JP (1) JP2567024B2 (es)
AT (1) ATE92526T1 (es)
AU (1) AU613344B2 (es)
DE (1) DE3882755D1 (es)
DK (1) DK84388A (es)
ES (1) ES2058156T3 (es)
GB (1) GB8706599D0 (es)
HU (1) HU211581A9 (es)
IE (1) IE62252B1 (es)
IL (1) IL85724A (es)
MY (1) MY103217A (es)
NZ (1) NZ223860A (es)
PH (1) PH25320A (es)
PT (1) PT87022B (es)
ZA (1) ZA881775B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225534A (en) * 1987-09-08 1993-07-06 Hoffmann-La Roche Inc. Recombinant malarial polypeptides
EP0309746A1 (de) * 1987-09-08 1989-04-05 F. Hoffmann-La Roche Ag Antimalaria-Vakzine
GB9002512D0 (en) * 1990-02-05 1990-04-04 3I Res Expl Ltd Polypeptides and dna encoding same
AUPO517897A0 (en) * 1997-02-19 1997-04-11 Csl Limited Chelating immunostimulating complexes
ZA981370B (en) * 1997-02-20 1998-09-07 Cerberus Developments Bv Method and apparatus for continuous flow isoelectric focusing for purifying biological substances
EP1754717A1 (en) * 2005-08-19 2007-02-21 Université de Lausanne Antigenic peptides and their use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK79985A (da) * 1984-02-22 1985-08-23 Wellcome Found Kloning af dna for protozoelle antigener og dets anvendelse
US4569794A (en) * 1984-12-05 1986-02-11 Eli Lilly And Company Process for purifying proteins and compounds useful in such process
EP0254862A1 (en) * 1986-06-26 1988-02-03 BEHRINGWERKE Aktiengesellschaft Vaccines against protozoan parasites
US4735799A (en) * 1987-01-14 1988-04-05 Patarroyo Manuel E Malaria vaccine
CA1340522C (en) * 1987-03-10 1999-05-04 Heinz Dobeli Fusion proteins containing neighbouring histidines for improved purification

Also Published As

Publication number Publication date
US5238836A (en) 1993-08-24
DK84388A (da) 1988-09-20
PH25320A (en) 1991-04-30
DK84388D0 (da) 1988-02-18
PT87022A (pt) 1988-04-01
IL85724A0 (en) 1988-08-31
AU1307788A (en) 1988-09-22
HU211581A9 (en) 1995-12-28
MY103217A (en) 1993-05-29
GB8706599D0 (en) 1987-04-23
IL85724A (en) 1994-11-28
NZ223860A (en) 1991-05-28
AU613344B2 (en) 1991-08-01
ATE92526T1 (de) 1993-08-15
IE62252B1 (en) 1995-01-11
PT87022B (pt) 1992-06-30
JP2567024B2 (ja) 1996-12-25
ZA881775B (en) 1988-09-19
JPS63275599A (ja) 1988-11-14
IE880809L (en) 1988-09-19
DE3882755D1 (de) 1993-09-09
EP0283829B1 (de) 1993-08-04
EP0283829A1 (de) 1988-09-28

Similar Documents

Publication Publication Date Title
KR950702839A (ko) 레트로, 인버소-, 및 레트로- 인버소 합성 펩티드 유사체(retro-, inverso-, and retro-inverso synthetic peptide analogues)
ES2091861T3 (es) Proteinas antigenicas y vacunas que las contienen para la prevencion de la coccidiosis.
GB2143830A (en) Expression of plasmodium falciparum polypeptides from cloned cdna
KR890004730A (ko) G_7rh에 대한 면역반응을 유발시키고 포유동물을 면역 불임시키기 위한 제제 및 방법
ES2058156T3 (es) Peptidos del antigeno de merozoitos del plasmodium falciparum.
SJÖLANDER et al. Immunogenicity in rabbits and monkeys of influenza ISCOMs conjugated with repeated sequences of the Plasmodium falciparum antigen Pf155/RESA
ES2006730A6 (es) Un metodo de preparar un peptido o polipeptido sintetico que presenta la antigenicidad de la totalidad o una parte de un antigeno de p. falciparum
BR9709993A (pt) Vacina preparação de vacina composição processo para produção de uma preparação imugênica e preparação imugênica
BR9604989A (pt) Polipeptídeos modificados para imunogenicidade aperfeiçoada e processo de sua produção
Hoffman et al. Plasmodium falciparum: sporozoite boosting of immunity due to a T-cell epitope on a sporozoite vaccine
MY102593A (en) Antigents of plasmodium falciparum
ATE94208T1 (de) Eimeria tenella-vakzin.
Bastian et al. Characterization of a reduced peptide bond analogue of a promiscuous CD4 T cell epitope derived from the Plasmodium falciparum malaria vaccine candidate merozoite surface protein 1
MY106275A (en) Plasmodium merozoite rhoptries antigen and derivatives thereof.
EP0392820A3 (en) Plasmodium circumsporozoite protein analogs lacking repeat sequences
IT1233419B (it) Peptidi sintetici immunologicamente attivi utili per la preparazione di un vaccino antimalaria
KR900701831A (ko) 열대열 말라리아 원충의 분열소체 표면 항원의 대립형질 변이주
ES2055783T3 (es) Peptidos sinteticos, inmunologicamente activos, utiles para la preparacion de vacunas contra la malaria.
ATE99955T1 (de) Als anti-malaria-impfstoff verwendbares immunologisch aktives peptidkonjugat ppd-(nanp)n.
TH4338A (th) พลาสโมเดียม ฟาลซิพารุมที่ไร้เพศระยะซึ่งอยู่ในเลือด
MY106940A (en) Allelic variants of plasmodium falciparum merozoite surface antigen.
GB2244273A (en) Allelic variants of plasmodium falciparum merozoite surface antigen.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 283829

Country of ref document: ES